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Erschienen in: Cardiovascular Drugs and Therapy 5/2022

04.05.2021 | Original Article

Effects of Major Antihypertensive Drug Classes on Erectile Function: a Network Meta-analysis

verfasst von: Ioannis T. Farmakis, Nikolaos Pyrgidis, Ioannis Doundoulakis, Ioannis Mykoniatis, Evangelos Akrivos, George Giannakoulas

Erschienen in: Cardiovascular Drugs and Therapy | Ausgabe 5/2022

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Abstract

Purpose

To determine the effect of major antihypertensive classes on erectile function (EF) in patients with or at high risk of cardiovascular disease.

Methods

We performed a systematic review and frequentist network meta-analysis of randomized controlled trials assessing the effect of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, β-blockers, calcium channel blockers, and thiazide diuretics on EF compared to each other and to placebo (PROSPERO: CRD42020189529). Similarly, we performed a network meta-analysis to explore the effect of different β-blockers on erectile function (nebivolol, other vasodilating and non-vasodilating β-blockers, placebo). Records were identified through search of PubMed, Cochrane Library, and Scopus databases and sources of grey literature until September 2020.

Results

We included 25 studies (7784 patients) in the qualitative and 16 studies in the quantitative synthesis. The risk of bias was concerning or high in the majority of studies, and inconsistency was also high. No significant differences in EF were demonstrated in the pairwise comparisons between major antihypertensive classes. Similarly, when placebo was set as the reference treatment group, no treatment strategy yielded significant effects on EF. In the β-blockers analysis, nebivolol contributed a beneficial effect on EF only when compared to non-vasodilatory β-blockers (OR 2.92, 95%CI 1.3–6.5) and not when compared to placebo (OR 2.87, 95%CI 0.75–11.04) or to other vasodilatory β-blockers (OR 2.15, 95%CI 0.6–7.77).

Conclusion

All antihypertensive medication classes seem to exert neutral or insignificant effects on EF. Further high-quality studies are needed to better explore the effects of antihypertensive medication on EF.
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Metadaten
Titel
Effects of Major Antihypertensive Drug Classes on Erectile Function: a Network Meta-analysis
verfasst von
Ioannis T. Farmakis
Nikolaos Pyrgidis
Ioannis Doundoulakis
Ioannis Mykoniatis
Evangelos Akrivos
George Giannakoulas
Publikationsdatum
04.05.2021
Verlag
Springer US
Erschienen in
Cardiovascular Drugs and Therapy / Ausgabe 5/2022
Print ISSN: 0920-3206
Elektronische ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-021-07197-9

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