Skip to main content
Erschienen in: European Radiology 9/2022

01.04.2022 | Imaging Informatics and Artificial Intelligence

Development and validation of a composite AI model for the diagnosis of levator ani muscle avulsion

verfasst von: Shuangyu Wu, Yong Ren, Xin Lin, Zeping Huang, Zhijuan Zheng, Xinling Zhang

Erschienen in: European Radiology | Ausgabe 9/2022

Einloggen, um Zugang zu erhalten

Abstract

Objective

To assess the feasibility and reliability of a composite AI model for the diagnosis of levator ani muscle (LAM) avulsion of tomographic ultrasound imaging (TUI).

Methods

Ultrasonic images of the pelvic floor from a total of 304 patients taken from January 2018 to October 2020 were included. All patients included underwent standardized interviews and transperineal ultrasound (TPUS). Transfer-learning and ensemble-learning methods were adopted to develop the proposed model on the basis of three classic convolutional neural networks (CNN). Confusion matrix (CM) and the ROC statistic were used to assess the effectiveness of the proposed model. Gradient-weighted class activation mappings (Grad-CAMs) were used to help enhance the interpretability of the proposed model.

Results

Of the 304 patients included, 208 were in the derivation cohort (108 LAM avulsion and 100 normal) and 96 (39 LAM avulsion and 57 normal) were in the validation cohort. The proposed model in LAM avulsion diagnosis outperformed other models and a junior clinician in both the test set of derivation cohort and the validation cohort, with accuracies of 0.95 and 0.81, and AUCs of 0.98 and 0.86, respectively. According to the heatmap of Grad-CAMs, the proposed model mainly localizes areas between the pubic symphysis and the bilateral insertion point of LAM when making a diagnosis, which is exactly the region of interest in clinical practice.

Conclusion

The proposed model using ultrasonic images of the pelvic floor may be a promising tool in assisting the diagnosis of LAM avulsion in clinical practice.

Key Points

• First AI–assisted model for levator ani muscle avulsion diagnosis
• Diagnosis accuracy of less-experienced clinicians could be improved using the proposed model.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Nyhus MO, Oversand SH, Salvesen O, Salvesen KA, Mathew S, Volloyhaug I (2020) Ultrasound assessment of pelvic floor muscle contraction: reliability and development of an ultrasound-based contraction scale. Ultrasound Obstet Gynecol 55:125–131CrossRef Nyhus MO, Oversand SH, Salvesen O, Salvesen KA, Mathew S, Volloyhaug I (2020) Ultrasound assessment of pelvic floor muscle contraction: reliability and development of an ultrasound-based contraction scale. Ultrasound Obstet Gynecol 55:125–131CrossRef
2.
Zurück zum Zitat Caudwell-Hall J, Kamisan Atan I, Martin A et al (2017) Intrapartum predictors of maternal levator ani injury. Acta Obstet Gynecol Scand 96:426–431CrossRef Caudwell-Hall J, Kamisan Atan I, Martin A et al (2017) Intrapartum predictors of maternal levator ani injury. Acta Obstet Gynecol Scand 96:426–431CrossRef
3.
Zurück zum Zitat Dietz HP, Lanzarone V (2005) Levator trauma after vaginal delivery. Obstet Gynecol 106:707–712CrossRef Dietz HP, Lanzarone V (2005) Levator trauma after vaginal delivery. Obstet Gynecol 106:707–712CrossRef
4.
Zurück zum Zitat Yu CH, Chan SSC, Cheung RYK, Chung TKH (2018) Prevalence of levator ani muscle avulsion and effect on quality of life in women with pelvic organ prolapse. Int Urogynecol J 29:729–733CrossRef Yu CH, Chan SSC, Cheung RYK, Chung TKH (2018) Prevalence of levator ani muscle avulsion and effect on quality of life in women with pelvic organ prolapse. Int Urogynecol J 29:729–733CrossRef
5.
Zurück zum Zitat Rodrigo N, Wong V, Shek KL, Martin A, Dietz HP (2014) The use of 3-dimensional ultrasound of the pelvic floor to predict recurrence risk after pelvic reconstructive surgery. Aust N Z J Obstet Gynaecol 54:206–211CrossRef Rodrigo N, Wong V, Shek KL, Martin A, Dietz HP (2014) The use of 3-dimensional ultrasound of the pelvic floor to predict recurrence risk after pelvic reconstructive surgery. Aust N Z J Obstet Gynaecol 54:206–211CrossRef
6.
Zurück zum Zitat Dietz HP, Chantarasorn V, Shek KL (2010) Levator avulsion is a risk factor for cystocele recurrence. Ultrasound Obstet Gynecol 36:76–80CrossRef Dietz HP, Chantarasorn V, Shek KL (2010) Levator avulsion is a risk factor for cystocele recurrence. Ultrasound Obstet Gynecol 36:76–80CrossRef
7.
Zurück zum Zitat Wong V, Shek KL, Goh J, Krause H, Martin A, Dietz HP (2014) Cystocele recurrence after anterior colporrhaphy with and without mesh use. Eur J Obstet Gynecol Reprod Biol 172:131–135CrossRef Wong V, Shek KL, Goh J, Krause H, Martin A, Dietz HP (2014) Cystocele recurrence after anterior colporrhaphy with and without mesh use. Eur J Obstet Gynecol Reprod Biol 172:131–135CrossRef
8.
Zurück zum Zitat Wong NKL, Cheung RYK, Lee LL, Wan OYK, Choy KW, Chan SSC (2021) Women with advanced pelvic organ prolapse and levator ani muscle avulsion would significantly benefit from mesh repair surgery. Ultrasound Obstet Gynecol 57:631–638CrossRef Wong NKL, Cheung RYK, Lee LL, Wan OYK, Choy KW, Chan SSC (2021) Women with advanced pelvic organ prolapse and levator ani muscle avulsion would significantly benefit from mesh repair surgery. Ultrasound Obstet Gynecol 57:631–638CrossRef
9.
Zurück zum Zitat Turel F, Shek KL, Dietz HP (2019) How valid is tomographic ultrasound imaging in diagnosing levator and anal sphincter trauma? J Ultrasound Med 38:889–894CrossRef Turel F, Shek KL, Dietz HP (2019) How valid is tomographic ultrasound imaging in diagnosing levator and anal sphincter trauma? J Ultrasound Med 38:889–894CrossRef
10.
Zurück zum Zitat Valsky DV, Lipschuetz M, Cohen SM et al (2015) Persistence of levator ani sonographic defect detected by three-dimensional transperineal sonography in primiparous women. Ultrasound Obstet Gynecol 46:724–729CrossRef Valsky DV, Lipschuetz M, Cohen SM et al (2015) Persistence of levator ani sonographic defect detected by three-dimensional transperineal sonography in primiparous women. Ultrasound Obstet Gynecol 46:724–729CrossRef
11.
Zurück zum Zitat Zhuang RR, Song YF, Chen ZQ et al (2011) Levator avulsion using a tomographic ultrasound and magnetic resonance-based model. Am J Obstet Gynecol 205(232):e231–e238 Zhuang RR, Song YF, Chen ZQ et al (2011) Levator avulsion using a tomographic ultrasound and magnetic resonance-based model. Am J Obstet Gynecol 205(232):e231–e238
12.
Zurück zum Zitat Yan Y, Dou C, Wang X et al (2017) Combination of tomographic ultrasound imaging and three-dimensional magnetic resonance imaging-based model to diagnose postpartum levator avulsion. Sci Rep 7:11235CrossRef Yan Y, Dou C, Wang X et al (2017) Combination of tomographic ultrasound imaging and three-dimensional magnetic resonance imaging-based model to diagnose postpartum levator avulsion. Sci Rep 7:11235CrossRef
13.
Zurück zum Zitat Dietz HP, Bernardo MJ, Kirby A, Shek KL (2011) Minimal criteria for the diagnosis of avulsion of the puborectalis muscle by tomographic ultrasound. Int Urogynecol J 22:699–704CrossRef Dietz HP, Bernardo MJ, Kirby A, Shek KL (2011) Minimal criteria for the diagnosis of avulsion of the puborectalis muscle by tomographic ultrasound. Int Urogynecol J 22:699–704CrossRef
17.
Zurück zum Zitat Shao L, Zhu F, Li X (2015) Transfer learning for visual categorization: a survey. IEEE Trans Neural Netw Learn Syst 26:1019–1034CrossRef Shao L, Zhu F, Li X (2015) Transfer learning for visual categorization: a survey. IEEE Trans Neural Netw Learn Syst 26:1019–1034CrossRef
18.
Zurück zum Zitat Xue LY, Jiang ZY, Fu TT et al (2020) Transfer learning radiomics based on multimodal ultrasound imaging for staging liver fibrosis. Eur Radiol 30:2973–2983CrossRef Xue LY, Jiang ZY, Fu TT et al (2020) Transfer learning radiomics based on multimodal ultrasound imaging for staging liver fibrosis. Eur Radiol 30:2973–2983CrossRef
19.
Zurück zum Zitat Ryu H, Shin SY, Lee JY, Lee KM, Kang HJ, Yi J (2021) Joint segmentation and classification of hepatic lesions in ultrasound images using deep learning. Eur Radiol 31:8733–8742CrossRef Ryu H, Shin SY, Lee JY, Lee KM, Kang HJ, Yi J (2021) Joint segmentation and classification of hepatic lesions in ultrasound images using deep learning. Eur Radiol 31:8733–8742CrossRef
20.
Zurück zum Zitat An N, Ding H, Yang J, Au R, Ang TFA (2020) Deep ensemble learning for Alzheimer’s disease classification. J Biomed Inform 105:103411CrossRef An N, Ding H, Yang J, Au R, Ang TFA (2020) Deep ensemble learning for Alzheimer’s disease classification. J Biomed Inform 105:103411CrossRef
21.
Zurück zum Zitat Selvaraju RR, Cogswell M, Das A, Vedantam R, Parikh D, Batra D (2017) Grad-CAM: visual explanations from deep networks via gradient-based localization. In: 2017 IEEE International Conference on Computer Vision (ICCV), pp 618–626CrossRef Selvaraju RR, Cogswell M, Das A, Vedantam R, Parikh D, Batra D (2017) Grad-CAM: visual explanations from deep networks via gradient-based localization. In: 2017 IEEE International Conference on Computer Vision (ICCV), pp 618–626CrossRef
22.
Zurück zum Zitat Steyerberg EW, Vergouwe Y (2014) Towards better clinical prediction models: seven steps for development and an ABCD for validation. Eur Heart J 35:1925–1931CrossRef Steyerberg EW, Vergouwe Y (2014) Towards better clinical prediction models: seven steps for development and an ABCD for validation. Eur Heart J 35:1925–1931CrossRef
23.
Zurück zum Zitat van den Noort F, Grob ATM, Slump CH, van der Vaart CH, van Stralen M (2018) Automatic segmentation of puborectalis muscle on three-dimensional transperineal ultrasound. Ultrasound Obstet Gynecol 52:97–102CrossRef van den Noort F, Grob ATM, Slump CH, van der Vaart CH, van Stralen M (2018) Automatic segmentation of puborectalis muscle on three-dimensional transperineal ultrasound. Ultrasound Obstet Gynecol 52:97–102CrossRef
24.
Zurück zum Zitat van den Noort F, van der Vaart CH, Grob ATM, van de Waarsenburg MK, Slump CH, van Stralen M (2019) Deep learning enables automatic quantitative assessment of puborectalis muscle and urogenital hiatus in plane of minimal hiatal dimensions. Ultrasound Obstet Gynecol 54:270–275CrossRef van den Noort F, van der Vaart CH, Grob ATM, van de Waarsenburg MK, Slump CH, van Stralen M (2019) Deep learning enables automatic quantitative assessment of puborectalis muscle and urogenital hiatus in plane of minimal hiatal dimensions. Ultrasound Obstet Gynecol 54:270–275CrossRef
25.
Zurück zum Zitat Garcia-Mejido JA, Fernandez-Palacin A, Bonomi-Barby MJ, De la Fuente VP, Iglesias E, Sainz JA (2020) Online learning for 3D/4D transperineal ultrasound of the pelvic floor. J Matern Fetal Neonatal Med 33:2805–2811CrossRef Garcia-Mejido JA, Fernandez-Palacin A, Bonomi-Barby MJ, De la Fuente VP, Iglesias E, Sainz JA (2020) Online learning for 3D/4D transperineal ultrasound of the pelvic floor. J Matern Fetal Neonatal Med 33:2805–2811CrossRef
26.
Zurück zum Zitat Siafarikas F, Staer-Jensen J, Braekken IH, Bo K, Engh ME (2013) Learning process for performing and analyzing 3D/4D transperineal ultrasound imaging and interobserver reliability study. Ultrasound Obstet Gynecol 41:312–317CrossRef Siafarikas F, Staer-Jensen J, Braekken IH, Bo K, Engh ME (2013) Learning process for performing and analyzing 3D/4D transperineal ultrasound imaging and interobserver reliability study. Ultrasound Obstet Gynecol 41:312–317CrossRef
Metadaten
Titel
Development and validation of a composite AI model for the diagnosis of levator ani muscle avulsion
verfasst von
Shuangyu Wu
Yong Ren
Xin Lin
Zeping Huang
Zhijuan Zheng
Xinling Zhang
Publikationsdatum
01.04.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 9/2022
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-022-08754-y

Weitere Artikel der Ausgabe 9/2022

European Radiology 9/2022 Zur Ausgabe

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.