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Allergo Journal
Erschienen in: Allergo Journal 4/2022

20.06.2022 | Pneumologie | Übersicht

Epithelial barrier hypothesis and the development of allergic and autoimmune diseases

verfasst von: Duygu Yazici, Ismail Ogulur, Ozan Kucukkase, Manru Li, Arturo O. Rinaldi, Yagiz Pat, Alexandra Wallimann, Sebastian Wawrocki, Zeynep Celebi Sozener, Betul Buyuktiryaki, Cansin Sackesen, Mubeccel Akdis, Yasutaka Mitamura, Cezmi Akdis

Erschienen in: Allergo Journal | Ausgabe 4/2022

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Abstract

The "epithelial barrier hypothesis" proposes that genetic predisposition to epithelial barrier damage, exposure to various epithelial barrier-damaging agents and chronic periepithelial inflammation are responsible for the development of allergic and autoimmune diseases. Particularly, the introduction of more than 200,000 new chemicals to our daily lives since the 1960s has played a major role in the pandemic increase of these diseases. The epithelial barrier constitutes the first line of physical, chemical, and immunological defence against external factors. A leaky epithelial barrier initiates the translocation of the microbiome from the surface of affected tissues to interepithelial and even deeper subepithelial areas. In tissues with a defective epithelial barrier, colonization of opportunistic pathogens, decreased microbiota biodiversity, local inflammation, and impaired regeneration and remodelling takes place. A dysregulated immune response against commensals and opportunistic pathogens starts. Migration of inflammatory cells to other tissues and their contribution to tissue injury and inflammation in the affected tissues are key events in the development and exacerbation of many chronic inflammatory diseases. Understanding the underlying factors that affect the integrity of epithelial barriers is essential to find preventive measures or effective treatments to restore its function. The aim of this review is to assess the origins of allergic and autoimmune diseases within the framework of the epithelial barrier hypothesis.
Cite this as Yazici D, Ogulur I, Kucukkase O, Li M, Rinaldi AO, Pat Y, Wallimann A, Wawrocki S, Sozener ZC, Buyuktiryaki B, Sackesen C, Akdis M, Mitamura Y, Akdis CA. Epithelial barrier hypothesis and the development of allergic and autoimmune diseases. Allergo J Int 2022;31:91-102
https://​doi.​org/​10.​1007/​s40629-022-00211-y
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Metadaten
Titel
Epithelial barrier hypothesis and the development of allergic and autoimmune diseases
verfasst von
Duygu Yazici
Ismail Ogulur
Ozan Kucukkase
Manru Li
Arturo O. Rinaldi
Yagiz Pat
Alexandra Wallimann
Sebastian Wawrocki
Zeynep Celebi Sozener
Betul Buyuktiryaki
Cansin Sackesen
Mubeccel Akdis
Yasutaka Mitamura
Cezmi Akdis
Publikationsdatum
20.06.2022
Verlag
Springer Medizin
Erschienen in
Allergo Journal / Ausgabe 4/2022
Print ISSN: 0941-8849
Elektronische ISSN: 2195-6405
DOI
https://doi.org/10.1007/s15007-022-5033-8

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Umfrage: Topika mit Dexpanthenol bei Radiodermatitis empfohlen

In der topischen Prävention der akuten Radiodermatitis werden Zubereitungen mit Dexpanthenol oder Harnstoff von deutschsprachigen Fachkreisen in der Radioonkologie am häufigsten empfohlen und als am wirksamsten bewertet. Bei der Behandlung der strahlenbedingten Hautschäden liegen Topika mit Dexpanthenol oder Kortikosteroide vorn [1]. 

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Handekzem: Adhärenz bei topischer Therapie nicht zufriedenstellend

Einer klinischen Studie zufolge wendet nur etwa die Hälfte der Ekzem-Patient:innen ihre topische Therapie mit Kortikosteroiden wie verordnet an. Darüber hinaus nahm die Adhärenz im Zeitverlauf weiter ab. Bei einer gleichzeitig applizierten barrierestabilisierenden Basiscreme blieb die Anwendungsfrequenz dagegen über die Zeit stabil [1]. 

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Bepanthen® unterstützt bei vielen Indikationen die Regeneration der Haut

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Bepanthen® Wund- und Heilsalbe wird heute wie bei der Einführung vor 70 Jahren erfolgreich bei kleinen Alltagsverletzungen eingesetzt. Moderne Forschung – Untersuchungen an Hautmodellen, Genexpressionsanalysen und klinische Studien – schafft darüber hinaus Evidenz für neue Anwendungsgebiete. So kann die Dexpanthenol-haltige Salbe heute z.B. zur Nachbehandlung einer Lasertherapie bei aktinischer Keratose oder Tattoo-Entfernung eingesetzt werden. Erfahren Sie hier mehr über moderne Forschung zu Bepanthen.

Bayer Vital GmbH

Weitere Lesetipps

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Dexpanthenol verstärkt die positiven Effekte der LASH-Methode

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Im Dialog mit jungen Dermatologen: Wund- und Narbenversorgung in der Praxis

Zeitdieben in der Praxis den Kampf ansagen

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Erfolgreiche Therapie von hypertrophen Narben und Keloiden

Versorgung von Menschen mit spastischer Bewegungsstörung nach Schlaganfall

Diagnose und Differenzierung von kutanen Zysten mit optischer Kohärenztomographie: eine Fallserie

Passend zum Thema

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Die entscheidende Rolle des Mikrobioms bei atopischer Dermatitis

Bei atopischer Dermatitis besteht eine direkte Korrelation des Schweregrad der Erkrankung und einer verminderten Diversität des Mikrobioms. Studiendaten zeigen, dass durch eine Behandlung mit Emollienzien plus, die Besiedelung mit Staphylokokken reduziert und das Mikrobiom stabilisiert werden kann.

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Welche Bedeutung hat das Mikrobiom bei Wundheilung und AD?

Warum hat das Mikrobiom der Haut in den letzten Jahren in der Wissenschaft an enormer Bedeutung gewonnen? Welche Möglichkeiten ergeben sich dadurch für die Behandlung bei Hautkrankheiten wie atopischer Dermatitis und der Wundheilung? Dies erläutert Prof. Thomas Luger im Interview.

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Neueste Erkenntnisse zum Hautmikrobiom: vier Experten im Gespräch

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Die Experten Prof. Luger (Münster), Prof. Zuberbier (Berlin), Prof. Thaçi (Lübeck) und PD Dr. Jansen (Essen) erörtern im von La Roche Posay unterstützen Expertenworkshop die Bedeutung des Mikrobioms für verschiedene Hautkrankheiten wie atopische Dermatitis, Akne oder Rosazea.

La Roche Posay
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