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Clinical Autonomic Research OnlineFirst articles

03.12.2023 | Letter to the Editor

Sympathetic vascular transduction and baroreflex sensitivity in the context of severe COPD

Chronic obstructive pulmonary disease (COPD) is an obstructive lung disease characterised by chronic bronchitis and emphysema, typically secondary to long-term cigarette smoking [ 1 ]. Patients classically present with significant hypoxaemia …

verfasst von:
Gianni Sesa-Ashton, Vaughan G. Macefield

30.11.2023 | Letter to the Editor

rs1801253 Gly/Gly carriage in the ADRB1 gene leads to unbalanced cardiac sympathetic modulation as assessed by spectral analysis of heart rate variability

The analysis of heart rate variability (HRV) has long been used as a standard non-invasive method for assessing autonomic nervous system (ANS) functions [ 1 , 2 ]. By computerized analysis of an electrocardiographic trace of sufficient length …

verfasst von:
E. Grossini, D. De Zanet, D. Apostolo, V. R. Mallela, G. La Rocca, A. Greco, G. Coratza, R. Minisini, M. Pirisi

20.11.2023 | Meeting Abstract

Abstracts of the 24th Congress of the European Federation of Autonomic Societies October 5–7, 2023, Dubrovnik, Croatia

16.11.2023 | REVIEW ARTICLE

The effects of oral contraceptives on resting autonomic function and the autonomic response to physiological stressors: a systematic review

Oral contraceptives (OC) are the second most popular short-acting contraceptive method, with current users accounting for 16% of the one billion reproductive-aged women worldwide [ 1 ]. OC prevent pregnancy through a combination of synthetic …

verfasst von:
T. J. Pereira, J. Bouakkar, H. Johnston, M. Pakosh, J. D. Drake, H. Edgell

16.11.2023 | Research Article

Serotonin reuptake inhibition for the prevention of vasovagal syncope: a systematic review and meta-analysis

Syncope is a common clinical condition with a lifetime cumulative incidence of at least 35% and a high rate of recurrence following initial presentation [ 1 , 2 ]. Nearly 60% of all syncope cases are attributable to vasovagal syncope. In patients …

verfasst von:
Priya Raj, Lucy Lei, Panagiota Flevaris, Satish Raj, Robert Sheldon

09.11.2023 | Research Article

Noninvasive low-level tragus stimulation attenuates inflammation and oxidative stress in acute heart failure

Acute decompensated heart failure (ADHF) is the most common cause of hospitalization in patients with heart failure [ 1 ]. Despite major advances in the management of chronic heart failure, limited treatment options are available for patients with …

verfasst von:
Tarun W. Dasari, Praloy Chakraborty, Peter Mukli, Khawaja Akhtar, Andriy Yabluchanskiy, Madeleine W. Cunningham, Anna Csiszar, Sunny S. Po

08.11.2023 | Research Article

Cholinesterase inhibitors associated with lower rate of mortality in dementia patients with heart failure: a nationwide propensity weighting study

Patients with heart failure (HF) have a disrupted balance between the sympathetic and parasympathetic systems [ 1 ]. In addition to the activation of the sympathetic nervous system, the impaired parasympathetic activity results in increased heart …

verfasst von:
Ming-Jer Hsieh, Cheng-Hung Lee, Dong-Yi Chen, Chia-Ling Wu, Yu-Tung Huang, Shang-Hung Chang

04.11.2023 | Editorial

Recent updates in autonomic research: new insights into vagal nerve activity during exercise, cardiac autonomic neuropathy and silent myocardial infarction in diabetes, and timing of orthostatic blood pressure change and future risk of dementia

Cardiovascular adjustments must occur during exercise to match increased metabolic demands from working muscles. The classic model of autonomic regulation during exercise proposes a feedforward mechanism, known as central command, and feedback …

verfasst von:
Guillaume Lamotte

31.10.2023 | Letter to the Editor

Inhalation of THC-containing cannabis selectively diminishes cardiac autonomic function in humans

verfasst von:
Massimo Nardone, Christian P. Cheung, Ryleigh E. Baker, Kathryn Pfundt, Jordan B. Lee, Jamie F. Burr, Philip J. Millar

28.10.2023 | Research Article

Sex differences in Black Veterans with PTSD: women versus men have higher sympathetic activity, inflammation, and blunted cardiovagal baroreflex sensitivity

Posttraumatic stress disorder (PTSD), a debilitating disorder that can develop in individuals after either witnessing or experiencing a traumatic event, is associated with an increased risk for developing hypertension and cardiovascular disease …

verfasst von:
Ida T. Fonkoue, Chowdhury Tasnova Tahsin, Toure N. Jones, Keyona N. King, Chowdhury Ibtida Tahmin, Jinhee Jeong, Deirdre Dixon, Dana R. DaCosta, Jeanie Park

Open Access 24.10.2023 | Research Article

Variability of cardioinhibition in vasovagal syncope: differences between subgroups during cardioinhibition and beyond

Vasovagal syncope (VVS) is the most common form of reflex syncope, with an estimated lifetime prevalence of > 30% [ 2 , 11 ]. Early concepts of VVS held that the decrease in blood pressure (BP) was due primarily to a parasympathetic decrease of …

verfasst von:
Ineke A. van Rossum, Frederik J. de Lange, David G. Benditt, Erik W. van Zwet, Marc van Houwelingen, Roland D. Thijs, J. Gert van Dijk

17.10.2023 | Viewpoint

Engaging patients in the management of orthostatic intolerance

Patients with recurrent VVS, POTS, and NOH suffer from chronic disabling orthostatic symptoms. With few exceptions, we do not have therapies that will cure the underlying disease. Therefore, the goal of treatment is to reduce symptoms, prevent …

verfasst von:
Juan Idiaquez, Juan Carlos Casar, Juan Francisco Idiaquez Rios, Italo Biaggioni

16.10.2023 | Research Article

Cardiac 18F-dopamine positron emission tomography predicts the type of phenoconversion of pure autonomic failure

Pure autonomic failure (PAF), previously called idiopathic orthostatic hypotension [ 52 ], asympathicotonic orthostatic hypotension [ 42 ], and Bradbury-Eggleston syndrome [ 1 ], is a rare form of chronic autonomic failure identified by orthostatic …

verfasst von:
Abhishek Lenka, Risa Isonaka, Courtney Holmes, David S. Goldstein

14.10.2023 | Editorial

Tackling the usefulness of neurofilament light chain in multiple system atrophy: diagnostic and prognostic perspectives

verfasst von:
Daniel G. Di Luca, Patricio Millar Vernetti

Open Access 04.10.2023 | Research Article

EFAS/EAN survey on the influence of the COVID-19 pandemic on European clinical autonomic education and research

With the rise of herd immunity, four years into the coronavirus disease 2019 (COVID-19) pandemic, diminishing numbers of newly diagnosed COVID-19 cases and deaths are registered worldwide [ 36 ]. Notwithstanding, the COVID-19 pandemic brought major …

verfasst von:
Alessandra Fanciulli, Magdalena Krbot Skorić, Fabian Leys, Diogo Reis Carneiro, Nicole Campese, Giovanna Calandra-Buonaura, Jennifer Camaradou, Giacomo Chiaro, Pietro Cortelli, Cristian Falup-Pecurariu, Roberta Granata, Pietro Guaraldi, Raimund Helbok, Max J. Hilz, Valeria Iodice, Jens Jordan, Evert C. A. Kaal, Anita Kamondi, Anne Pavy Le Traon, Isabel Rocha, Johann Sellner, Jean Michel Senard, Astrid Terkelsen, Gregor K. Wenning, Elena Moro, Thomas Berger, Roland D. Thijs, Walter Struhal, Mario Habek, the Collaborators of European Network of Neurological Autonomic Laboratories

30.09.2023 | Research Article

Augmented resting beat-to-beat blood pressure variability in patients with chronic kidney disease

Chronic kidney disease (CKD) affects approximately 15% of the US population and over 850 million people worldwide. CKD is a progressive disease characterized by irreversible kidney dysfunction that can lead to end-stage kidney disease and early …

verfasst von:
Jeann L. Sabino-Carvalho, Jinhee Jeong, Justin Sprick, Dana DaCosta, Massimo Nardone, Jeanie Park

30.09.2023 | Research Article

Characteristics of deceleration capacity and deceleration runs in vasovagal syncope

Vasovagal syncope (VVS), the most common cause of neurally mediated syncope, is characterized by a sudden decrease in heart rate (HR) and blood pressure and directly leads to global hypoperfusion and typical episodes of fainting [ 1 ]. Although VVS …

verfasst von:
Jiakun Li, Wei Sun, Xu Yang, Bin Tu, Simin Cai, Feng Hu, Zhiyuan Weng, Shangyu Liu, Zihao Lai, Lihui Zheng, Yan Yao

27.09.2023 | Review Article

Quantification of dynamic cerebral autoregulation: welcome to the jungle!

Patients with dysautonomia (e.g. postural orthostatic tachycardia syndrome (POTS), vasovagal syncope, baroreflex failure, pure autonomic failure, spinal cord injuries) often develop symptoms such as dizziness, syncope, blurred vision and brain fog …

verfasst von:
Patrice Brassard, Marc-Antoine Roy, Joel S. Burma, Lawrence Labrecque, Jonathan D. Smirl

21.09.2023 | Research Article

Effect of hypoglycemia on baroreflex sensitivity in individuals with type 2 diabetes: implications for autonomic control of cardiovascular function in diabetes

Hypoglycemia is an unfortunate and common occurrence in many individuals with diabetes [ 1 – 3 ]. The landmark 2008 Action to Control Cardiovascular Risk in Diabetes (ACCORD) clinical trial in > 10,000 individuals with type 2 diabetes at high risk …

verfasst von:
Andrea V. Haas, Andrew Koefoed, Rebecca M. Easly, Johanna Celli, Mahyar Heydarpour, Istvan Bonyhay, Roy Freeman, Gail K. Adler

21.09.2023 | Review Article

Assessment of comorbid symptoms in pediatric autonomic dysfunction

Pediatric patients with autonomic dysfunction can have specific disorders of orthostatic intolerance (OI), including postural orthostatic tachycardia syndrome (POTS). Presentations are often complex with a variety of co-existing symptoms and signs …

verfasst von:
Sally E. Tarbell, Erin L. Olufs, Philip R. Fischer, Gisela Chelimsky, Mohammed T. Numan, Marvin Medow, Hasan Abdallah, Shelley Ahrens, Jeffrey R. Boris, Ian J. Butler, Thomas C. Chelimsky, Craig Coleby, John E. Fortunato, Raewyn Gavin, Janice Gilden, Renato Gonik, Kelsey Klaas, Lauren Marsillio, Erin Marriott, Laura A. Pace, Paul Pianosi, Pippa Simpson, Julian Stewart, Natalie Van Waning, Debra E. Weese-Mayer