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Erschienen in: Cardiovascular Toxicology 2/2022

27.11.2021

Curcumin Ameliorates Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity Via Suppressing Oxidative Stress and Modulating iNOS, NF-κB, and TNF-α in Rats

verfasst von: Ghadha Ibrahim Fouad, Kawkab A. Ahmed

Erschienen in: Cardiovascular Toxicology | Ausgabe 2/2022

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Abstract

Doxorubicin (DOX) is one of the widely used anti-tumor drugs. However, DOX-induced cardiotoxicity (DIC) and hepatotoxicity (DIH) are among the side effects that limited its therapeutic efficiency and clinical applicability. This study aimed to investigate the cardioprotective and hepatoprotective potentials of curcumin (CMN)—a bioactive polyphenolic compound—in alleviating DOX-induced cardiotoxicity (DIC) and hepatotoxicity (DIH) in male rats. A single intraperitoneal (i.p.) dose of DOX (20 mg/kg) was used to induce DIC and DIH. DOX-intoxicated rats were co-treated with CMN (100 mg/kg, oral) for 10 days before and 5 days after a single dose of DOX. We studied the anti-inflammatory and anti-oxidative activities of CMN on biochemical and immunohistochemical aspects. DOX disrupted cardiac and hepatic functions and stimulated oxidative stress and inflammation in both tissues that was confirmed biochemically and immunohistochemically. DOX enhanced inflammatory interferon-gamma (IFN-γ) and upregulated immunoexpression of nuclear factor-κB (NF-κB), inducible nitric oxide synthase (iNOS), and tumor necrosis factor-alpha (TNF-α). DOX induced structural alterations in both cardiac and hepatic tissues. CMN demonstrated cardioprotective potential through reducing cardiac troponin I (cTn1) and aspartate amino transaminase (AST). In addition, CMN significantly ameliorated liver function through decreasing alanine amino transaminase (ALT) and, gamma-glutamyl transferase (GGT), total cholesterol (TC), and triglycerides (TG). CMN demonstrated anti-inflammatory potential through decreasing IFN-γ levels and immunoexpression of iNOS, NF-κB, and TNF-α. Histopathologically, CMN restored DOX-associated cardiac and liver structural alterations. CMN showed anti-oxidative and anti-inflammatory potentials in both the cardiac and hepatic tissues. In addition, cTn1, IFN-γ, and AST could be used as blood-based biomarkers.
Literatur
1.
Zurück zum Zitat Prša, P., Karademir, B., Biçim, G., Mahmoud, H., Dahan, I., Yalçın, A. S., et al. (2020). The potential use of natural products to negate hepatic, renal and neuronal toxicity induced by cancer therapeutics. Biochemical pharmacology, 173, 113551. PubMed Prša, P., Karademir, B., Biçim, G., Mahmoud, H., Dahan, I., Yalçın, A. S., et al. (2020). The potential use of natural products to negate hepatic, renal and neuronal toxicity induced by cancer therapeutics. Biochemical pharmacology, 173, 113551. PubMed
2.
Zurück zum Zitat Chari, R. V. (2008). Targeted cancer therapy: Conferring specificity to cytotoxic drugs. Accounts of chemical research, 41(1), 98–107. PubMed Chari, R. V. (2008). Targeted cancer therapy: Conferring specificity to cytotoxic drugs. Accounts of chemical research, 41(1), 98–107. PubMed
3.
Zurück zum Zitat Fraczkowska, K., Bacia, M., Przybyło, M., Drabik, D., Kaczorowska, A., Rybka, J., et al. (2018). Alterations of biomechanics in cancer and normal cells induced by doxorubicin. Biomedicine & Pharmacotherapy, 97, 1195–1203. Fraczkowska, K., Bacia, M., Przybyło, M., Drabik, D., Kaczorowska, A., Rybka, J., et al. (2018). Alterations of biomechanics in cancer and normal cells induced by doxorubicin. Biomedicine & Pharmacotherapy, 97, 1195–1203.
6.
Zurück zum Zitat Ibrahim Fouad, G., & Ahmed, K. A. (2021). The protective impact of Berberine against Doxorubicin-induced nephrotoxicity in Rats. Tissue and Cell, 1, 101612. Ibrahim Fouad, G., & Ahmed, K. A. (2021). The protective impact of Berberine against Doxorubicin-induced nephrotoxicity in Rats. Tissue and Cell, 1, 101612.
8.
Zurück zum Zitat Magdy, T., Burmeister, B. T., & Burridge, P. W. (2016). Validating the pharmacogenomics of chemotherapy-induced cardiotoxicity: What is missing? Pharmacology & Therapeutics, 168, 113–125. Magdy, T., Burmeister, B. T., & Burridge, P. W. (2016). Validating the pharmacogenomics of chemotherapy-induced cardiotoxicity: What is missing? Pharmacology & Therapeutics, 168, 113–125.
11.
Zurück zum Zitat Priya, L. B., Baskaran, R., Huang, C. Y., & Padma, V. V. (2017). Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin: Possible role in modulating NADPH oxidase/ROS-mediated NFκB redox signaling cascade. Scientific reports, 7(1), 1–13. Priya, L. B., Baskaran, R., Huang, C. Y., & Padma, V. V. (2017). Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin: Possible role in modulating NADPH oxidase/ROS-mediated NFκB redox signaling cascade. Scientific reports, 7(1), 1–13.
12.
Zurück zum Zitat Songbo, M., Lang, H., Xinyong, C., Bin, X., Ping, Z., & Liang, S. (2019). Oxidative stress injury in doxorubicin-induced cardiotoxicity. Toxicology letters, 307, 41–48. PubMed Songbo, M., Lang, H., Xinyong, C., Bin, X., Ping, Z., & Liang, S. (2019). Oxidative stress injury in doxorubicin-induced cardiotoxicity. Toxicology letters, 307, 41–48. PubMed
13.
Zurück zum Zitat Ichikawa, Y., Ghanefar, M., Bayeva, M., Wu, R., Khechaduri, A., Prasad, S. V. N., et al. (2014). Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation. The Journal of Clinical Investigation, 124(2), 617–630. PubMedPubMedCentral Ichikawa, Y., Ghanefar, M., Bayeva, M., Wu, R., Khechaduri, A., Prasad, S. V. N., et al. (2014). Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation. The Journal of Clinical Investigation, 124(2), 617–630. PubMedPubMedCentral
14.
Zurück zum Zitat Singh, M. K., Mohd, F., Ayaz, A., Ankur, S., & Jyoti, Y. (2012). Protective effect of Lagenaria siceraria against doxorubicin induced cardiotoxicity in wistar rats. International Journal of Drug Development and Research, 4(2), 298–305. Singh, M. K., Mohd, F., Ayaz, A., Ankur, S., & Jyoti, Y. (2012). Protective effect of Lagenaria siceraria against doxorubicin induced cardiotoxicity in wistar rats. International Journal of Drug Development and Research, 4(2), 298–305.
15.
Zurück zum Zitat Zhang, Y. W., Shi, J., Li, Y. J., & Wei, L. (2009). Cardiomyocyte death in doxorubicin-induced cardiotoxicity. Archivum Immunologiae et Therapiae Experimentalis, 57(6), 435–445. PubMedPubMedCentral Zhang, Y. W., Shi, J., Li, Y. J., & Wei, L. (2009). Cardiomyocyte death in doxorubicin-induced cardiotoxicity. Archivum Immunologiae et Therapiae Experimentalis, 57(6), 435–445. PubMedPubMedCentral
16.
Zurück zum Zitat Chopra, S., & Saxena, R. (2018). Drug-induced liver injury-perspectives from pathology. Current Pharmacology Reports, 4(3), 182–192. Chopra, S., & Saxena, R. (2018). Drug-induced liver injury-perspectives from pathology. Current Pharmacology Reports, 4(3), 182–192.
17.
Zurück zum Zitat Pedrycz, A., Wieczorski, M., & Czerny, K. (2004). Increased apoptosis in the adult rat liver after a single dose of adriamycin administration. Annales Universitatis Mariae Curie-Sklodowska D, 59(2), 313–318. Pedrycz, A., Wieczorski, M., & Czerny, K. (2004). Increased apoptosis in the adult rat liver after a single dose of adriamycin administration. Annales Universitatis Mariae Curie-Sklodowska D, 59(2), 313–318.
18.
Zurück zum Zitat Kalender, Y., Yel, M., & Kalender, S. (2005). Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats: The effects of vitamin E and catechin. Toxicology, 209(1), 39–45. PubMed Kalender, Y., Yel, M., & Kalender, S. (2005). Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats: The effects of vitamin E and catechin. Toxicology, 209(1), 39–45. PubMed
19.
Zurück zum Zitat Dunn, G. P., Ikeda, H., Bruce, A. T., Koebel, C., Uppaluri, R., Bui, J., et al. (2005). Interferon-γ and cancer immunoediting. Immunologic Research, 32(1), 231–245. PubMed Dunn, G. P., Ikeda, H., Bruce, A. T., Koebel, C., Uppaluri, R., Bui, J., et al. (2005). Interferon-γ and cancer immunoediting. Immunologic Research, 32(1), 231–245. PubMed
21.
Zurück zum Zitat Jorgovanovic, D., Song, M., Wang, L., & Zhang, Y. (2020). Roles of IFN-γ in tumor progression and regression: A review. Biomarker Research., 8(1), 1–16. Jorgovanovic, D., Song, M., Wang, L., & Zhang, Y. (2020). Roles of IFN-γ in tumor progression and regression: A review. Biomarker Research., 8(1), 1–16.
22.
Zurück zum Zitat Dobrzanski, M. J. (2013). Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy. Frontiers in Oncology, 3, 63. PubMedPubMedCentral Dobrzanski, M. J. (2013). Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy. Frontiers in Oncology, 3, 63. PubMedPubMedCentral
23.
Zurück zum Zitat Mandai, M., Hamanishi, J., Abiko, K., Matsumura, N., Baba, T., & Konishi, I. (2016). Dual faces of IFN-gamma in cancer progression: A role of pd-l1 induction in the determination of pro- and antitumor immunity. Clinical Cancer Research., 22, 2329–2334. PubMed Mandai, M., Hamanishi, J., Abiko, K., Matsumura, N., Baba, T., & Konishi, I. (2016). Dual faces of IFN-gamma in cancer progression: A role of pd-l1 induction in the determination of pro- and antitumor immunity. Clinical Cancer Research., 22, 2329–2334. PubMed
24.
Zurück zum Zitat Mojic, M., Takeda, K., & Hayakawa, Y. (2017). The dark side of IFN-gamma: Its role in promoting cancer immunoevasion. International Journal of Molecular Sciences, 19, 89. PubMedCentral Mojic, M., Takeda, K., & Hayakawa, Y. (2017). The dark side of IFN-gamma: Its role in promoting cancer immunoevasion. International Journal of Molecular Sciences, 19, 89. PubMedCentral
25.
Zurück zum Zitat Choudhari, A. S., Mandave, P. C., Deshpande, M., Ranjekar, P., & Prakash, O. (2020). Phytochemicals in cancer treatment: From preclinical studies to clinical practice. Frontiers in Pharmacology, 10, 1614. PubMedPubMedCentral Choudhari, A. S., Mandave, P. C., Deshpande, M., Ranjekar, P., & Prakash, O. (2020). Phytochemicals in cancer treatment: From preclinical studies to clinical practice. Frontiers in Pharmacology, 10, 1614. PubMedPubMedCentral
26.
Zurück zum Zitat Ojha, S., Venkataraman, B., Kurdi, A., Mahgoub, E., Sadek, B., & Rajesh, M. (2016). Plant-derived agents for counteracting cisplatin-induced nephrotoxicity.  Oxidative medicine and cellular longevity.‏ Ojha, S., Venkataraman, B., Kurdi, A., Mahgoub, E., Sadek, B., & Rajesh, M. (2016). Plant-derived agents for counteracting cisplatin-induced nephrotoxicity.  Oxidative medicine and cellular longevity.‏
27.
Zurück zum Zitat Tuorkey, M. J. (2015). Cancer therapy with phytochemicals: Present and future perspectives. Biomedical and Environmental Sciences, 28(11), 808–819. PubMed Tuorkey, M. J. (2015). Cancer therapy with phytochemicals: Present and future perspectives. Biomedical and Environmental Sciences, 28(11), 808–819. PubMed
28.
Zurück zum Zitat Sak, K. (2012). Chemotherapy and dietary phytochemical agents.  Chemotherapy research and practice.‏ Sak, K. (2012). Chemotherapy and dietary phytochemical agents.  Chemotherapy research and practice.‏
29.
Zurück zum Zitat González-Salazar, A., Molina-Jijón, E., Correa, F., Zarco-Márquez, G., Calderón-Oliver, M., Tapia, E., et al. (2011). Curcumin protects from cardiac reperfusion damage by attenuation of oxidant stress and mitochondrial dysfunction. Cardiovascular Toxicology, 11(4), 357. PubMed González-Salazar, A., Molina-Jijón, E., Correa, F., Zarco-Márquez, G., Calderón-Oliver, M., Tapia, E., et al. (2011). Curcumin protects from cardiac reperfusion damage by attenuation of oxidant stress and mitochondrial dysfunction. Cardiovascular Toxicology, 11(4), 357. PubMed
30.
Zurück zum Zitat Fan, X., Zhang, C., Liu, D. B., Yan, J., & Liang, H. P. (2013). The clinical applications of curcumin: Current state and the future. Current Pharmaceutical Design, 19(11), 2011–2031. PubMed Fan, X., Zhang, C., Liu, D. B., Yan, J., & Liang, H. P. (2013). The clinical applications of curcumin: Current state and the future. Current Pharmaceutical Design, 19(11), 2011–2031. PubMed
31.
Zurück zum Zitat Rezaee, R., Momtazi, A. A., Monemi, A., & Sahebkar, A. (2017). Curcumin: A potentially powerful tool to reverse cisplatin-induced toxicity. Pharmacological Research, 117, 218–227. PubMed Rezaee, R., Momtazi, A. A., Monemi, A., & Sahebkar, A. (2017). Curcumin: A potentially powerful tool to reverse cisplatin-induced toxicity. Pharmacological Research, 117, 218–227. PubMed
32.
Zurück zum Zitat Benzer, F., Kandemir, F. M., Ozkaraca, M., Kucukler, S., & Caglayan, C. (2018). Curcumin ameliorates doxorubicin-induced cardiotoxicity by abrogation of inflammation, apoptosis, oxidative DNA damage, and protein oxidation in rats. Journal of Biochemical and Molecular Toxicology, 32(2), e22030. Benzer, F., Kandemir, F. M., Ozkaraca, M., Kucukler, S., & Caglayan, C. (2018). Curcumin ameliorates doxorubicin-induced cardiotoxicity by abrogation of inflammation, apoptosis, oxidative DNA damage, and protein oxidation in rats. Journal of Biochemical and Molecular Toxicology, 32(2), e22030.
34.
Zurück zum Zitat Ma, Z., Wang, N., He, H., & Tang, X. (2019). Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application. Journal of Controlled Release., 316, 359–380. PubMed Ma, Z., Wang, N., He, H., & Tang, X. (2019). Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application. Journal of Controlled Release., 316, 359–380. PubMed
35.
Zurück zum Zitat Chen, K., Pan, H., Yan, Z., Li, Y., Ji, D., Yun, K., et al. (2021). A novel alginate/gelatin sponge combined with curcumin-loaded electrospun fibers for postoperative rapid hemostasis and prevention of tumor recurrence. International Journal of Biological Macromolecules., 182, 1339–1350. PubMed Chen, K., Pan, H., Yan, Z., Li, Y., Ji, D., Yun, K., et al. (2021). A novel alginate/gelatin sponge combined with curcumin-loaded electrospun fibers for postoperative rapid hemostasis and prevention of tumor recurrence. International Journal of Biological Macromolecules., 182, 1339–1350. PubMed
36.
Zurück zum Zitat Paul, S., & Sa, G. (2021). Curcumin as an adjuvant to cancer immunotherapy. Frontiers in Oncology., 11, 675. Paul, S., & Sa, G. (2021). Curcumin as an adjuvant to cancer immunotherapy. Frontiers in Oncology., 11, 675.
37.
Zurück zum Zitat Lv, X., Zhu, Y., Deng, Y., Zhang, S., Zhang, Q., Zhao, B., & Li, G. (2020). Glycyrrhizin improved autophagy flux via HMGB1-dependent Akt/mTOR signaling pathway to prevent Doxorubicin-induced cardiotoxicity. Toxicology, 441, 152508. PubMed Lv, X., Zhu, Y., Deng, Y., Zhang, S., Zhang, Q., Zhao, B., & Li, G. (2020). Glycyrrhizin improved autophagy flux via HMGB1-dependent Akt/mTOR signaling pathway to prevent Doxorubicin-induced cardiotoxicity. Toxicology, 441, 152508. PubMed
38.
Zurück zum Zitat Yu, W., Wu, J., Cai, F., Xiang, J., Zha, W., Fan, D., et al. (2012). Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats. PLoS ONE, 7(12), e52013. PubMedPubMedCentral Yu, W., Wu, J., Cai, F., Xiang, J., Zha, W., Fan, D., et al. (2012). Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats. PLoS ONE, 7(12), e52013. PubMedPubMedCentral
39.
Zurück zum Zitat Reitman, S., & Frankel, S. (1957). In vitro determination of transaminase activity in serum. American Journal of Clinical Pathology, 28(1), 56–63. PubMed Reitman, S., & Frankel, S. (1957). In vitro determination of transaminase activity in serum. American Journal of Clinical Pathology, 28(1), 56–63. PubMed
40.
Zurück zum Zitat Tietz, N. W., Burtis, C. A., Duncan, P., et al. (1983). A reference method for measurement of alkaline phosphatase activity in human serum. Clinical Chemistry, 29, 751–761. PubMed Tietz, N. W., Burtis, C. A., Duncan, P., et al. (1983). A reference method for measurement of alkaline phosphatase activity in human serum. Clinical Chemistry, 29, 751–761. PubMed
41.
Zurück zum Zitat Koracevic, D., Koracevic, G., Djordjevic, V., Andrejevic, S., & Cosic, V. (2001). Method for the measurement of antioxidant activity in human fluids. Journal of Clinical Pathology, 54(5), 356–361. PubMedPubMedCentral Koracevic, D., Koracevic, G., Djordjevic, V., Andrejevic, S., & Cosic, V. (2001). Method for the measurement of antioxidant activity in human fluids. Journal of Clinical Pathology, 54(5), 356–361. PubMedPubMedCentral
42.
Zurück zum Zitat Ohkawa, H., Ohishi, N., & Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95, 351. PubMed Ohkawa, H., Ohishi, N., & Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95, 351. PubMed
44.
Zurück zum Zitat Allain, C. C., Poon, L. S., Chan, C. S., Richmond, W., & Fu, P. C. (1974). Enzymatic determination of total serum cholesterol. Clinical Chemistry, 20(4), 470–475. PubMed Allain, C. C., Poon, L. S., Chan, C. S., Richmond, W., & Fu, P. C. (1974). Enzymatic determination of total serum cholesterol. Clinical Chemistry, 20(4), 470–475. PubMed
45.
Zurück zum Zitat Fassati, P., & Prencipe, L. (1982). Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clinical Chemistry, 28(10), 2077–2080. Fassati, P., & Prencipe, L. (1982). Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clinical Chemistry, 28(10), 2077–2080.
46.
Zurück zum Zitat Suvarna, S. K., Layton, C., & Bancroft, J. D. (2019). Bancroft’s Theory and Practice of Histological Techniques. Churchill Livingstone Elsevier. Suvarna, S. K., Layton, C., & Bancroft, J. D. (2019). Bancroft’s Theory and Practice of Histological Techniques. Churchill Livingstone Elsevier.
47.
Zurück zum Zitat Ahmed, K. A., Korany, R. M. S., El Halawany, H. A., & Ahmed, K. S. (2019). Spirulina platensis alleviates arsenic-induced toxicity in male rats: Biochemical, histopathological and immunohistochemical studies. Adv. Anim. Vet. Sci., 7(8), 701–710. Ahmed, K. A., Korany, R. M. S., El Halawany, H. A., & Ahmed, K. S. (2019). Spirulina platensis alleviates arsenic-induced toxicity in male rats: Biochemical, histopathological and immunohistochemical studies. Adv. Anim. Vet. Sci., 7(8), 701–710.
48.
Zurück zum Zitat Martín-Burriel, I., et al. (2004). Histopathological and molecular changes during apoptosis produced by 7H-dibenzo [c, g]-carbazole in mouse liver. Toxicologic Pathology, 32(2), 202–211. PubMed Martín-Burriel, I., et al. (2004). Histopathological and molecular changes during apoptosis produced by 7H-dibenzo [c, g]-carbazole in mouse liver. Toxicologic Pathology, 32(2), 202–211. PubMed
49.
Zurück zum Zitat Yu, J., Wang, C., Kong, Q., Wu, X., Lu, J. J., & Chen, X. (2018). Recent progress in doxorubicin-induced cardiotoxicity and protective potential of natural products. Phytomedicine, 40, 125–139. PubMed Yu, J., Wang, C., Kong, Q., Wu, X., Lu, J. J., & Chen, X. (2018). Recent progress in doxorubicin-induced cardiotoxicity and protective potential of natural products. Phytomedicine, 40, 125–139. PubMed
50.
Zurück zum Zitat Gonzalez, Y., Pokrzywinski, K. L., Rosen, E. T., Mog, S., Aryal, B., Chehab, L. M., Vijay, V., Moland, C. L., Desai, V. G., Dickey, J. S., et al. (2015). Reproductive hormone levels and differential mitochondria-related oxidative gene expression as potential mechanisms for gender differences in cardiosensitivity to doxorubicin in tumor-bearing spontaneously hypertensive rats. Cancer Chemotherapy and Pharmacology, 76(3), 447–459. PubMed Gonzalez, Y., Pokrzywinski, K. L., Rosen, E. T., Mog, S., Aryal, B., Chehab, L. M., Vijay, V., Moland, C. L., Desai, V. G., Dickey, J. S., et al. (2015). Reproductive hormone levels and differential mitochondria-related oxidative gene expression as potential mechanisms for gender differences in cardiosensitivity to doxorubicin in tumor-bearing spontaneously hypertensive rats. Cancer Chemotherapy and Pharmacology, 76(3), 447–459. PubMed
51.
Zurück zum Zitat O’brien, P. J., Smith, D. E. C., Knechtel, T. J., Marchak, M. A., Pruimboom-Brees, I., Brees, D. J., Spratt, D. P., Archer, F. J., Butler, P., Potter, A. N., & Provost, J. P. (2006). Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals. Laboratory Animals, 40(2), 153–171. PubMed O’brien, P. J., Smith, D. E. C., Knechtel, T. J., Marchak, M. A., Pruimboom-Brees, I., Brees, D. J., Spratt, D. P., Archer, F. J., Butler, P., Potter, A. N., & Provost, J. P. (2006). Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals. Laboratory Animals, 40(2), 153–171. PubMed
52.
Zurück zum Zitat Ahmed, L. A., Abdou, F. Y., El Fiky, A. A., Shaaban, E. A., & Ain-Shoka, A. A. (2021). Bradykinin-potentiating activity of a gamma-irradiated bioactive fraction isolated from scorpion ( Leiurus quinquestriatus) venom in rats with doxorubicin-induced acute cardiotoxicity: Favorable modulation of oxidative stress and inflammatory, fibrogenic and apoptotic pathways. Cardiovascular Toxicology, 21(2), 127–141. PubMed Ahmed, L. A., Abdou, F. Y., El Fiky, A. A., Shaaban, E. A., & Ain-Shoka, A. A. (2021). Bradykinin-potentiating activity of a gamma-irradiated bioactive fraction isolated from scorpion ( Leiurus quinquestriatus) venom in rats with doxorubicin-induced acute cardiotoxicity: Favorable modulation of oxidative stress and inflammatory, fibrogenic and apoptotic pathways. Cardiovascular Toxicology, 21(2), 127–141. PubMed
53.
Zurück zum Zitat Botelho, A. F. M., Lempek, M. R., Branco, S. E. M., Nogueira, M. M., de Almeida, M. E., Costa, A. G., et al. (2019). Coenzyme Q10 cardioprotective effects against doxorubicin-induced cardiotoxicity in Wistar Rat. Cardiovascular Toxicology, 1, 1–13. Botelho, A. F. M., Lempek, M. R., Branco, S. E. M., Nogueira, M. M., de Almeida, M. E., Costa, A. G., et al. (2019). Coenzyme Q10 cardioprotective effects against doxorubicin-induced cardiotoxicity in Wistar Rat. Cardiovascular Toxicology, 1, 1–13.
54.
Zurück zum Zitat Swain, S. M., Whaley, F. S., & Ewer, M. S. (2003). Congestive heart failure in patients treated with doxorubicin: A retrospective analysis of three trials. Cancer Interdisciplinary International Journal of the American Cancer Society, 97(11), 2869–2879. Swain, S. M., Whaley, F. S., & Ewer, M. S. (2003). Congestive heart failure in patients treated with doxorubicin: A retrospective analysis of three trials. Cancer Interdisciplinary International Journal of the American Cancer Society, 97(11), 2869–2879.
55.
Zurück zum Zitat Goudarzi, M., Fatemi, I., Siahpoosh, A., Sezavar, S. H., Mansouri, E., & Mehrzadi, S. (2018). Protective effect of ellagic acid against sodium arsenite-induced cardio-and hematotoxicity in rats. Cardiovascular Toxicology, 18(4), 337–345. PubMed Goudarzi, M., Fatemi, I., Siahpoosh, A., Sezavar, S. H., Mansouri, E., & Mehrzadi, S. (2018). Protective effect of ellagic acid against sodium arsenite-induced cardio-and hematotoxicity in rats. Cardiovascular Toxicology, 18(4), 337–345. PubMed
56.
Zurück zum Zitat Haybar, H., Goudarzi, M., Mehrzadi, S., Aminzadeh, A., Khodayar, M. J., Kalantar, M., & Fatemi, I. (2019). Effect of gemfibrozil on cardiotoxicity induced by doxorubicin in male experimental rats. Biomedicine & Pharmacotherapy, 109, 530–535. Haybar, H., Goudarzi, M., Mehrzadi, S., Aminzadeh, A., Khodayar, M. J., Kalantar, M., & Fatemi, I. (2019). Effect of gemfibrozil on cardiotoxicity induced by doxorubicin in male experimental rats. Biomedicine & Pharmacotherapy, 109, 530–535.
57.
Zurück zum Zitat Chen, Y., Jiang, W., Liu, X., Du, Y., Liu, L., Ordovas, J. M., et al. (2020). Curcumin supplementation improves heat-stress-induced cardiac injury of mice: Physiological and molecular mechanisms. The Journal of Nutritional Biochemistry, 78, 108331. PubMed Chen, Y., Jiang, W., Liu, X., Du, Y., Liu, L., Ordovas, J. M., et al. (2020). Curcumin supplementation improves heat-stress-induced cardiac injury of mice: Physiological and molecular mechanisms. The Journal of Nutritional Biochemistry, 78, 108331. PubMed
58.
Zurück zum Zitat Damodar, G., Smitha, T., Gopinath, S., Vijayakumar, S., & Rao, Y. (2014). An evaluation of hepatotoxicity in breast cancer patients receiving injection doxorubicin. Annals of Medical and Health Sciences Research, 4, 74–79. PubMedPubMedCentral Damodar, G., Smitha, T., Gopinath, S., Vijayakumar, S., & Rao, Y. (2014). An evaluation of hepatotoxicity in breast cancer patients receiving injection doxorubicin. Annals of Medical and Health Sciences Research, 4, 74–79. PubMedPubMedCentral
59.
Zurück zum Zitat Mohammed, H. S., Hosny, E. N., Khadrawy, Y. A., Magdy, M., Attia, Y. S., Sayed, O. A., & AbdElaal, M. (2020). Protective effect of curcumin nanoparticles against cardiotoxicity induced by doxorubicin in rat. Biochimica et Biophysica Acta Molecular Basis of Disease, 1866(5), 165665. PubMed Mohammed, H. S., Hosny, E. N., Khadrawy, Y. A., Magdy, M., Attia, Y. S., Sayed, O. A., & AbdElaal, M. (2020). Protective effect of curcumin nanoparticles against cardiotoxicity induced by doxorubicin in rat. Biochimica et Biophysica Acta Molecular Basis of Disease, 1866(5), 165665. PubMed
60.
Zurück zum Zitat Mete, R., Oran, M., Topcu, B., Oznur, M., Seber, E. S., Gedikbasi, A., & Yetisyigit, T. (2016). Protective effects of onion ( Allium cepa) extract against doxorubicin-induced hepatotoxicity in rats. Toxicology and Industrial Health, 32(3), 551–557. PubMed Mete, R., Oran, M., Topcu, B., Oznur, M., Seber, E. S., Gedikbasi, A., & Yetisyigit, T. (2016). Protective effects of onion ( Allium cepa) extract against doxorubicin-induced hepatotoxicity in rats. Toxicology and Industrial Health, 32(3), 551–557. PubMed
61.
Zurück zum Zitat Omobowale, T. O., Oyagbemi, A. A., Ajufo, U. E., Adejumobi, O. A., Ola-Davies, O. E., Adedapo, A. A., & Yakubu, M. A. (2018). Ameliorative effect of gallic acid in doxorubicin-induced hepatotoxicity in Wistar rats through antioxidant defense system. Journal of Dietary Supplements, 15(2), 183–196. PubMed Omobowale, T. O., Oyagbemi, A. A., Ajufo, U. E., Adejumobi, O. A., Ola-Davies, O. E., Adedapo, A. A., & Yakubu, M. A. (2018). Ameliorative effect of gallic acid in doxorubicin-induced hepatotoxicity in Wistar rats through antioxidant defense system. Journal of Dietary Supplements, 15(2), 183–196. PubMed
62.
Zurück zum Zitat Wang, Y., Mei, X., Yuan, J., Lu, W., Li, B., & Xu, D. (2015). Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats. Toxicology and Applied Pharmacology, 289(1), 1–11. PubMed Wang, Y., Mei, X., Yuan, J., Lu, W., Li, B., & Xu, D. (2015). Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats. Toxicology and Applied Pharmacology, 289(1), 1–11. PubMed
64.
Zurück zum Zitat Koenig, G., & Seneff, S. (2015). Gamma-glutamyltransferase: A predictive biomarker of cellular antioxidant inadequacy and disease risk.  Disease Markers.‏ Koenig, G., & Seneff, S. (2015). Gamma-glutamyltransferase: A predictive biomarker of cellular antioxidant inadequacy and disease risk.  Disease Markers.‏
65.
Zurück zum Zitat Mohamed, R. H., Karam, R. A., & Amer, M. G. (2011). Epicatechin attenuates doxorubicin-induced brain toxicity: Critical role of TNF-α, iNOS and NF-κB. Brain Research Bulletin, 86(1–2), 22–28. PubMed Mohamed, R. H., Karam, R. A., & Amer, M. G. (2011). Epicatechin attenuates doxorubicin-induced brain toxicity: Critical role of TNF-α, iNOS and NF-κB. Brain Research Bulletin, 86(1–2), 22–28. PubMed
66.
Zurück zum Zitat El-Moselhy, M. A., & El-Sheikh, A. A. (2014). Protective mechanisms of atorvastatin against doxorubicin-induced hepato-renal toxicity. Biomedicine & Pharmacotherapy, 68, 101–110. El-Moselhy, M. A., & El-Sheikh, A. A. (2014). Protective mechanisms of atorvastatin against doxorubicin-induced hepato-renal toxicity. Biomedicine & Pharmacotherapy, 68, 101–110.
67.
Zurück zum Zitat Chen, X., Zhang, Y., Zhu, Z., Liu, H., Guo, H., Xiong, C., et al. (2016). Protective effect of berberine on doxorubicin induced acute hepatorenal toxicity in rats. Molecular Medicine Reports, 13(5), 3953–3960. PubMed Chen, X., Zhang, Y., Zhu, Z., Liu, H., Guo, H., Xiong, C., et al. (2016). Protective effect of berberine on doxorubicin induced acute hepatorenal toxicity in rats. Molecular Medicine Reports, 13(5), 3953–3960. PubMed
68.
Zurück zum Zitat Kelleni, M. T., Amin, E. F., & Abdelrahman, A. M. (2015). Effect of metformin and sitagliptin on doxorubicin-induced cardiotoxicity in rats: impact of oxidative stress, inflammation, and apoptosis. Journal of Toxicology, 2015, 1–8. Kelleni, M. T., Amin, E. F., & Abdelrahman, A. M. (2015). Effect of metformin and sitagliptin on doxorubicin-induced cardiotoxicity in rats: impact of oxidative stress, inflammation, and apoptosis. Journal of Toxicology, 2015, 1–8.
69.
Zurück zum Zitat LeBaron, T. W., Kura, B., Kalocayova, B., Tribulova, N., & Slezak, J. (2019). A new approach for the prevention and treatment of cardiovascular disorders: Molecular hydrogen significantly reduces the effects of oxidative stress. Molecules, 24(11), 2076. PubMedCentral LeBaron, T. W., Kura, B., Kalocayova, B., Tribulova, N., & Slezak, J. (2019). A new approach for the prevention and treatment of cardiovascular disorders: Molecular hydrogen significantly reduces the effects of oxidative stress. Molecules, 24(11), 2076. PubMedCentral
70.
Zurück zum Zitat Sun, J., Sun, G., Cui, X., Meng, X., Qin, M., & Sun, X. (2016). Myricitrin protects against doxorubicin-induced cardiotoxicity by counteracting oxidative stress and inhibiting mitochondrial apoptosis via ERK/P53 pathway. Evidence-Based Complementary and Alternative Medicine, 2016, 1–5. Sun, J., Sun, G., Cui, X., Meng, X., Qin, M., & Sun, X. (2016). Myricitrin protects against doxorubicin-induced cardiotoxicity by counteracting oxidative stress and inhibiting mitochondrial apoptosis via ERK/P53 pathway. Evidence-Based Complementary and Alternative Medicine, 2016, 1–5.
71.
Zurück zum Zitat Durdagi, G., Pehlivan, D. Y., Oyar, E. O., Bahceci, S. A., & Ozbek, M. (2021). Effects of melatonin and adrenomedullin in reducing the cardiotoxic effects of doxorubicin in rats. Cardiovascular Toxicology, 21(5), 354–364. PubMed Durdagi, G., Pehlivan, D. Y., Oyar, E. O., Bahceci, S. A., & Ozbek, M. (2021). Effects of melatonin and adrenomedullin in reducing the cardiotoxic effects of doxorubicin in rats. Cardiovascular Toxicology, 21(5), 354–364. PubMed
72.
Zurück zum Zitat Zare, M. F. R., Rakhshan, K., Aboutaleb, N., Nikbakht, F., Naderi, N., Bakhshesh, M., & Azizi, Y. (2019). Apigenin attenuates doxorubicin induced cardiotoxicity via reducing oxidative stress and apoptosis in male rats. Life Sciences, 232, 116623. PubMed Zare, M. F. R., Rakhshan, K., Aboutaleb, N., Nikbakht, F., Naderi, N., Bakhshesh, M., & Azizi, Y. (2019). Apigenin attenuates doxorubicin induced cardiotoxicity via reducing oxidative stress and apoptosis in male rats. Life Sciences, 232, 116623. PubMed
73.
Zurück zum Zitat Shaker, R. A., Abboud, S. H., Assad, H. C., & Hadi, N. (2018). Enoxaparin attenuates doxorubicin induced cardiotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis. BMC Pharmacology and Toxicology, 19(1), 1–10. Shaker, R. A., Abboud, S. H., Assad, H. C., & Hadi, N. (2018). Enoxaparin attenuates doxorubicin induced cardiotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis. BMC Pharmacology and Toxicology, 19(1), 1–10.
74.
Zurück zum Zitat Tan, B. L., & Norhaizan, M. E. (2019). Curcumin combination chemotherapy: The implication and efficacy in cancer. Molecules, 24(14), 2527. PubMedCentral Tan, B. L., & Norhaizan, M. E. (2019). Curcumin combination chemotherapy: The implication and efficacy in cancer. Molecules, 24(14), 2527. PubMedCentral
75.
Zurück zum Zitat Ma, Y., Yang, L., Ma, J., Lu, L., Wang, X., Ren, J., & Yang, J. (2017). Rutin attenuates doxorubicin-induced cardiotoxicity via regulating autophagy and apoptosis. Biochimica et Biophysica Acta, 1863(8), 1904–1911. PubMed Ma, Y., Yang, L., Ma, J., Lu, L., Wang, X., Ren, J., & Yang, J. (2017). Rutin attenuates doxorubicin-induced cardiotoxicity via regulating autophagy and apoptosis. Biochimica et Biophysica Acta, 1863(8), 1904–1911. PubMed
76.
Zurück zum Zitat Rahman, I. (2002). Oxidative stress, transcription factors and chromatin remodelling in lung inflammation. Biochemical Pharmacology, 64(5–6), 935–942. PubMed Rahman, I. (2002). Oxidative stress, transcription factors and chromatin remodelling in lung inflammation. Biochemical Pharmacology, 64(5–6), 935–942. PubMed
77.
Zurück zum Zitat Aziz, M. M., Abd El Fattah, M. A., Ahmed, K. A., & Sayed, H. M. (2020). Protective effects of olmesartan and l-carnitine on doxorubicin-induced cardiotoxicity in rats. Canadian Journal of Physiology and Pharmacology, 98(4), 183–193. PubMed Aziz, M. M., Abd El Fattah, M. A., Ahmed, K. A., & Sayed, H. M. (2020). Protective effects of olmesartan and l-carnitine on doxorubicin-induced cardiotoxicity in rats. Canadian Journal of Physiology and Pharmacology, 98(4), 183–193. PubMed
79.
Zurück zum Zitat Ni, C., Ma, P., Wang, R., Lou, X., Liu, X., Qin, Y., et al. (2019). Doxorubicin-induced cardiotoxicity involves IFNγ-mediated metabolic reprogramming in cardiomyocytes. The Journal of Pathology, 247(3), 320–332. PubMed Ni, C., Ma, P., Wang, R., Lou, X., Liu, X., Qin, Y., et al. (2019). Doxorubicin-induced cardiotoxicity involves IFNγ-mediated metabolic reprogramming in cardiomyocytes. The Journal of Pathology, 247(3), 320–332. PubMed
80.
Zurück zum Zitat Levick, S. P., & Goldspink, P. H. (2014). Could interferon-gamma be a therapeutic target for treating heart failure? Heart Failure Reviews, 19(2), 227–236. PubMedPubMedCentral Levick, S. P., & Goldspink, P. H. (2014). Could interferon-gamma be a therapeutic target for treating heart failure? Heart Failure Reviews, 19(2), 227–236. PubMedPubMedCentral
81.
Zurück zum Zitat Sadek, K. M., Mahmoud, S. F., Zeweil, M. F., & Abouzed, T. K. (2021). Proanthocyanidin alleviates doxorubicin-induced cardiac injury by inhibiting NF-kB pathway and modulating oxidative stress, cell cycle, and fibrogenesis. Journal of Biochemical and Molecular Toxicology, 35(4), e22716. PubMed Sadek, K. M., Mahmoud, S. F., Zeweil, M. F., & Abouzed, T. K. (2021). Proanthocyanidin alleviates doxorubicin-induced cardiac injury by inhibiting NF-kB pathway and modulating oxidative stress, cell cycle, and fibrogenesis. Journal of Biochemical and Molecular Toxicology, 35(4), e22716. PubMed
82.
Zurück zum Zitat Cosper, P. F., Harvey, P. A., & Leinwand, L. A. (2012). Interferon-gamma causes cardiac myocyte atrophy via selective degradation of myosin heavy chain in a model of chronic myocarditis. American Journal of Pathology., 181, 2038–2046. Cosper, P. F., Harvey, P. A., & Leinwand, L. A. (2012). Interferon-gamma causes cardiac myocyte atrophy via selective degradation of myosin heavy chain in a model of chronic myocarditis. American Journal of Pathology., 181, 2038–2046.
83.
Zurück zum Zitat Sauter, K. A., Wood, L. J., Wong, J., Iordanov, M., & Magun, B. E. (2011). Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome: Progress at a snail’s pace. Cancer Biology & Therapy, 11(12), 1008–1016. Sauter, K. A., Wood, L. J., Wong, J., Iordanov, M., & Magun, B. E. (2011). Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome: Progress at a snail’s pace. Cancer Biology & Therapy, 11(12), 1008–1016.
84.
Zurück zum Zitat Ma, P., Qin, Y., Cao, H., Erben, U., Ni, C., & Qin, Z. (2020). Temporary blockade of interferon-γ ameliorates doxorubicin-induced cardiotoxicity without influencing the anti-tumor effect. Biomedicine & Pharmacotherapy, 130, 110587. Ma, P., Qin, Y., Cao, H., Erben, U., Ni, C., & Qin, Z. (2020). Temporary blockade of interferon-γ ameliorates doxorubicin-induced cardiotoxicity without influencing the anti-tumor effect. Biomedicine & Pharmacotherapy, 130, 110587.
85.
Zurück zum Zitat Qin, Z., Schwartzkopff, J., Pradera, F., Kammertœns, T., Seliger, B., Pircher, H., & Blankenstein, T. (2003). A critical requirement of interferon γ-mediated angiostasis for tumor rejection by CD8+ T cells. Cancer Research, 63(14), 4095–4100. PubMed Qin, Z., Schwartzkopff, J., Pradera, F., Kammertœns, T., Seliger, B., Pircher, H., & Blankenstein, T. (2003). A critical requirement of interferon γ-mediated angiostasis for tumor rejection by CD8+ T cells. Cancer Research, 63(14), 4095–4100. PubMed
86.
Zurück zum Zitat Todorović-Raković, N. (2021). The role of cytokines in the evolution of cancer: IFN-γ paradigm. Cytokine, 1, 155442. Todorović-Raković, N. (2021). The role of cytokines in the evolution of cancer: IFN-γ paradigm. Cytokine, 1, 155442.
87.
Zurück zum Zitat Aktaş, I., Özmen, Ö., Tutun, H., Yalçın, A., & Türk, A. (2020). Artemisinin attenuates doxorubicin induced cardiotoxicity and hepatotoxicity in rats. Biotechnic & Histochemistry, 95(2), 121–128. Aktaş, I., Özmen, Ö., Tutun, H., Yalçın, A., & Türk, A. (2020). Artemisinin attenuates doxorubicin induced cardiotoxicity and hepatotoxicity in rats. Biotechnic & Histochemistry, 95(2), 121–128.
88.
Zurück zum Zitat Akama, K. T., & Van Eldik, L. J. (2000). β-Amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1β-and tumor necrosis factor-α (TNFα)-dependent, and involves a TNFα receptor-associated factor-and NFκB-inducing kinase-dependent signaling mechanism. Journal of Biological Chemistry, 275(11), 7918–7924. Akama, K. T., & Van Eldik, L. J. (2000). β-Amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1β-and tumor necrosis factor-α (TNFα)-dependent, and involves a TNFα receptor-associated factor-and NFκB-inducing kinase-dependent signaling mechanism. Journal of Biological Chemistry, 275(11), 7918–7924.
89.
Zurück zum Zitat Elsharkawy, A. M., & Mann, D. A. (2007). Nuclear factor-κB and the hepatic inflammation-fibrosis-cancer axis. Hepatology, 46(2), 590–597. PubMed Elsharkawy, A. M., & Mann, D. A. (2007). Nuclear factor-κB and the hepatic inflammation-fibrosis-cancer axis. Hepatology, 46(2), 590–597. PubMed
90.
Zurück zum Zitat Aggarwal, B. B. (2003). Signalling pathways of the TNF superfamily: A double-edged sword. Nature Reviews Immunology, 3(9), 745–756. PubMed Aggarwal, B. B. (2003). Signalling pathways of the TNF superfamily: A double-edged sword. Nature Reviews Immunology, 3(9), 745–756. PubMed
91.
Zurück zum Zitat Ahmad, S., Abbas, M., Ullah, M. F., Aziz, M. H., Beylerli, O., Alam, M. A., et al. (2021). Long non-coding RNAs regulated NF-κB signaling in cancer metastasis: Micromanaging by not so small non-coding RNAs. Academic Press. Ahmad, S., Abbas, M., Ullah, M. F., Aziz, M. H., Beylerli, O., Alam, M. A., et al. (2021). Long non-coding RNAs regulated NF-κB signaling in cancer metastasis: Micromanaging by not so small non-coding RNAs. Academic Press.
92.
Zurück zum Zitat Lo, S. Z., Steer, J. H., & Joyce, D. A. (2011). TNF-α renders macrophages resistant to a range of cancer chemotherapeutic agents through NF-κB-mediated antagonism of apoptosis signaling. Cancer Letters, 307(1), 80–92. PubMed Lo, S. Z., Steer, J. H., & Joyce, D. A. (2011). TNF-α renders macrophages resistant to a range of cancer chemotherapeutic agents through NF-κB-mediated antagonism of apoptosis signaling. Cancer Letters, 307(1), 80–92. PubMed
93.
Zurück zum Zitat Chen, Y., Tang, Y., Zhang, Y. C., Huang, X. H., Xie, Y. Q., & Xiang, Y. (2015). A metabolomic study of rats with doxorubicin-induced cardiomyopathy and Shengmai injection treatment. PLoS ONE, 10(5), e0125209. PubMedPubMedCentral Chen, Y., Tang, Y., Zhang, Y. C., Huang, X. H., Xie, Y. Q., & Xiang, Y. (2015). A metabolomic study of rats with doxorubicin-induced cardiomyopathy and Shengmai injection treatment. PLoS ONE, 10(5), e0125209. PubMedPubMedCentral
94.
Zurück zum Zitat Mohebbati, R., Khajavi Rad, A., Naser Shafei, M., Soukhtanloo, M., Hosseinian, S., Beheshti, F., & Reza Khazdair, M. (2015). The effects of vitamin C on adriamycin-induced hypercholesterolemia in rat. Current Nutrition & Food Science, 11(4), 309–314. Mohebbati, R., Khajavi Rad, A., Naser Shafei, M., Soukhtanloo, M., Hosseinian, S., Beheshti, F., & Reza Khazdair, M. (2015). The effects of vitamin C on adriamycin-induced hypercholesterolemia in rat. Current Nutrition & Food Science, 11(4), 309–314.
95.
Zurück zum Zitat Lee, B. H., Taylor, M. G., Robinet, P., Smith, J. D., Schweitzer, J., Sehayek, E., et al. (2013). Dysregulation of cholesterol homeostasis in human prostate cancer through loss of ABCA1. Cancer Research, 73, 1211–1218. PubMed Lee, B. H., Taylor, M. G., Robinet, P., Smith, J. D., Schweitzer, J., Sehayek, E., et al. (2013). Dysregulation of cholesterol homeostasis in human prostate cancer through loss of ABCA1. Cancer Research, 73, 1211–1218. PubMed
96.
Zurück zum Zitat Liu, Z., Huang, P., Law, S., Tian, H., Leung, W., & Xu, C. (2018). Preventive effect of curcumin against chemotherapy-induced side-effects. Frontiers in Pharmacology, 9, 1374. PubMedPubMedCentral Liu, Z., Huang, P., Law, S., Tian, H., Leung, W., & Xu, C. (2018). Preventive effect of curcumin against chemotherapy-induced side-effects. Frontiers in Pharmacology, 9, 1374. PubMedPubMedCentral
Metadaten
Titel
Curcumin Ameliorates Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity Via Suppressing Oxidative Stress and Modulating iNOS, NF-κB, and TNF-α in Rats
verfasst von
Ghadha Ibrahim Fouad
Kawkab A. Ahmed
Publikationsdatum
27.11.2021
Verlag
Springer US
Erschienen in
Cardiovascular Toxicology / Ausgabe 2/2022
Print ISSN: 1530-7905
Elektronische ISSN: 1559-0259
DOI
https://doi.org/10.1007/s12012-021-09710-w

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