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01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

BMC Infectious Diseases 1/2021

The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients

Zeitschrift:
BMC Infectious Diseases > Ausgabe 1/2021
Autoren:
Simone Canovi, Giulia Besutti, Efrem Bonelli, Valentina Iotti, Marta Ottone, Laura Albertazzi, Alessandro Zerbini, Pierpaolo Pattacini, Paolo Giorgi Rossi, Rossana Colla, Tommaso Fasano, on behalf of the Reggio Emilia COVID-19 Working Group;
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Supplementary Information

The online version contains supplementary material available at https://​doi.​org/​10.​1186/​s12879-021-05855-9.

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Abstract

Background

Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients.

Methods

This was an observational cross-sectional study including consecutive patients presenting to the Reggio Emilia (Italy) province emergency rooms for suspected COVID-19 for one month during the outbreak peak, who underwent chest CT scan and laboratory testing at presentation and resulted positive for SARS-CoV-2.

Results

Included were 866 patients. Total leukocytes, neutrophils, C-reactive protein (CRP), creatinine, AST, ALT and LDH increase with worsening parenchymal involvement; an increase in platelets was appreciable with the highest burden of lung involvement. A decrease in lymphocyte counts paralleled worsening parenchymal extension, along with reduced arterial oxygen partial pressure and saturation. After correcting for parenchymal extension, ground-glass opacities were associated with reduced platelets and increased procalcitonin, consolidation with increased CRP and reduced oxygen saturation.

Conclusions

Pulmonary lesions induced by SARS-CoV-2 infection were associated with raised inflammatory response, impaired gas exchange and end-organ damage. These data suggest that lung lesions probably exert a central role in COVID-19 pathogenesis and clinical presentation.
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