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01.12.2010 | EDITORIAL

G-CSF and Erythropoietin Combination Therapy for Infarct Repair: Two Plus Two Equals Two?

Editorial to: “Cytokine Combination Theray with Erythropoietin and Granulocyte Colony Stimulating Factor in a Porcine Model of Acute Myocardial Infarction” by F.S. Angeli et al.

verfasst von: Carrie M. Quinn, Buddhadeb Dawn

Erschienen in: Cardiovascular Drugs and Therapy | Ausgabe 5-6/2010

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Excerpt

In the first study of cytokine-induced bone marrow cell (BMC) mobilization and infarct repair, therapy with a combination of granulocyte-colony stimulating factor (G-CSF) and stem cell factor (SCF) improved survival, reduced infarct size, and improved left ventricular (LV) function and remodeling in mice after coronary ligation [1]. Since the publication of this seminal report, a number of cytokines/growth factors have been utilized for cardiac repair with diverse dosage regimens and experimental conditions with variable results [2]. The studies of G-CSF therapy in clinical trials have also yielded divergent outcomes, and the results of recent meta-analyses suggest that G-CSF alone may not produce significant clinical benefits in unselected patients with acute myocardial infarction (MI) [3, 4]. As a result, the true utility of cytokine therapy for infarct repair remains largely unclear at this time, and further investigation is certainly warranted. …
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Metadaten
Titel
G-CSF and Erythropoietin Combination Therapy for Infarct Repair: Two Plus Two Equals Two?
Editorial to: “Cytokine Combination Theray with Erythropoietin and Granulocyte Colony Stimulating Factor in a Porcine Model of Acute Myocardial Infarction” by F.S. Angeli et al.
verfasst von
Carrie M. Quinn
Buddhadeb Dawn
Publikationsdatum
01.12.2010
Verlag
Springer US
Erschienen in
Cardiovascular Drugs and Therapy / Ausgabe 5-6/2010
Print ISSN: 0920-3206
Elektronische ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-010-6268-2

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