nach oben

Lasers in Medical Science

Erschienen in:

17.10.2020 | Original Article

Comparison of low-level light therapy and combination therapy of 5% minoxidil in the treatment of female pattern hair loss

verfasst von: Yang Liu, Lin-lang Jiang, Fang Liu, Qian Qu, Zhe-xiang Fan, Zhi Guo, Yong Miao, Zhi-qi Hu

Erschienen in: Lasers in Medical Science | Ausgabe 5/2021

Einloggen, um Zugang zu erhalten

Abstract

This study was conducted in order to compare the safety and efficacy of LLLT, 5% minoxidil, and combination therapy in the treatment of FPHL. A randomized controlled trial was developed to study the effect of LLLT on FPHL using a device called iHelmet®, which is equipped with 200 5mW laser diode source (650 nm) arrays. Ninety Ludwig’s types II–III FPHL patients were randomly divided into 3 groups: LLLT group (A), 5% minoxidil group (B), and combination group(C). Hair density, hair diameter, and scalp oil-secretion were detected to evaluate the treatment effect. Significant improvement of hair density and hair diameter was observed in all stages of FPHL after treatment. Oil-secretion of the three groups was decreased after treatment. The effectiveness of reducing oil-secretion in LLLT group and combination group was higher than minoxidil group (P < 0.05). For improving hair diameter and hair density, combination group was better than LLLT and minoxidil groups. No side effects were reported. Our study illustrated that LLLT is a safe and effective treatment for FPHL. Besides, LLLT can significantly improve its efficacy when used in combination with 5% minoxidil.

Gordon KA, Tosti A (2011) Alopecia: evaluation and treatment. Clin Cosmet Investig Dermatol 4:101–106CrossRef

Chan L, Cook DK (2018) Female pattern hair loss. Aust J Gen Pract 47(7):459–464CrossRef

Manabe M, Tsuboi R, Itami S et al (2018) Guidelines for the diagnosis and treatment of male-pattern and female-pattern hair loss, 2017 version. J Dermatol 45(9):1031–1043CrossRef

Poonia K, Thami GP, Bhalla M, Jaiswal S, Sandhu J (2019) Nonscarring diffuse hair loss in women: a clinico-etiological study from tertiary care center in North-West India. J Cosmet Dermatol 18(1):401–407CrossRef

Davis DS, Callender VD (2018) Review of quality of life studies in women with alopecia. Int J Womens Dermatol 4(1):18–22CrossRef

Mester E, Ludany G, Sellyei M et al (1968) Studies on the inhibiting and activating effects of laser beams. Langenbecks Arch Chir 322:1022–1027CrossRef

Barikbin B, Khodamrdi Z, Kholoosi L et al (2017) Comparison of the effects of 665 nm low level diode Laser Hat versus and a combination of 665 nm and 808nm low level diode Laser Scanner of hair growth in androgenic alopecia. J Cosmet Laser Ther

Esmat SM, Hegazy RA, Gawdat HI et al (2017) Low level light-minoxidil 5% combination versus either therapeutic modality alone in management of female patterned hair loss: a randomized controlled study. Lasers Surg Med 49(9):835–843CrossRef

Friedman S, Schnoor P (2017) Novel approach to treating androgenetic alopecia in females with photobiomodulation (low-level laser therapy). Dermatol Surg 43(6):856–867CrossRef

10.

Blum K, Han D, Madigan MA, Lohmann R, Braverman ER (2014) “Cold” X5 Hairlaser used to treat male androgenic alopecia and hair growth: an uncontrolled pilot study. BMC Res Notes 7:103CrossRef

11.

Jimenez JJ, Wikramanayake TC, Bergfeld W et al (2014) Efficacy and safety of a low-level laser device in the treatment of male and female pattern hair loss: a multicenter, randomized, sham device-controlled, double-blind study. Am J Clin Dermatol 15(2):115–127CrossRef

12.

Lanzafame RJ, Blanche RR, Chiacchierini RP, Kazmirek ER, Sklar JA (2014) The growth of human scalp hair in females using visible red light laser and LED sources. Lasers Surg Med 46(8):601–607CrossRef

13.

Munck A, Gavazzoni MF, Trueb RM (2014) Use of low-level laser therapy as monotherapy or concomitant therapy for male and female androgenetic alopecia. Int J Trichol 6(2):45–49CrossRef

14.

Kim H, Choi JW, Kim JY et al (2013) Low-level light therapy for androgenetic alopecia: a 24-week, randomized, double-blind, sham device-controlled multicenter trial. Dermatol Surg 39(8):1177–1183CrossRef

15.

Lanzafame RJ, Blanche RR, Bodian AB et al (2013) The growth of human scalp hair mediated by visible red light laser and LED sources in males. Lasers Surg Med 45(8):487–495CrossRef

16.

Leavitt M, Charles G, Heyman E, Michaels D (2009) HairMax LaserComb laser phototherapy device in the treatment of male androgenetic alopecia: a randomized, double-blind, sham device-controlled, multicentre trial. Clin Drug Investig 29(5):283–292CrossRef

17.

Avram MR, Rogers NE (2009) The use of low-level light for hair growth: part I. J Cosmet Laser Ther. 11(2):110–117CrossRef

18.

Avram MR, Leonard RJ, Epstein ES, Williams JL, Bauman AJ (2007) The current role of laser/light sources in the treatment of male and female pattern hair loss. J Cosmet Laser Ther. 9(1):27–28CrossRef

19.

Zhang T, Liu L, Fan J et al (2017) Low-level laser treatment stimulates hair growth via upregulating Wnt10b and beta-catenin expression in C3H/HeJ mice. Lasers Med Sci 32(5):1189–1195CrossRef

20.

Kim JE, Woo YJ, Sohn KM, Jeong KH, Kang H (2017) Wnt/beta-catenin and ERK pathway activation: a possible mechanism of photobiomodulation therapy with light-emitting diodes that regulate the proliferation of human outer root sheath cells. Lasers Surg Med 49(10):940–947CrossRef

21.

Wikramanayake TC, Rodriguez R, Choudhary S et al (2012) Effects of the Lexington LaserComb on hair regrowth in the C3H/HeJ mouse model of alopecia areata. Lasers Med Sci 27(2):431–436CrossRef

22.

Ghanaat M (2010) Types of hair loss and treatment options, including the novel low-level light therapy and its proposed mechanism. South Med J 103(9):917–921CrossRef

23.

Rasheed H, Mahgoub D, Hegazy R et al (2013) Serum ferritin and vitamin d in female hair loss: do they play a role? Skin Pharmacol Physiol 26(2):101–107CrossRef

24.

Olsen EA, Whiting DA, Savin R et al (2012) Global photographic assessment of men aged 18 to 60 years with male pattern hair loss receiving finasteride 1 mg or placebo. J Am Acad Dermatol 67(3):379–386CrossRef

25.

Eells JT, Wong-Riley MT, VerHoeve J et al (2004) Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy. Mitochondrion. 4(5–6):559–567CrossRef

26.

Chung H, Dai T, Sharma SK et al (2012) The nuts and bolts of low-level laser (light) therapy. Ann Biomed Eng 40(2):516–533CrossRef

27.

Lohr NL, Keszler A, Pratt P et al (2009) Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: potential role in cardioprotection. J Mol Cell Cardiol 47(2):256–263CrossRef

28.

Makihara E, Masumi S (2008) Blood flow changes of a superficial temporal artery before and after low-level laser irradiation applied to the temporomandibular joint area. Nihon Hotetsu Shika Gakkai Zasshi 52(2):167–170CrossRef

29.

Kure K, Isago T, Hirayama T (2015) Changes in the sebaceous gland in patients with male pattern hair loss (androgenic alopecia). J Cosmet Dermatol 14(3):178–184CrossRef

30.

Lattanand A, Johnson WC (1975) Male pattern alopecia a histopathologic and histochemical study. J Cutan Pathol 2(2):58–70CrossRef

31.

Heilmann S, Kiefer AK, Fricker N et al (2013) Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology. J Invest Dermatol. 133(6):1489–1496CrossRef

32.

Leiros GJ, Attorresi AI, Balana ME (2012) Hair follicle stem cell differentiation is inhibited through cross-talk between Wnt/beta-catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia. Br J Dermatol 166(5):1035–1042CrossRef

33.

Kretzschmar K, Cottle DL, Schweiger PJ, Watt FM (2015) The androgen receptor antagonizes Wnt/beta-catenin signaling in epidermal stem cells. J Invest Dermatol 135(11):2753–2763CrossRef

34.

Joo HJ, Jeong KH, Kim JE, Kang H (2017) Various wavelengths of light-emitting diode light regulate the proliferation of human dermal papilla cells and hair follicles via Wnt/beta-catenin and the extracellular signal-regulated kinase pathways. Ann Dermatol 29(6):747–754CrossRef

35.

Liu B, Chen X, Yi H et al (2017) beta-Catenin is involved in oleanolic acid-dependent promotion of proliferation in human hair matrix cells in an in vitro organ culture model. Fitoterapia 121:136–140CrossRef

36.

Gupta AK, Charrette A (2015) Topical minoxidil: systematic review and meta-analysis of its efficacy in androgenetic alopecia. Skinmed. 13(3):185–189PubMed

37.

Gupta AK, Foley KA (2014) 5% minoxidil: treatment for female pattern hair loss. Skin Therapy Lett 19(6):5–7PubMed

38.

Blume-Peytavi U, Hillmann K, Dietz E, Canfield D, Garcia BN (2011) A randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women. J Am Acad Dermatol 65(6):1126–1134.e2CrossRef

39.

Badri T, Kumar DD (2019) Minoxidil. Reactions Weekly 1778:309. https://doi.org/10.1007/s40278-019-71112-6

40.

Lee IJ, Jung JH, Lee YR, Kim JC, Hwang ST (2016) Guidelines on hair restoration for East Asian patients. Dermatol Surg 42(7):883–892CrossRef

Titel: Comparison of low-level light therapy and combination therapy of 5% minoxidil in the treatment of female pattern hair loss
verfasst von: Yang Liu
Lin-lang Jiang
Fang Liu
Qian Qu
Zhe-xiang Fan
Zhi Guo
Yong Miao
Zhi-qi Hu
Publikationsdatum: 17.10.2020
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 5/2021
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-020-03157-1

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2021

Nonsurgical periodontal therapy with/without 980 nm diode laser in patients after myocardial infarction: a randomized clinical trial

Reflectance confocal microscopy evaluation of pigmented lesions on tattooed skin

Effect of platelet-rich plasma on healing in laser pilonidoplasty for pilonidal sinus disease

Deciphering the molecular effects of non-ablative Er:YAG laser treatment in an in vitro model of the non-keratinized mucous membrane

Effect of 940 nm laser diode irradiation prior to bonding procedure on postoperative sensitivity following class II composite restorations: a split-mouth randomized clinical trial

Evaluation of photobiomodulation therapy to accelerate bone formation in the mid palatal suture after rapid palatal expansion: a randomized clinical trial