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Erschienen in: Herz 1/2021

29.08.2019 | Original articles

Case-control study on the association between the GATA2 gene and premature myocardial infarction in the Iranian population

verfasst von: Peyman Izadpanah, Ehsan Khabbzi, Saiedeh Erfanian, Simin Jafaripour, Mohammad Shojaie

Erschienen in: Herz | Ausgabe 1/2021

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Abstract

In recent decades, due to the high prevalence of coronary artery disease (CAD) and myocardial infarction (MI), numerous studies have attempted to elucidate genetic contributing factors in these complex disorders. A very interesting gene in this regard is GATA-binding protein 2 (GATA2), an important regulator of various gene expressions in vascular endothelial cells. Accordingly, the association of different GATA2 polymorphisms with CAD and MI has already been evaluated. Rs2713604 is a genetic marker whose association with CAD has not been reproduced in previous studies. Considering the importance of replicating the initial association, the present case-control study aimed to examine the association of this intronic variant with premature MI in a sample of the Iranian population. In this study, 193 participants from Jahrom Hospital (Jahrom, Iran) were consecutively recruited during a 1.5-year period, and, following blood sampling, genomic DNA was extracted. We then proceeded to genotype rs2713604 using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and statistically analyzed the data. After adjustment for hyperlipidemia, hypertension, and type 2 diabetes mellitus, the results of the multivariate regression analysis showed no significant association between rs2713604 and premature MI. Interestingly, the risk allele (A-allele) of rs2713604 displayed a slightly higher frequency among controls compared to cases.
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Metadaten
Titel
Case-control study on the association between the GATA2 gene and premature myocardial infarction in the Iranian population
verfasst von
Peyman Izadpanah
Ehsan Khabbzi
Saiedeh Erfanian
Simin Jafaripour
Mohammad Shojaie
Publikationsdatum
29.08.2019
Verlag
Springer Medizin
Erschienen in
Herz / Ausgabe 1/2021
Print ISSN: 0340-9937
Elektronische ISSN: 1615-6692
DOI
https://doi.org/10.1007/s00059-019-04841-x

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