Skip to main content
Erschienen in:

02.08.2019 | Ernährung | CME

Aspekte der Ernährung zur Prävention und Therapie chronisch neurologischer Erkrankungen

verfasst von: Dr. med. Dipl. oec. med. Verena Isabell Leussink

Erschienen in: Der Nervenarzt | Ausgabe 8/2019

Einloggen, um Zugang zu erhalten

Zusammenfassung

Chronisch neurodegenerative und neuroinflammatorische Erkrankungen, wie beispielsweise das idiopathische Parkinson-Syndrom, die amyotrophe Lateralsklerose und die Multiple Sklerose, stellen eine therapeutische Herausforderung dar. Ihre Ursachen sind nicht gut verstanden, eine Heilung ist für keines dieser Krankheitsbilder möglich. In den zurückliegenden Jahrzehnten haben sich die Lebens- und Ernährungsgewohnheiten in den modernen Industrienationen verändert und es mehren Hinweise, dass sich auch Krankheitsprävalenzen und klinische Präsentationen verändern. Epidemiologische Untersuchungen deuten darauf hin, dass es einen Zusammenhang zwischen Nahrungsmittelbestandteilen und der Pathogenese chronisch neurologischer Erkrankungen gibt. Ein profundes Verständnis solcher Zusammenhänge könnte eine verbesserte Krankheitsprävention sowie auch Therapie ermöglichen. Im vorliegenden Weiterbildungsartikel werden daher die aktuellen Erkenntnisse zu ausgewählten Nahrungsmittelbestandteilen und ihren Effekten auf Entstehung und Verlauf chronisch neurologischer Erkrankungen dargestellt.
Literatur
2.
Zurück zum Zitat Vaughn CB, Jakimovski D, Kavak KS et al (2019) Epidemiology and treatment of multiple sclerosis in elderly populations. Nat Rev Neurol 15(6):329–342CrossRefPubMed Vaughn CB, Jakimovski D, Kavak KS et al (2019) Epidemiology and treatment of multiple sclerosis in elderly populations. Nat Rev Neurol 15(6):329–342CrossRefPubMed
3.
Zurück zum Zitat Leussink VI, Hartung HP, Kieseier BC, Stettner M (2016) Subcutaneous immunoglobulins in the treatment of chronic immune-mediated neuropathies. Ther Adv Neurol Disord 9:336–343CrossRefPubMedPubMedCentral Leussink VI, Hartung HP, Kieseier BC, Stettner M (2016) Subcutaneous immunoglobulins in the treatment of chronic immune-mediated neuropathies. Ther Adv Neurol Disord 9:336–343CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Swank RL, Lerstad O, Strøm A, Backer J (1952) Multiple sclerosis in rural Norway its geographic and occupational incidence in relation to nutrition. N Engl J Med 246:722–728CrossRefPubMed Swank RL, Lerstad O, Strøm A, Backer J (1952) Multiple sclerosis in rural Norway its geographic and occupational incidence in relation to nutrition. N Engl J Med 246:722–728CrossRefPubMed
5.
Zurück zum Zitat Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A (2006) Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 296:2832–2838CrossRefPubMed Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A (2006) Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 296:2832–2838CrossRefPubMed
6.
Zurück zum Zitat Munger KL, Zhang SM, O’Reilly E et al (2004) Vitamin D intake and incidence of multiple sclerosis. Neurology 62:60–65CrossRefPubMed Munger KL, Zhang SM, O’Reilly E et al (2004) Vitamin D intake and incidence of multiple sclerosis. Neurology 62:60–65CrossRefPubMed
7.
Zurück zum Zitat Ascherio A, Munger KL (2016) Epidemiology of multiple sclerosis: From risk factors to prevention-An update. Semin Neurol 36:103–114CrossRefPubMed Ascherio A, Munger KL (2016) Epidemiology of multiple sclerosis: From risk factors to prevention-An update. Semin Neurol 36:103–114CrossRefPubMed
8.
Zurück zum Zitat Lucas RM, Ponsonby AL, Dear K et al (2011) Sun exposure and vitamin D are independent risk factors for CNS demyelination. Neurology 76:540–548CrossRefPubMed Lucas RM, Ponsonby AL, Dear K et al (2011) Sun exposure and vitamin D are independent risk factors for CNS demyelination. Neurology 76:540–548CrossRefPubMed
9.
Zurück zum Zitat Ponsonby AL, Lucas RM, van der Mei IA (2005) UVR, vitamin D and three autoimmune diseases—Multiple sclerosis, type 1 diabetes, rheumatoid arthritis. Photochem Photobiol 81:1267–1275CrossRefPubMed Ponsonby AL, Lucas RM, van der Mei IA (2005) UVR, vitamin D and three autoimmune diseases—Multiple sclerosis, type 1 diabetes, rheumatoid arthritis. Photochem Photobiol 81:1267–1275CrossRefPubMed
10.
Zurück zum Zitat Pereira-Santos M, Costa PR, Assis AM, Santos CA, Santos DB (2015) Obesity and vitamin D deficiency: A systematic review and meta-analysis. Obes Rev 16:341–349CrossRefPubMed Pereira-Santos M, Costa PR, Assis AM, Santos CA, Santos DB (2015) Obesity and vitamin D deficiency: A systematic review and meta-analysis. Obes Rev 16:341–349CrossRefPubMed
11.
Zurück zum Zitat von Geldern G, Mowry EM (2012) The influence of nutritional factors on the prognosis of multiple sclerosis. Nat Rev Neurol 8:678–689CrossRef von Geldern G, Mowry EM (2012) The influence of nutritional factors on the prognosis of multiple sclerosis. Nat Rev Neurol 8:678–689CrossRef
12.
Zurück zum Zitat Zhang SM, Willett WC, Hernan MA, Olek MJ, Ascherio A (2000) Dietary fat in relation to risk of multiple sclerosis among two large cohorts of women. Am J Epidemiol 152:1056–1064CrossRefPubMed Zhang SM, Willett WC, Hernan MA, Olek MJ, Ascherio A (2000) Dietary fat in relation to risk of multiple sclerosis among two large cohorts of women. Am J Epidemiol 152:1056–1064CrossRefPubMed
13.
Zurück zum Zitat Hoare S, Lithander F, van der Mei I, Ponsonby AL, Lucas R, Ausimmune Investigator Group (2016) Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination: Results from the Ausimmune Study. Mult Scler 22:884–892CrossRefPubMed Hoare S, Lithander F, van der Mei I, Ponsonby AL, Lucas R, Ausimmune Investigator Group (2016) Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination: Results from the Ausimmune Study. Mult Scler 22:884–892CrossRefPubMed
14.
Zurück zum Zitat Haghikia A, Linker RA (2018) Nutrition, microbiome and multiple sclerosis: Current knowledge from basic research and clinical practice. Nervenarzt 89:463–471CrossRefPubMed Haghikia A, Linker RA (2018) Nutrition, microbiome and multiple sclerosis: Current knowledge from basic research and clinical practice. Nervenarzt 89:463–471CrossRefPubMed
15.
Zurück zum Zitat Berer K, Gerdes LA, Cekanaviciute E et al (2017) Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A 114:10719–10724CrossRefPubMedPubMedCentral Berer K, Gerdes LA, Cekanaviciute E et al (2017) Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A 114:10719–10724CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Ghadirian P, Jain M, Ducic S, Shatenstein B, Morisset R (1998) Nutritional factors in the aetiology of multiple sclerosis: A case-control study in Montreal, Canada. Int J Epidemiol 27:845–852CrossRefPubMed Ghadirian P, Jain M, Ducic S, Shatenstein B, Morisset R (1998) Nutritional factors in the aetiology of multiple sclerosis: A case-control study in Montreal, Canada. Int J Epidemiol 27:845–852CrossRefPubMed
17.
Zurück zum Zitat Thomsen HL, Jessen EB, Passali M, Frederiksen JL (2019) The role of gluten in multiple sclerosis: A systematic review. Mult Scler Relat Disord 27:156–163CrossRefPubMed Thomsen HL, Jessen EB, Passali M, Frederiksen JL (2019) The role of gluten in multiple sclerosis: A systematic review. Mult Scler Relat Disord 27:156–163CrossRefPubMed
18.
Zurück zum Zitat Fitzgerald KC, Tyry T, Salter A et al (2018) A survey of dietary characteristics in a large population of people with multiple sclerosis. Mult Scler Relat Disord 22:12–18CrossRefPubMed Fitzgerald KC, Tyry T, Salter A et al (2018) A survey of dietary characteristics in a large population of people with multiple sclerosis. Mult Scler Relat Disord 22:12–18CrossRefPubMed
19.
Zurück zum Zitat Herden L, Weissert R (2018) The impact of coffee and caffeine on multiple sclerosis compared to other neurodegenerative diseases. Front Nutr 5:133CrossRefPubMedPubMedCentral Herden L, Weissert R (2018) The impact of coffee and caffeine on multiple sclerosis compared to other neurodegenerative diseases. Front Nutr 5:133CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Massa J, O’Reilly EJ, Munger KL, Ascherio A (2013) Caffeine and alcohol intakes have no association with risk of multiple sclerosis. Mult Scler 19:53–58CrossRefPubMed Massa J, O’Reilly EJ, Munger KL, Ascherio A (2013) Caffeine and alcohol intakes have no association with risk of multiple sclerosis. Mult Scler 19:53–58CrossRefPubMed
21.
Zurück zum Zitat Hedstrom AK, Mowry EM, Gianfrancesco MA et al (2016) High consumption of coffee is associated with decreased multiple sclerosis risk; results from two independent studies. J Neurol Neurosurg Psychiatry 87:454–460CrossRefPubMedPubMedCentral Hedstrom AK, Mowry EM, Gianfrancesco MA et al (2016) High consumption of coffee is associated with decreased multiple sclerosis risk; results from two independent studies. J Neurol Neurosurg Psychiatry 87:454–460CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Włodarek D (2019) Role of ketogenic diets in neurodegenerative diseases (Alzheimer’s disease and Parkinson’s disease). Nutrients 11:E169CrossRefPubMed Włodarek D (2019) Role of ketogenic diets in neurodegenerative diseases (Alzheimer’s disease and Parkinson’s disease). Nutrients 11:E169CrossRefPubMed
23.
Zurück zum Zitat Benlloch M, López-Rodríguez MM, Cuerda-Ballester M et al (2019) Satiating effect of a ketogenic diet and its impact on muscle improvement and oxidation state in multiple sclerosis patients. Nutrients 11:1156CrossRefPubMedCentral Benlloch M, López-Rodríguez MM, Cuerda-Ballester M et al (2019) Satiating effect of a ketogenic diet and its impact on muscle improvement and oxidation state in multiple sclerosis patients. Nutrients 11:1156CrossRefPubMedCentral
24.
Zurück zum Zitat Choi IY, Piccio L, Childress P et al (2016) A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms. Cell Rep 15:2136–2146CrossRefPubMedPubMedCentral Choi IY, Piccio L, Childress P et al (2016) A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms. Cell Rep 15:2136–2146CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Phillips MCL, Murtagh DKJ, Gilbertson LJ, Asztely FJS, Lynch CDP (2018) Low-fat versus ketogenic diet in Parkinson’s disease: A pilot randomized controlled trial. Mov Disord 33:1306–1314CrossRefPubMedPubMedCentral Phillips MCL, Murtagh DKJ, Gilbertson LJ, Asztely FJS, Lynch CDP (2018) Low-fat versus ketogenic diet in Parkinson’s disease: A pilot randomized controlled trial. Mov Disord 33:1306–1314CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Ari C, Poff AM, Held HE et al (2014) Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model. PLoS ONE 9:e103526CrossRefPubMedPubMedCentral Ari C, Poff AM, Held HE et al (2014) Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model. PLoS ONE 9:e103526CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Lee JE, Bisht B, Hall MJ et al (2017) A multimodal, nonpharmacologic intervention improves mood and cognitive function in people with multiple sclerosis. J Am Coll Nutr 36:150–168CrossRefPubMed Lee JE, Bisht B, Hall MJ et al (2017) A multimodal, nonpharmacologic intervention improves mood and cognitive function in people with multiple sclerosis. J Am Coll Nutr 36:150–168CrossRefPubMed
28.
Zurück zum Zitat Irish AK, Erickson CM, Wahls TL, Snetselaar LG, Darling WG (2017) Randomized control trial evaluation of a modified Paleolithic dietary intervention in the treatment of relapsing-remitting multiple sclerosis: A pilot study. Degener Neurol Neuromuscul Dis 7:1–18PubMedPubMedCentral Irish AK, Erickson CM, Wahls TL, Snetselaar LG, Darling WG (2017) Randomized control trial evaluation of a modified Paleolithic dietary intervention in the treatment of relapsing-remitting multiple sclerosis: A pilot study. Degener Neurol Neuromuscul Dis 7:1–18PubMedPubMedCentral
30.
Zurück zum Zitat Maraki MI, Yannakoulia M, Stamelou M et al (2019) Mediterranean diet adherence is related to reduced probability of prodromal Parkinson’s disease. Mov Disord 34:48–57CrossRefPubMed Maraki MI, Yannakoulia M, Stamelou M et al (2019) Mediterranean diet adherence is related to reduced probability of prodromal Parkinson’s disease. Mov Disord 34:48–57CrossRefPubMed
31.
Zurück zum Zitat Gao X, Chen H, Fung TT et al (2007) Prospective study of dietary pattern and risk of Parkinson disease. Am J Clin Nutr 86:1486–1494CrossRefPubMedPubMedCentral Gao X, Chen H, Fung TT et al (2007) Prospective study of dietary pattern and risk of Parkinson disease. Am J Clin Nutr 86:1486–1494CrossRefPubMedPubMedCentral
32.
Zurück zum Zitat Sunyach C, Michaud M, Arnoux T et al (2012) Olesoxime delays muscle denervation, astrogliosis, microglial activation and motoneuron death in an ALS mouse model. Neuropharmacology 62:2346–2352CrossRefPubMed Sunyach C, Michaud M, Arnoux T et al (2012) Olesoxime delays muscle denervation, astrogliosis, microglial activation and motoneuron death in an ALS mouse model. Neuropharmacology 62:2346–2352CrossRefPubMed
33.
Zurück zum Zitat Swank RL, Dugan BB (1990) Effect of low saturated fat diet in early and late cases of multiple sclerosis. Lancet 336:37–39CrossRefPubMed Swank RL, Dugan BB (1990) Effect of low saturated fat diet in early and late cases of multiple sclerosis. Lancet 336:37–39CrossRefPubMed
34.
Zurück zum Zitat Wills AM, Hubbard J, Macklin EA et al (2014) Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: A randomised, double-blind, placebo-controlled phase 2 trial. Lancet 383:2065–2072CrossRefPubMedPubMedCentral Wills AM, Hubbard J, Macklin EA et al (2014) Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: A randomised, double-blind, placebo-controlled phase 2 trial. Lancet 383:2065–2072CrossRefPubMedPubMedCentral
36.
Zurück zum Zitat Knekt P, Kilkkinen A, Rissanen H, Marniemi J, Sääksjärvi K, Heliovaara M (2010) Serum vitamin D and the risk of Parkinson disease. Arch Neurol 67:808–811CrossRefPubMedPubMedCentral Knekt P, Kilkkinen A, Rissanen H, Marniemi J, Sääksjärvi K, Heliovaara M (2010) Serum vitamin D and the risk of Parkinson disease. Arch Neurol 67:808–811CrossRefPubMedPubMedCentral
37.
Zurück zum Zitat Shrestha S, Lutsey PL, Alonso A, Huang X, Mosley TH Jr., Chen H (2016) Serum 25-hydroxyvitamin D concentrations in mid-adulthood and Parkinson’s disease risk. Mov Disord 31:972–978CrossRefPubMedPubMedCentral Shrestha S, Lutsey PL, Alonso A, Huang X, Mosley TH Jr., Chen H (2016) Serum 25-hydroxyvitamin D concentrations in mid-adulthood and Parkinson’s disease risk. Mov Disord 31:972–978CrossRefPubMedPubMedCentral
38.
39.
Zurück zum Zitat Healy-Stoffel M, Levant B (2018) N‑3 (omega-3) fatty acids: Effects on brain dopamine systems and potential role in the etiology and treatment of neuropsychiatric disorders. CNS Neurol Disord Drug Targets 17:216–232CrossRefPubMedPubMedCentral Healy-Stoffel M, Levant B (2018) N‑3 (omega-3) fatty acids: Effects on brain dopamine systems and potential role in the etiology and treatment of neuropsychiatric disorders. CNS Neurol Disord Drug Targets 17:216–232CrossRefPubMedPubMedCentral
41.
Zurück zum Zitat Di Lazzaro V, Capone F, Cammarota G, Di Giuda D, Ranieri F (2014) Dramatic improvement of parkinsonian symptoms after gluten-free diet introduction in a patient with silent celiac disease. J Neurol 261:443–445CrossRefPubMed Di Lazzaro V, Capone F, Cammarota G, Di Giuda D, Ranieri F (2014) Dramatic improvement of parkinsonian symptoms after gluten-free diet introduction in a patient with silent celiac disease. J Neurol 261:443–445CrossRefPubMed
42.
Zurück zum Zitat Noyce AJ, Bestwick JP, Silveira-Moriyama L et al (2012) Meta-analysis of early nonmotor features and risk factors for Parkinson disease. Ann Neurol 72:893–901CrossRefPubMedPubMedCentral Noyce AJ, Bestwick JP, Silveira-Moriyama L et al (2012) Meta-analysis of early nonmotor features and risk factors for Parkinson disease. Ann Neurol 72:893–901CrossRefPubMedPubMedCentral
43.
Zurück zum Zitat Ascherio A, Weisskopf MG, O’Reilly EJ et al (2004) Coffee consumption, gender, and Parkinson’s disease mortality in the cancer prevention study II cohort: The modifying effects of estrogen. Am J Epidemiol 160:977–984CrossRefPubMed Ascherio A, Weisskopf MG, O’Reilly EJ et al (2004) Coffee consumption, gender, and Parkinson’s disease mortality in the cancer prevention study II cohort: The modifying effects of estrogen. Am J Epidemiol 160:977–984CrossRefPubMed
45.
Zurück zum Zitat Fitzgerald KC, O’Reilly EJ, Falcone GJ et al (2014) Dietary omega-3 polyunsaturated fatty acid intake and risk for amyotrophic lateral sclerosis. JAMA Neurol 71:1102–1110CrossRefPubMedPubMedCentral Fitzgerald KC, O’Reilly EJ, Falcone GJ et al (2014) Dietary omega-3 polyunsaturated fatty acid intake and risk for amyotrophic lateral sclerosis. JAMA Neurol 71:1102–1110CrossRefPubMedPubMedCentral
46.
Zurück zum Zitat Veldink JH, Kalmijn S, Groeneveld GJ et al (2007) Intake of polyunsaturated fatty acids and vitamin E reduces the risk of developing amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 78:367–371CrossRefPubMed Veldink JH, Kalmijn S, Groeneveld GJ et al (2007) Intake of polyunsaturated fatty acids and vitamin E reduces the risk of developing amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 78:367–371CrossRefPubMed
47.
Zurück zum Zitat Wright ML, Fournier C, Houser MC, Tansey M, Glass J, Hertzberg VS (2018) Potential role of the gut microbiome in ALS: A systematic review. Biol Res Nurs 20:513–521CrossRefPubMed Wright ML, Fournier C, Houser MC, Tansey M, Glass J, Hertzberg VS (2018) Potential role of the gut microbiome in ALS: A systematic review. Biol Res Nurs 20:513–521CrossRefPubMed
48.
Zurück zum Zitat Turner MR, Chohan G, Quaghebeur G, Greenhall RC, Hadjivassiliou M, Talbot K (2007) A case of celiac disease mimicking amyotrophic lateral sclerosis. Nat Clin Pract Neurol 3:581–584CrossRefPubMed Turner MR, Chohan G, Quaghebeur G, Greenhall RC, Hadjivassiliou M, Talbot K (2007) A case of celiac disease mimicking amyotrophic lateral sclerosis. Nat Clin Pract Neurol 3:581–584CrossRefPubMed
49.
Zurück zum Zitat Gadoth A, Nefussy B, Bleiberg M, Klein T, Artman I, Drory VE (2015) Transglutaminase 6 antibodies in the serum of patients with amyotrophic lateral sclerosis. JAMA Neurol 72:676–681CrossRefPubMed Gadoth A, Nefussy B, Bleiberg M, Klein T, Artman I, Drory VE (2015) Transglutaminase 6 antibodies in the serum of patients with amyotrophic lateral sclerosis. JAMA Neurol 72:676–681CrossRefPubMed
50.
Zurück zum Zitat Fondell E, O’Reilly EI, Fitzgerald KC et al (2015) Intakes of caffeine, coffee and tea and risk of amyotrophic lateral sclerosis: Results from five cohort studies. Amyotroph Lateral Scler Frontotemporal Degener 16:366–371CrossRefPubMedPubMedCentral Fondell E, O’Reilly EI, Fitzgerald KC et al (2015) Intakes of caffeine, coffee and tea and risk of amyotrophic lateral sclerosis: Results from five cohort studies. Amyotroph Lateral Scler Frontotemporal Degener 16:366–371CrossRefPubMedPubMedCentral
51.
Zurück zum Zitat Simpson S Jr., Taylor B, Blizzard L et al (2010) Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis. Ann Neurol 68:193–203PubMed Simpson S Jr., Taylor B, Blizzard L et al (2010) Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis. Ann Neurol 68:193–203PubMed
52.
Zurück zum Zitat Runia TF, Hop WC, de Rijke YB, Buljevac D, Hintzen RQ (2012) Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis. Neurology 79:261–266CrossRefPubMed Runia TF, Hop WC, de Rijke YB, Buljevac D, Hintzen RQ (2012) Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis. Neurology 79:261–266CrossRefPubMed
53.
Zurück zum Zitat Ascherio A, Munger KL, White R et al (2014) Vitamin D as an early predictor of multiple sclerosis activity and progression. JAMA Neurol 71:306–314CrossRefPubMedPubMedCentral Ascherio A, Munger KL, White R et al (2014) Vitamin D as an early predictor of multiple sclerosis activity and progression. JAMA Neurol 71:306–314CrossRefPubMedPubMedCentral
54.
Zurück zum Zitat Endres S, Ghorbani R, Kelley VE et al (1989) The effect of dietary supplementation with n‑3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 320:265–271CrossRefPubMed Endres S, Ghorbani R, Kelley VE et al (1989) The effect of dietary supplementation with n‑3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 320:265–271CrossRefPubMed
55.
Zurück zum Zitat Gallai V, Sarchielli P, Trequattrini A et al (1995) Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n‑3 polyunsaturated fatty acids. J Neuroimmunol 56:143–153CrossRefPubMed Gallai V, Sarchielli P, Trequattrini A et al (1995) Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n‑3 polyunsaturated fatty acids. J Neuroimmunol 56:143–153CrossRefPubMed
56.
Zurück zum Zitat Rossetti RG, Seiler CM, DeLuca P, Laposata M, Zurier RB (1997) Oral administration of unsaturated fatty acids: Effects on human peripheral blood T lymphocyte proliferation. J Leukoc Biol 62:438–443CrossRefPubMed Rossetti RG, Seiler CM, DeLuca P, Laposata M, Zurier RB (1997) Oral administration of unsaturated fatty acids: Effects on human peripheral blood T lymphocyte proliferation. J Leukoc Biol 62:438–443CrossRefPubMed
57.
Zurück zum Zitat Bates D, Fawcett PR, Shaw DA, Weightman D (1977) Trial of polyunsaturated fatty acids in non-relapsing multiple sclerosis. Br Med J 2:932–933CrossRefPubMedPubMedCentral Bates D, Fawcett PR, Shaw DA, Weightman D (1977) Trial of polyunsaturated fatty acids in non-relapsing multiple sclerosis. Br Med J 2:932–933CrossRefPubMedPubMedCentral
58.
Zurück zum Zitat Tankou SK, Regev K, Healy BC et al (2018) A probiotic modulates the microbiome and immunity in multiple sclerosis. Ann Neurol 83:1147–1161CrossRefPubMedPubMedCentral Tankou SK, Regev K, Healy BC et al (2018) A probiotic modulates the microbiome and immunity in multiple sclerosis. Ann Neurol 83:1147–1161CrossRefPubMedPubMedCentral
59.
Zurück zum Zitat D’hooghe MB, Haentjens P, Nagels G, De Keyser J (2012) Alcohol, coffee, fish, smoking and disease progression in multiple sclerosis. Eur J Neurol 19:616–624CrossRefPubMed D’hooghe MB, Haentjens P, Nagels G, De Keyser J (2012) Alcohol, coffee, fish, smoking and disease progression in multiple sclerosis. Eur J Neurol 19:616–624CrossRefPubMed
60.
Zurück zum Zitat Taghizadeh M, Tamtaji OR, Dadgostar E et al (2017) The effects of omega-3 fatty acids and vitamin E co-supplementation on clinical and metabolic status in patients with Parkinson’s disease: A randomized, double-blind, placebo-controlled trial. Neurochem Int 108:183–189CrossRefPubMed Taghizadeh M, Tamtaji OR, Dadgostar E et al (2017) The effects of omega-3 fatty acids and vitamin E co-supplementation on clinical and metabolic status in patients with Parkinson’s disease: A randomized, double-blind, placebo-controlled trial. Neurochem Int 108:183–189CrossRefPubMed
61.
Zurück zum Zitat Cassani E, Privitera G, Pezzoli G et al (2011) Use of probiotics for the treatment of constipation in Parkinson’s disease patients. Minerva Gastroenterol Dietol 57:117–121PubMed Cassani E, Privitera G, Pezzoli G et al (2011) Use of probiotics for the treatment of constipation in Parkinson’s disease patients. Minerva Gastroenterol Dietol 57:117–121PubMed
62.
Zurück zum Zitat Barichella M, Pacchetti C, Bolliri C et al (2016) Probiotics and prebiotic fiber for constipation associated with Parkinson disease: An RCT. Neurology 87:1274–1280CrossRefPubMed Barichella M, Pacchetti C, Bolliri C et al (2016) Probiotics and prebiotic fiber for constipation associated with Parkinson disease: An RCT. Neurology 87:1274–1280CrossRefPubMed
Metadaten
Titel
Aspekte der Ernährung zur Prävention und Therapie chronisch neurologischer Erkrankungen
verfasst von
Dr. med. Dipl. oec. med. Verena Isabell Leussink
Publikationsdatum
02.08.2019
Verlag
Springer Medizin
Erschienen in
Der Nervenarzt / Ausgabe 8/2019
Print ISSN: 0028-2804
Elektronische ISSN: 1433-0407
DOI
https://doi.org/10.1007/s00115-019-0756-9

Weitere Artikel der Ausgabe 8/2019

Der Nervenarzt 8/2019 Zur Ausgabe