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Erschienen in: Die Innere Medizin 7/2020

03.06.2020 | Kolorektales Karzinom | CME

Personalisierte Systemtherapie beim metastasierten kolorektalen Karzinom

verfasst von: Prof. Dr. med. R.-D. Hofheinz, S. Stintzing

Erschienen in: Die Innere Medizin | Ausgabe 7/2020

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Zusammenfassung

Der vorliegende Beitrag widmet sich der Therapie des metastasierten kolorektalen Karzinoms (Stadium IV). Therapieziele und Vorgehensweise richten sich nach dem Resektabilitätsstatus der Metastasen: Resektable Leber- oder Lungenmetastasen werden primär reseziert, eine perioperative Chemotherapie erscheint verzichtbar. Bei potenziell resektablen Metastasen wird mit einer Konversionstherapie versucht, eine potenziell kurative Resektion zu ermöglichen. Bei Irresektabilität liegt eine palliative Therapiesituation vor. Dann wird mit Induktions- und Erhaltungstherapien sowie Therapiepausen ein verlängertes Überleben bei Erhalt der Lebensqualität angestrebt – beginnend mit der individuell bestmöglichen Therapie. Für einen Teil der Patienten im Stadium IV gibt es prinzipiell molekular gezielte Therapien. Auf die Studienlage und Zulassungssituation wird ausführlich eingegangen. Mit besserer molekularer Charakterisierung der Tumoren wird sich die Therapie weiter individualisieren lassen.
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Metadaten
Titel
Personalisierte Systemtherapie beim metastasierten kolorektalen Karzinom
verfasst von
Prof. Dr. med. R.-D. Hofheinz
S. Stintzing
Publikationsdatum
03.06.2020
Verlag
Springer Medizin
Erschienen in
Die Innere Medizin / Ausgabe 7/2020
Print ISSN: 2731-7080
Elektronische ISSN: 2731-7099
DOI
https://doi.org/10.1007/s00108-020-00808-x

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