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Erschienen in:

01.08.2008

Caffeinated Coffee Blunts the Myocardial Protective Effects of Statins against Ischemia–Reperfusion Injury in the Rat

verfasst von: Yumei Ye, Ghassan H. Abu Said, Yu Lin, Saraswathy Manickavasagam, Michael G. Hughes, David J. McAdoo, Regino J. Perez-Polo, Yochai Birnbaum

Erschienen in: Cardiovascular Drugs and Therapy | Ausgabe 4/2008

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Abstract

Purpose

We asked whether caffeinated coffee (CC) blunts the infarct size (IS)-limiting effects of atorvastatin (ATV).

Background

Adenosine receptor activation is essential for mediating the IS-limiting effects of statins. Caffeine is a nonspecific adenosine receptor blocker, and thus drinking CC may block the myocardial protective effects of statins.

Methods

Rat received 3-day ATV (10 mg/kg/day) or water by oral gavage once daily. Drinking water was replaced by water + sugar (7.5 g/100 ml), CC with sugar, or decaffeinated coffee (DC) with sugar. On the 4th day, rats were anesthetized and underwent 30 min of coronary artery occlusion and 4 h reperfusion. Area at risk was assessed by blue dye and infarct size by TTC.

Results

Body weight and area at risk was comparable among groups. IS was 25.1 ± 3.9% of the area at risk in the control group. In rats not receiving ATV, CC (25.5 ± 3.1%) and DC (34.0 ± 2.8%) did not affect IS. IS was significantly reduced by ATV in the water + sugar (11.7 ± 0.7%, p = 0.015) and DC (11.5 ± 1.0%; p < 0.001) groups, but not in the CC group (32.3 ± 3.0%; p = 0.719). ATV increased myocardial levels of Ser-473 phosphorylated Akt in the water + sugar and DC groups, but not in the CC group.

Conclusions

CC, but not DC, abrogated the IS-limiting effects of ATV by blocking the adenosine receptors and preventing the phosphorylation of Akt. CC did not affect IS in rats not receiving ATV.
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Metadaten
Titel
Caffeinated Coffee Blunts the Myocardial Protective Effects of Statins against Ischemia–Reperfusion Injury in the Rat
verfasst von
Yumei Ye
Ghassan H. Abu Said
Yu Lin
Saraswathy Manickavasagam
Michael G. Hughes
David J. McAdoo
Regino J. Perez-Polo
Yochai Birnbaum
Publikationsdatum
01.08.2008
Verlag
Springer US
Erschienen in
Cardiovascular Drugs and Therapy / Ausgabe 4/2008
Print ISSN: 0920-3206
Elektronische ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-008-6105-z

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