Skip to main content
Erschienen in: European Journal of Pediatrics 8/2020

05.06.2020 | COVID-19 | Original Article Zur Zeit gratis

Point-of-care lung ultrasound in three neonates with COVID-19

verfasst von: R. Gregorio-Hernández, A. B. Escobar-Izquierdo, J. Cobas-Pazos, A. Martínez-Gimeno

Erschienen in: European Journal of Pediatrics | Ausgabe 8/2020

Einloggen, um Zugang zu erhalten

Abstract

Since March 2020, the world is involved in the COVID-19 pandemic, a disease caused by a novel virus called SARS-CoV-2. Some authors have described the ultrasonographic findings of COVID-19 pneumonia in adults and children, but data on neonates are lacking. Our objective was to describe the ultrasonographic lung pattern on newborns with SARS-CoV-2 infection during the COVID-19 pandemic. Newborns who tested positive for SARS-CoV-2 PCR in respiratory samples and were evaluated with point-of-care lung ultrasound (LU) from March to April 2020 were included. LU was performed bedside by a single investigator at the time of diagnosis and every 48 h during the first week following diagnosis. Six areas were studied. Three neonates were included. Infants’ comorbidities included meconium aspiration syndrome, bronchopulmonary dysplasia, and Hirschsprung’s disease. One required mechanical ventilation. No deaths occurred. LU showed B-lines, consolidation, and spared areas. No pneumothorax or pleural effusion was observed
Conclusions: LU could be of value when managing COVID-19 neonates. We describe the findings of lung ultrasound monitoring during the first week following diagnosis in three neonates with SARS-CoV-2 infection.
What is known:
• Lung ultrasound (LU) is a useful tool in COVID-19 management in adults. To date, no report on LU and neonates with SARS-CoV-2 infection has been published.
What is new:
• This study adds evidence about LU findings in neonates with SARS-CoV-2 infection.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Cucinotta D, Vanelli M (2020) WHO declares COVID-19 a pandemic. Acta Biomed. 91(1):157–160 PubMed Cucinotta D, Vanelli M (2020) WHO declares COVID-19 a pandemic. Acta Biomed. 91(1):157–160 PubMed
3.
Zurück zum Zitat Kurepa D, Zaghloul N, Watkins L, Liu J (2018) Neonatal lung ultrasound exam guidelines. J Perinatol. 38(1):11–22 CrossRef Kurepa D, Zaghloul N, Watkins L, Liu J (2018) Neonatal lung ultrasound exam guidelines. J Perinatol. 38(1):11–22 CrossRef
4.
Zurück zum Zitat Sharma D, Farahbakhsh N (2019) Role of chest ultrasound in neonatal lung disease: a review of current evidences. J Matern Neonatal Med. 32(2):310–316 CrossRef Sharma D, Farahbakhsh N (2019) Role of chest ultrasound in neonatal lung disease: a review of current evidences. J Matern Neonatal Med. 32(2):310–316 CrossRef
5.
Zurück zum Zitat Raimondi F, Yousef N, Migliaro F, Capasso L, De Luca D (2018) Point-of-care lung ultrasound in neonatology: classification into descriptive and functional applications [published online ahead of print, 2018 Jul 20]. Pediatr Res. 20:1–8 Raimondi F, Yousef N, Migliaro F, Capasso L, De Luca D (2018) Point-of-care lung ultrasound in neonatology: classification into descriptive and functional applications [published online ahead of print, 2018 Jul 20]. Pediatr Res. 20:1–8
7.
Zurück zum Zitat Vetrugno L, Bove T, Orso D, Barbariol F, Bassi F, Boero E, Ferrari G, Kong R (2020) Our Italian experience using lung ultrasound for identification, grading and serial follow-up of severity of lung involvement for management of patients with COVID-19. Echocardiography. 37(4):625–627 CrossRef Vetrugno L, Bove T, Orso D, Barbariol F, Bassi F, Boero E, Ferrari G, Kong R (2020) Our Italian experience using lung ultrasound for identification, grading and serial follow-up of severity of lung involvement for management of patients with COVID-19. Echocardiography. 37(4):625–627 CrossRef
9.
Zurück zum Zitat Peng QY, Wang XT, Zhang LN, Critical C, Ultrasound C, Group S (2020) Findings of lung ultrasonography of novel corona virus pneumonia during the 2019–2020 epidemic. Intensive Care Med. 87:6–7 Peng QY, Wang XT, Zhang LN, Critical C, Ultrasound C, Group S (2020) Findings of lung ultrasonography of novel corona virus pneumonia during the 2019–2020 epidemic. Intensive Care Med. 87:6–7
10.
Zurück zum Zitat Berce V, Tomazin M, Gorenjak M, Berce T, Lovrenčič B (2019) The usefulness of lung ultrasound for the aetiological diagnosis of community-acquired pneumonia in children. Sci Rep. 9(1):17957 CrossRef Berce V, Tomazin M, Gorenjak M, Berce T, Lovrenčič B (2019) The usefulness of lung ultrasound for the aetiological diagnosis of community-acquired pneumonia in children. Sci Rep. 9(1):17957 CrossRef
11.
Zurück zum Zitat Musolino AM, Supino MC, Buonsenso D, Ferro V, Valentini P, Magistrelli A et al (2020) Lung ultrasound in children with COVID-19: preliminary findings. Ultrasound Med Biol S0301-5629(20):30198–30198 Musolino AM, Supino MC, Buonsenso D, Ferro V, Valentini P, Magistrelli A et al (2020) Lung ultrasound in children with COVID-19: preliminary findings. Ultrasound Med Biol S0301-5629(20):30198–30198
12.
Zurück zum Zitat Wang L, Shi Y, Xiao T, Fu J, Feng X, Mu D et al (2020) Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition). Ann Transl Med. 8(3):47–47 CrossRef Wang L, Shi Y, Xiao T, Fu J, Feng X, Mu D et al (2020) Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition). Ann Transl Med. 8(3):47–47 CrossRef
15.
Zurück zum Zitat Shah PS, Diambomba Y, Acharya G, Morris SK, Bitnun A (2020) Classification system and case definition for SARS-CoV-2 infection in pregnant women, fetuses, and neonates. Acta Obstet Gynecol Scand. 99(5):565–568 CrossRef Shah PS, Diambomba Y, Acharya G, Morris SK, Bitnun A (2020) Classification system and case definition for SARS-CoV-2 infection in pregnant women, fetuses, and neonates. Acta Obstet Gynecol Scand. 99(5):565–568 CrossRef
17.
Zurück zum Zitat Brat R, Yousef N, Klifa R, Reynaud S, Shankar Aguilera S, De Luca D (2015) Lung ultrasonography score to evaluate oxygenation and surfactant need in neonates treated with continuous positive airway pressure. JAMA Pediatr. 169(8):e151797 CrossRef Brat R, Yousef N, Klifa R, Reynaud S, Shankar Aguilera S, De Luca D (2015) Lung ultrasonography score to evaluate oxygenation and surfactant need in neonates treated with continuous positive airway pressure. JAMA Pediatr. 169(8):e151797 CrossRef
18.
Zurück zum Zitat Ludvigsson JF (2020) Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 109(6):1088–1095 CrossRef Ludvigsson JF (2020) Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 109(6):1088–1095 CrossRef
19.
Zurück zum Zitat Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D (2020) Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis S1473-3099(20):30198-5 Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D (2020) Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis S1473-3099(20):30198-5
20.
Zurück zum Zitat Tagarro A, Epalza C, Santos M, Sanz-Santaeufemia FJ, Otheo E, Moraleda C et al (2020) Screening and severity of coronavirus disease 2019 (COVID-19) in Children in Madrid. Spain. JAMA Pediatr. 8:e201346 Tagarro A, Epalza C, Santos M, Sanz-Santaeufemia FJ, Otheo E, Moraleda C et al (2020) Screening and severity of coronavirus disease 2019 (COVID-19) in Children in Madrid. Spain. JAMA Pediatr. 8:e201346
22.
Zurück zum Zitat Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W et al (2020) Correlation of Chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases. Radiology. 26:200642 CrossRef Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W et al (2020) Correlation of Chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases. Radiology. 26:200642 CrossRef
23.
Zurück zum Zitat Escourrou G, De Luca D (2016) Lung ultrasound decreased radiation exposure in preterm infants in a neonatal intensive care unit. Acta Paediatr. 105(5):e237–e239 CrossRef Escourrou G, De Luca D (2016) Lung ultrasound decreased radiation exposure in preterm infants in a neonatal intensive care unit. Acta Paediatr. 105(5):e237–e239 CrossRef
24.
Zurück zum Zitat Liu J, Copetti R, Sorantin E, Lovrenski J, Rodriguez-Fanjul J, Kurepa D et al (2019) Protocol and guidelines for point-of-care lung ultrasound in diagnosing neonatal pulmonary diseases based on international expert consensus. J Vis Exp (145). https://​doi.​org/​10.​3791/​58990 Liu J, Copetti R, Sorantin E, Lovrenski J, Rodriguez-Fanjul J, Kurepa D et al (2019) Protocol and guidelines for point-of-care lung ultrasound in diagnosing neonatal pulmonary diseases based on international expert consensus. J Vis Exp (145). https://​doi.​org/​10.​3791/​58990
25.
Zurück zum Zitat Liu J, Chen S-W, Liu F, Wang Y, Kong X-Y, Li Q-P, Huang JJ (2014) BPD, not BPD, or iatrogenic BPD. Medicine (Baltimore). 93(23):e133 CrossRef Liu J, Chen S-W, Liu F, Wang Y, Kong X-Y, Li Q-P, Huang JJ (2014) BPD, not BPD, or iatrogenic BPD. Medicine (Baltimore). 93(23):e133 CrossRef
26.
Zurück zum Zitat Piastra M, Yousef N, Brat R, Manzoni P, Mokhtari M, De Luca D (2014) Lung ultrasound findings in meconium aspiration syndrome. Early Hum Dev. 90:S41–S43 CrossRef Piastra M, Yousef N, Brat R, Manzoni P, Mokhtari M, De Luca D (2014) Lung ultrasound findings in meconium aspiration syndrome. Early Hum Dev. 90:S41–S43 CrossRef
27.
Zurück zum Zitat Chen S-W, Fu W, Liu J, Wang Y (2017) Routine application of lung ultrasonography in the neonatal intensive care unit. Medicine (Baltimore). 96(2):e5826 CrossRef Chen S-W, Fu W, Liu J, Wang Y (2017) Routine application of lung ultrasonography in the neonatal intensive care unit. Medicine (Baltimore). 96(2):e5826 CrossRef
28.
Zurück zum Zitat De Martino L, Yousef N, Ben-Ammar R, Raimondi F, Shankar-Aguilera S, De Luca D (2018) Lung ultrasound score predicts surfactant need in extremely preterm neonates. Pediatrics. 142(3):e20180463 CrossRef De Martino L, Yousef N, Ben-Ammar R, Raimondi F, Shankar-Aguilera S, De Luca D (2018) Lung ultrasound score predicts surfactant need in extremely preterm neonates. Pediatrics. 142(3):e20180463 CrossRef
29.
Zurück zum Zitat Yousef N, Vigo G, Shankar-Aguilera S, De Luca D (2020) Semiquantitative ultrasound assessment of lung aeration correlates with lung tissue inflammation. Ultrasound Med Biol. 46(5):1258–1262 CrossRef Yousef N, Vigo G, Shankar-Aguilera S, De Luca D (2020) Semiquantitative ultrasound assessment of lung aeration correlates with lung tissue inflammation. Ultrasound Med Biol. 46(5):1258–1262 CrossRef
30.
Zurück zum Zitat Pang H, Zhang B, Shi J, Zang J, Qiu L (2019) Diagnostic value of lung ultrasound in evaluating the severity of neonatal respiratory distress syndrome. Eur J Radiol. 116:186–191 CrossRef Pang H, Zhang B, Shi J, Zang J, Qiu L (2019) Diagnostic value of lung ultrasound in evaluating the severity of neonatal respiratory distress syndrome. Eur J Radiol. 116:186–191 CrossRef
31.
Zurück zum Zitat Canarutto D, Priolo A, Russo G, Pitea M, Vigone MC, Barera G (2020) COVID-19 infection in a paucisymptomatic infant: raising the index of suspicion in epidemic settings. Pediatr Pulmonol. 55(6):E4–E5 CrossRef Canarutto D, Priolo A, Russo G, Pitea M, Vigone MC, Barera G (2020) COVID-19 infection in a paucisymptomatic infant: raising the index of suspicion in epidemic settings. Pediatr Pulmonol. 55(6):E4–E5 CrossRef
Metadaten
Titel
Point-of-care lung ultrasound in three neonates with COVID-19
verfasst von
R. Gregorio-Hernández
A. B. Escobar-Izquierdo
J. Cobas-Pazos
A. Martínez-Gimeno
Publikationsdatum
05.06.2020

Weitere Artikel der Ausgabe 8/2020

European Journal of Pediatrics 8/2020 Zur Ausgabe

Passend zum Thema

ANZEIGE

Kennen Sie den Stellenwert der Pneumokokken-Serotypen 22F & 33F?

Pneumokokken-Erkrankungen stellen ein ernstes Risiko für Säuglinge und Kleinkinder dar. Was die Pneumokokken-Serotypen 22F und 33F damit zu tun haben erfahren Sie hier.

ANZEIGE

15 Jahre HPV-Impfung: Wo stehen wir?

HPV-Impfstoffe sind mittlerweile seit mehr als 15 Jahren in Deutschland verfügbar. Mehr zur Entwicklung der HPV-Impfung und der aktuellen Situation.

ANZEIGE

Impfungen – vom Säugling bis zum Senior

Als eines der global führenden Gesundheitsunternehmen besitzt MSD mehr als 100 Jahre Erfahrung in der Entwicklung von Impfstoffen. Hier finden Sie Informationen zu einigen der von der STIKO empfohlenen Immunisierungen, z.B. der MMRV- und der HPV-Impfung sowie der Pneumokokken-Impfung für Senioren.