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Cardiovascular Toxicology OnlineFirst articles

22.06.2019

Role of ATP-Sensitive Potassium Channel (KATP) and eNOS in Mediating the Protective Effect of Nicorandil in Cyclophosphamide-Induced Cardiotoxicity

Cyclophosphamide (CP) is a widely used chemotherapeutic agent but its clinical usefulness is challenged with different forms of toxicities. No studies have evaluated the possible protective effect of nicorandil (NIC) in CP-induced cardiotoxicity.

verfasst von:
Marwa M. M. Refaie, Sayed Shehata, Maram El-Hussieny, Wedad M. Abdelraheem, Asmaa M. A. Bayoumi

11.06.2019

The Protective Effect of Crataegus aronia Against High-Fat Diet-Induced Vascular Inflammation in Rats Entails Inhibition of the NLRP-3 Inflammasome Pathway

Local aseptic vascular inflammation plays an important role in all phases of atherosclerosis from its initiation to its clinical manifestations, including plaque rupture [ 1 ]. The accumulation of intracellular oxidized low-density lipoprotein …

verfasst von:
Abdullah S. Shatoor, Suliman Al Humayed

07.06.2019

Action Potential Triangulation Explains Acute Proarrhythmic Effect of Aliskiren in a Whole-Heart Model of Atrial Fibrillation

Recent experimental studies showed a protective effect of the renin inhibitor aliskiren regarding atrial structural remodeling. Purpose of this study was to assess acute electrophysiologic effects of aliskiren in a whole-heart model of atrial …

verfasst von:
Christian Ellermann, André Mittelstedt, Julian Wolfes, Kevin Willy, Patrick Leitz, Florian Reinke, Lars Eckardt, Gerrit Frommeyer