Inflammation Research OnlineFirst articles

24.04.2024 | Original Research Paper

A single dose of angiotensin-(1–7) resolves eosinophilic inflammation and protects the lungs from a secondary inflammatory challenge

According to the traditional concept of the resolution of inflammation, a series of active events are coordinated by pro-resolutive mediators to cease inflammation and reestablish homeostasis of tissues [ 1 – 3 ]. However, the immunological …

verfasst von:: Giselle Santos Magalhaes, Juliana Fabiana Gregorio, Vinicius Amorim Beltrami, Franciel Batista Felix, Livia Oliveira-Campos, Caio Santos Bonilha, Renato Fraga Righetti, Iolanda de Fátima Lopes Calvo Tibério, Frederico B. De Sousa, Barbara Maximino Rezende, Andréa Teixeira-Carvalho, Robson AS Santos, Maria José Campagnole-Santos, Maria da Gloria Rodrigues-Machado, Mauro Martins Teixeira, Vanessa Pinho

20.04.2024 | Original Research Paper

Tumor necrosis factor receptor-associated factor 5 protects against intimal hyperplasia by regulation of macrophage polarization via directly targeting PPARγ

Revascularization procedures have been performed to treat symptomatic coronary artery diseases, including angioplasty, atherectomy, percutaneous transluminal coronary intervention, and coronary artery bypass grafting [ 1 – 3 ]. However, the …

verfasst von:: Wen-Lin Cheng, Sheng-ping Chao, Fang Zhao, Huan-Huan Cai, Ziyue Zeng, Jian-Lei Cao, Zhili Jin, Ke-Qiong Deng, Xiaorong Hu, Hairong Wang, Zhibing Lu

Open Access 17.04.2024 | Original Research Paper

PLD2 deletion ameliorates sepsis-induced cardiomyopathy by suppressing cardiomyocyte pyroptosis via the NLRP3/caspase 1/GSDMD pathway

Despite improvements in critical care, sepsis affects more than 50 million individuals and accounts for 11 million deaths annually, making it a leading causes of death worldwide [ 1 , 2 ]. Most patients with sepsis have abnormal cardiac function …

verfasst von:: Jun Li, Da Teng, Wenjuan Jia, Lei Gong, Haibin Dong, Chunxiao Wang, Lihui Zhang, Bowen Xu, Wenlong Wang, Lin Zhong, Jianxun Wang, Jun Yang

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Open Access 16.04.2024 | Original Research Paper

Viperin inhibits interferon-γ production to promote Mycobacterium tuberculosis survival by disrupting TBK1-IKKε-IRF3-axis and JAK-STAT signaling

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) infection is a worldwide disease that affects one-third of the world's population [ 1 ]. Mtb is an intracellular pathogen living in macrophage, which is the first line of host defense …

verfasst von:: Yao Liang, Yun Liang, Qi Wang, Qianna Li, Yingqi Huang, Rong Li, Xiaoxin Pan, Linmiao Lie, Hui Xu, Zhenyu Han, Honglin Liu, Qian Wen, Chaoying Zhou, Li Ma, Xinying Zhou

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15.04.2024 | Original Research Paper

Integration of multiomics analyses reveals unique insights into CD24-mediated immunosuppressive tumor microenvironment of breast cancer

Breast cancer is a malignant tumor that occurs in the breast tissue, usually originating in the glandular tissue of the breast, and can develop in various parts of the breast such as the breast lobules, ducts and glandular interstitium [ 1 ].

verfasst von:: Haihong Hu, Hongxia Zhu, Wendi Zhan, Bo Hao, Ting Yan, Jingdi Zhang, Siyu Wang, Xuefeng Xu, Taolan Zhang

15.04.2024 | Original Research Paper

Impacts of liver macrophages, gut microbiota, and bile acid metabolism on the differences in iHFC diet-induced MASH progression between TSNO and TSOD mice

Metabolic dysfunction-associated steatotic liver disease (MASLD) [ 1 ], a newly updated term for non-alcoholic fatty liver disease, represents an emerging global metabolic disorder characterized by the accumulation of fat within the liver [ 2 ].

verfasst von:: Naoya Igarashi, Kaichi Kasai, Yuki Tada, Koudai Kani, Miyuna Kato, Shun Takano, Kana Goto, Yudai Matsuura, Mayuko Ichimura-Shimizu, Shiro Watanabe, Koichi Tsuneyama, Yukihiro Furusawa, Yoshinori Nagai

14.04.2024 | Review

Acute lung injury: a view from the perspective of necroptosis

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common critical illness in the ICU, with an in-hospital mortality rate of 34.9%–46.1%. Approximately 10.4% of ICU patients meet the diagnostic criteria for ARDS, and …

verfasst von:: Jinyan Dong, Weihong Liu, Wenli Liu, Yuqi Wen, Qingkuo Liu, Hongtao Wang, Guohan Xiang, Yang Liu, Hao Hao

09.04.2024 | Original Research Paper

Macrophage-enriched novel functional long noncoding RNAs LRRC75A-AS1 and GAPLINC regulate polarization and innate immune responses

Monocytes and macrophages (Mφs) are members of the mononuclear phagocyte system (MPS) that constantly patrol peripheral tissues and are actively recruited to the sites of injury and infection [ 1 – 5 ]. Infiltrating monocytes, under the influence …

verfasst von:: Araceli Valverde, Raza Ali Naqvi, Afsar R. Naqvi

09.04.2024 | Review

Tryptophan catabolism via the kynurenine pathway regulates infection and inflammation: from mechanisms to biomarkers and therapies

l -tryptophan ( l -Trp) is an aromatic essential amino acid derived exclusively from dietary intake in humans [ 1 ]. Organisms including bacteria, fungi and plants originally synthesize Trp from molecules such as phosphoenolpyruvate, and fuel the …

verfasst von:: Jingpu Zhang, Yanlei Liu, Xiao Zhi, Li Xu, Jie Tao, Daxiang Cui, Tie Fu Liu

08.04.2024 | Original Research Paper

Consistent efficacy outcomes between phase 2 and phase 3 trials in Crohn’s disease or ulcerative colitis in adults: a meta-analysis

A vast number of people throughout the world suffer from inflammatory bowel disease (IBD), a chronic disorder marked by inflammation of the gastrointestinal system [ 1 ]. Two main types of IBD are Crohn’s disease (CD) and ulcerative colitis (UC) [ …

verfasst von:: Ziqi Wan, Qingwei Jiang, Runing Zhou, Xiang Li, Wei Han, Bing Xu, Mingyue Guo, Gechong Ruan, Xiaoyin Bai, Guanqiao Li, Hong Yang

08.04.2024 | Original Research Paper

Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice

Mast cells (MCs) also called mastocytes, as multifunctional immune cells with secretory granules filled with immune and inflammatory mediators, including histamine, tumor necrosis factor-alpha (TNF-α) and β-tryptase, play a critical role in …

verfasst von:: Pan Su, Zibo Li, Xiangli Yan, Baoying Wang, Ming Bai, Yucheng Li, Erping Xu

08.04.2024 | Original Research Paper

Transcriptomic analysis reveals molecular characterization and immune landscape of PANoptosis-related genes in atherosclerosis

Atherosclerosis is a chronic inflammatory condition characterized by abnormal lipid deposition in the arteries. It serves as the primary pathological feature of atherosclerotic cardiovascular disease (ASCVD) and is frequently associated with major …

verfasst von:: Zhipeng Zheng, Kaiyuan Li, Zhiyuan Yang, Xiaowen Wang, Cheng Shen, Yubin Zhang, Huimin Lu, Zhifeng Yin, Min Sha, Jun Ye, Li Zhu

02.04.2024 | Review

Recognition of Mycobacterium tuberculosis by macrophage Toll-like receptor and its role in autophagy

Mycobacterium tuberculosis (MTB) is the causative agent of tuberculosis, which is widely spread and highly infectious and poses a serious threat to human health and even life. The World Health Organization estimates that around one-fourth of the …

verfasst von:: Linna Wei, Liping Liu, Zudi Meng, Kai Qi, Xuehan Gao, Jihong Feng, Junmin Luo

02.04.2024 | Review

γδ T cells in oral diseases

γδ T cells are a distinct subset of T cells characterized by the presence of T cell receptor (TCR) γ and δ chains, exhibiting diverse tissue localization [ 1 ]. In contrast to conventional αβ T cells, γδ T cells are not restricted by major …

verfasst von:: Xin-Yi Wei, Ya-Qin Tan, Gang Zhou

31.03.2024 | Review

Immunopathogenesis of urticaria: a clinical perspective on histamine and cytokine involvement

Urticaria encompasses a collection of disorders characterized by a distinctive pattern of cutaneous reactions. It is estimated that approximately 20% of individuals worldwide will experience urticaria at some point during their lifespan [ 1 , 2 ].

verfasst von:: Rudranil Bhowmik, Md. Adil Shaharyar, Arnab Sarkar, Avishek Mandal, Kumar Anand, Humira Shabana, Achintya Mitra, Sanmoy Karmakar

Open Access 28.03.2024 | Review

Inflammation in heart failure: pathophysiology and therapeutic strategies

A role for inflammation in the development and progression of heart failure (HF) has been proposed for decades. Multiple studies have demonstrated the potential involvement of several groups of cytokines and chemokines in acute and chronic HF …

verfasst von:: Jacinthe Boulet, Vikas S. Sridhar, Nadia Bouabdallaoui, Jean-Claude Tardif, Michel White

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27.03.2024 | Original Research Paper

Bakuchicin alleviates ovalbumin-induced allergic asthma by regulating M2 macrophage polarization

Asthma is a chronic airway disease characterized by respiratory symptoms including dyspnea, bronchospasm, and mucus overproduction, resulting in breathing limitations due to exposure to allergens. Inhalation of allergens induces the upregulation …

verfasst von:: Yeon-Yong Kim, Seungwon Jeong, Seung Woong Lee, Seung-Jae Lee, Mun-Chual Rho, Sang-Hyun Kim, Soyoung Lee

27.03.2024 | Original Research Paper

Causal role of myeloid cells in Parkinson’s disease: Mendelian randomization study

Parkinson's disease (PD) is the second most common neurodegenerative disease among older adults [ 1 ] and is characterized by motor symptoms such as bradykinesia, static tremor, and myotonia, as well as non-motor symptoms such as cognitive …

verfasst von:: Wei Quan, Yidan Qin, Jia Li, Lin Wang, Jia Song, Jing Xu, Jiajun Chen

20.03.2024 | Original Research Paper

Identification of a novel ADCC-related gene signature for predicting the prognosis and therapy response in lung adenocarcinoma

Globally, lung cancer maintains its unfortunate position as the leading cause of cancer-related mortalities [ 1 ], with lung adenocarcinoma (LUAD) accounting for the most prevalent histological subtype [ 2 , 3 ]. Despite significant advancements in …

verfasst von:: Liangyu Zhang, Xun Zhang, Maohao Guan, Jianshen Zeng, Fengqiang Yu, Fancai Lai

20.03.2024 | Author Correction

Author Correction: Porphyromonas gingivalis promotes the progression of oral squamous cell carcinoma by stimulating the release of neutrophil extracellular traps in the tumor immune microenvironment

verfasst von:: Zhi-chen Guo, Si-li Jing, Xin-yu Jia, Sadam Ahmed Elayah, Lin-yang Xie, Hao Cui, Jun-bo Tu, Si-jia Na

Springer Medizin