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Erschienen in: Infection 4/2022

18.08.2021 | COVID-19 | Review Zur Zeit gratis

Comprehensive estimation for the length and dispersion of COVID-19 incubation period: a systematic review and meta-analysis

verfasst von: Yongyue Wei, Liangmin Wei, Yihan Liu, Lihong Huang, Sipeng Shen, Ruyang Zhang, Jiajin Chen, Yang Zhao, Hongbing Shen, Feng Chen

Erschienen in: Infection | Ausgabe 4/2022

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Abstract

Purpose

To estimate the central tendency and dispersion for incubation period of COVID-19 and, in turn, assess the effect of a certain length of quarantine for close contacts in active monitoring.

Methods

Literature related to SARS-CoV-2 and COVID-19 was searched through April 26, 2020. Quality was assessed according to Agency for Healthcare Research and Quality guidelines. Log-normal distribution for the incubation period was assumed to estimate the parameters for each study. Incubation period median and dispersion were estimated, and distribution was simulated.

Results

Fifty-six studies encompassing 4095 cases were included in this meta-analysis. The estimated median incubation period for general transmissions was 5.8 days [95% confidence interval (95% CI): 5.3, 6.2]. Incubation period was significantly longer for asymptomatic transmissions (median: 7.7 days; 95% CI 6.3, 9.4) than for general transmissions (P = 0.0408). Median and dispersion were higher for SARS-CoV-2 incubation compared to other viral respiratory infections. Furthermore, about 12 in 10,000 contacts in active monitoring would develop symptoms after 14 days, or below 1 in 10,000 for asymptomatic transmissions. Meta-regression suggested that each 10-year increase in age resulted in an average 16% increment in length of median incubation (incubation period ratio, 1.16, 95% CI 1.01, 1.32; P = 0.0250).

Conclusion

This study estimated the median and dispersion of the SARS-CoV-2 incubation period more precisely. A 14-day quarantine period is sufficient to trace and identify symptomatic infections.
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Metadaten
Titel
Comprehensive estimation for the length and dispersion of COVID-19 incubation period: a systematic review and meta-analysis
verfasst von
Yongyue Wei
Liangmin Wei
Yihan Liu
Lihong Huang
Sipeng Shen
Ruyang Zhang
Jiajin Chen
Yang Zhao
Hongbing Shen
Feng Chen
Publikationsdatum
18.08.2021
Verlag
Springer Berlin Heidelberg
Schlagwort
COVID-19
Erschienen in
Infection / Ausgabe 4/2022
Print ISSN: 0300-8126
Elektronische ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-021-01682-x

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