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Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie

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25.06.2021 | Original Article

Assessment of salivary stress and pain biomarkers and their relation to self-reported pain intensity during orthodontic tooth movement: a longitudinal and prospective study

verfasst von: Associate Professor Nehir Canigur Bavbek, DDS, PhD, Erdal Bozkaya, DDS, PhD, Associate Professor Sila Cagri Isler, DDS, PhD, Sehri Elbeg, MD, PhD, Associate Professor Ahu Uraz, DDS, PhD, Professor Sema Yuksel, DDS, PhD

Erschienen in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie | Ausgabe 5/2022

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Abstract

Purpose

The aim of this prospective study was to evaluate the relationship between pain intensity and concentrations of salivary pain and stress biomarkers during orthodontic tooth movement.

Methods

Eighteen patients (8 males, 10 females; mean age 14.57 ± 2.39 years) who needed orthodontic treatment with maxillary premolar extraction and segmental canine distalization participated in this study. Baseline samples were collected (T1), and orthodontic attachments were placed to maxillary first molars, second premolars, and canines. Then extractions were performed. After 1‑month follow-up, canine distalization started with a segmental wire (T2). Concentrations of salivary α‑amylase (sAA), cortisol, secretory immunoglobulin A (sIgA) and chromogranin A (CgA) were examined at T1, T2, and on days 4 (T3), 7 (T4), 14 (T5), and 30 (T6) after starting retraction. Participants also scored their pain on a visual analogue scale (VAS). Pain catastrophizing behavior and dental anxiety levels of the participants were evaluated by the Pain Catastrophizing Scale (PCS) and Corah’s Dental Anxiety Scale (C-DAS), respectively. Repeated measure ANOVA, Mann–Whitney U test and Spearman’s rank correlation coefficient analysis were used for statistical evaluations (p < 0.05).

Results

The maximum values for sAA were seen at T1. Males had higher sAA levels than females with statistical differences at T1, T3, and T4. No significant differences for cortisol, sIgA, and CgA concentrations were observed. The highest mean VAS score was recorded at T3. No correlations were detected between any salivary biomarkers, VAS, C‑DAS, and PCS scores.

Conclusions

The stress of starting orthodontic treatment increased sAA levels more than the pain that was experienced during orthodontic tooth movement. Being male was a predictor of higher sAA concentrations. Orthodontic tooth movement did not cause significant alterations in salivary pain and stress biomarkers.

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Titel: Assessment of salivary stress and pain biomarkers and their relation to self-reported pain intensity during orthodontic tooth movement: a longitudinal and prospective study
verfasst von: Associate Professor Nehir Canigur Bavbek, DDS, PhD
Erdal Bozkaya, DDS, PhD
Associate Professor Sila Cagri Isler, DDS, PhD
Sehri Elbeg, MD, PhD
Associate Professor Ahu Uraz, DDS, PhD
Professor Sema Yuksel, DDS, PhD
Publikationsdatum: 25.06.2021
Verlag: Springer Medizin
Erschienen in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie / Ausgabe 5/2022
Print ISSN: 1434-5293
Elektronische ISSN: 1615-6714
DOI: https://doi.org/10.1007/s00056-021-00311-4

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Assessment of salivary stress and pain biomarkers and their relation to self-reported pain intensity during orthodontic tooth movement: a longitudinal and prospective study

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