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European Journal of Applied Physiology

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20.07.2022 | Original Article

Correlation between impaired hemodynamic response and cardiopulmonary fitness in middle-aged type 2 diabetes mellitus patients: a case–control study

verfasst von: Jinjin Xie, Lianhua Yin, Jia Huang, Ying Xu, Yannan Chen, Jiawei Qin, Zhizhen Liu, Jing Tao

Erschienen in: European Journal of Applied Physiology | Ausgabe 10/2022

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Abstract

Purpose

Impaired cardiorespiratory fitness (CRF) is a predictor of mortality in patients with type 2 diabetes mellitus (T2DM). It is still not known how the exercise hemodynamic response correlates with CRF. The purpose was to assess the correlation between hemodynamic changes and CRF in middle-aged patients with T2DM.

Methods

After 1:1 matching by age and sex, 139 T2DM patients and 139 non-T2DM controls who completed the exercise treadmill test were included. Maximal aerobic capacity (VO_2max), exercise-induced changes in heart rate (ΔHR), systolic blood pressure (ΔSBP), diastolic blood pressure (ΔDBP), and rate-pressure product (ΔRPP) were measured. HRR₁ was calculated as the maximum heart rate minus the heart rate after 1 min of rest.

Results

Compared to the control population, T2DM patients had decreased ΔHR (87 (77, 97) v 93 (84, 104) bpm, p < 0.05), ΔRPP (3833.64 ± 1670.34 v 4381.16 ± 1587.78 bpm∙mmHg, p < 0.05), HRR₁ (21 (14, 27) v 21 (17, 27) bpm, p < 0.05), and VO_2max (32.76 ± 5.63 v 34.68 ± 5.70 ml/kg/min, p < 0.05). Multiple linear regression analysis showed that ΔHR and HRR₁, yielded a positive correlation with VO_2max in T2DM patients (β = 0.325, P < 0.001; β = 0.173, P = 0.01).

Conclusion

The presence of impaired hemodynamic response and VO_2max in middle-aged T2DM patients and the association of impaired ΔHR, HRR₁, and VO_2max may indicate a physiological pathway of impaired CRF, and our results support the need for cardiorespiratory screening and individualized treatment of middle-aged T2DM patients.

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Titel: Correlation between impaired hemodynamic response and cardiopulmonary fitness in middle-aged type 2 diabetes mellitus patients: a case–control study
verfasst von: Jinjin Xie
Lianhua Yin
Jia Huang
Ying Xu
Yannan Chen
Jiawei Qin
Zhizhen Liu
Jing Tao
Publikationsdatum: 20.07.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 10/2022
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-022-05008-z

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Correlation between impaired hemodynamic response and cardiopulmonary fitness in middle-aged type 2 diabetes mellitus patients: a case–control study

Abstract

Purpose

Methods

Results

Conclusion

Neu im Fachgebiet Arbeitsmedizin

Elterliches Belastungserleben, Unaufmerksamkeits‑/Hyperaktivitätssymptome und elternberichtete ADHS bei Kindern und Jugendlichen: Ergebnisse aus der KiGGS-Studie

Substanzkonsum und Nutzung von sozialen Medien, Computerspielen und Glücksspielen unter Auszubildenden an beruflichen Schulen

Berufsbelastung und Stressbewältigung von weiblichen und männlichen Auszubildenden

Rauschtrinken in der frühen Adoleszenz

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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