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08.02.2024 | Research

Burden of Candida-related vascular graft infection: a nested-case control study

verfasst von: Thomas Caulier, Eric Senneville, Jonathan Sobocinski, Olivier Leroy, Pierre Patoz, Nicolas Blondiaux, Hugues Georges, Delannoy Pierre-Yves, PierVito d’Elia, Olivier Robineau

Erschienen in: Infection

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Abstract

Purpose

We aimed to assess risk factors of candida-related Vascular Graft Infections (VGIs).

Methods

We did a case–control study (1:4) matched by age and year of infection, nested in a cohort of patient with a history of VGIs. Cases were defined by a positive culture for Candida spp. in biological samples and controls were defined by a positive culture for bacterial strains only in biological samples. Risk factors for Candida-related VGIs were investigated using multivariate logistic regression. Mortality were compared using survival analysis.

Results

16 Candida-related VGIs were matched to 64 bacterial-related VGIs. The two groups were comparable regarding medical history and clinical presentation. Candida-related VGIs were associated with bacterial strains in 88% (14/16). Gas/fluid-containing collection on abdominal CT scan and the presence of an aortic endoprosthesis were risk factors for Candida spp.-related VGIs [RRa 10.43 [1.81–60.21] p = 0.009 RRa and 6.46 [1.17–35.73] p = 0.03, respectively]. Candida-related VGIs were associated with a higher mortality when compared to bacterial-related VGIs (p = 0.002).

Conclusions

Candida-related VGIs are severe. Early markers of Candida spp. infection are needed to improve their outcome. The suspicion of aortic endoprosthesis infection may necessitate probabilistic treatment with antifungal agents.
Literatur
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Zurück zum Zitat Schoell T, Manceau G, Chiche L, Gaudric J, Gibert H, Tresallet C, et al. Surgery for secondary aorto-enteric fistula or erosion (SAEFE) complicating aortic graft replacement: a retrospective analysis of 32 patients with particular focus on digestive management. World J Surg. 2015;39:283–91. https://doi.org/10.1007/s00268-014-2750-5.CrossRefPubMed Schoell T, Manceau G, Chiche L, Gaudric J, Gibert H, Tresallet C, et al. Surgery for secondary aorto-enteric fistula or erosion (SAEFE) complicating aortic graft replacement: a retrospective analysis of 32 patients with particular focus on digestive management. World J Surg. 2015;39:283–91. https://​doi.​org/​10.​1007/​s00268-014-2750-5.CrossRefPubMed
Metadaten
Titel
Burden of Candida-related vascular graft infection: a nested-case control study
verfasst von
Thomas Caulier
Eric Senneville
Jonathan Sobocinski
Olivier Leroy
Pierre Patoz
Nicolas Blondiaux
Hugues Georges
Delannoy Pierre-Yves
PierVito d’Elia
Olivier Robineau
Publikationsdatum
08.02.2024
Verlag
Springer Berlin Heidelberg
Erschienen in
Infection
Print ISSN: 0300-8126
Elektronische ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-023-02172-y

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