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Erschienen in: Current Diabetes Reports 8/2022

20.06.2022 | Pathogenesis of Type 2 Diabetes and Insulin Resistance (M-E Patti, Section Editor)

Gut Factors Mediating the Physiological Impact of Bariatric Surgery

verfasst von: Maigen Bethea, Darleen A. Sandoval

Erschienen in: Current Diabetes Reports | Ausgabe 8/2022

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Abstract

Despite decades of obesity research and various public health initiatives, obesity remains a major public health concern. Our most drastic but most effective treatment of obesity is bariatric surgery with weight loss and improvements in co-morbidities, including resolution of type 2 diabetes (T2D). However, the mechanisms by which surgery elicits metabolic benefits are still not well understood. One proposed mechanism is through signals generated by the intestine (nutrients, neuronal, and/or endocrine) that communicate nutrient status to the brain. In this review, we discuss the contributions of gut-brain communication to the physiological regulation of body weight and its impact on the success of bariatric surgery. Advancing our understanding of the mechanisms that drive bariatric surgery-induced metabolic benefits will ultimately lead to the identification of novel, less invasive strategies to treat obesity.
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Metadaten
Titel
Gut Factors Mediating the Physiological Impact of Bariatric Surgery
verfasst von
Maigen Bethea
Darleen A. Sandoval
Publikationsdatum
20.06.2022
Verlag
Springer US
Erschienen in
Current Diabetes Reports / Ausgabe 8/2022
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-022-01478-9

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