42. Gerinnungsphysiologie bei Totgeburten

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Zurück zum Zitat Aracic N, Roje D, Drmic Hofman I, Capkun V, Stefanovic V (2015) Low molecular weight heparin treatment and impact of inherited thrombophilia type in pregnancies with previous adverse outcome. J Matern Fetal Neonatal Med 28: 306–310CrossRefPubMed Aracic N, Roje D, Drmic Hofman I, Capkun V, Stefanovic V (2015) Low molecular weight heparin treatment and impact of inherited thrombophilia type in pregnancies with previous adverse outcome. J Matern Fetal Neonatal Med 28: 306–310CrossRefPubMed

Zurück zum Zitat Beeksma FA, Erwich JJ, Khong TY (2012) Placental fetal vascular thrombosis lesions and maternal thrombophilia. Pathology 44: 24–28CrossRefPubMed Beeksma FA, Erwich JJ, Khong TY (2012) Placental fetal vascular thrombosis lesions and maternal thrombophilia. Pathology 44: 24–28CrossRefPubMed

Zurück zum Zitat Bertolaccini ML, Mepani K, Sanna G, Hughes GR, Khamashta MA (2007) Factor XII autoantibodies as a novel marker for thrombosis and adverse obstetric history in patients with systemic lupus erythematosus. Ann Rheum Dis 66: 533–536CrossRefPubMed Bertolaccini ML, Mepani K, Sanna G, Hughes GR, Khamashta MA (2007) Factor XII autoantibodies as a novel marker for thrombosis and adverse obstetric history in patients with systemic lupus erythematosus. Ann Rheum Dis 66: 533–536CrossRefPubMed

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Zurück zum Zitat Frias AE Jr, Luikenaar RA, Sullivan AE, Lee RM, Porter TF, Branch DW, Silver RM (2004) Poor obstetric outcome in subsequent pregnancies in women with prior fetal death. Obstet Gynecol 104: 521–526CrossRefPubMed Frias AE Jr, Luikenaar RA, Sullivan AE, Lee RM, Porter TF, Branch DW, Silver RM (2004) Poor obstetric outcome in subsequent pregnancies in women with prior fetal death. Obstet Gynecol 104: 521–526CrossRefPubMed

Zurück zum Zitat Ghidini A (2014) Overview of low molecular weight heparin for preventative treatment of adverse obstetric outcomes related to abnormal placentation. Prenat Diagn 34: 649–654PubMed Ghidini A (2014) Overview of low molecular weight heparin for preventative treatment of adverse obstetric outcomes related to abnormal placentation. Prenat Diagn 34: 649–654PubMed

Zurück zum Zitat Hansen AT, Schmidt M, Horváth-Puhó E, Pedersen L, Rothman KJ, Hvas AM, Sørensen HT (2015) Preconception venous thromboembolism and placenta-mediated pregnancy complications. J Thromb Haemost 13: 1635–1641CrossRefPubMed Hansen AT, Schmidt M, Horváth-Puhó E, Pedersen L, Rothman KJ, Hvas AM, Sørensen HT (2015) Preconception venous thromboembolism and placenta-mediated pregnancy complications. J Thromb Haemost 13: 1635–1641CrossRefPubMed

Zurück zum Zitat Hvas AM, Ingerslev J, Salvig JD (2009) Thrombophilia risk factors are associated with intrauterine foetal death and pregnancy-related venous thromboembolism. Scand J Clin Lab Invest 69: 288–294CrossRefPubMed Hvas AM, Ingerslev J, Salvig JD (2009) Thrombophilia risk factors are associated with intrauterine foetal death and pregnancy-related venous thromboembolism. Scand J Clin Lab Invest 69: 288–294CrossRefPubMed

Zurück zum Zitat James AH, Jamison MG (2007) Bleeding events and other complications during pregnancy and childbirth in women with von Willebrand disease. J Thromb Haemost 5: 1165–1169CrossRefPubMed James AH, Jamison MG (2007) Bleeding events and other complications during pregnancy and childbirth in women with von Willebrand disease. J Thromb Haemost 5: 1165–1169CrossRefPubMed

Zurück zum Zitat de Jong PG, Goddijn M, Middeldorp S (2013) Antithrombotic therapy for pregnancy loss. Hum Reprod Update 19: 656–673CrossRefPubMed de Jong PG, Goddijn M, Middeldorp S (2013) Antithrombotic therapy for pregnancy loss. Hum Reprod Update 19: 656–673CrossRefPubMed

Zurück zum Zitat Kumar M, Mehta P (1994) Congenital coagulopathies and pregnancy: report of four pregnancies in a factor X-deficient woman. Am J Hematol 46: 241–244CrossRefPubMed Kumar M, Mehta P (1994) Congenital coagulopathies and pregnancy: report of four pregnancies in a factor X-deficient woman. Am J Hematol 46: 241–244CrossRefPubMed

Zurück zum Zitat Kupferminc MJ, Rimon E, Many A, Sharon M, Lessing JB, Gamzu R (2011) Low molecular weight heparin treatment during subsequent pregnancies of women with inherited thrombophilia and previous severe pregnancy complications. J Matern Fetal Neonatal Med 24: 1042–1045CrossRefPubMed Kupferminc MJ, Rimon E, Many A, Sharon M, Lessing JB, Gamzu R (2011) Low molecular weight heparin treatment during subsequent pregnancies of women with inherited thrombophilia and previous severe pregnancy complications. J Matern Fetal Neonatal Med 24: 1042–1045CrossRefPubMed

Zurück zum Zitat Martinelli I, Ruggenenti P, Cetin I, Pardi G, Perna A, Vergani P, Acaia B, Facchinetti F, La Sala GB, Bozzo M, Rampello S, Marozio L, Diadei O, Gherardi G, Carminati S, Remuzzi G, Mannucci PM (2012) Heparin in pregnant women with previous placenta-mediated pregnancy complications: a prospective, randomized, multicenter, controlled clinical trial. Blood 119: 3269–3275CrossRefPubMedPubMedCentral Martinelli I, Ruggenenti P, Cetin I, Pardi G, Perna A, Vergani P, Acaia B, Facchinetti F, La Sala GB, Bozzo M, Rampello S, Marozio L, Diadei O, Gherardi G, Carminati S, Remuzzi G, Mannucci PM (2012) Heparin in pregnant women with previous placenta-mediated pregnancy complications: a prospective, randomized, multicenter, controlled clinical trial. Blood 119: 3269–3275CrossRefPubMedPubMedCentral

Zurück zum Zitat Mitic G, Kovac M, Povazan L, Magic Z, Djordjevic V, Salatic I, Mitic I, Novakov-Mikic A (2010) Inherited thrombophilia is associated with pregnancy losses that occur after 12th gestational week in Serbian population. Clin Appl Thromb Hemost 16: 435–439CrossRefPubMed Mitic G, Kovac M, Povazan L, Magic Z, Djordjevic V, Salatic I, Mitic I, Novakov-Mikic A (2010) Inherited thrombophilia is associated with pregnancy losses that occur after 12th gestational week in Serbian population. Clin Appl Thromb Hemost 16: 435–439CrossRefPubMed

Zurück zum Zitat Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, De Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4: 295–306CrossRefPubMed Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, De Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4: 295–306CrossRefPubMed

Zurück zum Zitat Mutlu I, Mutlu MF, Biri A, Bulut B, Erdem M, Erdem A (2015) Effects of anticoagulant therapy on pregnancy outcomes in patients with thrombophilia and previous poor obstetric history. Blood Coagul Fibrinolysis 26: 267–273CrossRefPubMed Mutlu I, Mutlu MF, Biri A, Bulut B, Erdem M, Erdem A (2015) Effects of anticoagulant therapy on pregnancy outcomes in patients with thrombophilia and previous poor obstetric history. Blood Coagul Fibrinolysis 26: 267–273CrossRefPubMed

Zurück zum Zitat Rai R, Cohen H, Dave M, Regan L (1997) Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). BMJ 314: 253–257CrossRefPubMedPubMedCentral Rai R, Cohen H, Dave M, Regan L (1997) Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). BMJ 314: 253–257CrossRefPubMedPubMedCentral

Zurück zum Zitat Rawlinson WD, Hall B, Jones CA, Jeffery HE, Arbuckle SM, Graf N, Howard J, Morris JM (2008) Viruses and other infections in stillbirth: what is the evidence and what should we be doing? Pathology 40: 149–160CrossRefPubMed Rawlinson WD, Hall B, Jones CA, Jeffery HE, Arbuckle SM, Graf N, Howard J, Morris JM (2008) Viruses and other infections in stillbirth: what is the evidence and what should we be doing? Pathology 40: 149–160CrossRefPubMed

Zurück zum Zitat Rey E, Kahn SR, David M, Shrier I (2003) Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 361: 901–908CrossRefPubMed Rey E, Kahn SR, David M, Shrier I (2003) Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 361: 901–908CrossRefPubMed

Zurück zum Zitat Rimon E, Ascher-Landsberg J, Carmi N, Many A, Deutsch V, Kupferminc MJ (2012) Severe pregnancy complications are associated with elevated factor VIII plasma activity. Blood Coagul Fibrinolysis 23: 184–188CrossRefPubMed Rimon E, Ascher-Landsberg J, Carmi N, Many A, Deutsch V, Kupferminc MJ (2012) Severe pregnancy complications are associated with elevated factor VIII plasma activity. Blood Coagul Fibrinolysis 23: 184–188CrossRefPubMed

Zurück zum Zitat Robertson L, Wu O, Langhorne P, Twaddle S, Clark P, Lowe GD, Walker ID, Greaves M, Brenkel I, Regan L, Greer IA (2006) The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study. Thrombophilia in pregnancy: a systematic review. Br J Haematol 132: 171–196CrossRefPubMed Robertson L, Wu O, Langhorne P, Twaddle S, Clark P, Lowe GD, Walker ID, Greaves M, Brenkel I, Regan L, Greer IA (2006) The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study. Thrombophilia in pregnancy: a systematic review. Br J Haematol 132: 171–196CrossRefPubMed

Zurück zum Zitat Rodger MA, Carrier M, Le Gal G, Martinelli I, Perna A, Rey E, de Vries JI, Gris JC (2014) Meta-analysis of low-molecular-weight heparin to prevent recurrent placenta-mediated pregnancy complications. Blood 123: 822–828CrossRefPubMed Rodger MA, Carrier M, Le Gal G, Martinelli I, Perna A, Rey E, de Vries JI, Gris JC (2014) Meta-analysis of low-molecular-weight heparin to prevent recurrent placenta-mediated pregnancy complications. Blood 123: 822–828CrossRefPubMed

Zurück zum Zitat Rodger MA, Hague WM, Kingdom J, Kahn SR, Karovitch A, Sermer M, Clement AM, Coat S, Chan WS, Said J, Rey E, Robinson S, Khurana R, Demers C, Kovacs MJ, Solymoss S, Hinshaw K, Dwyer J, Smith G, McDonald S, Newstead-Angel J, McLeod A, Khandelwal M, Silver RM, Le Gal G, Greer IA, Keely E, Rosene-Montella K, Walker M, Wells PS (2014) Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial. Lancet 384: 1673–1683CrossRefPubMed Rodger MA, Hague WM, Kingdom J, Kahn SR, Karovitch A, Sermer M, Clement AM, Coat S, Chan WS, Said J, Rey E, Robinson S, Khurana R, Demers C, Kovacs MJ, Solymoss S, Hinshaw K, Dwyer J, Smith G, McDonald S, Newstead-Angel J, McLeod A, Khandelwal M, Silver RM, Le Gal G, Greer IA, Keely E, Rosene-Montella K, Walker M, Wells PS (2014) Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial. Lancet 384: 1673–1683CrossRefPubMed

Zurück zum Zitat Rogenhofer N, Bohlmann MK, Beuter-Winkler P, Würfel W, Rank A, Thaler CJ, Toth B (2014) Prevention, management and extent of adverse pregnancy outcomes in women with hereditary Antithrombin deficiency. Ann Hematol 93: 385–392CrossRefPubMed Rogenhofer N, Bohlmann MK, Beuter-Winkler P, Würfel W, Rank A, Thaler CJ, Toth B (2014) Prevention, management and extent of adverse pregnancy outcomes in women with hereditary Antithrombin deficiency. Ann Hematol 93: 385–392CrossRefPubMed

Zurück zum Zitat Silver RM (2007) Fetal death. Obstet Gynecol 109: 153–167CrossRefPubMed Silver RM (2007) Fetal death. Obstet Gynecol 109: 153–167CrossRefPubMed