Skip to main content

Cardiovascular Drugs and Therapy OnlineFirst articles

10.05.2024 | Original Article

Discharge of Acute Coronary Syndrome Patients on Sub-Optimal Dual Anti-Platelet Therapy: A Single Center Experience

Since the early 1990’s, dual anti-platelet therapy has been the standard of care after coronary stenting to prevent stent thrombosis. Ticlopidine was the first P2Y 12 drug, but it was replaced in the early 2000’s by clopidogrel. The 2004 American …

verfasst von:
Jeffrey B Booker, Alexander J Nihart, Matthew J Campen, Eduardo Medrano-Rodriguez, James C Blankenship

10.05.2024 | Trial Designs

Rationale and Design of Prospective, Multicenter, Double-Arm Clinical Trial to Investigate the Efficacy of Tofogliflozin on Left Ventricular Diastolic Dysfunction in Patients with Heart Failure with Preserved Ejection Fraction and Type 2 Diabetes Mellitus (TOP-HFPEF Trial)

Heart failure with preserved ejection fraction (HFpEF) accounts for half of hospitalizations due to heart failure (HF) [ 1 ] and has become a major global health problem. In Japan, patients with HFpEF experience cardiovascular (CV) death at a rate …

verfasst von:
Shin Ito, Yuri Nakajima, Hiroki Fukuda, Chisato Izumi, Gaku Nakazawa, Hajime Yamashita, Hideo Matsuhisa, Moriaki Inoko, Shigeru Toyoda, Shin Takiuchi, Toru Kataoka, Yasuhiro Izumiya, Yukio Abe, Takashi Sozu, Yasushi Sakata, Masanori Emoto, Teruo Inoue, Masafumi Kitakaze

08.05.2024 | Original Article

LncRNA Gm15834 Aggravates Cardiac Hypertrophy by Interacting with Sam68 and Activating NF-κB Mediated Inflammation

Cardiac hypertrophy is the compensatory response to pressure overload of heart and prolonged cardiac hypertrophy is considered as a high risk factor of heart failure [ 1 , 2 ]. Previous studies have revealed that some pathological processes were …

verfasst von:
Yongsheng Liu, Man Jiang, Meitian Zhang, Yawen Xie, Lixin Wang, Pilong Shi, Qianlong Zhang, Qianhui Zhang, Kai Liu, Jiajun Zhou, Chao Song, Hongli Sun

06.05.2024 | Editorial

Left Ventricular Thrombus After Myocardial Infarction: Opinions and Equipoise

Controversy remains over whether to treat with prophylactic anticoagulation to reduce thromboembolic events [ 2 , 3 ]. A recent meta-analysis concluded that the risks of stroke from LVT are balanced by the risks of bleeding and the authors conclude …

verfasst von:
Shannon Clay, James C. Blankenship

24.04.2024 | Original Article

miR-210-5p Promotes Pulmonary Hypertension by Blocking ATP2A2

Pulmonary hypertension is a chronic progressive and fatal disease. It is extremely disabling and lethal, with 1-, 3-, and 5-year survival rates of 88.2%, 72.2%, and 59.4%, respectively, and severely affects patients’ quality of life [ 1 ]. Despite …

verfasst von:
Boxiang Wang, Yidin Xu, Yilun Huang, Siming Shao, Dongshan Xu, Yiying Zhang, Lingxia Pang, Zhuofan Nan, Qianxi Ye, Yang Wang, Wantie Wang, Keke Jin, Linbo Yuan

02.04.2024 | Routine Article

Outcomes With Hybrid Catheter-Directed Therapy Compared With Aspiration Thrombectomy for Patients With Intermediate-High Risk Pulmonary Embolism

Pulmonary embolism (PE) remains the third leading cause of cardiovascular mortality leading to hundreds of thousands of deaths worldwide every year [ 1 – 3 ]. PE is characterized by a wide spectrum of clinical presentations, which should be …

verfasst von:
Sylwia Sławek-Szmyt, Aleksander Araszkiewicz, Stanisław Jankiewicz, Marek Grygier, Tatiana Mularek-Kubzdela, Maciej Lesiak

Open Access 20.03.2024 | Original Article

Predictors of Plasma Levels of Direct Oral Anticoagulants Among Patients with Atrial Fibrillation in Need of Elective Cardiac Procedures

Direct oral anticoagulants (DOACs) are the first-line anticoagulant therapy for the treatment of atrial fibrillation (AF) in patients with increased thromboembolic risk [ 1 ]. The timing of DOACs discontinuation before elective invasive surgery is …

verfasst von:
Vincenzo Russo, Eleonora Caiazza, Fiorella Chiara Delle Femine, Enrica Pezzullo, Sara Sarpa, Antonio Ianniciello, Caturano Alfredo, Antonello D’Andrea, Paolo Golino, Gerardo Nigro

Open Access 16.03.2024 | Review Article

A Comprehensive Overview on Chemotherapy-Induced Cardiotoxicity: Insights into the Underlying Inflammatory and Oxidative Mechanisms

While oncotherapy has made rapid progress in recent years, side effects of anti-cancer drugs and treatments have also come to the fore. These side effects include cardiotoxicity, which can cause irreversible cardiac damages with long-term …

verfasst von:
András Nagy, Denise Börzsei, Alexandra Hoffmann, Szilvia Török, Médea Veszelka, Nikoletta Almási, Csaba Varga, Renáta Szabó

15.03.2024 | Original Article

Surgical Treatment for Type A Aortic Dissection after Endovascular Aortic Repair: A 12-year, Single-Center Study

Thoracic endovascular aortic repair (TEVAR) is a preferred treatment modality for thoracic aortic aneurysms as well as dissections, especially in patients who are at a high risk of conventional open surgical repair [ 1 , 2 ]. With the development …

verfasst von:
Yuan Xue, Shipan Wang, Xuehuan Zhang, Xiaomeng Wang, Yue Shi, Hongjia Zhang, Duanduan Chen, Haiyang Li

Open Access 12.03.2024 | Review Article

Effectiveness of Vasopressin Against Cardiac Arrest: A Systematic Review of Systematic Reviews

Cardiac arrest (CA) refers to an abrupt interruption of blood flow to the brain and other organs because of the ineffective pumping of the heart. This medical emergency is a common cause of mortality worldwide [ 1 ]. A systematic review (SR) of 67 …

verfasst von:
Jonathan Ka-Ming Ho, Hon-Lon Tam, Leona Yuen-Ling Leung

11.03.2024 | Original Article

The Impacts of Nirmatrelvir–Ritonavir on Myocardial Injury and Long-Term Cardiovascular Outcomes in Hospitalized Patients with COVID-19 amid the Omicron Wave of the Pandemic

Although the pathogenicity and clinical severity of omicron COVID-19 appear to be weakened compared with previous variants, it tends to evolve toward more transmissible, and the number of hospital admissions and cardiovascular complications might …

verfasst von:
Jun Gu, Zhi-Hua Han, Chang-qian Wang, Jun-feng Zhang

Open Access 06.03.2024 | Short Communication

Evinacumab Reduces Triglyceride-Rich Lipoproteins in Patients with Hyperlipidemia: A Post-Hoc Analysis of Three Randomized Clinical Trials

Individuals with elevated levels of low-density lipoprotein cholesterol (LDL-C) have an increased risk for atherosclerotic cardiovascular disease (ASCVD) [ 1 ]. For individuals with elevated LDL-C, lipid-lowering therapies (LLTs) are effective in …

verfasst von:
Robert S. Rosenson, Daniel J. Rader, Shazia Ali, Poulabi Banerjee, Jennifer McGinniss, Robert Pordy

Open Access 04.03.2024 | Review Article

Exercise Improves Heart Function after Myocardial Infarction: The Merits of AMPK

Myocardial infarction (MI), a disease with a high incidence of cardiovascular disease, presents a pressing challenge in the diagnosis and treatment of noncommunicable diseases. The annual increase in incidence and the diagnosis of MI at younger …

verfasst von:
Xiaodi Zhang, Yi Zhao, Dafen Guo, Mingxian Luo, Qing Zhang, Li Zhang, Dengshen Zhang

28.02.2024 | Original Article

Aloperine Alleviates Myocardial Injury Induced by Myocardial Ischemia and Reperfusion by Activating the ERK1/2/β-catenin Signaling Pathway

Cardiovascular diseases (CVDs) are the leading cause of death globally and account for one-third of all deaths worldwide. Ischemic heart disease is the most prevalent cardiovascular disease and a dominant contributor to disability [ 1 ]. Myocardial …

verfasst von:
Shichao Wei, Feng Ju, Junshen Xiao, Jiaxue Li, Ting Liu, Zhaoyang Hu

24.02.2024 | Original Article

An Integrated Network Pharmacology and RNA-seq Approach for Exploring the Protective Effect of Andrographolide in Doxorubicin-Induced Cardiotoxicity

As a broad-spectrum anticancer drug, doxorubicin (Dox) is widely applied to the clinical treatment of breast cancer, acute leukemia, malignant lymphoma, and other cancerous diseases. When the clinical dose of Dox exceeds 400 mg/cm 2 –700 mg/cm 2 …

verfasst von:
Sa Liu, Jiaqin Liu, Nan Su, Shanshan Wei, Ning Xie, Xiangyun Li, Suifen Xie, Jian Liu, Bikui Zhang, Wenqun Li, Shengyu Tan

Open Access 16.02.2024 | Review Article

A Practical Approach to the Management of Residual Cardiovascular Risk: United Arab Emirates Expert Consensus Panel on the Evidence for Icosapent Ethyl and Omega-3 Fatty Acids

While the cardiovascular (CV) risk incurred from long-standing dyslipidemia, hypertension, diabetes, and other conditions is firmly established, residual CV risk has only recently become of interest in the race to prevent or mitigate CV diseases …

verfasst von:
Hani Sabbour, Deepak L. Bhatt, Yaser Elhenawi, Asma Aljaberi, Layal Bennani, Tarek Fiad, Khwaja Hasan, Shahrukh Hashmani, Rabih A. Hijazi, Zafar Khan, Ronney Shantouf

16.02.2024 | Original Article

Isoimperatorin Inhibits Angiogenesis by Suppressing VEGFR2 Signaling Pathway

Angiogenesis refers to the biological process whereby new blood vessels are generated from existing ones. It is a crucial biological mechanism that involves in many physiological and pathological processes, such as embryogenesis, tumor growth, and …

verfasst von:
Yating Xu, Di Xia, Shan Deng, Minglu Liang

07.02.2024 | Review Article

Safety and Effectiveness of Antidysrhythmic Drugs for Pharmacologic Cardioversion of Recent-Onset Atrial Fibrillation: a Systematic Review and Bayesian Network Meta-analysis

Atrial fibrillation (AF) is the most common, clinically significant dysrhythmia with a global prevalence of 33.5 million [ 1 ]. The numbers are highest in developed nations [ 2 ], and it is estimated that the prevalence will increase to 12.1 …

verfasst von:
Ian S. deSouza, Pragati Shrestha, Robert Allen, Jessica Koos, Henry Thode Jr.

06.02.2024 | Original Article

Acute Kidney Injury in Different Anticoagulation Strategies: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data

Anticoagulation-related nephropathy (ARN) is an underdiagnosed but clinically significant complication of anticoagulation which is associated with elevated renal morbidity and all-cause mortality [ 1 ]. ARN is a recently identified subtype of acute …

verfasst von:
Qiuyu Xu, Gang Chen, Sanxi Ai, Ke Zheng, Bin Zhao, Xuemei Li

30.01.2024 | Review Article

Changes in Heart Rate Variability Parameters Following Radiofrequency Ablation in Patients with Atrial Fibrillation: A Systematic Review and Meta-Analysis

Atrial fibrillation (AF) is a common heart condition that can result in serious complications, including heart failure, stroke, cardiomyopathies, and valvular heart disease, leading to increased mortality and morbidity rates [ 1 ]. Pulmonary veins …

verfasst von:
Mahsa Mansourian, Zahra Teimouri-jervekani, Azam Soleimani, Rasool Nouri, Hamidreza Marateb, Marjan Mansourian