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16.04.2021 | Review Article

Cilostazol: a Review of Basic Mechanisms and Clinical Uses

verfasst von: Riyad Y. Kherallah, Muzamil Khawaja, Michael Olson, Dominick Angiolillo, Yochai Birnbaum

Erschienen in: Cardiovascular Drugs and Therapy | Ausgabe 4/2022

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Abstract

Primarily used in the treatment of intermittent claudication, cilostazol is a 2-oxyquinolone derivative that works through the inhibition of phosphodiesterase III and related increases in cyclic adenosine monophosphate (cAMP) levels. However, cilostazol has been implicated in a number of other basic pathways including the inhibition of adenosine reuptake, the inhibition of multidrug resistance protein 4, among others. It has been observed to exhibit antiplatelet, antiproliferative, vasodilatory, and ischemic-reperfusion protective properties. As such, cilostazol has been investigated for clinical use in a variety of settings including intermittent claudication, as an adjunctive for reduction of restenosis after coronary and peripheral endovascular interventions, and in the prevention of secondary stroke, although its widespread implementation for indications other than intermittent claudication has been limited by relatively modest effect sizes and lack of studies in western populations. In this review, we highlight the pleiotropic effects of cilostazol and the evidence for its clinical use.
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Metadaten
Titel
Cilostazol: a Review of Basic Mechanisms and Clinical Uses
verfasst von
Riyad Y. Kherallah
Muzamil Khawaja
Michael Olson
Dominick Angiolillo
Yochai Birnbaum
Publikationsdatum
16.04.2021
Verlag
Springer US
Erschienen in
Cardiovascular Drugs and Therapy / Ausgabe 4/2022
Print ISSN: 0920-3206
Elektronische ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-021-07187-x

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