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Erschienen in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie 5/2021

Open Access 02.09.2020 | Original Article

Effect of the caries-protective self-assembling peptide P11-4 on shear bond strength of metal brackets

verfasst von: Thomas Knaup, Heike Korbmacher-Steiner, Prof. (apl.) Dr. med. dent. Anahita Jablonski-Momeni

Erschienen in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie | Ausgabe 5/2021

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Abstract

Purpose

During orthodontic treatment with fixed appliances, demineralization around brackets often occurs. The aim of this in vitro study was to investigate the effect of the caries-protective self-assembling peptide P11‑4 (SAP P11-4) on the shear bond strength of metal brackets.

Methods

In all, 45 extracted human wisdom teeth were available for the study. The teeth were randomly divided into 3 groups (each n = 15) and pretreated as follows: test group 1: application of SAP P11‑4 (Curodont Repair, Windisch, Switzerland) and storage for 24 h in artificial saliva; test group 2: application of SAP P11‑4; control group: no pretreatment with SAP P11‑4. A conventional metal maxillary incisor bracket (Discovery, Dentaurum, Ispringen) was adhesively bonded to each buccal surface. The shear bond strength was tested according to DIN 13990. After shearing, the Adhesive Remnant Index (ARI) was determined microscopically (10 × magnification). Analysis of variance (ANOVA) was used to check the groups for significant differences (α = 0.05). The distribution of the ARI scores was determined with the χ 2 test.

Results

There was no significant difference in shear forces between the groups (p = 0.121): test group 1 = 17.0 ± 4.51 MPa, test group 2 = 14.01 ± 2.51 MPa, control group 15.54 ± 4.34 MPa. The distribution of the ARI scores between the groups did not vary (p-values = 0.052–0.819).

Conclusion

The application of the caries protective SAP P11‑4 before bonding of brackets did not affect the shear bond strength. Therefore, pretreatment of the enamel surface with SAP P11‑4 shortly before bracket insertion can be considered.
Literatur
1.
Zurück zum Zitat Aggeli A, Fytas G, Vlassopoulos D, McLeish TC, Mawer PJ, Boden N (2001) Structure and dynamics of self-assembling beta-sheet peptide tapes by dynamic light scattering. Biomacromolecules 2:378–388 PubMedCrossRef Aggeli A, Fytas G, Vlassopoulos D, McLeish TC, Mawer PJ, Boden N (2001) Structure and dynamics of self-assembling beta-sheet peptide tapes by dynamic light scattering. Biomacromolecules 2:378–388 PubMedCrossRef
2.
Zurück zum Zitat Alkilzy M, Tarabaih A, Santamaria RM, Splieth CH (2018) Self-assembling peptide p11‑4 and fluoride for regenerating enamel. J Dent Res 97:148–154 PubMedCrossRef Alkilzy M, Tarabaih A, Santamaria RM, Splieth CH (2018) Self-assembling peptide p11‑4 and fluoride for regenerating enamel. J Dent Res 97:148–154 PubMedCrossRef
3.
Zurück zum Zitat Artun J, Bergland S (1984) Clinical trials with crystal growth conditioning as an alternative to acid-etch enamel pretreatment. Am J Orthod 85:333–340 PubMedCrossRef Artun J, Bergland S (1984) Clinical trials with crystal growth conditioning as an alternative to acid-etch enamel pretreatment. Am J Orthod 85:333–340 PubMedCrossRef
4.
Zurück zum Zitat Banks PA, Richmond S (1994) Enamel sealants: a clinical evaluation of their value during fixed appliance therapy. Eur J Orthod 16:19–25 PubMedCrossRef Banks PA, Richmond S (1994) Enamel sealants: a clinical evaluation of their value during fixed appliance therapy. Eur J Orthod 16:19–25 PubMedCrossRef
5.
Zurück zum Zitat Barbosa-Martins LF, de Sousa JP, de Castilho ARF, Puppin-Rontani J, Davies RPW, Puppin-Rontani RM (2018) Enhancing bond strength on demineralized dentin by pre-treatment with selective remineralising agents. J Mech Behav Biomed Mater 81:214–221 PubMedCrossRef Barbosa-Martins LF, de Sousa JP, de Castilho ARF, Puppin-Rontani J, Davies RPW, Puppin-Rontani RM (2018) Enhancing bond strength on demineralized dentin by pre-treatment with selective remineralising agents. J Mech Behav Biomed Mater 81:214–221 PubMedCrossRef
7.
Zurück zum Zitat Bechtold TE, Sobiegalla A, Markovic M, Berneburg M, Göz GR (2013) In vivo effectiveness of enamel sealants around orthodontic brackets. J Orofac Orthop 74:447–457 PubMedCrossRef Bechtold TE, Sobiegalla A, Markovic M, Berneburg M, Göz GR (2013) In vivo effectiveness of enamel sealants around orthodontic brackets. J Orofac Orthop 74:447–457 PubMedCrossRef
8.
Zurück zum Zitat Benham AW, Campbell PM, Buschang PH (2009) Effectiveness of pit and fissure sealants in reducing white spot lesions during orthodontic treatment. A pilot study. Angle Orthod 79:338–345 PubMedCrossRef Benham AW, Campbell PM, Buschang PH (2009) Effectiveness of pit and fissure sealants in reducing white spot lesions during orthodontic treatment. A pilot study. Angle Orthod 79:338–345 PubMedCrossRef
9.
Zurück zum Zitat Bishara SE, Oonsombat C, Soliman MM, Warren J (2005) Effects of using a new protective sealant on the bond strength of orthodontic brackets. Angle Orthod 75:243–246 PubMed Bishara SE, Oonsombat C, Soliman MM, Warren J (2005) Effects of using a new protective sealant on the bond strength of orthodontic brackets. Angle Orthod 75:243–246 PubMed
10.
Zurück zum Zitat Bröseler F, Tietmann C, Bommer C, Drechsel T, Heinzel-Gutenbrunner M, Jepsen S (2020) Randomised clinical trial investigating self-assembling peptide P11‑4 in the treatment of early caries. Clin Oral Invest 24:123–132 CrossRef Bröseler F, Tietmann C, Bommer C, Drechsel T, Heinzel-Gutenbrunner M, Jepsen S (2020) Randomised clinical trial investigating self-assembling peptide P11‑4 in the treatment of early caries. Clin Oral Invest 24:123–132 CrossRef
11.
Zurück zum Zitat Buren JL, Staley RN, Wefel J, Qian F (2008) Inhibition of enamel dem-ineralization by an enamel sealant, pro seal: an in-vitro study. Am J Orthod Dentofacial Orthop 133(Suppl 4):S88–S94 PubMedCrossRef Buren JL, Staley RN, Wefel J, Qian F (2008) Inhibition of enamel dem-ineralization by an enamel sealant, pro seal: an in-vitro study. Am J Orthod Dentofacial Orthop 133(Suppl 4):S88–S94 PubMedCrossRef
12.
Zurück zum Zitat Coordes SL, Jost-Brinkmann PG, Präger TM, Bartzela T, Visel D, Jäcker T, Müller-Hartwich R (2018) A comparison of different sealants preventing demineralization around brackets. J Orofac Orthop 79:49–56 PubMedCrossRef Coordes SL, Jost-Brinkmann PG, Präger TM, Bartzela T, Visel D, Jäcker T, Müller-Hartwich R (2018) A comparison of different sealants preventing demineralization around brackets. J Orofac Orthop 79:49–56 PubMedCrossRef
13.
Zurück zum Zitat Cosma LL, Şuhani RD, Mesaroş A, Badea ME (2019) Current treatment modalities of orthodontically induced white spot lesions and their outcome—a literature review. Med Pharm Rep 92:25–30 PubMedPubMedCentral Cosma LL, Şuhani RD, Mesaroş A, Badea ME (2019) Current treatment modalities of orthodontically induced white spot lesions and their outcome—a literature review. Med Pharm Rep 92:25–30 PubMedPubMedCentral
14.
Zurück zum Zitat Daratsianos N, Schütz B, Reimann S, Weber A, Papageorgiou SN, Jäger A, Bourauel C (2019) The influence of enamel sandblasting on the shear bond strength and fractography of the bracket-adhesive-enamel complex tested in vitro by the DIN 13990:2017-04 standard. Clin Oral Investig 7:2975–2985 CrossRef Daratsianos N, Schütz B, Reimann S, Weber A, Papageorgiou SN, Jäger A, Bourauel C (2019) The influence of enamel sandblasting on the shear bond strength and fractography of the bracket-adhesive-enamel complex tested in vitro by the DIN 13990:2017-04 standard. Clin Oral Investig 7:2975–2985 CrossRef
15.
Zurück zum Zitat Diedrich P (1981) Die Verbundfestigkeit verschiedener orthodontischer Adhäsive zum konditionierten Schmelz und zur Bracketbasis. Fortschr Kieferorthop 42:305–320 CrossRef Diedrich P (1981) Die Verbundfestigkeit verschiedener orthodontischer Adhäsive zum konditionierten Schmelz und zur Bracketbasis. Fortschr Kieferorthop 42:305–320 CrossRef
16.
Zurück zum Zitat El Bokle D, Munir H (2008) An in vitro study of the effect of Pro Seal varnish on the shear bond strength of orthodontic brackets. World J Orthod 9:141–146 PubMed El Bokle D, Munir H (2008) An in vitro study of the effect of Pro Seal varnish on the shear bond strength of orthodontic brackets. World J Orthod 9:141–146 PubMed
17.
Zurück zum Zitat Enaia M, Bock N, Ruf S (2011) White-spot lesions during multibracket appliance treatment: a challenge for clinical excellence. Am J Orthod Dentofacial Orthop 140:e17–e24 PubMedCrossRef Enaia M, Bock N, Ruf S (2011) White-spot lesions during multibracket appliance treatment: a challenge for clinical excellence. Am J Orthod Dentofacial Orthop 140:e17–e24 PubMedCrossRef
18.
Zurück zum Zitat Fornell A‑C, Sköld-Larsson K, Hallgren A, Bergstrand F, Twetman S (2002) Effect of a hydrophobic tooth coating on gingival health, mutans streptococci, and enamel demineralization in adolescents with fixed orthodontic appliances. Acta Odontol Scand 60:37–41 PubMedCrossRef Fornell A‑C, Sköld-Larsson K, Hallgren A, Bergstrand F, Twetman S (2002) Effect of a hydrophobic tooth coating on gingival health, mutans streptococci, and enamel demineralization in adolescents with fixed orthodontic appliances. Acta Odontol Scand 60:37–41 PubMedCrossRef
19.
Zurück zum Zitat Hammad SM, Knösel M (2016) Efficacy of a new sealant to prevent white spot lesions during fixed orthodontic treatment: a 12-month, single-center, randomized controlled clinical trial. J Orofac Orthop 77:439–445 PubMedCrossRef Hammad SM, Knösel M (2016) Efficacy of a new sealant to prevent white spot lesions during fixed orthodontic treatment: a 12-month, single-center, randomized controlled clinical trial. J Orofac Orthop 77:439–445 PubMedCrossRef
20.
Zurück zum Zitat Höchli D, Hersberger-Zurfluh M, Papageorgiou SN, Eliades T (2017) Interventions for orthodontically induced white spot lesions: a systematic review and meta-analysis. Eur J Orthod 39:122–133 PubMed Höchli D, Hersberger-Zurfluh M, Papageorgiou SN, Eliades T (2017) Interventions for orthodontically induced white spot lesions: a systematic review and meta-analysis. Eur J Orthod 39:122–133 PubMed
21.
Zurück zum Zitat Hornby K, Evans M, Long M, Joiner A, Laucello M, Salvaderi A (2009) Enamel benefits of a new hydroxyapatite containing fluoride toothpaste. Int Dent J 59:325–331 CrossRef Hornby K, Evans M, Long M, Joiner A, Laucello M, Salvaderi A (2009) Enamel benefits of a new hydroxyapatite containing fluoride toothpaste. Int Dent J 59:325–331 CrossRef
22.
Zurück zum Zitat Hu W, Featherstone JD (2005) Prevention of enamel demineralization: an in-vitro study using light-cured filled sealant. Am J Orthod Dentofacial Orthop 128:592–600 PubMedCrossRef Hu W, Featherstone JD (2005) Prevention of enamel demineralization: an in-vitro study using light-cured filled sealant. Am J Orthod Dentofacial Orthop 128:592–600 PubMedCrossRef
23.
Zurück zum Zitat Jablonski-Momeni A, Heinzel-Gutenbrunner M (2014) Efficacy of the self-assembling peptide P11‑4 in constructing a remineralization scaffold on artificially-induced enamel lesions on smooth surfaces. J Orofac Orthop 75:175–190 PubMedCrossRef Jablonski-Momeni A, Heinzel-Gutenbrunner M (2014) Efficacy of the self-assembling peptide P11‑4 in constructing a remineralization scaffold on artificially-induced enamel lesions on smooth surfaces. J Orofac Orthop 75:175–190 PubMedCrossRef
25.
Zurück zum Zitat Kind L, Stevanovic S, Wuttig S, Wimberger S, Hofer J, Müller B, Pieles U (2017) Biomimetic remineralization of carious lesions by self-assembling peptide. J Dent 96:790–797 Kind L, Stevanovic S, Wuttig S, Wimberger S, Hofer J, Müller B, Pieles U (2017) Biomimetic remineralization of carious lesions by self-assembling peptide. J Dent 96:790–797
26.
Zurück zum Zitat Kirkham J, Firth A, Vernals D, Boden N, Robinson C, Shore RC, Brookes SJ, Aggeli A (2007) Self-assembling peptide scaffolds promote enamel remineralization. J Dent Res 86:426–430 PubMedCrossRef Kirkham J, Firth A, Vernals D, Boden N, Robinson C, Shore RC, Brookes SJ, Aggeli A (2007) Self-assembling peptide scaffolds promote enamel remineralization. J Dent Res 86:426–430 PubMedCrossRef
27.
Zurück zum Zitat Kirschneck C, Rohn C, Proff P, Reicheneder C (2019) Influence of enamel sealing with a light-cured filled sealant before bracket bonding on the bond failure rate during fixed orthodontic therapy. J Orofac Orthop 80:136–143 PubMedCrossRef Kirschneck C, Rohn C, Proff P, Reicheneder C (2019) Influence of enamel sealing with a light-cured filled sealant before bracket bonding on the bond failure rate during fixed orthodontic therapy. J Orofac Orthop 80:136–143 PubMedCrossRef
29.
Zurück zum Zitat Lowder PD, Foley T, Banting DW (2008) Bond strength of 4 orthodontic adhesives used with a caries-protective resin sealant. Am J Orthod Dentofacial Orthop 134:291–295 PubMedCrossRef Lowder PD, Foley T, Banting DW (2008) Bond strength of 4 orthodontic adhesives used with a caries-protective resin sealant. Am J Orthod Dentofacial Orthop 134:291–295 PubMedCrossRef
30.
Zurück zum Zitat Machiulskiene V, Campus G, Carvalho JC, Dige I, Ekstrand KR, Jablonski-Momeni A et al (2019) Terminology of dental caries and dental caries management: consensus report of a workshop organized by ORCA and cariology research group of IADR (review). Caries Res 7:1–8 Machiulskiene V, Campus G, Carvalho JC, Dige I, Ekstrand KR, Jablonski-Momeni A et al (2019) Terminology of dental caries and dental caries management: consensus report of a workshop organized by ORCA and cariology research group of IADR (review). Caries Res 7:1–8
31.
Zurück zum Zitat Mahajan V (2013) Effect of light-cured filled sealant on the shear bond strength of metal, ceramic and titanium brackets bonded with resin-modified glass ionomer cement. Indian J Dent Res 24:745–749 PubMedCrossRef Mahajan V (2013) Effect of light-cured filled sealant on the shear bond strength of metal, ceramic and titanium brackets bonded with resin-modified glass ionomer cement. Indian J Dent Res 24:745–749 PubMedCrossRef
32.
Zurück zum Zitat Migliorati M, Isaia L, Cassaro A, Rivetti A, Silvestrini-Biavati F, Gastaldo L et al (2014) Efficacy of professional hygiene and prophylaxis on preventing plaque increase in orthodontic patients with multibracket appliances: a systematic review. Eur J Orthod 37:297–307 PubMedCrossRef Migliorati M, Isaia L, Cassaro A, Rivetti A, Silvestrini-Biavati F, Gastaldo L et al (2014) Efficacy of professional hygiene and prophylaxis on preventing plaque increase in orthodontic patients with multibracket appliances: a systematic review. Eur J Orthod 37:297–307 PubMedCrossRef
33.
Zurück zum Zitat Mohammed H, Rizk MZ, Wafaie K, Ulhaq A, Almuzian M (2019) Reminders improve oral hygiene and adherence to appointments in orthodontic patients: a systematic review and meta-analysis. Eur J Orthod 41:204–213 PubMedCrossRef Mohammed H, Rizk MZ, Wafaie K, Ulhaq A, Almuzian M (2019) Reminders improve oral hygiene and adherence to appointments in orthodontic patients: a systematic review and meta-analysis. Eur J Orthod 41:204–213 PubMedCrossRef
34.
Zurück zum Zitat Montasser MA, Drummond JL, Evans CA (2008) Rebonding of orthodontic brackets. Part I, a laboratory and clinical study. Angle Orthod 78:531–536 PubMedCrossRef Montasser MA, Drummond JL, Evans CA (2008) Rebonding of orthodontic brackets. Part I, a laboratory and clinical study. Angle Orthod 78:531–536 PubMedCrossRef
37.
Zurück zum Zitat O’Reilly MT, De Jesús VJ, Hatch JP (2013) Effectiveness of a sealant compared with no sealant in preventing enamel demineralization in patients with fixed orthodontic appliances: a prospective clinical trial. Am J Orthod Dentofacial Orthop 143:837–844 PubMedCrossRef O’Reilly MT, De Jesús VJ, Hatch JP (2013) Effectiveness of a sealant compared with no sealant in preventing enamel demineralization in patients with fixed orthodontic appliances: a prospective clinical trial. Am J Orthod Dentofacial Orthop 143:837–844 PubMedCrossRef
38.
Zurück zum Zitat Ogaard B, Rølla G, Arends J (1988) Orthodontic appliances and enamel demineralization. Part 1. Lesion development. Am J Orthod Dentofacial Orthop 94:68–73 PubMedCrossRef Ogaard B, Rølla G, Arends J (1988) Orthodontic appliances and enamel demineralization. Part 1. Lesion development. Am J Orthod Dentofacial Orthop 94:68–73 PubMedCrossRef
39.
Zurück zum Zitat Papageorgiou SN, Dimitraki D, Kotsanos N, Bekes K, van Waes H (2017) Performance of pit and fissure sealants according to tooth characteristics: a systematic review and meta-analysis. J Dent 66:8–17 PubMedCrossRef Papageorgiou SN, Dimitraki D, Kotsanos N, Bekes K, van Waes H (2017) Performance of pit and fissure sealants according to tooth characteristics: a systematic review and meta-analysis. J Dent 66:8–17 PubMedCrossRef
40.
Zurück zum Zitat Paschos E, Okuka S, Ilie N, Huth KC, Hickel R, Rudzki-Janson I (2006) Investigation of shear-peel bond strength of orthodontic brackets on enamel after using Pro Seal. J Orofac Orthop 67:196–206 PubMedCrossRef Paschos E, Okuka S, Ilie N, Huth KC, Hickel R, Rudzki-Janson I (2006) Investigation of shear-peel bond strength of orthodontic brackets on enamel after using Pro Seal. J Orofac Orthop 67:196–206 PubMedCrossRef
41.
Zurück zum Zitat Pickett KL, Sadowsky PL, Jacobson A, Lacefield W (2001) Orthodontic in vivo bond strength: comparison with in vitro results. Angle Orthod 71:141–148 PubMed Pickett KL, Sadowsky PL, Jacobson A, Lacefield W (2001) Orthodontic in vivo bond strength: comparison with in vitro results. Angle Orthod 71:141–148 PubMed
44.
Zurück zum Zitat Ren Y, Jongsma MA, Mei L, van der Mei HC, Busscher HJ (2014) Orthodontic treatment with fixed appliances and biofilm formation—a potential public health threat? Clin Oral Investig 18:1711–1718 PubMedCrossRef Ren Y, Jongsma MA, Mei L, van der Mei HC, Busscher HJ (2014) Orthodontic treatment with fixed appliances and biofilm formation—a potential public health threat? Clin Oral Investig 18:1711–1718 PubMedCrossRef
45.
Zurück zum Zitat Reynolds IR (1975) A review of direct orthodontic bonding. Br J Orthod 2:171–178 CrossRef Reynolds IR (1975) A review of direct orthodontic bonding. Br J Orthod 2:171–178 CrossRef
46.
Zurück zum Zitat Sonesson M, Bergstrand F, Gizani S, Twetman S (2017) Management of post-orthodontic white spot lesions: an updated systematic review. Eur J Orthod 39:116–121 PubMed Sonesson M, Bergstrand F, Gizani S, Twetman S (2017) Management of post-orthodontic white spot lesions: an updated systematic review. Eur J Orthod 39:116–121 PubMed
47.
Zurück zum Zitat Sundararaj D, Venkatachalapathy S, Tandon A, Pereira A (2015) Critical evaluation of incidence and prevalence of white spot lesions during fixed orthodontic appliance treatment: a meta-analysis. J Int Soc Prev Community Dent 5:433–439 PubMedPubMedCentralCrossRef Sundararaj D, Venkatachalapathy S, Tandon A, Pereira A (2015) Critical evaluation of incidence and prevalence of white spot lesions during fixed orthodontic appliance treatment: a meta-analysis. J Int Soc Prev Community Dent 5:433–439 PubMedPubMedCentralCrossRef
48.
Zurück zum Zitat Tasios T, Papageorgiou SN, Papadopoulos MA, Tsapas A, Haidich AB (2019) Prevention of orthodontic enamel demineralization: a systematic review with meta-analyses. Orthod Craniofac 22:225–235 CrossRef Tasios T, Papageorgiou SN, Papadopoulos MA, Tsapas A, Haidich AB (2019) Prevention of orthodontic enamel demineralization: a systematic review with meta-analyses. Orthod Craniofac 22:225–235 CrossRef
49.
Zurück zum Zitat Tran P, Hamood A, Mosley T, Gray T, Jarvis C, Webster D, Amaechi B, Enos T, Reid T (2013) Organo-selenium-containing dental sealant inhibits bacterial biofilm. J Dent Res 92:461–466 PubMedPubMedCentralCrossRef Tran P, Hamood A, Mosley T, Gray T, Jarvis C, Webster D, Amaechi B, Enos T, Reid T (2013) Organo-selenium-containing dental sealant inhibits bacterial biofilm. J Dent Res 92:461–466 PubMedPubMedCentralCrossRef
50.
Zurück zum Zitat Wenderoth CJ, Weinstein M, Borislow AJ (1999) Effectiveness of a fluoride-releasing sealant in reducing decalcification during orthodontic treatment. Am J Orthod Dentofacial Orthop 116:629–634 PubMedCrossRef Wenderoth CJ, Weinstein M, Borislow AJ (1999) Effectiveness of a fluoride-releasing sealant in reducing decalcification during orthodontic treatment. Am J Orthod Dentofacial Orthop 116:629–634 PubMedCrossRef
Metadaten
Titel
Effect of the caries-protective self-assembling peptide P11-4 on shear bond strength of metal brackets
verfasst von
Thomas Knaup
Heike Korbmacher-Steiner
Prof. (apl.) Dr. med. dent. Anahita Jablonski-Momeni
Publikationsdatum
02.09.2020
Verlag
Springer Medizin
Erschienen in
Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie / Ausgabe 5/2021
Print ISSN: 1434-5293
Elektronische ISSN: 1615-6714
DOI
https://doi.org/10.1007/s00056-020-00247-1