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01.10.2021 | Original Article

Effect of transcranial near-infrared photobiomodulation on cognitive outcomes in D-galactose/AlCl₃ induced brain aging in BALB/c mice

verfasst von: Leila Hosseini, Narmin Farazi, Marjan Erfani, Javad Mahmoudi, Morteza Akbari, Seyed Hojjat Hosseini, Saeed Sadigh-Eteghad

Erschienen in: Lasers in Medical Science | Ausgabe 3/2022

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Abstract

Brain photobiomodulation (PBM) therapy (PBMT) modulates various biological and cognitive processes in senescence rodent models. This study was designed to investigate the effects of transcranial near-infrared (NIR) laser treatment on D-galactose (D-gal)/aluminum chloride (AlCl₃) induced inflammation, synaptic dysfunction, and cognitive impairment in mice. The aged mouse model was induced by subcutaneously injecting D-gal (60 mg/kg/day) followed by intragastrically administering AlCl₃ (200 mg/kg/day) for 2 months. NIR PBM (810 nm laser, 32, 16, and 8 J/cm²) was administered transcranially every other day (3 days/week) for 2 months. Social, contextual, and spatial memories were assessed by social interaction test, passive avoidance test, and Lashley III maze, respectively. Then, tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and synaptic markers including growth-associated protein 43 (GAP-43), post-synaptic density-95 (PSD-95), and synaptophysin (SYN) levels were measured in the hippocampus using western blot method. Behavioral results revealed that NIR PBM at fluencies of 16 and 8 J/cm² could reduce D-gal/AlCl3 impaired social and spatial memories. Treatment with NIR attenuated neuroinflammation through down-regulation of TNF-α and IL-6. Additionally, NIR significantly inhibited the down-regulation of GAP-43 and SYN. The results indicate that transcranial PBM at the fluencies 16 and 8 J/cm² effectively prevents cognitive impairment in mice model of aging by inhibiting the production of the inflammatory cytokines and enhancing synaptic markers.

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Titel: Effect of transcranial near-infrared photobiomodulation on cognitive outcomes in D-galactose/AlCl3 induced brain aging in BALB/c mice
verfasst von: Leila Hosseini
Narmin Farazi
Marjan Erfani
Javad Mahmoudi
Morteza Akbari
Seyed Hojjat Hosseini
Saeed Sadigh-Eteghad
Publikationsdatum: 01.10.2021
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 3/2022
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-021-03433-8

Springer Medizin

Abstract

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