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Calcified Tissue International OnlineFirst articles

21.04.2024 | Original Research

Absence of E2f1 Negates Pro-osteogenic Impacts of p21 Absence

Loss of p21 leads to increased bone formation post-injury; however, the mechanism(s) by which this occurs remains undetermined. E2f1 is downstream of p21 and as a transcription factor can act directly on gene expression; yet it is unknown if E2f1 …

verfasst von:
Priyatha Premnath, Theodore Lun, Humza Siddiqui, Alana Ruth Stahl, Aria Ahadzadeh Ardebili, Alexandra Olsen, Roman Krawetz

20.04.2024 | Original Research

Probiotics Supplements Improve the Sarcopenia-Related Quality of Life in Older Adults with Age-Related Muscle Decline

A pathological increase in intestinal leak is implicated in age-associated muscle loss, termed sarcopenia, and reduced sarcopenia-related quality-of-life (SarQoL). However, the potential therapies remain elusive. We investigated the effects of …

verfasst von:
Rizwan Qaisar, Ayousha Burki, Asima Karim, M. Shahid Iqbal, Firdos Ahmad

20.04.2024 | Original Research

Metabolic and Skeletal Characterization of the KK/Ay Mouse Model—A Polygenic Mutation Model of Obese Type 2 Diabetes

Type 2 diabetes (T2D) increases fracture incidence and fracture-related mortality rates (KK.Cg-Ay/J. The Jackson Laboratory; Available from: ). While numerous mouse models for T2D exist, few effectively stimulate …

verfasst von:
Nusaiba N. Chowdhury, Rachel K. Surowiec, Rachel K. Kohler, Olivia N. Reul, Dyann M. Segvich, Joseph M. Wallace

19.04.2024 | Review

Extra-Skeletal Manifestations in Osteogenesis Imperfecta Mouse Models

Osteogenesis imperfecta (OI) is a rare heritable connective tissue disorder of skeletal fragility with an incidence of roughly 1:15,000. Approximately 85% of the pathogenic variants responsible for OI are in the type I collagen genes, COL1A1 and …

verfasst von:
Tara K. Crawford, Brittany N. Lafaver, Charlotte L. Phillips

18.04.2024 | Original Research

Effects of Testosterone in Mediating the Relationship Between Daytime Napping and Osteoporosis in European Populations: A Mendelian Randomization Study

We aimed to explore the causal effect of daytime napping on the risk of osteoporosis and the mediation role of testosterone in explaining this relationship. Summary data for Mendelian randomization (MR) analysis were obtained from the IEU OpenGWAS …

verfasst von:
Yuhao Zhang, Zhengfa Jiang, Guowei Shang, Zongmian Song, Keya Mao, Songfeng Chen, Hongjian Liu

Open Access 16.04.2024 | Original Research

Development and Internal Validation of a Multivariable Prediction Model for Mortality After Hip Fracture with Machine Learning Techniques

In order to estimate the likelihood of 1, 3, 6 and 12 month mortality in patients with hip fractures, we applied a variety of machine learning methods using readily available, preoperative data. We used prospectively collected data from a single …

verfasst von:
Mathias Mosfeldt, Henrik Løvendahl Jørgensen, Jes Bruun Lauritzen, Karl-Åke Jansson

Open Access 16.04.2024 | Original Research

Neuropathic and Nociplastic Pain Profiles are Common in Adult Chronic Nonbacterial Osteitis (CNO)

Chronic nonbacterial osteitis (CNO) is a rare musculoskeletal disease causing chronic bone pain. It is known that chronic musculoskeletal pain may involve other mechanisms than nociceptive pain only. We investigate the prevalence of neuropathic …

verfasst von:
Anne T. Leerling, Marieke Niesters, Marcel Flendrie, Marije Tel, Natasha M. Appelman-Dijkstra, Olaf M. Dekkers, Elizabeth M. Winter

01.04.2024 | Correction

Correction to: BMP2 Modified by the m6A Demethylation Enzyme ALKBH5 in the Ossification of the Ligamentum Flavum Through the AKT Signaling Pathway

verfasst von:
Hai-Feng Wang, Ming-jie Kuang, Shi-jie Han, An-bang Wang, Jie Qiu, Feng Wang, Bing-yi Tan, Da-Chuan Wang

31.03.2024 | Original Research

The Impact of Non-alcohol Fatty Liver Disease on Bone Mineral Density is Mediated by Sclerostin by Mendelian Randomization Study

Non-alcoholic fatty liver disease (NAFLD) has been found to be associated with osteoporosis (OP) in observational studies. However, the precise causal relationship between NAFLD and OP remains unclear. Here, we used Mendelian randomization (MR) to …

verfasst von:
Yuan Liu, Mengqin Yuan, Jian He, Longjiao Cai, Aimin Leng

Open Access 29.03.2024 | Review

Medical Management for Fracture Prevention in Children with Osteogenesis Imperfecta

There are no licensed treatments for children with osteogenesis imperfecta. Children currently receive off-label treatment with bisphosphonates, without any consistent approach to dose, drug or route of administration. Meta-analyses suggest that …

verfasst von:
Paul Arundel, Nick Bishop

Open Access 26.03.2024 | Original Research

Opportunistic Identification of Vertebral Compression Fractures on CT Scans of the Chest and Abdomen, Using an AI Algorithm, in a Real-Life Setting

This study evaluated the performance of a vertebral fracture detection algorithm (HealthVCF) in a real-life setting and assessed the impact on treatment and diagnostic workflow. HealthVCF was used to identify moderate and severe vertebral …

verfasst von:
Magnus Grønlund Bendtsen, Mette Friberg Hitz

25.03.2024 | Original Research

Systemic Inflammatory Regulators Associated with Osteoporosis: A Bidirectional Mendelian Randomization Study

To elucidate the precise upstream and downstream regulatory mechanisms of inflammatory factors in osteoporosis (OP) progression and to establish a causal relationship between inflammatory factors and OP. We conducted bidirectional Mendelian …

verfasst von:
Lei Xu, Hui Li, Bin Liu, Xiaoqiang Han, Haibiao Sun

24.03.2024 | Original Research

Secular Trends in Peak Bone Mineral Density: The National Health and Nutrition Examination Survey 1999–2018

Peak bone mineral density (BMD) is one of the most important factors influencing the development of osteoporosis. It was predicted that a 10% increase in peak BMD will delay the onset of osteoporosis by 13 years. However, changes in peak BMD over …

verfasst von:
Xiaohua Zhang, Linghua Yang, Juan Zhang, Lisa M. Lix, William D. Leslie, Bo Kan, Shuman Yang

20.03.2024 | Case Reports

Paget Disease of Bone Harboring Bone Metastatic Neuroendocrine Cancer: A Case Report

In this case report, we describe an uncommon case of neuroendocrine cancer of unknown origin began with cauda equina syndrome in a patient affected by Paget disease of bone (PDB). A 76-year-old man with diagnosis of PDB, without history of pain or …

verfasst von:
Silvia Irina Briganti, Oreste Lanza, Elvira Fioriti, Gaetano Leto, Sofia Battisti, Nicola Napoli, Rocky Strollo

Open Access 20.03.2024 | Original Research

Pre-proenkephalin 1 is Downregulated Under Unloading and is Involved in Osteoblast Biology

Pre-proenkephalin 1 (Penk1) is a pro-neuropeptide that belongs to the typical opioid peptide’s family, having analgesic properties. We previously found Penk1 to be the most downregulated gene in a whole gene profiling analysis performed in …

verfasst von:
Chiara Puri, Charlotte Dannenberg, Argia Ucci, Marco Ponzetti, Elisa Pucci, Luciana Silvestri, Patrick Lau, Petra Frings-Meuthen, Martina Heer, Nadia Rucci, Anna Teti, Antonio Maurizi

Open Access 18.03.2024 | Original Research

Fracture Risk and Health Profiles Differ According to Relationship Status: Findings from the Hertfordshire Cohort Study

Registry studies have suggested associations between relationship status and fracture risk. We considered associations between relationship status and incident fracture in the Hertfordshire Cohort Study, comprising community-dwelling older adults …

verfasst von:
Leo D. Westbury, Camille Pearse, Gregorio Bevilacqua, Nicholas R. Fuggle, Kate A. Ward, Cyrus Cooper, Elaine M. Dennison

16.03.2024 | Original Research

Postoperative Bisphosphonates Use is Associated with Reduced Adverse Outcomes After Primary Total Joint Arthroplasty of Hip and Knee: A Nationwide Population-Based Cohort Study

Bisphosphonates have been associated with a decreased risk of revision surgery after total joint arthroplasty of the hip or knee (TJA) because of their effects on decreased periprosthetic bone loss and prosthetic migration. However, the results in …

verfasst von:
Jen-Ta Shih, Timothy L. Tan, Pei-Hung Shen, Tsu-Te Yeh, Chia-Chun Wu, Ru-Yu Pan, Wu-Chien Chien, Chi-Hsiang Chung, Sheng-Hao Wang

12.03.2024 | Review

Current and Developing Pharmacologic Agents for Improving Skeletal Health in Adults with Osteogenesis Imperfecta

Osteogenesis imperfecta (OI) is a genetic disorder characterized by increased bone fragility largely caused by defects in structure, synthesis, or post-translational processing of type I collagen. Drugs currently used to improve skeletal health in …

verfasst von:
Winnie Liu, Lindsey Nicol, Eric Orwoll

11.03.2024 | Original Research

Roles of Plasminogen Activator Inhibitor-1 in Heterotopic Ossification Induced by Achilles Tenotomy in Thermal Injured Mice

Heterotopic ossification (HO) is the process by which ectopic bone forms at an extraskeletal site. Inflammatory conditions induce plasminogen activator inhibitor 1 (PAI-1), an inhibitor of fibrinolysis, which regulates osteogenesis. In the present …

verfasst von:
Yuya Mizukami, Naoyuki Kawao, Takashi Ohira, Daiki Hashimoto, Kiyotaka Okada, Osamu Matsuo, Hiroshi Kaji

27.02.2024 | Letter to the Editor

Osteosarcopenia: Adjust for the BMI or Bare the Bias

verfasst von:
Ahmad J. Abdulsalam, Mahmud Fazıl Aksakal, Murat Kara, Levent Özçakar