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2016 | Humangenetik | OriginalPaper | Buchkapitel

3. Genetik und Epigenetik von allergischen Erkrankungen und Asthma

verfasst von : S. Weidinger, Prof. Dr. med., M. Kabesch, Prof. Dr. med. univ., E. Rodriguez, Dr. rer. nat.

Erschienen in: Allergologie

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Allergische Erkrankungen sind sehr heterogene Krankheitsbilder, deren Entstehung und Verlauf in erheblichem Maße durch erbliche Faktoren beeinflusst werden. Durch den Einsatz moderner molekulargenetischer Methoden konnten innerhalb der letzten 10 Jahre eine Vielzahl bislang unbekannter genetischer Risikofaktoren identifiziert werden. Obwohl die zugrunde liegenden kausalen Mechanismen häufig noch unzureichend verstanden sind, haben die bisherigen Erkenntnisse schon jetzt pathophysiologische Konzepte nachhaltig verändert und wichtige Stimuli zur Entwicklung gezielter präventiver und therapeutischer Ansätze gegeben. Insbesondere wurde die wichtige Bedeutung epithelialer Mechanismen in der Ätiologie allergischer Erkrankungen deutlich. Erste Studien deuten außerdem darauf hin, dass epigenetischen Faktoren in der Pathogenese eine wichtige Rolle zukommt. Die fortschreitende Entwicklung molekularbiologischer Strategien und die Integration klinischer und molekularer Daten werden zur weiteren Aufklärung erblicher Mechanismen und zur Abgrenzung von Patientensubgruppen beitragen und so die Entwicklung einer stratifizierten Medizin im Bereich der Allergologie befördern.
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Metadaten
Titel
Genetik und Epigenetik von allergischen Erkrankungen und Asthma
verfasst von
S. Weidinger, Prof. Dr. med.
M. Kabesch, Prof. Dr. med. univ.
E. Rodriguez, Dr. rer. nat.
Copyright-Jahr
2016
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-37203-2_3

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