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Erschienen in:
14.07.2021 | Experimental Study
Bromelain-ferula gum-loaded polyurethane nanofibers for bedsore healing in rats
Erschienen in: European Journal of Plastic Surgery | Ausgabe 5/2021
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Background
Designing and preparing new dressing are encouraged to repair wounds in the hospitalized patients. In the present study, a new sandwich configuration, the polyurethane-polyvinyl alcohol (PU-PVA) dressing containing ferula gum (Fg) and bromelain (Br), was prepared with antibacterial property for bedsore treating.
Methods
PVA nanofibers containing bromelain were contained between two adjacent layers of the PU nanofibers containing Fg. Ischemia–reperfusion (I/R) injury was induced to the back region of rats on the left shoulder by five cycles per day for 5 days. The synthesized dressing was used for 10 days and was exchanged each day.
Results
According to the histological images using H&E staining method, the epidermal and dermal damages, bleeding and infiltration of monocytes, and neutrophils were observed in the PVA-Br and PU-Fg groups. The granulation, infiltration, bleeding, and inflammation were significantly decreased in the PU-F/PVA-Br/PU-Fg group. This group had more regular collagen fibers than the other groups, and the tissue was seemed to be the negative control group. The sore area in the PU-F/PVA-Br/PU-Fg group was significantly decreased compared with the other groups (p < 0.001).
Conclusions
The prepared dressing containing Br and Fg showed the healing properties in the skin of rats with bedsores. There is a need to test the synthesized dressing in the clinical setting to reach an effective result.
Level of evidence: Not ratable.