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Erschienen in: Archives of Osteoporosis 1/2022

01.12.2022 | Original Article

Bone mineral density, nutrient intake, and physical activity among young women from Uganda

verfasst von: Renee Heffron, Timothy R. Muwonge, Jade Boyer, Flavia Matovu, Yasaman Zia, Monica Bagaya, Timothy Ssebuliba, Susan Morrison, Felix Bambia, Rogers Nsubuga, Josephine Badaru, Gabrielle Stein, Kenneth K. Mugwanya, Christina Wyatt, Jared M. Baeten, Michael T. Yin, Andrew Mujugira, for the Kampala Women’s Bone Study Team

Erschienen in: Archives of Osteoporosis | Ausgabe 1/2022

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Abstract

Summary

Few studies have characterized bone mineral density (BMD) among health young African women. In our study of 496 Ugandan women age ≤25 years, we found that women had healthy BMD that were lower on average than the standard reference ranges. Reference ranges available for BMD measurements need greater precision.

Purpose

Data describing bone mineral density (BMD), nutrient intake, and body composition among healthy, young women in sub-Saharan Africa are limited. Using baseline data from a cohort of young, healthy Ugandan women, we summarize bone health and associated risk factors for reduced bone mass.

Methods

Using baseline data from Ugandan women ages 16–25 years who enrolled in an ongoing cohort study of bone health with concurrent use of injectable contraception and oral HIV pre-exposure prophylaxis, we describe the distribution of BMD, nutrient intake, physical activity, and body composition. The association of low BMD (1 or more standard deviations below the age, sex, and race-matched reference range from the USA) and calcium intake, vitamin D intake, physical activity, and body composition was estimated using multivariable logistic regression.

Results

In 496 healthy, Ugandan women with median age of 20 years (interquartile range [IQR] 19–21) and median fat:lean mass ratio of 0.55 (IQR 0.46–0.64), median lumbar spine and total hip BMD was 0.9g/cm2 (IQR 0.9–1.0) each. For lumbar spine, Z-score distributions were lower overall than the reference population and 9.3% and 36.3% of women had Z-score >2 and >1 standard deviations below the reference range, respectively. For total hip, Z-scores were similar to the reference population and 1.0% and 12.3% of women had Z-score >2 and >1 standard deviations below the reference range, respectively. In the week prior to enrollment, 41.1% of women consumed >7 servings of calcium, 56.5% had >7 servings of vitamin D, and 98.6% reported ≥2.5 h of physical activity. Having greater body fat was associated with greater frequency of low lumbar spine BMD (p<0.01 for fat:lean mass ratio, total body fat percentage, waist circumference, and BMI).

Conclusion

Young Ugandan women exhibited healthy levels of BMD that were lower than the reference range population.
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Metadaten
Titel
Bone mineral density, nutrient intake, and physical activity among young women from Uganda
verfasst von
Renee Heffron
Timothy R. Muwonge
Jade Boyer
Flavia Matovu
Yasaman Zia
Monica Bagaya
Timothy Ssebuliba
Susan Morrison
Felix Bambia
Rogers Nsubuga
Josephine Badaru
Gabrielle Stein
Kenneth K. Mugwanya
Christina Wyatt
Jared M. Baeten
Michael T. Yin
Andrew Mujugira
for the Kampala Women’s Bone Study Team
Publikationsdatum
01.12.2022
Verlag
Springer London
Erschienen in
Archives of Osteoporosis / Ausgabe 1/2022
Print ISSN: 1862-3522
Elektronische ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-022-01155-0

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