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Lasers in Medical Science

Erschienen in:

19.08.2021 | Review Article

Effects of low-level light therapy on xerostomia related to hyposalivation: a systematic review and meta-analysis of clinical trials

verfasst von: Aljaž Golež, Igor Frangež, Ksenija Cankar, Helena Ban Frangež, Maja Ovsenik, Lidija Nemeth

Erschienen in: Lasers in Medical Science | Ausgabe 2/2022

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Abstract

Hyposalivation is a condition represented by a reduced salivary flow and may include symptoms such as mouth dryness (xerostomia), loss of taste, pain, dysphagia, and dysphonia, all of which greatly affect an individual’s quality of life.

The aim of the present study was to systematically review the effects of low-level light therapy irradiation (photobiomodulation) on salivary gland function in patients with hyposalivation.

The main question of the systematic review was: “Does low-level light irradiation therapy of the salivary glands affect salivary flow rate or indicators of salivary function (ion and protein concentrations) in patients with xerostomia or hyposalivation?” The question was based on the PICO (participant, intervention, control, outcome) principle and followed the PRISMA guidelines. Databases were explored and papers published between the years 1997 and 2020 were reviewed for the following Mesh-term keywords and their corresponding entry terms in different combinations: “Low-level light therapy,” “Xerostomia,” “Saliva,” “Salivary glands,” “Salivation.”

The initial sample consisted of 220 articles. Of those, 47 articles were used for full-text analysis and 18 were used for a systematic review, 14 were used in meta-analysis. According to their individual quality, most articles were classified as high quality of evidence according to the GRADE score. Meta-analysis of the evidence observed increase of unstimulated salivary flow 0.51 SMD compared to placebo (95% CI: 0.16–0.86), I² = 50%, p = 0.005.

The findings of our review revealed evidence of a beneficial effect of photobiomodulation therapy on salivary gland function. The therapy alleviates xerostomia and hyposalivation. However, these effects are reported short term only and did not induce lasting effects of photobiomodulation therapy on patients’ quality of life.

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Titel: Effects of low-level light therapy on xerostomia related to hyposalivation: a systematic review and meta-analysis of clinical trials
verfasst von: Aljaž Golež
Igor Frangež
Ksenija Cankar
Helena Ban Frangež
Maja Ovsenik
Lidija Nemeth
Publikationsdatum: 19.08.2021
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 2/2022
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-021-03392-0

Springer Medizin

Abstract

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Microbicidal effect of 405-nm blue LED light on Candida albicans and Streptococcus mutans dual-species biofilms on denture base resin