The novel coronavirus disease 2019 (COVID-19) outbreak was initially identified in Wuhan, China, at the end of 2019, and it rapidly spread in other countries throughout the world, resulting in a global pandemic [
1]. After the incubation period of COVID-19 which is generally within 14 days, symptomatic infection can occur [
2,
3]. The hall mark of symptomatic COVID-19 infection is that there are various presenting symptoms including fever, myalgia, cough, sore throat, diarrhea, and loss of smell or taste, which can cause mild illness or may progress to critical illness [
2,
3]. In the Republic of Korea (ROK), the first case of COVID-19 was reported in early January 2020, and the number of new cases was on the gradual increase until late February 2020 when large clusters of new cases were identified in Daegu city and the adjacent province of Gyeongsangbuk-do [
4]. The massive outbreak of COVID-19 in Daegu city and province of Gyeongsangbuk-do caused the exponential increase in the new cases exceeding 5000 within 6 weeks [
4]. As a result of the on-going outbreak and a sudden influx of patients diagnosed with COVID-19, there were shortages of hospital beds and other resources in the local hospitals in Daegu city and province of Gyeongsangbuk-do. Such strain on hospital resources led to unprecedented numbers of home isolation of COVID-19 patients. Also, there were deaths of COVID-19 patients under home isolation while awaiting hospital admission [
5]. One of the possible causes of death was delayed recognition of clinical deterioration from lack of monitoring in home isolation. Therefore, to address the safety of home-isolated COVID-19 patients and the allocation of scarce hospital resources, the community treatment center (CTC) with a digital health care monitoring system was designed and implemented as a part of the triage and management efforts for the COVID-19 patients by the Government of the ROK [
4]. The patients confirmed to have COVID-19 were categorized into four classes (mild, moderate, severe, extremely severe) according to the severity of clinical presentation [
4]. The COVID-19 patients with moderate, severe, and extremely severe classes were immediately hospitalized for treatment, and the COVID-19 patients with the mild class were sent to the CTC for isolation under close monitoring [
4]. As of Mar 18, 2020, there were 12 CTCs in active operation for the COVID-19 patients in the ROK [
6]. This establishment of the CTC COVID-19 patients’ management system by the Government of the ROK created a unique opportunity to propose and assess the role of the CTC and the feasibility of the digital health care monitoring system in the setting of the COVID-19 pandemic. Thus, we report our experience in one of the 12 CTCs, the Gyeongbuk-Daegu 2 CTC, located in Gyeongju, Gyeongsangbuk-do, which was deemed the epicenter of the COVID-19 outbreak in the ROK.