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Erschienen in:

01.06.2018 | Arzneimittel

Hormonwirkungen chinesischer Arzneidrogen

verfasst von: Dr. med. Axel Wiebrecht

Erschienen in: Chinesische Medizin / Chinese Medicine | Ausgabe 2/2018

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Zusammenfassung

Chinesische Arzneidrogen wurden in der Chinesischen Medizin von früh an für Funktionsstörungen und Krankheiten des reproduktiven Systems eingesetzt. Daher verwundert es nicht, dass sich unter diesen viele mit hormonartigen Effekten finden lassen. Diese wurden von der westlichen TCM-Welt bisher so gut wie gar nicht zur Kenntnis genommen. Am meisten untersucht und nachgewiesen sind die Phytoöstrogeneffekte, dazu kommen progesteronartige, androgenartige, ihre jeweiligen antagonistischen Wirkungen sowie weitere. Bei den östrogenartig wirkenden Drogen stellt sich die Frage eines potenziellen Proliferationseffektes bei Mammakarzinomen, zumal viele von ihnen in vitro das Wachstum humaner Mammakarzinomzellen stimulieren. Soja und Sojaisoflavone können in dieser Hinsicht als sicher gelten, jedoch kann man diese Aussage nicht einfach auf andere Drogen mit Phytoöstrogencharakter extrapolieren. Vielmehr bedarf jede Arzneidroge einer gesonderten Betrachtung. Epidemiologische Studien zur Auswirkung einer chinesischen Arzneitherapie auf die Inzidenz oder — bei Einnahme nach Diagnosestellung — auf den Verlauf östrogenabhängiger Tumore liegen nur ganz vereinzelt vor. Diese sprechen nicht für eine erhöhte Inzidenz eines Mammakarzinoms, eines Endometriumkarzinoms oder den ungünstigen Verlauf eines Mammakarzinoms, sondern eher für das Gegenteil. Angesichts der In-vitro- und In-vivo-Ergebnisse und des nicht beweisenden Charakters epidemiologischer Studien ist der Einsatz der in Frage stehenden Arzneidrogen sehr sorgsam gegenüber den Risiken abzuwägen und im Zweifelsfall Zurückhaltung zu üben.
Für eine Reihe von Arzneidrogen sind androgenartige Wirkungen demonstriert worden, ohne dass Untersuchungen zum Einfluss dieser Drogen auf das Wachstum von Prostatakarzinomzellen gefunden wurden. Sie sollten bei manifestem Prostatakarzinom gemieden werden, während Arzneidrogen mit antiandrogenen Eigenschaften und/oder Nachweis von proliferationshemmenden Einflüssen auf Prostatakarzinomzellen verstärkt für eine Therapie in Erwägung gezogen werden können. Für eine genauere Risikobestimmung von Arzneidrogen mit phytohormonartigen Wirkungen bei hormonabhängigen Tumoren bedarf es weiterer Forschungen. Arzneidrogen und Rezepturen mit antiprolactinartiger Wirkung können bei Hyperprolactinämie mit verschiedenartigen klinischen Bildern erfolgreich eingesetzt werden, einige klinische Studien liegen dazu vor.
Literatur
[1]
Zurück zum Zitat Jefferson WN, Williams CJ. Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomes. Reprod Toxicol 2011;31:272–9CrossRefPubMed Jefferson WN, Williams CJ. Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomes. Reprod Toxicol 2011;31:272–9CrossRefPubMed
[2]
Zurück zum Zitat Chen A, Rogan WJ. Isoflavones in soy infant formula: a review of evidence for endocrine and other activity in infants. Annu Rev Nutr 2004;24:33–54CrossRefPubMed Chen A, Rogan WJ. Isoflavones in soy infant formula: a review of evidence for endocrine and other activity in infants. Annu Rev Nutr 2004;24:33–54CrossRefPubMed
[3]
Zurück zum Zitat Kuiper GG, Lemmen JG, Carlsson B, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998;139:4252–63CrossRefPubMed Kuiper GG, Lemmen JG, Carlsson B, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998;139:4252–63CrossRefPubMed
[4]
Zurück zum Zitat Magee PJ, Rowland IR. Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer. Br J Nutr 2004;91:513–31CrossRefPubMed Magee PJ, Rowland IR. Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer. Br J Nutr 2004;91:513–31CrossRefPubMed
[5]
Zurück zum Zitat Kohama T, Kobayashi H, Inoue M. The effect of soybeans on the anovulatory cycle. J Med Food 2005;8:550–1CrossRefPubMed Kohama T, Kobayashi H, Inoue M. The effect of soybeans on the anovulatory cycle. J Med Food 2005;8:550–1CrossRefPubMed
[6]
Zurück zum Zitat Mumford SL, Sundaram R, Schisterman EF, et al. Higher urinary lignan concentrations in women but not men are positively associated with shorter time to pregnancy. J Nutr 2014;144:352–8PubMedPubMedCentralCrossRef Mumford SL, Sundaram R, Schisterman EF, et al. Higher urinary lignan concentrations in women but not men are positively associated with shorter time to pregnancy. J Nutr 2014;144:352–8PubMedPubMedCentralCrossRef
[7]
Zurück zum Zitat Xia Y, Chen M, Zhu P, et al. Urinary phytoestrogen levels related to idiopathic male infertility in Chinese men. Environ Int 2013;59:161–7CrossRefPubMed Xia Y, Chen M, Zhu P, et al. Urinary phytoestrogen levels related to idiopathic male infertility in Chinese men. Environ Int 2013;59:161–7CrossRefPubMed
[8]
Zurück zum Zitat Mitchell JH, Cawood E, Kinniburgh D, et al. Effect of a phytoestrogen food supplement on reproductive health in normal males. Clin Sci 2001;100:613–8CrossRef Mitchell JH, Cawood E, Kinniburgh D, et al. Effect of a phytoestrogen food supplement on reproductive health in normal males. Clin Sci 2001;100:613–8CrossRef
[9]
Zurück zum Zitat Unfer V, Casini ML, Costabile L, et al. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study. Fertil Steril 2004;82:145–8CrossRefPubMed Unfer V, Casini ML, Costabile L, et al. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study. Fertil Steril 2004;82:145–8CrossRefPubMed
[10]
Zurück zum Zitat Unfer V, Casini ML, Costabile L, et al. High dose of phytoestrogens can reverse the antiestrogenic effects of clomiphene citrate on the endometrium in patients undergoing intrauterine insemination: a randomized trial. J Soc Gynecol Investig 2004;11:323–8CrossRefPubMed Unfer V, Casini ML, Costabile L, et al. High dose of phytoestrogens can reverse the antiestrogenic effects of clomiphene citrate on the endometrium in patients undergoing intrauterine insemination: a randomized trial. J Soc Gynecol Investig 2004;11:323–8CrossRefPubMed
[11]
Zurück zum Zitat Chandrareddy A, Muneyyirci-Delale O, McFarlane SI, et al. Adverse effects of phytoestrogens on reproductive health: a report of three cases. Complement Ther Clin Pract 2008;14:132–5CrossRefPubMed Chandrareddy A, Muneyyirci-Delale O, McFarlane SI, et al. Adverse effects of phytoestrogens on reproductive health: a report of three cases. Complement Ther Clin Pract 2008;14:132–5CrossRefPubMed
[12]
Zurück zum Zitat Liu ZJ, Zhang BH and Hu X. Traditional Chinese medicines such as heche dazao capsules should not be prescribed for patients with sex-hormone-dependent tumors. Clin Pharmacol Ther 2010;88:306CrossRefPubMed Liu ZJ, Zhang BH and Hu X. Traditional Chinese medicines such as heche dazao capsules should not be prescribed for patients with sex-hormone-dependent tumors. Clin Pharmacol Ther 2010;88:306CrossRefPubMed
[13]
[14]
Zurück zum Zitat Rietjens I, Louisse J, Beekmann K. The potential health effects of dietary phytoestrogens. Br J Pharmacol 2017;174:1263–80CrossRefPubMed Rietjens I, Louisse J, Beekmann K. The potential health effects of dietary phytoestrogens. Br J Pharmacol 2017;174:1263–80CrossRefPubMed
[15]
Zurück zum Zitat Chang H, Xie Q, Zhang QY, et al. Flavonoids, flavonoid subclasses and breast cancer risk: a meta-analysis of epidemiologic studies. PLoS One 2013;8:e54318CrossRef Chang H, Xie Q, Zhang QY, et al. Flavonoids, flavonoid subclasses and breast cancer risk: a meta-analysis of epidemiologic studies. PLoS One 2013;8:e54318CrossRef
[16]
Zurück zum Zitat Anderson LN, Cotterchio M, Boucher BA, et al. Phytoestrogen intake from foods, during adolescence and adulthood, and risk of breast cancer by estrogen and progesterone receptor tumor subgroup among Ontario women. Int J Cancer 2013;132:1683–92CrossRefPubMed Anderson LN, Cotterchio M, Boucher BA, et al. Phytoestrogen intake from foods, during adolescence and adulthood, and risk of breast cancer by estrogen and progesterone receptor tumor subgroup among Ontario women. Int J Cancer 2013;132:1683–92CrossRefPubMed
[17]
Zurück zum Zitat Nechuta SJ, Caan BJ, Chen WY, et al. Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women. Am J Clin Nutr 2012;96:123–32PubMedPubMedCentralCrossRef Nechuta SJ, Caan BJ, Chen WY, et al. Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women. Am J Clin Nutr 2012;96:123–32PubMedPubMedCentralCrossRef
[18]
Zurück zum Zitat Alipour S, Jafari-Adli S, Eskandari A. Benefits and harms of phytoestrogen consumption in breast cancer survivors. Asian Pac J Cancer Prev 2015;16:3091–396CrossRefPubMed Alipour S, Jafari-Adli S, Eskandari A. Benefits and harms of phytoestrogen consumption in breast cancer survivors. Asian Pac J Cancer Prev 2015;16:3091–396CrossRefPubMed
[19]
Zurück zum Zitat Omoto Y, Iwase H. Clinical significance of estrogen receptor beta in breast and prostate cancer from biological aspects. Cancer Sci 2015;106:337–43PubMedPubMedCentralCrossRef Omoto Y, Iwase H. Clinical significance of estrogen receptor beta in breast and prostate cancer from biological aspects. Cancer Sci 2015;106:337–43PubMedPubMedCentralCrossRef
[20]
Zurück zum Zitat Rosselli M, Reinhart K, Imthurn B, et al. Cellular and biochemical mechanisms by which environmental oestrogens influence reproductive function. Hum Reprod Update 2000;6:332–50CrossRefPubMed Rosselli M, Reinhart K, Imthurn B, et al. Cellular and biochemical mechanisms by which environmental oestrogens influence reproductive function. Hum Reprod Update 2000;6:332–50CrossRefPubMed
[21]
Zurück zum Zitat Cai K, Feng H, Tian WY. [Effects of pure breed fermentation on major effective components in Sojae Semen praeparatum] (Chinese). Gansu Zhongyi Xueyuan Xuebao 2006;23:39–41 Cai K, Feng H, Tian WY. [Effects of pure breed fermentation on major effective components in Sojae Semen praeparatum] (Chinese). Gansu Zhongyi Xueyuan Xuebao 2006;23:39–41
[22]
Zurück zum Zitat Niu LY, Du HN, Liu J, et al. [Comparative analysis of isoflavone contents in Semen Sojae praeparatum before and after processing] (Chinese). Dadou Kexue 2008;27:672–4,678 Niu LY, Du HN, Liu J, et al. [Comparative analysis of isoflavone contents in Semen Sojae praeparatum before and after processing] (Chinese). Dadou Kexue 2008;27:672–4,678
[24]
Zurück zum Zitat Bensky D, Clavey S and Stöger E. Chinese Herbal Medicine. Materia Medica. 3rd ed. Seattle, WA: Eastland Press, 2004 Bensky D, Clavey S and Stöger E. Chinese Herbal Medicine. Materia Medica. 3rd ed. Seattle, WA: Eastland Press, 2004
[25]
Zurück zum Zitat Magee PJ, Rowland I. Soy products in the management of breast cancer. Curr Opin Clin Nutr Metab Care 2012;15:586–91CrossRefPubMed Magee PJ, Rowland I. Soy products in the management of breast cancer. Curr Opin Clin Nutr Metab Care 2012;15:586–91CrossRefPubMed
[26]
Zurück zum Zitat Tan YY, Zhang Q. [Inhibitory effects of Dandouchi extract on proliferation of breast cancer cells] (Chinese). Zhongguo Shiyan Fangji Xue Zazhi 2011;17:220–2 Tan YY, Zhang Q. [Inhibitory effects of Dandouchi extract on proliferation of breast cancer cells] (Chinese). Zhongguo Shiyan Fangji Xue Zazhi 2011;17:220–2
[27]
Zurück zum Zitat Tan YY, Zhang Q. [Anti-proliferative effects of Sojae Semen praeparatum and black soybean extract and content determination of four isoflavone components] (Chinese). Zhonghua Zhong Yiyao Zazhi 2012;27:1547–9 Tan YY, Zhang Q. [Anti-proliferative effects of Sojae Semen praeparatum and black soybean extract and content determination of four isoflavone components] (Chinese). Zhonghua Zhong Yiyao Zazhi 2012;27:1547–9
[28]
Zurück zum Zitat Chiu JH, Chang CJ, Wu JC, et al. Screening to identify commonly used Chinese herbs that affect ERBB2 and ESR1 gene expression using the human breast cancer MCF-7 cell line. Evid Based Complement Alternat Med 2014:965486 Chiu JH, Chang CJ, Wu JC, et al. Screening to identify commonly used Chinese herbs that affect ERBB2 and ESR1 gene expression using the human breast cancer MCF-7 cell line. Evid Based Complement Alternat Med 2014:965486
[29]
Zurück zum Zitat Chen JL, Chang CJ, Wang JY, et al. In vitro and in vivo effects of Jia-Wei-Xiao-Yao-San in human breast cancer MCF-7 cells treated with tamoxifen. Integr Cancer Ther 2014;13:226–39CrossRefPubMed Chen JL, Chang CJ, Wang JY, et al. In vitro and in vivo effects of Jia-Wei-Xiao-Yao-San in human breast cancer MCF-7 cells treated with tamoxifen. Integr Cancer Ther 2014;13:226–39CrossRefPubMed
[30]
Zurück zum Zitat Lai JN, Wu CT, Wang JD. Prescription pattern of Chinese herbal products for breast cancer in Taiwan: a population-based study. Evid Based Complement Alternat Med 2012:891893 Lai JN, Wu CT, Wang JD. Prescription pattern of Chinese herbal products for breast cancer in Taiwan: a population-based study. Evid Based Complement Alternat Med 2012:891893
[31]
Zurück zum Zitat Lee YW, Chen TL, Shih YR, et al. Adjunctive traditional Chinese medicine therapy improves survival in patients with advanced breast cancer: a population-based study. Cancer 2014;120:1338–44CrossRefPubMed Lee YW, Chen TL, Shih YR, et al. Adjunctive traditional Chinese medicine therapy improves survival in patients with advanced breast cancer: a population-based study. Cancer 2014;120:1338–44CrossRefPubMed
[32]
Zurück zum Zitat Kim IG, Kang SC, Kim KC, et al. Screening of estrogenic and antiestrogenic activities from medicinal plants. Environ Toxicol Pharmacol 2008;25:75–82CrossRefPubMed Kim IG, Kang SC, Kim KC, et al. Screening of estrogenic and antiestrogenic activities from medicinal plants. Environ Toxicol Pharmacol 2008;25:75–82CrossRefPubMed
[33]
Zurück zum Zitat Kang HK, Choi YH, Kwon H, et al. Estrogenic/antiestrogenic activities of a Epimedium koreanum extract and its major components: in vitro and in vivo studies. Food Chem Toxicol 2012;50:2751–9CrossRefPubMed Kang HK, Choi YH, Kwon H, et al. Estrogenic/antiestrogenic activities of a Epimedium koreanum extract and its major components: in vitro and in vivo studies. Food Chem Toxicol 2012;50:2751–9CrossRefPubMed
[34]
Zurück zum Zitat Li G, Sepkovic DW, Bradlow HL, et al. Lycium barbarum inhibits growth of estrogen receptor positive human breast cancer cells by favorably altering estradiol metabolism. Nutr Cancer 2009;61:408–14CrossRefPubMed Li G, Sepkovic DW, Bradlow HL, et al. Lycium barbarum inhibits growth of estrogen receptor positive human breast cancer cells by favorably altering estradiol metabolism. Nutr Cancer 2009;61:408–14CrossRefPubMed
[35]
Zurück zum Zitat Palda AZ, Rana KS, Sheng P, et al. [Experimental study on estrogenic activities of nine kinds of Chinese herbal medicines] (Chinese). Shi Zhen Guoyi Guoyao 2008;19:2237–8 Palda AZ, Rana KS, Sheng P, et al. [Experimental study on estrogenic activities of nine kinds of Chinese herbal medicines] (Chinese). Shi Zhen Guoyi Guoyao 2008;19:2237–8
[36]
Zurück zum Zitat Hirata JD, Swiersz LM, Zell B, et al. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997;68:981–6CrossRefPubMed Hirata JD, Swiersz LM, Zell B, et al. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997;68:981–6CrossRefPubMed
[37]
Zurück zum Zitat Zava DT, Dollbaum CM, et al. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369–78CrossRefPubMed Zava DT, Dollbaum CM, et al. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369–78CrossRefPubMed
[38]
Zurück zum Zitat Liu J, Burdette JE, Xu H, et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 2001;49:2472–9CrossRefPubMed Liu J, Burdette JE, Xu H, et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 2001;49:2472–9CrossRefPubMed
[39]
Zurück zum Zitat Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002;9:145–50CrossRefPubMed Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002;9:145–50CrossRefPubMed
[40]
Zurück zum Zitat Oerter Klein K, Janfaza M, Wong JA, et al. Estrogen bioactivity in fo-ti and other herbs used for their estrogen-like effects as determined by a recombinant cell bioassay. J Clin Endocrinol Metab 2003;88:4077–9CrossRef Oerter Klein K, Janfaza M, Wong JA, et al. Estrogen bioactivity in fo-ti and other herbs used for their estrogen-like effects as determined by a recombinant cell bioassay. J Clin Endocrinol Metab 2003;88:4077–9CrossRef
[41]
Zurück zum Zitat Elm MS, Houghton FD, Eagon PK. Estrogenicity of medicinal botanicals used as immune modulators. Proc Amer Assoc Cancer Res, abstract 5785. Cancer Res 2005;65:1360 Elm MS, Houghton FD, Eagon PK. Estrogenicity of medicinal botanicals used as immune modulators. Proc Amer Assoc Cancer Res, abstract 5785. Cancer Res 2005;65:1360
[42]
Zurück zum Zitat Houghton FD, Elm MS, Eagon PK. Effect of medicinal botanicals in breast cancer cell lines with different estrogen receptor expression. Proc Amer Assoc Cancer Res, abstract 5786. Cancer Res 2005;65:1360 Houghton FD, Elm MS, Eagon PK. Effect of medicinal botanicals in breast cancer cell lines with different estrogen receptor expression. Proc Amer Assoc Cancer Res, abstract 5786. Cancer Res 2005;65:1360
[43]
Zurück zum Zitat Lau CB, Ho TC, Chan TW, et al. Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal symptoms in women with breast cancer: is it appropriate? Menopause 2005;12:734–40PubMedCrossRef Lau CB, Ho TC, Chan TW, et al. Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal symptoms in women with breast cancer: is it appropriate? Menopause 2005;12:734–40PubMedCrossRef
[44]
Zurück zum Zitat Circosta C, Pasquale RD, Palumbo DR, et al. Estrogenic activity of standardized extract of Angelica sinensis. Phytother Res 2006;20:665–9PubMedCrossRef Circosta C, Pasquale RD, Palumbo DR, et al. Estrogenic activity of standardized extract of Angelica sinensis. Phytother Res 2006;20:665–9PubMedCrossRef
[45]
Zurück zum Zitat Hao QX, Wang JF, Niu JZ, et al. [Effects of the pharmacological serum of Siwu Decoction and its ingredient herbs on proliferation and cell cycle of breast cancer cell line MCF-7 cells] (Chinese). Zhong Yiyao Xuebao 2008;36:10–4 Hao QX, Wang JF, Niu JZ, et al. [Effects of the pharmacological serum of Siwu Decoction and its ingredient herbs on proliferation and cell cycle of breast cancer cell line MCF-7 cells] (Chinese). Zhong Yiyao Xuebao 2008;36:10–4
[46]
Zurück zum Zitat Hao QX, F WJ, Niu JZ, et al. [Study on phytoestrogenic-like efffects of four kinds of Chinese medicine including Radix Rehmanniae preparata, Radix Paeoniae alba, Radix Angelicae sinensis, Rhizoma Chuanxiong] (Chinese). Zhongguo Zhong Yao Za Zhi 2009;34:620–4PubMed Hao QX, F WJ, Niu JZ, et al. [Study on phytoestrogenic-like efffects of four kinds of Chinese medicine including Radix Rehmanniae preparata, Radix Paeoniae alba, Radix Angelicae sinensis, Rhizoma Chuanxiong] (Chinese). Zhongguo Zhong Yao Za Zhi 2009;34:620–4PubMed
[47]
Zurück zum Zitat Hao QX, Wang JF, Niu JZ, et al. [Study on the phytoestrogenic effects of Siwu decoction and its ingredient herbs] (Chinese). Zhonghua Zhong Yiyao Xue Kan 2009;27:738–1 Hao QX, Wang JF, Niu JZ, et al. [Study on the phytoestrogenic effects of Siwu decoction and its ingredient herbs] (Chinese). Zhonghua Zhong Yiyao Xue Kan 2009;27:738–1
[48]
Zurück zum Zitat Liu M, Fan J, Wang S, et al. Transcriptional profiling of Chinese medicinal formula Si-Wu-Tang on breast cancer cells reveals phytoestrogenic activity. BMC Complement Altern Med 2013;13:11PubMedPubMedCentralCrossRef Liu M, Fan J, Wang S, et al. Transcriptional profiling of Chinese medicinal formula Si-Wu-Tang on breast cancer cells reveals phytoestrogenic activity. BMC Complement Altern Med 2013;13:11PubMedPubMedCentralCrossRef
[49]
Zurück zum Zitat Deng Y, Ren PF and Zhang YP. [Effects of Danggui of different producing areas of Gansu on the uterus and female hormones of rats] (Chinese). Xibu Zhong Yiyao 2013;26:10–3 Deng Y, Ren PF and Zhang YP. [Effects of Danggui of different producing areas of Gansu on the uterus and female hormones of rats] (Chinese). Xibu Zhong Yiyao 2013;26:10–3
[50]
Zurück zum Zitat Lim DW, Kim YT. Anti-osteoporotic effects of Angelica sinensis (Oliv.) Diels extract on ovariectomized rats and its oral toxicity in rats. Nutrients 2014;6:4362–72PubMedPubMedCentralCrossRef Lim DW, Kim YT. Anti-osteoporotic effects of Angelica sinensis (Oliv.) Diels extract on ovariectomized rats and its oral toxicity in rats. Nutrients 2014;6:4362–72PubMedPubMedCentralCrossRef
[51]
Zurück zum Zitat Tiosano D, Paris F, Grimaldi M, et al. Evidence of ERalpha and ERbeta selectivity and partial estrogen agonism in traditional Chinese medicine. Reprod Biol Endocrinol 2014;12:97PubMedPubMedCentralCrossRef Tiosano D, Paris F, Grimaldi M, et al. Evidence of ERalpha and ERbeta selectivity and partial estrogen agonism in traditional Chinese medicine. Reprod Biol Endocrinol 2014;12:97PubMedPubMedCentralCrossRef
[52]
Zurück zum Zitat Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295–300CrossRefPubMed Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295–300CrossRefPubMed
[53]
Zurück zum Zitat Murashima T, Yamasaki M, Nishizawa Y, et al. Proliferation of estrogen-responsive mouse tumor cell line B-1F stimulated by Saiboku-to, but inhibited by Scutellaria baicalensis, a component of Saiboku-to. Oncol Rep 2009;22:257–64PubMed Murashima T, Yamasaki M, Nishizawa Y, et al. Proliferation of estrogen-responsive mouse tumor cell line B-1F stimulated by Saiboku-to, but inhibited by Scutellaria baicalensis, a component of Saiboku-to. Oncol Rep 2009;22:257–64PubMed
[54]
Zurück zum Zitat Campbell MJ, Hamilton B, Shoemaker M, et al. Antiproliferative activity of Chinese medicinal herbs on breast cancer cells in vitro. Anticancer Res 2002;22:3843–52PubMed Campbell MJ, Hamilton B, Shoemaker M, et al. Antiproliferative activity of Chinese medicinal herbs on breast cancer cells in vitro. Anticancer Res 2002;22:3843–52PubMed
[55]
Zurück zum Zitat Zhao PW, Wang DW, Wang LQ, et al. [Screening of ten kinds of Chinese herbal drugs including Herba Epimedii with estrogenic effects by uterus growth test in mice] (Chinese). Beijing Zhong Yiyao Daxue Xuebao 2006;29:686–9 Zhao PW, Wang DW, Wang LQ, et al. [Screening of ten kinds of Chinese herbal drugs including Herba Epimedii with estrogenic effects by uterus growth test in mice] (Chinese). Beijing Zhong Yiyao Daxue Xuebao 2006;29:686–9
[56]
Zurück zum Zitat Zhao PW, Wang DW, Niu JZ, et al. [Evaluation on phytoestrogen effects of ten kinds of Chinese medicine including flos carthami] (Chinese). Zhongguo Zhongyao Zazhi 2007;32:436–9PubMed Zhao PW, Wang DW, Niu JZ, et al. [Evaluation on phytoestrogen effects of ten kinds of Chinese medicine including flos carthami] (Chinese). Zhongguo Zhongyao Zazhi 2007;32:436–9PubMed
[57]
Zurück zum Zitat Niu JZ, Zhao PW, Wang JF, et al. [Phytoestrogenic activity of five kinds of Chinese herbal medicines including Fructus Psoraleae] (Chinese). Beijing Zhong Yiyao Daxue Xuebao 2008;31:676–81 Niu JZ, Zhao PW, Wang JF, et al. [Phytoestrogenic activity of five kinds of Chinese herbal medicines including Fructus Psoraleae] (Chinese). Beijing Zhong Yiyao Daxue Xuebao 2008;31:676–81
[58]
Zurück zum Zitat Chang HM, But PPH. Pharmacology and Applications of Chinese Materia Medica (Vol. II). 1st ed. New Jersey, London, Singapore, Hong Kong: World Scientific Publishing Co., 1987CrossRef Chang HM, But PPH. Pharmacology and Applications of Chinese Materia Medica (Vol. II). 1st ed. New Jersey, London, Singapore, Hong Kong: World Scientific Publishing Co., 1987CrossRef
[59]
Zurück zum Zitat Fu L, Peng Y, Xu HT, et al. [Influence of deer antler on promotimg uterus growth of ovarectomized mice] (Chinese). Dalian Yike Daxue Xuebao 2007;29:30–2 Fu L, Peng Y, Xu HT, et al. [Influence of deer antler on promotimg uterus growth of ovarectomized mice] (Chinese). Dalian Yike Daxue Xuebao 2007;29:30–2
[60]
Zurück zum Zitat Cheng JJ, Xia W, Gao J, et al. [The influence of pilose antler on sexual organ growth and serum estradiol in ovarectomized female mice] (Chinese). Shiyan Dongwu Kexue 2012;29:8–10 Cheng JJ, Xia W, Gao J, et al. [The influence of pilose antler on sexual organ growth and serum estradiol in ovarectomized female mice] (Chinese). Shiyan Dongwu Kexue 2012;29:8–10
[61]
Zurück zum Zitat Lim LS, Shen P, Gong YH, et al. Dynamics of progestogenic activity in serum following administration of Ligusticum chuanxiong. Life Sci 2006;79:1274–80CrossRefPubMed Lim LS, Shen P, Gong YH, et al. Dynamics of progestogenic activity in serum following administration of Ligusticum chuanxiong. Life Sci 2006;79:1274–80CrossRefPubMed
[62]
Zurück zum Zitat Sun WS, Imai A, Tagami K, et al. In vitro stimulation of granulosa cells by a combination of different active ingredients of unkei-to. Am J Chin Med 2004;32:569–78CrossRefPubMed Sun WS, Imai A, Tagami K, et al. In vitro stimulation of granulosa cells by a combination of different active ingredients of unkei-to. Am J Chin Med 2004;32:569–78CrossRefPubMed
[63]
Zurück zum Zitat Huang BM, Hsiao KY, Chuang PC, et al. Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium. Biol Reprod 2004;70:1358–64CrossRefPubMed Huang BM, Hsiao KY, Chuang PC, et al. Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium. Biol Reprod 2004;70:1358–64CrossRefPubMed
[64]
Zurück zum Zitat Hahne JC, Meyer SR, Dietl J, et al. The effect of Cordyceps extract and a mixture of Ganoderma lucidum/Agaricus Blazi Murill extract on human endometrial cancer cell lines in vitro. Int J Oncol 2014;45:373–82CrossRefPubMed Hahne JC, Meyer SR, Dietl J, et al. The effect of Cordyceps extract and a mixture of Ganoderma lucidum/Agaricus Blazi Murill extract on human endometrial cancer cell lines in vitro. Int J Oncol 2014;45:373–82CrossRefPubMed
[65]
Zurück zum Zitat Vijayanarayana K, Rodrigues RS, Chandrashekhar KS, et al.. Evaluation of estrogenic activity of alcoholic extract of rhizomes of Curculigo orchioides. J Ethnopharmacol 2007;114:241–5CrossRefPubMed Vijayanarayana K, Rodrigues RS, Chandrashekhar KS, et al.. Evaluation of estrogenic activity of alcoholic extract of rhizomes of Curculigo orchioides. J Ethnopharmacol 2007;114:241–5CrossRefPubMed
[66]
Zurück zum Zitat Kang SC, Lee CM, Choi H, et al. Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities. Phytother Res 2006;20:1017–9CrossRefPubMed Kang SC, Lee CM, Choi H, et al. Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities. Phytother Res 2006;20:1017–9CrossRefPubMed
[67]
Zurück zum Zitat Umehara K, Nemoto K, Ohkubo T, et al. Isolation of a new 15-membered macrocyclic glycolipid lactone, Cuscutic Resinoside a from the seeds of Cuscuta chinensis: a stimulator of breast cancer cell proliferation. Planta Med 2004;70:299–304CrossRefPubMed Umehara K, Nemoto K, Ohkubo T, et al. Isolation of a new 15-membered macrocyclic glycolipid lactone, Cuscutic Resinoside a from the seeds of Cuscuta chinensis: a stimulator of breast cancer cell proliferation. Planta Med 2004;70:299–304CrossRefPubMed
[68]
Zurück zum Zitat Yang L, Chen Q, Wang F, et al. Antiosteoporotic compounds from seeds of Cuscuta chinensis. J Ethnopharmacol 2011;135:553–60CrossRefPubMed Yang L, Chen Q, Wang F, et al. Antiosteoporotic compounds from seeds of Cuscuta chinensis. J Ethnopharmacol 2011;135:553–60CrossRefPubMed
[69]
Zurück zum Zitat Yang LJ, Lu D, Guo J, et al. Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19). J Ethnopharmacol 2013;145:715–21CrossRefPubMed Yang LJ, Lu D, Guo J, et al. Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19). J Ethnopharmacol 2013;145:715–21CrossRefPubMed
[70]
Zurück zum Zitat Liu ZP, Lu CQ, Chen JS. [Correlation comparison of uterotrophic assay and E-SCREEN assay for estrogenic activities] (Chinese). Weisheng Yanjiu 2004;33 Liu ZP, Lu CQ, Chen JS. [Correlation comparison of uterotrophic assay and E-SCREEN assay for estrogenic activities] (Chinese). Weisheng Yanjiu 2004;33
[71]
Zurück zum Zitat Wang F, Zheng YZ, Xiao HB, et al. [Effect of administration of Herba Epimedii at the optimal time on levels of sexual hormones] (Chinese). Zhongyi Zazhi 2001;42:619–20 Wang F, Zheng YZ, Xiao HB, et al. [Effect of administration of Herba Epimedii at the optimal time on levels of sexual hormones] (Chinese). Zhongyi Zazhi 2001;42:619–20
[72]
Zurück zum Zitat De Naeyer A, Pocock V, Milligan S, et al. Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum. Fitoterapia 2005;76:35–40CrossRefPubMed De Naeyer A, Pocock V, Milligan S, et al. Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum. Fitoterapia 2005;76:35–40CrossRefPubMed
[73]
Zurück zum Zitat Yap SP, Shen P, Butler MS, et al. New estrogenic prenylflavone from Epimedium brevicornum inhibits the growth of breast cancer cells. Planta Med 2005;71:114–9CrossRefPubMed Yap SP, Shen P, Butler MS, et al. New estrogenic prenylflavone from Epimedium brevicornum inhibits the growth of breast cancer cells. Planta Med 2005;71:114–9CrossRefPubMed
[74]
Zurück zum Zitat Yap SP, Shen P, Li J, et al. Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. J Ethnopharmacol 2007;113:218–24CrossRefPubMed Yap SP, Shen P, Li J, et al. Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. J Ethnopharmacol 2007;113:218–24CrossRefPubMed
[75]
Zurück zum Zitat Yan FF, Liu Y, Liu YF, et al. Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in postmenopausal women. Phytother Res 2008;22:1224–8CrossRefPubMed Yan FF, Liu Y, Liu YF, et al. Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in postmenopausal women. Phytother Res 2008;22:1224–8CrossRefPubMed
[76]
Zurück zum Zitat Islam MN, Kim U, Kim DH, et al. High-performance liquid chromatography-based multivariate analysis to predict the estrogenic activity of an Epimedium koreanum extract. Biosci Biotechnol Biochem 2012;76:923–7CrossRefPubMed Islam MN, Kim U, Kim DH, et al. High-performance liquid chromatography-based multivariate analysis to predict the estrogenic activity of an Epimedium koreanum extract. Biosci Biotechnol Biochem 2012;76:923–7CrossRefPubMed
[77]
Zurück zum Zitat Forgo I, Kayasseh L and Staub JJ. Einfluss eines standardisierten Ginseng-Extrakts auf das Allgemeinbefinden, die Reaktionsfähigkeit, Lungenfunktion und die gonalen Hormone. Med Welt 1981;32:751–6PubMed Forgo I, Kayasseh L and Staub JJ. Einfluss eines standardisierten Ginseng-Extrakts auf das Allgemeinbefinden, die Reaktionsfähigkeit, Lungenfunktion und die gonalen Hormone. Med Welt 1981;32:751–6PubMed
[78]
Zurück zum Zitat Pearce PT, Zois I, Wynne KN, et al. Panax ginseng and Eleuthrococcus senticosus extracts—in vitro studies on binding to steroid receptors. Endocrinol Jpn 1982;29:567–73CrossRefPubMed Pearce PT, Zois I, Wynne KN, et al. Panax ginseng and Eleuthrococcus senticosus extracts—in vitro studies on binding to steroid receptors. Endocrinol Jpn 1982;29:567–73CrossRefPubMed
[79]
Zurück zum Zitat Salvati G, Genovesi G, Marcellini L, et al. Effects of Panax Ginseng C.A. Meyer saponins on male fertility. Panminerva Med 1996;38:249–54PubMed Salvati G, Genovesi G, Marcellini L, et al. Effects of Panax Ginseng C.A. Meyer saponins on male fertility. Panminerva Med 1996;38:249–54PubMed
[80]
Zurück zum Zitat Polan ML, Hochberg RB, Trant AS, et al. Estrogen bioassay of ginseng extract and ArginMax, a nutritional supplement for the enhancement of female sexual function. J Womens Health 2004;13:427–30CrossRef Polan ML, Hochberg RB, Trant AS, et al. Estrogen bioassay of ginseng extract and ArginMax, a nutritional supplement for the enhancement of female sexual function. J Womens Health 2004;13:427–30CrossRef
[81]
Zurück zum Zitat Lee JI, Ha YW, Choi TW, et al. Cellular uptake of ginsenosides in Korean white ginseng and red ginseng and their apoptotic activities in human breast cancer cells. Planta Med 2011;77:133–40CrossRefPubMed Lee JI, Ha YW, Choi TW, et al. Cellular uptake of ginsenosides in Korean white ginseng and red ginseng and their apoptotic activities in human breast cancer cells. Planta Med 2011;77:133–40CrossRefPubMed
[83]
Zurück zum Zitat Xu Y, Ding J, Ma XP, et al. Treatment with Panax ginseng antagonizes the estrogen decline in ovariectomized mice. Int J Mol Sci 2014;15:7827–40PubMedPubMedCentralCrossRef Xu Y, Ding J, Ma XP, et al. Treatment with Panax ginseng antagonizes the estrogen decline in ovariectomized mice. Int J Mol Sci 2014;15:7827–40PubMedPubMedCentralCrossRef
[84]
Zurück zum Zitat Ding J, Xu Y, Ma X, et al. Estrogenic effect of the extract of Renshen (Radix Ginseng) on reproductive tissues in immature mice. J Tradit Chin Med 2015;35:460–7CrossRefPubMed Ding J, Xu Y, Ma X, et al. Estrogenic effect of the extract of Renshen (Radix Ginseng) on reproductive tissues in immature mice. J Tradit Chin Med 2015;35:460–7CrossRefPubMed
[85]
Zurück zum Zitat Takeuchi T, Nishii O, Okamura T, et al. Effect of traditional herbal medicine, shakuyaku-kanzo-to on total and free serum testosterone levels. Am J Chin Med 1989;17:35–44CrossRefPubMed Takeuchi T, Nishii O, Okamura T, et al. Effect of traditional herbal medicine, shakuyaku-kanzo-to on total and free serum testosterone levels. Am J Chin Med 1989;17:35–44CrossRefPubMed
[86]
Zurück zum Zitat Hsieh TC, Wu JM. Mechanism of action of herbal supplement PC-SPES: elucidation of effects of individual herbs of PC-SPES on proliferation and prostate specific gene expression in androgen-dependent LNCaP cells. Int J Oncol 2002;20:583–8PubMed Hsieh TC, Wu JM. Mechanism of action of herbal supplement PC-SPES: elucidation of effects of individual herbs of PC-SPES on proliferation and prostate specific gene expression in androgen-dependent LNCaP cells. Int J Oncol 2002;20:583–8PubMed
[87]
Zurück zum Zitat Jo EH, Hong HD, Ahn NC, et al. Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell. J Agric Food Chem 2004;52:1715–9CrossRefPubMed Jo EH, Hong HD, Ahn NC, et al. Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell. J Agric Food Chem 2004;52:1715–9CrossRefPubMed
[88]
Zurück zum Zitat Jo EH, Kim SH, Ra JC, et al. Chemopreventive properties of the ethanol extract of Chinese licorice (Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells. Cancer Lett 2005;230:239–47CrossRefPubMed Jo EH, Kim SH, Ra JC, et al. Chemopreventive properties of the ethanol extract of Chinese licorice (Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells. Cancer Lett 2005;230:239–47CrossRefPubMed
[89]
Zurück zum Zitat Sigurjonsdottir HA, Axelson M, Johannsson G, et al. Liquorice in moderate doses does not affect sex steroid hormones of biological importance although the effect differs between the genders. Horm Res 2006;65:106–10PubMed Sigurjonsdottir HA, Axelson M, Johannsson G, et al. Liquorice in moderate doses does not affect sex steroid hormones of biological importance although the effect differs between the genders. Horm Res 2006;65:106–10PubMed
[90]
Zurück zum Zitat Hu C, Liu H, Du J, et al. Estrogenic activities of extracts of Chinese licorice (Glycyrrhiza uralensis) root in MCF-7 breast cancer cells. J Steroid Biochem Mol Biol 2009;113:209–16CrossRefPubMed Hu C, Liu H, Du J, et al. Estrogenic activities of extracts of Chinese licorice (Glycyrrhiza uralensis) root in MCF-7 breast cancer cells. J Steroid Biochem Mol Biol 2009;113:209–16CrossRefPubMed
[91]
Zurück zum Zitat Mao M, Li W, Wang W, et al. [Adverse reaction induced by licorice preparations: clinical analysis of 93 cases] (Chinese). Zhongguo Zhong Yao Za Zhi 2013;38:3768–72PubMed Mao M, Li W, Wang W, et al. [Adverse reaction induced by licorice preparations: clinical analysis of 93 cases] (Chinese). Zhongguo Zhong Yao Za Zhi 2013;38:3768–72PubMed
[92]
Zurück zum Zitat Li YX, Fan H, Zhang JS, et al. [In vitro evaluation of anticancer activity of extracts from Chinese medicinal herbs] (Chinese). Zhongguo Yaoke Daxue Xuebao 1999;30:37–42 Li YX, Fan H, Zhang JS, et al. [In vitro evaluation of anticancer activity of extracts from Chinese medicinal herbs] (Chinese). Zhongguo Yaoke Daxue Xuebao 1999;30:37–42
[93]
Zurück zum Zitat Matsuda H, Shimoda H, Morikawa T, et al. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorg Med Chem Lett 2001;11:1839–42CrossRefPubMed Matsuda H, Shimoda H, Morikawa T, et al. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorg Med Chem Lett 2001;11:1839–42CrossRefPubMed
[94]
Zurück zum Zitat Xue XO, Jin HT, Niu JZ, et al. [Effects of extract of root of Kudzu vine on mammary gland and uterus development] (Chinese). Zhongguo Zhongyao Zazhi 2003;28:560–2PubMed Xue XO, Jin HT, Niu JZ, et al. [Effects of extract of root of Kudzu vine on mammary gland and uterus development] (Chinese). Zhongguo Zhongyao Zazhi 2003;28:560–2PubMed
[95]
Zurück zum Zitat Boue SM, Wiese TE, Nehls S, et al. Evaluation of the estrogenic effects of legume extracts containing phytoestrogens. J Agric Food Chem 2003;51:2193–9CrossRefPubMed Boue SM, Wiese TE, Nehls S, et al. Evaluation of the estrogenic effects of legume extracts containing phytoestrogens. J Agric Food Chem 2003;51:2193–9CrossRefPubMed
[96]
Zurück zum Zitat Lin YJ, Hou YC, Lin CH, et al. Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. Biochem Biophys Res Commun 2009;378:683–8CrossRefPubMed Lin YJ, Hou YC, Lin CH, et al. Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. Biochem Biophys Res Commun 2009;378:683–8CrossRefPubMed
[97]
Zurück zum Zitat Zheng XK, Liu ZY, Jiang Y, et al. [Evaluation of the estrogenic effects of Rehmannia glutinosa Libosch] (Chinese). Zhonggou Yaoxue Zazhi 2013;48:1831–6 Zheng XK, Liu ZY, Jiang Y, et al. [Evaluation of the estrogenic effects of Rehmannia glutinosa Libosch] (Chinese). Zhonggou Yaoxue Zazhi 2013;48:1831–6
[98]
Zurück zum Zitat Gao ZP. [ER, PR are up-regulated by Rehmannia in aging female mice] (Chinese). Shanxi Zhongyi Xueyuan Xuebao 2000;1:1–3 Gao ZP. [ER, PR are up-regulated by Rehmannia in aging female mice] (Chinese). Shanxi Zhongyi Xueyuan Xuebao 2000;1:1–3
[99]
Zurück zum Zitat Guo WY, Liu CC, Dong YD, et al. [Effect of Chinese medicine on the reproductive system and the behavior of castrated mice] (Chinese). Jiangxi Zhong Yiyao Daxue Xuebao 2015;27:82–5 Guo WY, Liu CC, Dong YD, et al. [Effect of Chinese medicine on the reproductive system and the behavior of castrated mice] (Chinese). Jiangxi Zhong Yiyao Daxue Xuebao 2015;27:82–5
[100]
Zurück zum Zitat Chen JL, Wang JY, Tsai YF, et al. In vivo and in vitro demonstration of herb-drug interference in human breast cancer cells treated with tamoxifen and trastuzumab. Menopause 2013;20:646–54CrossRefPubMed Chen JL, Wang JY, Tsai YF, et al. In vivo and in vitro demonstration of herb-drug interference in human breast cancer cells treated with tamoxifen and trastuzumab. Menopause 2013;20:646–54CrossRefPubMed
[101]
Zurück zum Zitat Romm A. Plant profiles. Wild yam. In: Romm A, ed. Botanical medicine for women’s health. St. Louis, Mo.: Churchill Livingstone/Elsevier, 2010:550–2CrossRef Romm A. Plant profiles. Wild yam. In: Romm A, ed. Botanical medicine for women’s health. St. Louis, Mo.: Churchill Livingstone/Elsevier, 2010:550–2CrossRef
[102]
Zurück zum Zitat Ahmed HM, Yeh JY, Tang YC, et al. Molecular screening of Chinese medicinal plants for progestogenic and anti-progestogenic activity. J Biosci 2014;39:453–61CrossRefPubMed Ahmed HM, Yeh JY, Tang YC, et al. Molecular screening of Chinese medicinal plants for progestogenic and anti-progestogenic activity. J Biosci 2014;39:453–61CrossRefPubMed
[103]
Zurück zum Zitat Armanini D, Bonanni G and Palermo M. Reduction of serum testosterone in men by licorice. N Engl J Med 1999;341:1158CrossRefPubMed Armanini D, Bonanni G and Palermo M. Reduction of serum testosterone in men by licorice. N Engl J Med 1999;341:1158CrossRefPubMed
[104]
Zurück zum Zitat Armanini D, Bonanni G, Mattarello MJ, et al. Licorice consumption and serum testosterone in healthy man. Exp Clin Endocrinol Diabetes 2003;111:341–3CrossRefPubMed Armanini D, Bonanni G, Mattarello MJ, et al. Licorice consumption and serum testosterone in healthy man. Exp Clin Endocrinol Diabetes 2003;111:341–3CrossRefPubMed
[105]
Zurück zum Zitat Tang W, Eisenbrand G. Handbook of Chinese Medicinal Plants. Chemistry, Pharmacology, Toxicology. Vol. 1. Weinheim: WILEY-VCH Verlag GmbH & Co., 2011 Tang W, Eisenbrand G. Handbook of Chinese Medicinal Plants. Chemistry, Pharmacology, Toxicology. Vol. 1. Weinheim: WILEY-VCH Verlag GmbH & Co., 2011
[106]
Zurück zum Zitat Wang XS, Jie GY, Shi XL, et al. [Effects of Herba Epimedii and other Chinese herbal medicines on reproductive endocrine hormones of SD male rats] (Chinese). Zhongguo Zhong Yiyao Keji 2005;12:380–1 Wang XS, Jie GY, Shi XL, et al. [Effects of Herba Epimedii and other Chinese herbal medicines on reproductive endocrine hormones of SD male rats] (Chinese). Zhongguo Zhong Yiyao Keji 2005;12:380–1
[107]
Zurück zum Zitat Hsu CC, Huang YL, Tsai SJ, et al. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 2003;73:2127–36CrossRefPubMed Hsu CC, Huang YL, Tsai SJ, et al. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 2003;73:2127–36CrossRefPubMed
[108]
Zurück zum Zitat Qureshi S, Shah AH, Ageel AM. Toxicity studies on Alpinia galanga and Curcuma longa. Planta Med 1992;58:124–7CrossRefPubMed Qureshi S, Shah AH, Ageel AM. Toxicity studies on Alpinia galanga and Curcuma longa. Planta Med 1992;58:124–7CrossRefPubMed
[109]
Zurück zum Zitat Xiong YB, Zhou CH. [The effects of extracts from Herba Epimedii and Semen Cuscutae on the function of male reproduction] (Chinese). Zhongguo Yaoxue Zazhi 1994;29:89–91 Xiong YB, Zhou CH. [The effects of extracts from Herba Epimedii and Semen Cuscutae on the function of male reproduction] (Chinese). Zhongguo Yaoxue Zazhi 1994;29:89–91
[110]
Zurück zum Zitat Su J, Chen SH, Lv GJ, et al. [Effects on reproduction and sex hormones of kidney-yang deficient rats treated by Cortex Eucommiae and Semen Cuscutae] (Chinese). Zhejiang Zhong Yiyao Daxue Xuebao 2014;38:1087–90 Su J, Chen SH, Lv GJ, et al. [Effects on reproduction and sex hormones of kidney-yang deficient rats treated by Cortex Eucommiae and Semen Cuscutae] (Chinese). Zhejiang Zhong Yiyao Daxue Xuebao 2014;38:1087–90
[112]
Zurück zum Zitat Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton: CRC Press, 1999 Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton: CRC Press, 1999
[113]
Zurück zum Zitat Chen KH, Fang J, Kuang XW, et al. [Effects of the fruit of Rubus chingii Hu on hypothalamus-pituitary-sex gland axis in rats] (Chinese). Zhongguo Zhongyao Zazhi 1996;21:560–2PubMed Chen KH, Fang J, Kuang XW, et al. [Effects of the fruit of Rubus chingii Hu on hypothalamus-pituitary-sex gland axis in rats] (Chinese). Zhongguo Zhongyao Zazhi 1996;21:560–2PubMed
[114]
Zurück zum Zitat Xu JX. [Treatment of hyperprolactinemic impotence by jiawei shaoyao gancao tang: A clinical observation of 58 cases] (Chinese). Xin Zhongyi 2003;35:21–2 Xu JX. [Treatment of hyperprolactinemic impotence by jiawei shaoyao gancao tang: A clinical observation of 58 cases] (Chinese). Xin Zhongyi 2003;35:21–2
[115]
Zurück zum Zitat Shoemaker M, Hamilton B, Dairkee SH, et al. In vitro anticancer activity of twelve Chinese medicinal herbs. Phytother Res 2005;19:649–51CrossRefPubMed Shoemaker M, Hamilton B, Dairkee SH, et al. In vitro anticancer activity of twelve Chinese medicinal herbs. Phytother Res 2005;19:649–51CrossRefPubMed
[116]
Zurück zum Zitat Kumar N, Rungseevijitprapa W, Narkkhong NA, et al. 5alpha-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment. J Ethnopharmacol 2012;139:765–71CrossRefPubMed Kumar N, Rungseevijitprapa W, Narkkhong NA, et al. 5alpha-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment. J Ethnopharmacol 2012;139:765–71CrossRefPubMed
[117]
Zurück zum Zitat Zhang B, Zhang RW, Yin XQ, et al. Inhibitory activities of some traditional Chinese herbs against testosterone 5alpha-reductase and effects of Cacumen platycladi on hair re-growth in testosterone-treated mice. J Ethnopharmacol 2016;177:1–9CrossRefPubMed Zhang B, Zhang RW, Yin XQ, et al. Inhibitory activities of some traditional Chinese herbs against testosterone 5alpha-reductase and effects of Cacumen platycladi on hair re-growth in testosterone-treated mice. J Ethnopharmacol 2016;177:1–9CrossRefPubMed
[118]
Zurück zum Zitat Bonham M, Posakony J, Coleman I, et al. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clin Cancer Res 2005;11:3905–14CrossRefPubMed Bonham M, Posakony J, Coleman I, et al. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clin Cancer Res 2005;11:3905–14CrossRefPubMed
[119]
Zurück zum Zitat Fujita R, Liu J, Shimizu K, et al. Anti-androgenic activities of Ganoderma lucidum. J Ethnopharmacol 2005;102:107-12CrossRefPubMed Fujita R, Liu J, Shimizu K, et al. Anti-androgenic activities of Ganoderma lucidum. J Ethnopharmacol 2005;102:107-12CrossRefPubMed
[120]
Zurück zum Zitat Mosaddegh M, Naghibi F, Abbasi PR, et al. The effect of liquorice extract on serum testosterone level in healthy male volunteers. J Pharm Pharmacol 2003;55:S87–8CrossRef Mosaddegh M, Naghibi F, Abbasi PR, et al. The effect of liquorice extract on serum testosterone level in healthy male volunteers. J Pharm Pharmacol 2003;55:S87–8CrossRef
[121]
Zurück zum Zitat Armanini D, Mattarello MJ, Fiore C, et al. Licorice reduces serum testosterone in healthy women. Steroids 2004;69:763–6CrossRefPubMed Armanini D, Mattarello MJ, Fiore C, et al. Licorice reduces serum testosterone in healthy women. Steroids 2004;69:763–6CrossRefPubMed
[122]
Zurück zum Zitat Murphy LL, Cadena RS, Chavez D, et al. Effect of American ginseng (Panax quinquefolium) on male copulatory behavior in the rat. Physiol Behav 1998;64:445–50CrossRefPubMed Murphy LL, Cadena RS, Chavez D, et al. Effect of American ginseng (Panax quinquefolium) on male copulatory behavior in the rat. Physiol Behav 1998;64:445–50CrossRefPubMed
[123]
Zurück zum Zitat Murata K, Takeshita F, Samukawa K, et al. Effects of ginseng rhizome and ginsenoside Ro on testosterone 5alpha-reductase and hair re-growth in testosterone-treated mice. Phytother Res 2012;26:48–53CrossRefPubMed Murata K, Takeshita F, Samukawa K, et al. Effects of ginseng rhizome and ginsenoside Ro on testosterone 5alpha-reductase and hair re-growth in testosterone-treated mice. Phytother Res 2012;26:48–53CrossRefPubMed
[124]
Zurück zum Zitat Cho CH, Bae JS, Kim YU. 5alpha-reductase inhibitory components as antiandrogens from herbal medicine. J Acupunct Meridian Stud 2010;3:116–8CrossRefPubMed Cho CH, Bae JS, Kim YU. 5alpha-reductase inhibitory components as antiandrogens from herbal medicine. J Acupunct Meridian Stud 2010;3:116–8CrossRefPubMed
[125]
Zurück zum Zitat Kassem A, Al-Aghbari A, Al-Habori M, et al. Evaluation of the potential antifertility effect of fenugreek seeds in male and female rabbits. Contraception 2006;73:301–6CrossRefPubMed Kassem A, Al-Aghbari A, Al-Habori M, et al. Evaluation of the potential antifertility effect of fenugreek seeds in male and female rabbits. Contraception 2006;73:301–6CrossRefPubMed
[126]
Zurück zum Zitat Poole C, Bushey B, Foster C, et al. The effects of a commercially available botanical supplement on strength, body composition, power output, and hormonal profiles in resistance-trained males. J Int Soc Sports Nutr 2010;7:34PubMedPubMedCentralCrossRef Poole C, Bushey B, Foster C, et al. The effects of a commercially available botanical supplement on strength, body composition, power output, and hormonal profiles in resistance-trained males. J Int Soc Sports Nutr 2010;7:34PubMedPubMedCentralCrossRef
[127]
Zurück zum Zitat Yaginuma T, Izumi R, Yasui H, et al. [Effect of traditional herbal medicine on serum testosterone levels and its induction of regular ovulation in hyperandrogenic and oligomenorrheic women] (Japanese). Nihon Sanka Fujinka Gakkai Zasshi 1982;34:939–44PubMed Yaginuma T, Izumi R, Yasui H, et al. [Effect of traditional herbal medicine on serum testosterone levels and its induction of regular ovulation in hyperandrogenic and oligomenorrheic women] (Japanese). Nihon Sanka Fujinka Gakkai Zasshi 1982;34:939–44PubMed
[128]
Zurück zum Zitat Takahashi K, Yoshino K, Shirai T, et al. Effect of a traditional herbal medicine (shakuyaku-kanzo-to) on testosterone secretion in patients with polycystic ovary syndrome detected by ultrasound. Nihon Sanka Fujinka Gakkai Zasshi 1988;40:789–2PubMed Takahashi K, Yoshino K, Shirai T, et al. Effect of a traditional herbal medicine (shakuyaku-kanzo-to) on testosterone secretion in patients with polycystic ovary syndrome detected by ultrasound. Nihon Sanka Fujinka Gakkai Zasshi 1988;40:789–2PubMed
[129]
Zurück zum Zitat Takahashi K, Kitao M. Effect of TJ-68 (shakuyaku-kanzo-to) on polycystic ovarian disease. Int J Fertil Menopausal Stud 1994;39:69–76PubMed Takahashi K, Kitao M. Effect of TJ-68 (shakuyaku-kanzo-to) on polycystic ovarian disease. Int J Fertil Menopausal Stud 1994;39:69–76PubMed
[130]
Zurück zum Zitat Yuan HN, Wang CY, Sze CW, et al. A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. J Clin Psychopharmacol 2008;28:264–370CrossRefPubMed Yuan HN, Wang CY, Sze CW, et al. A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. J Clin Psychopharmacol 2008;28:264–370CrossRefPubMed
[131]
Zurück zum Zitat Wang D, Wong HK, Zhang L, et al. Not only dopamine D2 receptors involved in Peony-Glycyrrhiza Decoction, an herbal preparation against antipsychotic-associated hyperprolactinemia. Prog Neuropsychopharmacol Biol Psychiatry 2012;39:332–8CrossRefPubMed Wang D, Wong HK, Zhang L, et al. Not only dopamine D2 receptors involved in Peony-Glycyrrhiza Decoction, an herbal preparation against antipsychotic-associated hyperprolactinemia. Prog Neuropsychopharmacol Biol Psychiatry 2012;39:332–8CrossRefPubMed
[132]
Zurück zum Zitat Wang D, Wang W, Zhou Y, et al. Studies on the regulatory effect of Peony-Glycyrrhiza Decoction on prolactin hyperactivity and underlying mechanism in hyperprolactinemia rat model. Neurosci Lett 2015;606:60–5CrossRefPubMed Wang D, Wang W, Zhou Y, et al. Studies on the regulatory effect of Peony-Glycyrrhiza Decoction on prolactin hyperactivity and underlying mechanism in hyperprolactinemia rat model. Neurosci Lett 2015;606:60–5CrossRefPubMed
[133]
Zurück zum Zitat Briggs GG, Freeman RK, Summer JY. Drugs in pregnancy and lactation. A reference guide to fetal and neonatal risk. 9th ed. Philadelphia: Lippincott Williams & Wilkins, 2011 Briggs GG, Freeman RK, Summer JY. Drugs in pregnancy and lactation. A reference guide to fetal and neonatal risk. 9th ed. Philadelphia: Lippincott Williams & Wilkins, 2011
[134]
Zurück zum Zitat Wiebrecht A. Sicherheit in der Chinesischen Arzneitherapie. In: Focks C, ed. Leitfaden Chinesische Medizin. 7th ed. München: Elsevier, 2017:978–1028 Wiebrecht A. Sicherheit in der Chinesischen Arzneitherapie. In: Focks C, ed. Leitfaden Chinesische Medizin. 7th ed. München: Elsevier, 2017:978–1028
[135]
Zurück zum Zitat Manson JE, Chlebowski RT, Stefanick ML, et al. Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women’s Health Initiative randomized trials. JAMA 2013;310:1353–68CrossRefPubMed Manson JE, Chlebowski RT, Stefanick ML, et al. Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women’s Health Initiative randomized trials. JAMA 2013;310:1353–68CrossRefPubMed
[136]
Zurück zum Zitat Tsai YT, Lai JN, Lo PC, et al. Prescription of Chinese herbal products is associated with a decreased risk of invasive breast cancer. Medicine 2017;96:e7918PubMedPubMedCentralCrossRef Tsai YT, Lai JN, Lo PC, et al. Prescription of Chinese herbal products is associated with a decreased risk of invasive breast cancer. Medicine 2017;96:e7918PubMedPubMedCentralCrossRef
[137]
Zurück zum Zitat Tsai YT, Lai JN, Wu CT, et al. Concurrent use in Taiwan of Chinese herbal medicine therapies among hormone users aged 55 years to 79 years and its association with breast cancer risk: A population-based study. Evid Based Complement Alternat Med 2014;2014:683570PubMedPubMedCentral Tsai YT, Lai JN, Wu CT, et al. Concurrent use in Taiwan of Chinese herbal medicine therapies among hormone users aged 55 years to 79 years and its association with breast cancer risk: A population-based study. Evid Based Complement Alternat Med 2014;2014:683570PubMedPubMedCentral
[138]
Zurück zum Zitat Budhathoki S, Iwasaki M, Sawada N, et al. Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study. BJOG 2014;122:304–11CrossRefPubMed Budhathoki S, Iwasaki M, Sawada N, et al. Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study. BJOG 2014;122:304–11CrossRefPubMed
[139]
Zurück zum Zitat Zhang GQ, Chen JL, Liu Q, et al. Soy intake is associated with lower endometrial cancer risk: A systematic review and meta-analysis of observational studies. Medicine 2015;94:e2281PubMedPubMedCentralCrossRef Zhang GQ, Chen JL, Liu Q, et al. Soy intake is associated with lower endometrial cancer risk: A systematic review and meta-analysis of observational studies. Medicine 2015;94:e2281PubMedPubMedCentralCrossRef
[140]
Zurück zum Zitat Hu YC, Wu CT, Lai J, et al. Detection of a negative correlation between prescription of Chinese herbal products containing coumestrol, genistein or daidzein and risk of subsequent endometrial cancer among tamoxifen-treated female breast cancer survivors in Taiwan between 1998 and 2008: A population-based study. J Ethnopharmacol 2015;169:356–62PubMedCrossRef Hu YC, Wu CT, Lai J, et al. Detection of a negative correlation between prescription of Chinese herbal products containing coumestrol, genistein or daidzein and risk of subsequent endometrial cancer among tamoxifen-treated female breast cancer survivors in Taiwan between 1998 and 2008: A population-based study. J Ethnopharmacol 2015;169:356–62PubMedCrossRef
[141]
Zurück zum Zitat Hsu WL, Tsai YT, Wu CT, et al. The prescription pattern of Chinese herbal products containing ginseng among tamoxifen-treated female breast cancer survivors in Taiwan: A population-based study. Evid Based Complement Alternat Med 2015:385204 Hsu WL, Tsai YT, Wu CT, et al. The prescription pattern of Chinese herbal products containing ginseng among tamoxifen-treated female breast cancer survivors in Taiwan: A population-based study. Evid Based Complement Alternat Med 2015:385204
[142]
Zurück zum Zitat Wu CT, Lai JN, Tsai YT. The prescription pattern of Chinese herbal products that contain dang-qui and risk of endometrial cancer among tamoxifen-treated female breast cancer survivors in Taiwan: a population-based study. PLoS One 2014;9:e113887PubMedPubMedCentralCrossRef Wu CT, Lai JN, Tsai YT. The prescription pattern of Chinese herbal products that contain dang-qui and risk of endometrial cancer among tamoxifen-treated female breast cancer survivors in Taiwan: a population-based study. PLoS One 2014;9:e113887PubMedPubMedCentralCrossRef
[143]
Zurück zum Zitat Tsai YT, Lai JN, Wu CT. The use of Chinese herbal products and its influence on tamoxifen induced endometrial cancer risk among female breast cancer patients: A population-based study. J Ethnopharmacol 2014;155:1256–62CrossRefPubMed Tsai YT, Lai JN, Wu CT. The use of Chinese herbal products and its influence on tamoxifen induced endometrial cancer risk among female breast cancer patients: A population-based study. J Ethnopharmacol 2014;155:1256–62CrossRefPubMed
[144]
Zurück zum Zitat Qu XL, Fang Y, Zhang M, et al. Phytoestrogen intake and risk of ovarian cancer: a meta-analysis of 10 observational studies. Asian Pac J Cancer Prev 2014;15:9085–91CrossRefPubMed Qu XL, Fang Y, Zhang M, et al. Phytoestrogen intake and risk of ovarian cancer: a meta-analysis of 10 observational studies. Asian Pac J Cancer Prev 2014;15:9085–91CrossRefPubMed
[145]
Zurück zum Zitat He JJ, Wang S, Zhou M, et al. Phytoestrogens and risk of prostate cancer: a meta-analysis of observational studies. World J Surg Oncol 2015;13:231PubMedPubMedCentralCrossRef He JJ, Wang S, Zhou M, et al. Phytoestrogens and risk of prostate cancer: a meta-analysis of observational studies. World J Surg Oncol 2015;13:231PubMedPubMedCentralCrossRef
[146]
Zurück zum Zitat Zhang Q, Feng H, Qluwakemi B, et al. Phytoestrogens and risk of prostate cancer: an updated meta-analysis of epidemiologic studies. Int J Food Sci Nutr 2017;68:28–42CrossRefPubMed Zhang Q, Feng H, Qluwakemi B, et al. Phytoestrogens and risk of prostate cancer: an updated meta-analysis of epidemiologic studies. Int J Food Sci Nutr 2017;68:28–42CrossRefPubMed
[147]
Zurück zum Zitat Reger MK, Zollinger TW, Liu Z, et al. Dietary intake of isoflavones and coumestrol and the risk of prostate cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Int J Cancer 2017;142:719–28CrossRefPubMed Reger MK, Zollinger TW, Liu Z, et al. Dietary intake of isoflavones and coumestrol and the risk of prostate cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Int J Cancer 2017;142:719–28CrossRefPubMed
[148]
Zurück zum Zitat Chi F, Wu R, Zeng YC, et al. Post-diagnosis soy food intake and breast cancer survival: a meta-analysis of cohort studies. Asian Pac J Cancer Prev 2013;14:2407–12CrossRefPubMed Chi F, Wu R, Zeng YC, et al. Post-diagnosis soy food intake and breast cancer survival: a meta-analysis of cohort studies. Asian Pac J Cancer Prev 2013;14:2407–12CrossRefPubMed
[149]
Zurück zum Zitat Kang X, Zhang Q, Wang S, et al. Effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapy. CMAJ 2010;182:1857–62PubMedPubMedCentralCrossRef Kang X, Zhang Q, Wang S, et al. Effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapy. CMAJ 2010;182:1857–62PubMedPubMedCentralCrossRef
[150]
Zurück zum Zitat Woo HD, Park KS, Ro J, et al. Differential influence of dietary soy intake on the risk of breast cancer recurrence related to HER2 status. Nutr Cancer 2012;64:198–205CrossRefPubMed Woo HD, Park KS, Ro J, et al. Differential influence of dietary soy intake on the risk of breast cancer recurrence related to HER2 status. Nutr Cancer 2012;64:198–205CrossRefPubMed
[151]
Zurück zum Zitat Cui Y, Shu XO, Gao YT, et al. Association of ginseng use with survival and quality of life among breast cancer patients. Am J Epidemiol 2006;163:645–53CrossRefPubMed Cui Y, Shu XO, Gao YT, et al. Association of ginseng use with survival and quality of life among breast cancer patients. Am J Epidemiol 2006;163:645–53CrossRefPubMed
[152]
Zurück zum Zitat Liu B, Edgerton S, Yang X, et al. Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention. Cancer Res 2005;65:879–86PubMed Liu B, Edgerton S, Yang X, et al. Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention. Cancer Res 2005;65:879–86PubMed
[153]
Zurück zum Zitat Kuang AS, Ding T, Chen JL et al. [The effect of Maiya (Hordeum Dislichon) on serum prolactin level and its attempt in the treatment of patients with galactorrhea] (Chinese). Zhong Xiyi Jiehe Zazhi Nian Di Juan Di 1984;4:134–6,130 Kuang AS, Ding T, Chen JL et al. [The effect of Maiya (Hordeum Dislichon) on serum prolactin level and its attempt in the treatment of patients with galactorrhea] (Chinese). Zhong Xiyi Jiehe Zazhi Nian Di Juan Di 1984;4:134–6,130
[154]
Zurück zum Zitat Min JX, Hu J, Wu QH. [Effect of Hordei Semen germinatum on hyperprolactinemia in the rat model] (Chinese). Jiangxi Zhong Yiyao 2017;48:59–60 Min JX, Hu J, Wu QH. [Effect of Hordei Semen germinatum on hyperprolactinemia in the rat model] (Chinese). Jiangxi Zhong Yiyao 2017;48:59–60
[155]
Zurück zum Zitat Kiyama R. Estrogenic potentials of traditional Chinese medicine. Am J Chin Med 2017;45:1365–99CrossRefPubMed Kiyama R. Estrogenic potentials of traditional Chinese medicine. Am J Chin Med 2017;45:1365–99CrossRefPubMed
Metadaten
Titel
Hormonwirkungen chinesischer Arzneidrogen
verfasst von
Dr. med. Axel Wiebrecht
Publikationsdatum
01.06.2018
Verlag
Springer Medizin
Erschienen in
Chinesische Medizin / Chinese Medicine / Ausgabe 2/2018
Print ISSN: 0930-2786
Elektronische ISSN: 2196-5668
DOI
https://doi.org/10.1007/s00052-018-0183-1

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