Introduction
Materials and Methods
Patients
Blood sampling and measurements
Determination of thromboembolic events
Statistical analysis
Results
Patient characteristics
COVID-19 | Sepsis | |
---|---|---|
Baseline characteristics
| ||
Patients, n | 20 | 20 |
Gender M/F, n | 19/1 | 15/5 |
Age, y / range | 62 (43–80) | 62 (45–76) |
Comorbidities, n (%)
| ||
Hypertension | 8 (40) | 11 (55) |
Diabetes | 4 (20) | 7 (35) |
Cardiovascular disease | 7 (35) | 9 (45) |
COPD | 3 (15) | 3 (15) |
Disease severity
| ||
Mechanical ventilation, n (%) | 20 (100 %) | 20 (100 %) |
CVVHD, n (%) | 15 (75) | 11 (55) |
SOFA-Score on ICU admission | 11 ± 3 | 12 ± 3 |
Thromboembolic events, n (%) | 7 (35) | 0 |
Length of ICU stay, days (range) | 14 (4–23) | 11 (3–21) |
Length of hospital stay, days (range) | 23 (13–28) | 27 (14–29) |
ICU mortality, n (%) | 9 (45) | 8 (40) |
Hospital mortality, n (%) | 9 (45) | 8 (40) |
Comparison of haemostasis parameters
COVID-19 | Sepsis | P value | |
---|---|---|---|
Standard laboratory values
| |||
Hb, g/dl (normal, 13.7–17.2) | 9.5 ± 1 | 8.3 ± 1.5 | |
Plts, x 109/l (normal, 140–320) | 272 ± 152 | 140 ± 90 | |
INR | 1.16 ± 0.16 | 1.20 ± 0.28 | |
aPTT, s (normal, 24.4–32.4) Heparin dose, IU/h, range (mean) | 43 ± 12.9 400–1200 (730) | 32 ± 7.6 400–1000 (480) | |
Fibrinogen, mg/dl (normal, 188–384) | 757 ± 135 | 498 ± 132 |
< 0.0001
|
D-dimer, mg/l (normal, < 0.52) | 16.4 ± 10.7 | 5.4 ± 6.0 | 0.14 |
EXTEM
| |||
*CT, s (normal, 38–79) Median 25 % percentile − 75 % percentile | 90.5 76.2–104.5 | 81 67.3–93.3 | 0.112 |
*CFT, s (normal, 34–159) Median 25 % percentile − 75 % percentile | 58 47.8–81.5 | 76 54.3–139.8 | 0.066 |
A10, mm (normal, 43–65) | 64.6 ± 12.3 | 54.7 ± 16.4 | 0.076 |
MCF, mm (normal, 50–72) | 70.4 ± 10.4 | 60.6 ± 14.8 |
0.022
|
ML % 60 (normal, 6 %-10 %) | 0.6 ± 1.2 | 3.3 ± 3.7 |
0.013
|
INTEM
| |||
*CT, s (normal, 100–240) Median 25 % percentile − 75 % percentile | 293.5 220.8–429.5 | 232.5 188.3–248 |
0.016
|
*CFT, s (normal, 30–110) Median 25 % percentile − 75 % percentile | 66.5 54–129.8 | 79 53.3–128.5 | 0.888 |
A10, mm (normal, 44–66) | 62 ± 15 | 54.5 ± 16 | 0.158 |
MCF, mm (normal, 50–72) | 68.6 ± 11.4 | 59.2 ± 15.8 | 0.057 |
FIBTEM
| |||
MCF, mm (normal, 9–25) | 38.4 ± 10.1 | 29.6 ± 10.8 |
0.012
|
APTEM
| |||
*CFT, s (normal, 35–160) Median 25 % percentile − 75 % percentile | 56 45.5–70.5 | 86.5 60.3–123 | 0.02 |
MCF, mm (normal, 53–72) | 69.1 ± 11 | 56 ± 15.2 | 0.003 |