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Cardiovascular Toxicology
Erschienen in: Cardiovascular Toxicology 7/2022

04.05.2022

Evaluating the Role of lncRNAs in the Incidence of Cardiovascular Diseases in Androgenetic Alopecia Patients

verfasst von: Masoumeh Roohaninasab, Shadnaz fakhteh yavari, Motahareh Babazadeh, Rozita Adldoosti Hagh, Mahboubeh Pazoki, Mehran Amrovani

Erschienen in: Cardiovascular Toxicology | Ausgabe 7/2022

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Abstract

Hair loss occurs in patients with Androgenetic Alopecia (AGA). The pattern of hair loss is different between men and women. The main cause of hair loss is increased cell apoptosis and decreased regeneration, proliferation and differentiation processes in hair follicles. Long Non-Coding RNAs (lncRNAs) are one of the most important molecules that regulate the processes of apoptosis, regeneration, proliferation and differentiation in hair follicles. Since studies have shown that lncRNAs can be effective in the development of cardiotoxicity and induction of cardiovascular disease (CVD); so effective lncRNAs in the regulation of regeneration, proliferation, differentiation and apoptosis of hair follicles can be involved in the development of CVD in AGA patients with. Therefore, this study investigated the lncRNAs involved in increasing apoptosis and reducing the processes of regeneration, proliferation and differentiation of hair follicles. The aim of the current study was to evaluate the role of lncRNAs as a risk factor in the incidence of CVD in AGA patients; it will help to design treatment strategies by targeting signaling pathways without any cardiotoxicity complications.
Literatur
1.
Yang, M., Weng, T., Zhang, W., Zhang, M., He, X., Han, C., & Wang, X. (2021). The roles of non-coding RNA in the development and regeneration of hair follicles: current status and further perspectives. Frontiers in Cell and Developmental Biology, 9, 2891.CrossRef
2.
Salman, K. E., Altunay, I. K., Kucukunal, N. A., & Cerman, A. A. (2017). Frequency, severity and related factors of androgenetic alopecia in dermatology outpatient clinic: Hospital-based cross-sectional study in Turkey. Anais Brasileiros de Dermatologia, 92, 35–40.PubMedPubMedCentralCrossRef
3.
4.
Arias-Santiago, S., Gutierrez-Salmeron, M. T., Buendia-Eisman, A., Giron-Prieto, M. S., & Naranjo-Sintes, R. (2010). A comparative study of dyslipidaemia in men and woman with androgenic alopecia. Acta Dermato-Venereologica, 90, 485.PubMedCrossRef
5.
Ahouansou, S., Le Toumelin, P., Crickx, B., & Descamps, V. (2007). Association of androgenetic alopecia and hypertension. European Journal of Dermatology, 17(3), 220–222.PubMed
6.
Banger, H. S., Malhotra, S. K., Singh, S., & Mahajan, M. (2015). Is early onset androgenic alopecia a marker of metabolic syndrome and carotid artery atherosclerosis in young Indian male patients? International Journal of Trichology, 7(4), 141.PubMedPubMedCentralCrossRef
7.
Sharma, L., Dubey, A., Gupta, P., & Agrawal, A. (2013). Androgenetic alopecia and risk of coronary artery disease. Indian Dermatology Online Journal, 4(4), 283.PubMedPubMedCentralCrossRef
8.
Kessler, E. L., Rivaud, M. R., Vos, M. A., & van Veen, T. A. (2019). Sex-specific influence on cardiac structural remodeling and therapy in cardiovascular disease. Biology of Sex Differences, 10(1), 1–11.CrossRef
9.
Danesh-Shakiba, M., Poorolajal, J., & Alirezaei, P. (2020). Androgenetic alopecia: Relationship to anthropometric indices, blood pressure and life-style habits. Clinical, Cosmetic and Investigational Dermatology, 13, 137.PubMedPubMedCentralCrossRef
10.
11.
Zhang, B. F., Jiang, H., Chen, J., Hu, Q., Yang, S., Liu, X. P., & Liu, G. (2020). LncRNA H19 ameliorates myocardial infarction-induced myocardial injury and maladaptive cardiac remodelling by regulating KDM3A. Journal of Cellular and Molecular Medicine, 24(1), 1099–1115.PubMedCrossRef
12.
Lin, B.-J., Lin, G.-Y., Zhu, J.-Y., Yin, G.-Q., Huang, D., & Yan, Y.-Y. (2020). LncRNA-PCAT1 maintains characteristics of dermal papilla cells and promotes hair follicle regeneration by regulating miR-329/Wnt10b axis. Experimental Cell Research, 394(1), 112031.PubMedCrossRef
13.
Chen, Q., Feng, C., Liu, Y., Li, Q., Qiu, F., Wang, M., Shen, Z. D., & Fu, G. (2019). Long non-coding RNA PCAT-1 promotes cardiac fibroblast proliferation via upregulating TGF-beta1. European Review for Medical and Pharmacological Sciences, 23(23), 10517–10522.PubMed
14.
Li, C., Chang, L., Chen, Z., Liu, Z., Wang, Y., & Ye, Q. (2017). The role of lncRNA MALAT1 in the regulation of hepatocyte proliferation during liver regeneration. International Journal of Molecular Medicine, 39(2), 347–356.PubMedPubMedCentralCrossRef
15.
Li, D., Zhang, C., Li, J., Che, J., Yang, X., Xian, Y., Li, X., & Cao, C. (2019). Long non-coding RNA MALAT1 promotes cardiac remodeling in hypertensive rats by inhibiting the transcription of MyoD. Aging (Albany NY), 11(20), 8792.CrossRef
16.
Li, X., Zhao, J., Geng, J., Chen, F., Wei, Z., Liu, C., Zhang, X., Li, Q., Zhang, J., & Gao, L. (2019). Long non-coding RNA MEG3 knockdown attenuates endoplasmic reticulum stress-mediated apoptosis by targeting p53 following myocardial infarction. Journal of Cellular and Molecular Medicine, 23(12), 8369–8380.PubMedPubMedCentralCrossRef
17.
Wang, W.-L., Chen, L.-J., Wei, S.-Y., Shih, Y.-T., Huang, Y.-H., Lee, P.-L., Lee, C. I., Wang, M. C., Lee, D. Y., & Chien, S. (2021). Mechanoresponsive smad5 enhances MiR-487a processing to promote vascular endothelial proliferation in response to disturbed flow. Frontiers in Cell and Developmental Biology, 9, 647714.PubMedPubMedCentralCrossRef
18.
Li, X., He, X., Wang, H., Li, M., Huang, S., Chen, G., Jing, Y., Wang, S., Chen, Y., & Liao, W. (2018). Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration. Cardiovascular Research, 114(12), 1642–1655.PubMedPubMedCentralCrossRef
19.
Li, X., Sun, Y., Huang, S., Chen, Y., Chen, X., Li, M., Si, X., He, X., Zheng, H., & Zhong, L. (2019). Inhibition of AZIN2-sv induces neovascularization and improves prognosis after myocardial infarction by blocking ubiquitin-dependent talin1 degradation and activating the Akt pathway. eBioMedicine, 39, 69–82.PubMedCrossRef
20.
Wang, D., Xu, X., Pan, J., Zhao, S., Li, Y., Wang, Z., Yang, J., Zhang, X., Wang, Y., & Liu, M. (2021). GAS5 knockdown alleviates spinal cord injury by reducing VAV1 expression via RNA binding protein CELF2. Scientific Reports, 11(1), 1–11.
21.
Zhou, X.-H., Chai, H.-X., Bai, M., & Zhang, Z. (2020). LncRNA-GAS5 regulates PDCD4 expression and mediates myocardial infarction-induced cardiomyocytes apoptosis via targeting MiR-21. Cell Cycle, 19(11), 1363–1377.PubMedPubMedCentralCrossRef
22.
Soliman, A. R., Ahmed, R. M., Yousry, A., Abdelaziz, T. S., & Selem, A. H. (2020). Plasma N-terminal pro-brain natriuretic peptide level as a marker of adverse outcome in patients with co-existing diabetes, chronic kidney disease and heart failure. Journal of Renal Injury Prevention, 10(3), e20–e20.CrossRef
23.
Yin, G., Peng, Y., Lin, Y., Wang, P., Li, Z., Wang, R., & Lin, H. (2021). Long non-coding RNA MSTRG. 24008. 1 regulates the regeneration of the sciatic nerve via the miR-331–3p–NLRP3/MAL axis. Frontiers in Cell and Developmental Biology, 9, 1452.CrossRef
24.
Yousefi, F., Soltani, B. M., & Rabbani, S. (2021). MicroRNA-331 inhibits isoproterenol-induced expression of profibrotic genes in cardiac myofibroblasts via the TGFβ/smad3 signaling pathway. Scientific Reports, 11(1), 1–12.CrossRef
25.
Wang, Y., Zhao, Z.-J., Kang, X.-R., Bian, T., Shen, Z.-M., Jiang, Y., Sun, B., Hu, H. B., & Chen, Y.-S. (2020). lncRNA DLEU2 acts as a miR-181a sponge to regulate SEPP1 and inhibit skeletal muscle differentiation and regeneration. Aging (Albany NY), 12(23), 24033.CrossRef
26.
Hori, D., Dunkerly-Eyring, B., Nomura, Y., Biswas, D., Steppan, J., Henao-Mejia, J., Adachi, H., Santhanam, L., Berkowitz, D. E., & Steenbergen, C. (2017). miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling. PLoS ONE, 12(3), e0174108.PubMedPubMedCentralCrossRef
27.
Li, R., Li, B., Cao, Y., Li, W., Dai, W., Zhang, L., Zhang, X., Ning, C., Li, H., & Yao, Y. (2021). Long non-coding RNA Mir22hg-derived miR-22-3p promotes skeletal muscle differentiation and regeneration by inhibiting HDAC4. Molecular Therapy-Nucleic Acids, 24, 200–211.PubMedPubMedCentralCrossRef
28.
Wang, R., Xu, Y., Zhang, W., Fang, Y., Yang, T., Zeng, D., Wei, T., Liu, J., Zhou, H., & Li, Y. (2021). Inhibiting miR-22 alleviates cardiac dysfunction by regulating Sirt1 in septic cardiomyopathy. Frontiers in Cell and Developmental Biology, 9, 675.
29.
Lin, B.-J., Zhu, J.-Y., Ye, J., Lu, S.-D., Liao, M.-D., Meng, X.-C., & Yin, G.-Q. (2020). LncRNA-XIST promotes dermal papilla induced hair follicle regeneration by targeting miR-424 to activate hedgehog signaling. Cellular Signalling, 72, 109623.PubMedCrossRef
30.
Lin, B., Xu, J., Wang, F., Wang, J., Zhao, H., & Feng, D. (2020). LncRNA XIST promotes myocardial infarction by regulating FOS through targeting miR-101a-3p. Aging (Albany NY), 12(8), 7232.CrossRef
31.
Wang, L., Zhao, Y., Bao, X., Zhu, X., Kwok, Y.K.-Y., Sun, K., Chen, X., Huang, Y., Jauch, R., & Esteban, M. A. (2015). LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration. Cell Research, 25(3), 335–350.PubMedPubMedCentralCrossRef
32.
Kakoki, M., Ramanathan, P. V., Hagaman, J. R., Grant, R., Wilder, J. C., Taylor, J. M., Charles Jennette, J., Smithies, O., & Maeda-Smithies, N. (2021). Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling. Communications Biology, 4(1), 1–12.CrossRef
33.
Peracheh, M., Teymouri, B., Noori, N., Arbabzadeh, T., & Ghasemi, M. (2021). Evaluating the agreement of ultrasound imaging and beta-human chorionic gonadotropin (β-hCG) measurement in confirming completed medical abortion: Cross-sectional study. Qatar Medical Journal, 2021(2), 22.PubMedPubMedCentralCrossRef
34.
Wang, D., Chen, Y., Liu, M., Cao, Q., Wang, Q., Zhou, S., Wang, Y., Mao, S., Gu, X., & Luo, Z. (2020). The long noncoding RNA Arrl1 inhibits neurite outgrowth by functioning as a competing endogenous RNA during neuronal regeneration in rats. Journal of Biological Chemistry, 295(25), 8374–8386.PubMedPubMedCentralCrossRef
35.
Zhou, W., He, X., Chen, Z., Fan, D., Wang, Y., Feng, H., Zhang, G., Lu, A., & Xiao, L. (2019). LncRNA HOTAIR-mediated Wnt/β-catenin network modeling to predict and validate therapeutic targets for cartilage damage. BMC Bioinformatics, 20(1), 1–13.CrossRef
36.
Dai, W., Chao, X., Li, S., Zhou, S., Zhong, G., & Jiang, Z. (2020). Long noncoding RNA HOTAIR functions as a competitive endogenous RNA to regulate Connexin43 remodeling in atrial fibrillation by sponging microRNA-613. Cardiovascular Therapeutics, 2020, 1.CrossRef
37.
38.
Niu, Y.-N., Wang, K., Jin, S., Fan, D.-D., Wang, M.-S., Xing, N.-Z., & Xia, S.-J. (2016). The intriguing role of fibroblasts and c-Jun in the chemopreventive and therapeutic effect of finasteride on xenograft models of prostate cancer. Asian Journal of Andrology, 18(6), 913.PubMed
39.
An, N., Peng, J., He, G., Fan, X., Li, F., & Chen, H. (2018). Involvement of activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling pathway in proliferation of urethral plate fibroblasts in finasteride-induced rat hypospadias. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 24, 8984.CrossRef
40.
Ge, Z., Yin, C., Li, Y., Tian, D., Xiang, Y., Li, Q., Tang, Y., & Zhang, Y. (2022). Long noncoding RNA NEAT1 promotes cardiac fibrosis in heart failure through increased recruitment of EZH2 to the Smad7 promoter region. Journal of Translational Medicine, 20(1), 1–16.CrossRef
41.
Zhang, S., Wu, K., Liu, Y., Lin, Y., Zhang, X., Zhou, J., Zhang, H., Pan, T., & Fu, Y. (2016). Finasteride enhances the generation of human myeloid-derived suppressor cells by up-regulating the COX2/PGE2 pathway. PLoS ONE, 11(6), e0156549.PubMedPubMedCentralCrossRef
42.
Hao, H., Hu, S., Wan, Q., Xu, C., Chen, H., Zhu, L., Xu, Z., Meng, J., Breyer, R. M., & Li, N. (2018). A protective role of microsomal prostaglandin E synthase-1 derived PGE2 and the endothelial EP4 receptor in vascular responses to injury. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(5), 1115.PubMedPubMedCentralCrossRef
43.
Zhao, R., Wang, X., Jiang, C., Shi, F., Zhu, Y., Yang, B., Zhuo, J., Jing, Y., Luo, G., & Xia, S. (2018). Finasteride accelerates prostate wound healing after thulium laser resection through DHT and AR signalling. Cell Proliferation, 51(3), e12415.PubMedCrossRef
44.
Miao, K., Zhou, L., Ba, H., Li, C., Gu, H., Yin, B., Wang, J., Yang, X. P., Li, Z., & Wang, D. W. (2020). Transmembrane tumor necrosis factor alpha attenuates pressure-overload cardiac hypertrophy via tumor necrosis factor receptor 2. PLoS Biology, 18(12), e3000967.PubMedPubMedCentralCrossRef
45.
Shao, S., Zhang, X., Duan, L., Fang, H., Rao, S., Liu, W., Guo, B., & Zhang, X. (2018). Lysyl hydroxylase inhibition by minoxidil blocks collagen deposition and prevents pulmonary fibrosis via TGF-β1/Smad3 signaling pathway. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 24, 8592.CrossRef
46.
Huang, P., Wang, L., Li, Q., Tian, X., Xu, J., Xu, J., Xiong, Y., Chen, G., Qian, H., & Jin, C. (2020). Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA H19. Cardiovascular Research, 116(2), 353–367.PubMedCrossRef
47.
Choi, N., Shin, S., Song, S. U., & Sung, J.-H. (2018). Minoxidil promotes hair growth through stimulation of growth factor release from adipose-derived stem cells. International Journal of Molecular Sciences, 19(3), 691.PubMedCentralCrossRef
48.
Chen, Y.-L., Tsai, Y.-T., Lee, C.-Y., Lee, C.-H., Chen, C.-Y., Liu, C.-M., Chen, J. J., Loh, S. H., & Tsai, C.-S. (2014). Urotensin II inhibits doxorubicin-induced human umbilical vein endothelial cell death by modulating ATF expression and via the ERK and Akt pathway. PLoS ONE, 9(9), e106812.PubMedPubMedCentralCrossRef
49.
Kwon, O. S., Pyo, H. K., Oh, Y. J., Han, J. H., Lee, S. R., Chung, J. H., Eun, H. C., & Kim, K. H. (2007). Promotive effect of minoxidil combined with all-trans retinoic acid (tretinoin) on human hair growth in vitro. Journal of Korean medical science, 22(2), 283–289.PubMedPubMedCentralCrossRef
50.
Garat, C. V., Majka, S. M., Sullivan, T. M., Crossno, J. T., Jr., Reusch, J. E., & Klemm, D. J. (2020). CREB depletion in smooth muscle cells promotes medial thickening, adventitial fibrosis and elicits pulmonary hypertension. Pulmonary Circulation, 10(2), 2045894019898374.PubMedPubMedCentralCrossRef
51.
Tong, S., Ji, Q., Du, Y., Zhu, X., Zhu, C., & Zhou, Y. (2019). Sfrp5/Wnt pathway: A protective regulatory system in atherosclerotic cardiovascular disease. Journal of Interferon & Cytokine Research, 39(8), 472–482.CrossRef
52.
Wei, Y., Wang, T., Zhang, N., Ma, Y., Shi, S., Zhang, R., Zheng, X., & Zhao, L. (2021). LncRNA TRHDE-AS1 inhibit the scar fibroblasts proliferation via miR-181a-5p/PTEN axis. Journal of Molecular Histology, 52(2), 419–426.PubMedPubMedCentralCrossRef
53.
Li, F.-J., Zhang, C.-L., Luo, X.-J., Peng, J., & Yang, T.-L. (2019). Involvement of the MiR-181b-5p/HMGB1 pathway in Ang II-induced phenotypic transformation of smooth muscle cells in hypertension. Aging and Disease, 10(2), 231.PubMedPubMedCentralCrossRef
54.
Sun, Y., Zhou, Q., Li, J., Zhao, C., Yu, Z., & Zhu, Q. (2019). LncRNA RP11-422N16. 3 inhibits cell proliferation and EMT, and induces apoptosis in hepatocellular carcinoma cells by sponging miR-23b-3p. OncoTargets and Therapy, 12, 10943.PubMedPubMedCentralCrossRef
55.
Iaconetti, C., De Rosa, S., Polimeni, A., Sorrentino, S., Gareri, C., Carino, A., Sabatino, J., Colangelo, M., Curcio, A., & Indolfi, C. (2015). Down-regulation of miR-23b induces phenotypic switching of vascular smooth muscle cells in vitro and in vivo. Cardiovascular Research, 107(4), 522–533.PubMedCrossRef
56.
Cao, F., Wang, Z., Feng, Y., Zhu, H., Yang, M., Zhang, S., & Wang, X. (2020). lncRNA TPTEP1 competitively sponges miR-328-5p to inhibit the proliferation of non-small cell lung cancer cells. Oncology Reports, 43(5), 1606–1618.PubMedPubMedCentral
57.
Zhang, C., Wang, L., & Shen, Y. (2021). Circ_0004104 knockdown alleviates oxidized low-density lipoprotein-induced dysfunction in vascular endothelial cells through targeting miR-328-3p/TRIM14 axis in atherosclerosis. BMC Cardiovascular Disorders, 21(1), 1–12.CrossRef
58.
Zhou, X., Chen, H., Zhu, L., Hao, B., Zhang, W., Hua, J., Gu, H., Jin, W., & Zhang, G. (2016). Helicobacter pylori infection related long noncoding RNA (lncRNA) AF147447 inhibits gastric cancer proliferation and invasion by targeting MUC2 and up-regulating miR-34c. Oncotarget, 7(50), 82770.PubMedPubMedCentralCrossRef
59.
Bernardo, B. C., Gao, X.-M., Winbanks, C. E., Boey, E. J., Tham, Y. K., Kiriazis, H., Gregorevic, P., Obad, S., Kauppinen, S., & Du, X.-J. (2012). Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function. Proceedings of the National Academy of Sciences, 109(43), 17615–17620.CrossRef
60.
Deng, Y., Wei, Z., Huang, M., Xu, G., Wei, W., Peng, B., Nong, S., & Qin, H. (2020). Long non-coding RNA F11-AS1 inhibits HBV-related hepatocellular carcinoma progression by regulating NR1I3 via binding to microRNA-211-5p. Journal of Cellular and Molecular Medicine, 24(2), 1848–1865.PubMedCrossRef
61.
Xu, F., Zhong, J. Y., Lin, X., Shan, S. K., Guo, B., Zheng, M. H., Wang, Y., Li, F., Cui, R. R., & Wu, F. (2020). Melatonin alleviates vascular calcification and ageing through exosomal miR-204/miR-211 cluster in a paracrine manner. Journal of pineal research, 68(3), e12631.PubMedPubMedCentralCrossRef
62.
Yang, Z., Wang, Z., & Duan, Y. (2020). LncRNA MEG3 inhibits non-small cell lung cancer via interaction with DKC1 protein. Oncology Letters, 20(3), 2183–2190.PubMedPubMedCentralCrossRef
63.
Zou, L., Ma, X., Lin, S., Wu, B., Chen, Y., & Peng, C. (2019). Long noncoding RNA-MEG3 contributes to myocardial ischemia–reperfusion injury through suppression of miR-7–5p expression. Bioscience Reports. https://​doi.​org/​10.​1042/​BSR20190210
64.
Liu, L., Wang, H.-J., Meng, T., Lei, C., Yang, X.-H., Wang, Q.-S., Jin, B., & Zhu, J.-F. (2019). lncRNA GAS5 inhibits cell migration and invasion and promotes autophagy by targeting miR-222-3p via the GAS5/PTEN-signaling pathway in CRC. Molecular Therapy-Nucleic Acids, 17, 644–656.PubMedPubMedCentralCrossRef
65.
He, X., Wang, S., Li, M., Zhong, L., Zheng, H., Sun, Y., Lai, Y., Chen, X., Wei, G., & Si, X. (2019). Long noncoding RNA GAS5 induces abdominal aortic aneurysm formation by promoting smooth muscle apoptosis. Theranostics, 9(19), 5558.PubMedPubMedCentralCrossRef
66.
Ji, T., Zhang, Y., Wang, Z., Hou, Z., Gao, X., & Zhang, X. (2020). FOXD3-AS1 suppresses the progression of non-small cell lung cancer by regulating miR-150/SRCIN1axis. Cancer Biomarkers, 29(3), 417–427.PubMedCrossRef
67.
Tong, G., Wang, Y., Xu, C., Xu, Y., Ye, X., Zhou, L., Zhu, G., Zhou, Z., & Huang, J. (2019). Long non-coding RNA FOXD3-AS1 aggravates ischemia/reperfusion injury of cardiomyocytes through promoting autophagy. American Journal of Translational Research, 11(9), 5634.PubMedPubMedCentral
68.
69.
Fan, C., Cui, X., Chen, S., Huang, S., & Jiang, H. (2020). LncRNA LOC100912373 modulates PDK1 expression by sponging miR-17-5p to promote the proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. American Journal of Translational Research, 12(12), 7709.PubMedPubMedCentral
70.
Zadeh, F. J., Ghasemi, Y., Bagheri, S., Maleknia, M., Davari, N., & Rezaeeyan, H. (2020). Do exosomes play role in cardiovascular disease development in hematological malignancy? Molecular Biology Reports, 47(7), 5487–5493.PubMedCrossRef
71.
Zhang, J., Li, Y., Liu, Y., Xu, G., Hei, Y., Lu, X., & Liu, W. (2021). Long non-coding RNA NEAT1 regulates glioma cell proliferation and apoptosis by competitively binding to microRNA-324-5p and upregulating KCTD20 expression. Oncology Reports, 46(1), 1–17.CrossRef
72.
Zhang, M., Wang, X., Yao, J., & Qiu, Z. (2019). Long non-coding RNA NEAT1 inhibits oxidative stress-induced vascular endothelial cell injury by activating the miR-181d-5p/CDKN3 axis. Artificial Cells, Nanomedicine, and Biotechnology, 47(1), 3129–3137.PubMedCrossRef
73.
Zadeh, F. J., Mohammadtaghizadeh, M., Bahadori, H., Saki, N., & Rezaeeyan, H. (2020). The role of exogenous fibrinogen in cardiac surgery: Stop bleeding or induce cardiovascular disease. Molecular Biology Reports, 47(10), 8189–8198.PubMedCrossRef
74.
Cai, B., Zheng, Y., Ma, S., Xing, Q., Wang, X., Yang, B., Yin, G., & Guan, F. (2018). Long non-coding RNA regulates hair follicle stem cell proliferation and differentiation through PI3K/AKT signal pathway. Molecular Medicine Reports, 17(4), 5477–5483.PubMed
75.
Cai, B., Wang, X., Liu, H., Ma, S., Zhang, K., Zhang, Y., Li, Q., Wang, J., Yao, M., & Guan, F. (2019). Up-regulated lncRNA5322 elevates MAPK1 to enhance proliferation of hair follicle stem cells as a ceRNA of microRNA-19b-3p. Cell Cycle, 18(14), 1588–1600.PubMedPubMedCentralCrossRef
76.
Xu, J., Tang, Y., Bei, Y., Ding, S., Che, L., Yao, J., Wang, H., Lv, D., & Xiao, J. (2016). miR-19b attenuates H2O2-induced apoptosis in rat H9C2 cardiomyocytes via targeting PTEN. Oncotarget, 7(10), 10870.PubMedPubMedCentralCrossRef
77.
Zadeh, F. J., Akbari, T., Samimi, A., Davari, N., & Rezaeeyan, H. (2020). The role of molecular mechanism of ten-eleven translocation2 (TET2) family proteins in pathogenesis of cardiovascular diseases (CVDs). Molecular Biology Reports, 47(7), 5503–5509.PubMedCrossRef
78.
Haybar, H., Rezaeeyan, H., Shahjahani, M., Shirzad, R., & Saki, N. (2019). T-bet transcription factor in cardiovascular disease: attenuation or inflammation factor? Journal of Cellular Physiology, 234(6), 7915–7922.PubMedCrossRef
79.
Jiang, H., Li, X., Wang, W., & Dong, H. (2020). Long non-coding RNA SNHG3 promotes breast cancer cell proliferation and metastasis by binding to microRNA-154-3p and activating the notch signaling pathway. BMC Cancer, 20(1), 1–13.CrossRef
80.
Dong, P., Liu, W., & Wang, Z. (2018). MiR-154 promotes myocardial fibrosis through beta-catenin signaling pathway. European Review for Medical and Pharmacological Sciences, 22(7), 2052–2060.PubMed
81.
He, R., Zhang, W., Chen, S., Liu, Y., Yang, W., & Li, J. (2020). Transcriptional profiling reveals the regulatory role of DNER in promoting pancreatic neuroendocrine neoplasms. Frontiers in Genetics, 11, 1502.CrossRef
82.
Quillard, T., Coupel, S., Coulon, F., Fitau, J., Chatelais, M., Cuturi, M., Chiffoleau, E., & Charreau, B. (2008). Impaired Notch4 activity elicits endothelial cell activation and apoptosis: Implication for transplant arteriosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(12), 2258–2265.PubMedCrossRef
83.
Li, J., Zhang, Q., Fan, X., Mo, W., Dai, W., Feng, J., Wu, L., Liu, T., Li, S., & Xu, S. (2017). The long noncoding RNA TUG1 acts as a competing endogenous RNA to regulate the Hedgehog pathway by targeting miR-132 in hepatocellular carcinoma. Oncotarget, 8(39), 65932.PubMedPubMedCentralCrossRef
84.
Xing, Z., Li, S., Liu, Z., Zhang, C., Meng, M., & Bai, Z. (2020). The long non-coding RNA LINC00473 contributes to cell proliferation via JAK-STAT3 signaling pathway by regulating miR-195-5p/SEPT2 axis in prostate cancer. Bioscience Reports. https://​doi.​org/​10.​1042/​BSR20191850
85.
Fu, C., Li, D., Zhang, X., Liu, N., Chi, G., & Jin, X. (2018). LncRNA PVT1 facilitates tumorigenesis and progression of glioma via regulation of MiR-128-3p/GREM1 axis and BMP signaling pathway. Neurotherapeutics, 15(4), 1139–1157.PubMedPubMedCentralCrossRef
86.
Su, Q., Liu, Y., Lv, X.-W., Dai, R.-X., Yang, X.-H., & Kong, B.-H. (2020). LncRNA TUG1 mediates ischemic myocardial injury by targeting miR-132-3p/HDAC3 axis. American Journal of Physiology-Heart and Circulatory Physiology, 318(2), H332–H344.PubMedCrossRef
87.
Sun, B., Meng, M., Wei, J., & Wang, S. (2020). Long noncoding RNA PVT1 contributes to vascular endothelial cell proliferation via inhibition of miR-190a-5p in diagnostic biomarker evaluation of chronic heart failure. Experimental and Therapeutic Medicine, 19(5), 3348–3354.PubMedPubMedCentral
88.
Du, H., Zhang, H., Yang, R., Qiao, L., Shao, H., & Zhang, X. (2021). Small interfering RNA-induced silencing lncRNA PVT1 inhibits atherosclerosis via inactivating the MAPK/NF-κB pathway. Aging (Albany NY), 13(21), 24449.CrossRef
89.
Li, Q., Wang, X.-J., & Jin, J.-H. (2019). SOX2-induced upregulation of lncRNA LINC01510 promotes papillary thyroid carcinoma progression by modulating miR-335/SHH and activating Hedgehog pathway. Biochemical and Biophysical Research Communications, 520(2), 277–283.PubMedCrossRef
90.
Wang, A., Dai, L., Yang, L., Wang, Y., Hao, X., Liu, Z., & Chen, P. (2021). Upregulation of miR-335 reduces myocardial injury following myocardial infarction via targeting MAP3K2. European Review for Medical and Pharmacological Sciences, 25(1), 344–352.PubMed
91.
Si, Y., Bai, J., Wu, J., Li, Q., Mo, Y., Fang, R., & Lai, W. (2018). LncRNA PlncRNA-1 regulates proliferation and differentiation of hair follicle stem cells through TGF-β1-mediated Wnt/β-catenin signal pathway. Molecular Medicine Reports, 17(1), 1191–1197.PubMed
92.
Chen, Z., Zhang, Z., Zhao, D., Feng, W., Meng, F., Han, S., Lin, B., & Shi, X. (2019). Long noncoding RNA (lncRNA) FOXD2-AS1 promotes cell proliferation and metastasis in hepatocellular carcinoma by regulating MiR-185/AKT axis. Medical Science Monitor, 25, 9618.PubMedPubMedCentralCrossRef
93.
Ge, X., Li, G.-Y., Jiang, L., Jia, L., Zhang, Z., Li, X., Wang, R., Zhou, M., Zhou, Y., & Zeng, Z. (2019). Long noncoding RNA CAR10 promotes lung adenocarcinoma metastasis via miR-203/30/SNAI axis. Oncogene, 38(16), 3061–3076.PubMedPubMedCentralCrossRef
94.
Li, M., Xie, Z., Wang, P., Li, J., Liu, W., Tang, S. A., Liu, Z., Wu, X., Wu, Y., & Shen, H. (2018). The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA. Cell Death & Disease, 9(5), 1–13.CrossRef
95.
Han, Y., Wu, N., Xia, F., Liu, S., & Jia, D. (2020). Long non-coding RNA GAS5 regulates myocardial ischemia-reperfusion injury through the PI3K/AKT apoptosis pathway by sponging miR-532-5p. International Journal of Molecular Medicine, 45(3), 858–872.PubMedPubMedCentral
96.
Liu, Z., Liu, L., Zhong, Y., Cai, M., Gao, J., Tan, C., Han, X., Guo, R., & Han, L. (2019). LncRNA H19 over-expression inhibited Th17 cell differentiation to relieve endometriosis through miR-342-3p/IER3 pathway. Cell & Bioscience, 9(1), 1–10.CrossRef
97.
Liu, F., Yang, X.-C., Chen, M.-L., Zhuang, Z.-W., Jiang, Y., Wang, J., & Zhou, Y.-J. (2020). LncRNA H19/Runx2 axis promotes VSMCs transition via MAPK pathway. American Journal of Translational Research, 12(4), 1338.PubMedPubMedCentral
98.
99.
He, S., Yang, S., Zhang, Y., Li, X., Gao, D., Zhong, Y., Cao, L., Ma, H., Liu, Y., & Li, G. (2019). LncRNA ODIR1 inhibits osteogenic differentiation of hUC-MSCs through the FBXO25/H2BK120ub/H3K4me3/OSX axis. Cell Death & Disease, 10(12), 1–16.CrossRef
100.
Wang, C.-G., Hu, Y.-H., Su, S.-L., & Zhong, D. (2020). LncRNA DANCR and miR-320a suppressed osteogenic differentiation in osteoporosis by directly inhibiting the Wnt/β-catenin signaling pathway. Experimental & Molecular Medicine, 52(8), 1310–1325.CrossRef
101.
Xiang, J., Fu, H. Q., Xu, Z., Fan, W. J., Liu, F., & Chen, B. (2020). lncRNA SNHG1 attenuates osteogenic differentiation via the miR-101/DKK1 axis in bone marrow mesenchymal stem cells. Molecular Medicine Reports, 22(5), 3715–3722.PubMedPubMedCentral
102.
Li, D., Tian, Y., Yin, C., Huai, Y., Zhao, Y., Su, P., Wang, X., Pei, J., Zhang, K., & Yang, C. (2019). Silencing of lncRNA AK045490 promotes osteoblast differentiation and bone formation via β-Catenin/TCF1/Runx2 signaling axis. International Journal of Molecular Sciences, 20(24), 6229.PubMedCentralCrossRef
103.
Li, D., Liu, Y., Gao, W., Han, J., Yuan, R., Zhang, M., & Ge, Z. (2020). LncRNA HCG11 inhibits adipocyte differentiation in human adipose-derived mesenchymal stem cells by sponging miR-204-5p to upregulate SIRT1. Cell Transplantation, 29, 0963689720968090.PubMedCentralCrossRef
104.
Guo, R., Zou, B., Liang, Y., Bian, J., Xu, J., Zhou, Q., Zhang, C., Chen, T., Yang, M., & Wang, H. (2021). LncRNA RCAT1 promotes tumor progression and metastasis via miR-214-5p/E2F2 axis in renal cell carcinoma. Cell Death & Disease, 12(7), 1–14.CrossRef
105.
Jin, F., Li, M., Li, X., Zheng, Y., Zhang, K., Liu, X., Cai, B., & Yin, G. (2022). PlncRNA-1 stimulates hair follicle stem cell differentiation in wound healing via the EZH2/ZEB1/MAPK1 axis. The Journal of Gene Medicine, 2022, e3408.
106.
Yu, L., Qu, H., Yu, Y., Li, W., Zhao, Y., & Qiu, G. (2018). Lnc RNA-PCAT 1 targeting miR-145-5p promotes TLR 4-associated osteogenic differentiation of adipose-derived stem cells. Journal of Cellular and Molecular Medicine, 22(12), 6134–6147.PubMedPubMedCentralCrossRef
107.
Yu, Y., Chen, Y., Zhang, X., Lu, X., Hong, J., Guo, X., & Zhou, D. (2018). Knockdown of lncRNA KCNQ1OT1 suppresses the adipogenic and osteogenic differentiation of tendon stem cell via downregulating miR-138 target genes PPARγ and RUNX2. Cell Cycle, 17(19–20), 2374–2385.PubMedPubMedCentralCrossRef
108.
Zhang, M., Li, F., Sun, J.-W., Li, D.-H., Li, W.-T., Jiang, R.-R., Li, Z. J., Liu, X. J., Han, R. L., & Li, G.-X. (2019). LncRNA IMFNCR promotes intramuscular adipocyte differentiation by sponging miR-128-3p and miR-27b-3p. Frontiers in Genetics, 10, 42.PubMedPubMedCentralCrossRef
109.
Cao, X., Zhang, Z., Wang, Y., Shan, W., Wang, R., Mao, S., Ding, S., Pang, C., Li, B., & Zhou, J. (2021). MiR-27a-3p/Hoxa10 axis regulates angiotensin ii-induced cardiomyocyte hypertrophy by targeting Kv4. 3 expression. Frontiers in Pharmacology, 12, 970.CrossRef
110.
111.
Wang, Y., Zhu, P., Luo, J., Wang, J., Liu, Z., Wu, W., Du, Y., Ye, B., Wang, D., & He, L. (2019). LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling. The EMBO Journal, 38(17), e101110.PubMedPubMedCentralCrossRef
112.
Wang, Y., Wang, K., Hu, Z., Zhou, H., Zhang, L., Wang, H., Li, G., Zhang, S., Cao, X., & Shi, F. (2018). MicroRNA-139-3p regulates osteoblast differentiation and apoptosis by targeting ELK1 and interacting with long noncoding RNA ODSM. Cell Death & Disease, 9(11), 1–16.CrossRef
113.
Shi, Z.-L., Zhang, H., Fan, Z.-Y., Ma, W., Song, Y.-Z., Li, M., Li, T. Q., Cao, S. X., & Feng, G.-J. (2020). Long noncoding RNA LINC00314 facilitates osteogenic differentiation of adipose-derived stem cells through the hsa-miR-129-5p/GRM5 axis via the Wnt signaling pathway. Stem Cell Research & Therapy, 11(1), 1–14.CrossRef
114.
Zhang, H., Zhang, X., & Zhang, J. (2018). MiR-129-5p inhibits autophagy and apoptosis of H9c2 cells induced by hydrogen peroxide via the PI3K/AKT/mTOR signaling pathway by targeting ATG14. Biochemical and Biophysical Research Communications, 506(1), 272–277.PubMedCrossRef
115.
Jiang, W., Liu, Y., Liu, R., Zhang, K., & Zhang, Y. (2015). The lncRNA DEANR1 facilitates human endoderm differentiation by activating FOXA2 expression. Cell Reports, 11(1), 137–148.PubMedCrossRef
116.
Gao, Z., Wang, Q., Ji, M., Guo, X., Li, L., & Su, X. (2021). Exosomal lncRNA UCA1 modulates cervical cancer stem cell self-renewal and differentiation through microRNA-122-5p/SOX2 axis. Journal of Translational Medicine, 19(1), 1–11.CrossRef
117.
Zhou, G., Li, C., Feng, J., Zhang, J., & Fang, Y. (2018). lncRNA UCA1 is a novel regulator in cardiomyocyte hypertrophy through targeting the miR-184/HOXA9 axis. Cardiorenal Medicine, 8(2), 130–139.PubMedPubMedCentralCrossRef
118.
Zhou, W., Wang, L., Miao, Y., & Xing, R. (2018). Novel long noncoding RNA GACAT3 promotes colorectal cancer cell proliferation, invasion, and migration through miR-149. OncoTargets and Therapy, 11, 1543.PubMedPubMedCentralCrossRef
119.
Zhu, Z., Li, J., Tong, R., Zhang, X., & Yu, B. (2021). miR-149 alleviates Ox-LDL-induced endothelial cell injury by promoting autophagy through Akt/mTOR pathway. Cardiology Research and Practice, 2021, 1.CrossRef
120.
Chen, C., Wang, X., Liu, T., Tang, X., Liu, Y., Liu, T., & Zhu, J. (2020). Overexpression of long non-coding RNA RP11-363E7. 4 inhibits proliferation and invasion in gastric cancer. Cell Biochemistry and Function, 38(7), 921–931.PubMedPubMedCentralCrossRef
121.
122.
123.
Liu, C., Guo, X., Bai, S., Zeng, G., & Wang, H. (2020). lncRNA CASC2 downregulation participates in rheumatoid arthritis, and CASC2 overexpression promotes the apoptosis of fibroblast-like synoviocytes by downregulating IL-17. Molecular Medicine Reports, 21(5), 2131–2137.PubMedPubMedCentral
124.
Cao, X., & Fan, Q.-L. (2020). LncRNA MIR503HG promotes high-glucose-induced proximal tubular cell apoptosis by targeting miR-503-5p/bcl-2 pathway. Diabetes, Metabolic Syndrome and Obesity, 13, 4507.PubMedPubMedCentralCrossRef
125.
Tang, C., Cai, Y., Jiang, H., Lv, Z., Yang, C., Xu, H., Li, Z., & Li, Y. (2020). LncRNA MAGI2-AS3 inhibits bladder cancer progression by targeting the miR-31-5p/TNS1 axis. Aging (Albany NY), 12(24), 25547.CrossRef
126.
Li, X., Zhou, S., Fan, T., & Feng, X. (2020). lncRNA DGCR 5/miR-27a-3p/BNIP3 promotes cell apoptosis in pancreatic cancer by regulating the p38 MAPK pathway. International Journal of Molecular Medicine, 46(2), 729–739.PubMedPubMedCentralCrossRef
127.
Zhang, R., Feng, Y., Lu, J., Ge, Y., & Li, H. (2021). lncRNA Ttc3-209 promotes the apoptosis of retinal ganglion cells in retinal ischemia reperfusion injury by targeting the miR-484/Wnt8a axis. Investigative Ophthalmology & Visual Science, 62(3), 13–13.CrossRef
128.
Ren, K., Sun, J., Liu, L., Yang, Y., Li, H., Wang, Z., Deng, J., Hou, M., Qiu, J., & Zhao, W. (2021). TP53-activated lncRNA GHRLOS regulates cell proliferation, invasion, and apoptosis of non-small cell lung cancer by modulating the miR-346/APC axis. Frontiers in Oncology, 11, 1282.CrossRef
129.
Zhang, G., Li, S., Lu, J., Ge, Y., Wang, Q., Ma, G., Zhao, Q., Wu, D., Gong, W., & Du, M. (2018). LncRNA MT1JP functions as a ceRNA in regulating FBXW7 through competitively binding to miR-92a-3p in gastric cancer. Molecular Cancer, 17(1), 1–11.PubMedPubMedCentralCrossRef
130.
Liu, Y., Cai, X., Cai, Y., & Chang, Y. (2021). lncRNA OIP5-AS1 suppresses cell proliferation and invasion of endometrial cancer by regulating PTEN/AKT via sponging miR-200c-3p. Journal of Immunology Research, 2021, 1.
131.
Wang, M., Liu, Y., Li, C., Zhang, Y., Zhou, X., & Lu, C. (2019). Long noncoding RNA OIP5-AS1 accelerates the ox-LDL mediated vascular endothelial cells apoptosis through targeting GSK-3β via recruiting EZH2. American journal of Translational Research, 11(3), 1827.PubMedPubMedCentral
132.
Wang, Y., Wang, H., Ruan, J., Zheng, W., Yang, Z., & Pan, W. (2020). Long non-coding RNA OIP5-AS1 suppresses multiple myeloma progression by sponging miR-27a-3p to activate TSC1 expression. Cancer cell international, 20(1), 1–13.
133.
Chu, Q., Xu, T., Zheng, W., Chang, R., & Zhang, L. (2020). Long noncoding RNA MARL regulates antiviral responses through suppression miR-122-dependent MAVS downregulation in lower vertebrates. PLoS Pathogens, 16(7), e1008670.PubMedPubMedCentralCrossRef
134.
135.
Hu, C., Huang, S., Wu, F., & Ding, H. (2018). miR-98 inhibits cell proliferation and induces cell apoptosis by targeting MAPK6 in HUVECs. Experimental and Therapeutic Medicine, 15(3), 2755–2760.PubMedPubMedCentral
136.
Sun, C., Liu, H., Guo, J., Yu, Y., Yang, D., He, F., & Du, Z. (2017). MicroRNA-98 negatively regulates myocardial infarction-induced apoptosis by down-regulating Fas and caspase-3. Scientific Reports, 7(1), 1–11.
137.
Wang, Z., & Xu, R. (2020). lncRNA PART1 promotes breast cancer cell progression by directly targeting miR-4516. Cancer Management and Research, 12, 7753.PubMedPubMedCentralCrossRef
138.
Zhang, Y., Lu, P., Du, H., & Zhang, L. (2019). LINK-A lncRNA promotes proliferation and inhibits apoptosis of mantle cell lymphoma cell by upregulating survivin. Medical Science Monitor, 25, 365.PubMedPubMedCentralCrossRef
139.
Wang, J., Shen, C., Li, R., Wang, C., Xiao, Y., Kuang, Y., Lao, M., Xu, S., Shi, M., & Cai, X. (2021). Increased long noncoding RNA LINK-A contributes to rheumatoid synovial inflammation and aggression. JCI Insight, 6(23), e146757.PubMedPubMedCentralCrossRef
140.
Li, E.-Y., Zhao, P.-J., Jian, J., Yin, B.-Q., Sun, Z.-Y., Xu, C.-X., Tang, Y. C., & Wu, H. (2019). LncRNA MIAT overexpression reduced neuron apoptosis in a neonatal rat model of hypoxic-ischemic injury through miR-211/GDNF. Cell Cycle, 18(2), 156–166.PubMedCrossRef
141.
Cao, X., Ma, Q., Wang, B., Qian, Q., Liu, N., Liu, T., & Dong, X. (2021). Silencing long non-coding RNA MIAT ameliorates myocardial dysfunction induced by myocardial infarction via MIAT/miR-10a-5p/EGR2 axis. Aging (Albany NY), 13(8), 11188.CrossRef
142.
Li, X., Song, F., & Sun, H. (2020). Long non-coding RNA AWPPH interacts with ROCK2 and regulates the proliferation and apoptosis of cancer cells in pediatric T-cell acute lymphoblastic leukemia. Oncology Letters, 20(5), 1–1.
Metadaten
Titel
Evaluating the Role of lncRNAs in the Incidence of Cardiovascular Diseases in Androgenetic Alopecia Patients
verfasst von
Masoumeh Roohaninasab
Shadnaz fakhteh yavari
Motahareh Babazadeh
Rozita Adldoosti Hagh
Mahboubeh Pazoki
Mehran Amrovani
Publikationsdatum
04.05.2022
Verlag
Springer US
Erschienen in
Cardiovascular Toxicology / Ausgabe 7/2022
Print ISSN: 1530-7905
Elektronische ISSN: 1559-0259
DOI
https://doi.org/10.1007/s12012-022-09742-w

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