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Erschienen in: Clinical Autonomic Research 2/2022

28.02.2022 | Research Article

Impaired sympathetic neural recruitment during exercise pressor reflex activation in women with post-traumatic stress disorder

verfasst von: Andrew W. D’Souza, Jeung-Ki Yoo, Ryosuke Takeda, Mark B. Badrov, Elizabeth H. Anderson, Jessica I. Wiblin, Carol S. North, Alina Suris, Michael D. Nelson, J. Kevin Shoemaker, Qi Fu

Erschienen in: Clinical Autonomic Research | Ausgabe 2/2022

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Abstract

Muscle sympathetic nerve activity (MSNA) increases during isometric exercise via increased firing of low-threshold action potentials (AP), recruitment of larger, higher-threshold APs, and synaptic delay modifications. Recent work found that women with post-traumatic stress disorder (PTSD) demonstrate exaggerated early-onset MSNA responses to exercise; however, it is unclear how PTSD affects AP recruitment patterns during fatiguing exercise. We hypothesized that women with PTSD (n = 11, 43 [11] [SD] years) would exhibit exaggerated sympathetic neural recruitment compared to women without PTSD (controls; n = 13, 40 [8] years). MSNA and AP discharge patterns (via microneurography and a continuous wavelet transform) were measured during 1 min of baseline, isometric handgrip exercise (IHG) to fatigue, 2 min of post-exercise circulatory occlusion (PECO), and 3 min of recovery. Women with PTSD were unable to increase AP content per burst compared to controls throughout IHG and PECO (main effect of group: P = 0.026). Furthermore, relative to controls, women with PTSD recruited fewer AP clusters per burst during the first (controls: ∆1.3 [1.2] vs. PTSD: ∆−0.2 [0.8]; P = 0.016) and second minute (controls: ∆1.2 [1.1] vs. PTSD: ∆−0.1 [0.8]; P = 0.022) of PECO, and fewer subpopulations of larger, previously silent axons during the first (controls: ∆5 [4] vs. PTSD: ∆1 [2]; P = 0.020) and second minute (controls: ∆4 [2] vs. PTSD: ∆1 [2]; P = 0.021) of PECO. Conversely, PTSD did not modify the AP cluster size–latency relationship during baseline, the end of IHG, or PECO (all P = 0.658–0.745). Collectively, these data indicate that women with PTSD demonstrate inherent impairments in the fundamental neural coding patterns elicited by the sympathetic nervous system during IHG and exercise pressor reflex activation.
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Metadaten
Titel
Impaired sympathetic neural recruitment during exercise pressor reflex activation in women with post-traumatic stress disorder
verfasst von
Andrew W. D’Souza
Jeung-Ki Yoo
Ryosuke Takeda
Mark B. Badrov
Elizabeth H. Anderson
Jessica I. Wiblin
Carol S. North
Alina Suris
Michael D. Nelson
J. Kevin Shoemaker
Qi Fu
Publikationsdatum
28.02.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Autonomic Research / Ausgabe 2/2022
Print ISSN: 0959-9851
Elektronische ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-022-00858-1

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