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Erschienen in: Cardiovascular Drugs and Therapy 6/2022

15.09.2021 | COVID-19 | Original Article Zur Zeit gratis

Efficacy of Statin Therapy in Patients with Hospital Admission for COVID-19

verfasst von: Daein Choi, Qinzhong Chen, Sascha N. Goonewardena, Hannah Pacheco, Priscilla Mejia, Robin L. Smith, Robert S. Rosenson

Erschienen in: Cardiovascular Drugs and Therapy | Ausgabe 6/2022

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Abstract

Purpose

COVID-19 is characterized by dysfunctional immune responses and metabolic derangements, which in some, lead to multi-organ failure and death. Statins are foundational lipid-lowering therapeutics for cardiovascular disease and also possess beneficial immune-modulating properties. Because of these immune-modulating properties, some have suggested their use in COVID-19. We sought to investigate the association between statin use and mortality in patients hospitalized with COVID-19.

Methods

Five thousand three hundred seventy-five COVID-19 patients admitted to Mount Sinai Health System hospitals in New York between February 27, 2020, and December 3, 2020, were included in this analysis. Statin use was classified as either non-user, low-to-moderate-intensity user, or high-intensity user. Multivariate Cox proportional hazards models were used to evaluate in-hospital mortality rate. Considered covariates were age, sex, race, and comorbidities.

Results

Compared to non-statin users, both low-to-moderate-intensity (adjusted hazard ratio; aHR 0.62, 95% confidential intervals; CI 0.51–0.76) and high-intensity statin users (aHR 0.53, 95% CI 0.43–0.65) had a reduced risk of death. Subgroup analysis of 723 coronary artery disease patients showed decreased mortality among high-intensity statin users compared to non-users (aHR 0.51, 95% CI 0.36–0.71).

Conclusions

Statin use in patients hospitalized with COVID-19 was associated with a reduced in-hospital mortality. The protective effect of statin was greater in those with coronary artery disease. These data support continued use of statin therapy in hospitalized patients with COVID-19. Clinical trials are needed to prospectively determine if statin use is effective in lowering the mortality in COVID-19 and other viral infections.
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Metadaten
Titel
Efficacy of Statin Therapy in Patients with Hospital Admission for COVID-19
verfasst von
Daein Choi
Qinzhong Chen
Sascha N. Goonewardena
Hannah Pacheco
Priscilla Mejia
Robin L. Smith
Robert S. Rosenson
Publikationsdatum
15.09.2021
Verlag
Springer US
Erschienen in
Cardiovascular Drugs and Therapy / Ausgabe 6/2022
Print ISSN: 0920-3206
Elektronische ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-021-07263-2

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