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Erschienen in: Monatsschrift Kinderheilkunde 2/2021

06.11.2020 | Konjunktivitis | CME

Reaktive Arthritis – ein Update

verfasst von: Dr. T. Hospach, K. Minden, H.-I. Huppertz

Erschienen in: Monatsschrift Kinderheilkunde | Ausgabe 2/2021

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Zusammenfassung

Die reaktive Arthritis, eine Form der seronegativen Spondylarthritis, tritt nach einer urogenitalen oder gastrointestinalen Infektion auf und ist durch eine asymmetrische Oligoarthritis gekennzeichnet. Extraartikuläre Manifestationen wie Fieber, Konjunktivitis oder Hautaffektionen können vorkommen. Die Diagnose – insbesondere die Abgrenzung zur septischen Infektion des Bewegungsapparates – kann schwierig sein; für die Behandlung ist die Unterscheidung elementar. Die Ätiopathogenese der reaktiven Arthritis ist noch nicht vollständig verstanden. Bakterielle Fragmente – sogar lebensfähige Chlamydien – wurden innerhalb des Gelenks isoliert. Die meisten randomisierten Studien haben jedoch keine Wirksamkeit einer Antibiotikatherapie nachgewiesen. Die Krankheit kann chronisch und destruierend verlaufen, sodass eine Langzeittherapie nötig wird. Neben krankheitsmodifizierenden entzündungshemmenden Medikamenten scheinen Biologika in diesen Fällen wirksam zu sein.
Literatur
1.
Zurück zum Zitat Ahvonen P, Sievers K (1969) Yersinia enterocolitica infection associated with brucella agglutinins. Clinical features of 24 patients. Acta Med Scand 185(1–2):121–125 PubMed Ahvonen P, Sievers K (1969) Yersinia enterocolitica infection associated with brucella agglutinins. Clinical features of 24 patients. Acta Med Scand 185(1–2):121–125 PubMed
2.
Zurück zum Zitat Pacheco-Tena C et al (1999) A proposal for the classification of patients for clinical and experimental studies on reactive arthritis. J Rheumatol 26(6):1338–1346 PubMed Pacheco-Tena C et al (1999) A proposal for the classification of patients for clinical and experimental studies on reactive arthritis. J Rheumatol 26(6):1338–1346 PubMed
3.
Zurück zum Zitat Braun J et al (2000) On the difficulties of establishing a consensus on the definition of and diagnostic investigations for reactive arthritis. Results and discussion of a questionnaire prepared for the 4th International Workshop on Reactive Arthritis, Berlin, Germany, July 3–6, 1999. J Rheumatol 27(9):2185–2192 PubMed Braun J et al (2000) On the difficulties of establishing a consensus on the definition of and diagnostic investigations for reactive arthritis. Results and discussion of a questionnaire prepared for the 4th International Workshop on Reactive Arthritis, Berlin, Germany, July 3–6, 1999. J Rheumatol 27(9):2185–2192 PubMed
4.
Zurück zum Zitat Rudwaleit M et al (2011) The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general. Ann Rheum Dis 70(1):25–31 PubMedCrossRef Rudwaleit M et al (2011) The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general. Ann Rheum Dis 70(1):25–31 PubMedCrossRef
5.
Zurück zum Zitat Saxena N, Misra R, Aggarwal A (2006) Is the enthesitis-related arthritis subtype of juvenile idiopathic arthritis a form of chronic reactive arthritis? Rheumatology 45(9):1129–1132 PubMedCrossRef Saxena N, Misra R, Aggarwal A (2006) Is the enthesitis-related arthritis subtype of juvenile idiopathic arthritis a form of chronic reactive arthritis? Rheumatology 45(9):1129–1132 PubMedCrossRef
6.
Zurück zum Zitat Gracey E, Inman RD (2011) Chlamydia-induced ReA: immune imbalances and persistent pathogens. Nat Rev Rheumatol 8(1):55–59 PubMedCrossRef Gracey E, Inman RD (2011) Chlamydia-induced ReA: immune imbalances and persistent pathogens. Nat Rev Rheumatol 8(1):55–59 PubMedCrossRef
8.
Zurück zum Zitat Lockie GN, Hunder GG (1971) Reiter’s syndrome in children. A case report and review. Arthritis Rheum 14(6):767–772 PubMedCrossRef Lockie GN, Hunder GG (1971) Reiter’s syndrome in children. A case report and review. Arthritis Rheum 14(6):767–772 PubMedCrossRef
9.
Zurück zum Zitat Friis J (1980) Reiter’s disease with childhood onset having special reference to HLA B27. Report of a case and a review. Scand J Rheumatol 9(4):250–252 PubMedCrossRef Friis J (1980) Reiter’s disease with childhood onset having special reference to HLA B27. Report of a case and a review. Scand J Rheumatol 9(4):250–252 PubMedCrossRef
10.
Zurück zum Zitat Cuttica RJ et al (1992) Juvenile onset Reiter’s syndrome. A retrospective study of 26 patients. Clin Exp Rheumatol 10(3):285–288 PubMed Cuttica RJ et al (1992) Juvenile onset Reiter’s syndrome. A retrospective study of 26 patients. Clin Exp Rheumatol 10(3):285–288 PubMed
11.
Zurück zum Zitat Hussein A (1987) Spectrum of post-enteritic reactive arthritis in childhood. Monatsschr Kinderheilkd 135(2):93–98 PubMed Hussein A (1987) Spectrum of post-enteritic reactive arthritis in childhood. Monatsschr Kinderheilkd 135(2):93–98 PubMed
12.
Zurück zum Zitat Townes JM et al (2008) Reactive arthritis following culture-confirmed infections with bacterial enteric pathogens in Minnesota and Oregon: a population-based study. Ann Rheum Dis 67(12):1689–1696 PubMedCrossRef Townes JM et al (2008) Reactive arthritis following culture-confirmed infections with bacterial enteric pathogens in Minnesota and Oregon: a population-based study. Ann Rheum Dis 67(12):1689–1696 PubMedCrossRef
13.
14.
Zurück zum Zitat Lee AT, Hall RG, Pile KD (2005) Reactive joint symptoms following an outbreak of Salmonella typhimurium phage type 135a. J Rheumatol 32(3):524–527 PubMed Lee AT, Hall RG, Pile KD (2005) Reactive joint symptoms following an outbreak of Salmonella typhimurium phage type 135a. J Rheumatol 32(3):524–527 PubMed
15.
Zurück zum Zitat Breban M, Beaufrere M, Glatigny S (2020) The microbiome in spondyloarthritis. Best Pract Res Clin Rheumatol p:101495 Breban M, Beaufrere M, Glatigny S (2020) The microbiome in spondyloarthritis. Best Pract Res Clin Rheumatol p:101495
16.
Zurück zum Zitat García-Kutzbach A et al (2018) Reactive arthritis: update 2018. Clin Rheumatol 37(4):869–874 PubMedCrossRef García-Kutzbach A et al (2018) Reactive arthritis: update 2018. Clin Rheumatol 37(4):869–874 PubMedCrossRef
17.
Zurück zum Zitat Lucchino B et al (2019) Reactive arthritis: current treatment challenges and future perspectives. Clin Exp Rheumatol 37(6):1065–1076 PubMed Lucchino B et al (2019) Reactive arthritis: current treatment challenges and future perspectives. Clin Exp Rheumatol 37(6):1065–1076 PubMed
18.
Zurück zum Zitat Zeidler H, Hudson AP (2014) New insights into 〈em〉Chlamydia〈/em〉 and arthritis. Promise of a cure? Ann Rheum Dis 73(4):637–644 PubMedCrossRef Zeidler H, Hudson AP (2014) New insights into 〈em〉Chlamydia〈/em〉 and arthritis. Promise of a cure? Ann Rheum Dis 73(4):637–644 PubMedCrossRef
19.
Zurück zum Zitat Meyer-Bahlburg A et al (2001) Infection of synovial fibroblasts in culture by Yersinia enterocolitica and Salmonella enterica serovar Enteritidis: ultrastructural investigation with respect to the pathogenesis of reactive arthritis. Infect Immun 69(12):7915–7921 PubMedPubMedCentralCrossRef Meyer-Bahlburg A et al (2001) Infection of synovial fibroblasts in culture by Yersinia enterocolitica and Salmonella enterica serovar Enteritidis: ultrastructural investigation with respect to the pathogenesis of reactive arthritis. Infect Immun 69(12):7915–7921 PubMedPubMedCentralCrossRef
20.
Zurück zum Zitat Huppertz HI, Heesemann J (1996) Experimental Yersinia infection of human synovial cells: persistence of live bacteria and generation of bacterial antigen deposits including “ghosts,” nucleic acid-free bacterial rods. Infect Immun 64(4):1484–1487 PubMedPubMedCentralCrossRef Huppertz HI, Heesemann J (1996) Experimental Yersinia infection of human synovial cells: persistence of live bacteria and generation of bacterial antigen deposits including “ghosts,” nucleic acid-free bacterial rods. Infect Immun 64(4):1484–1487 PubMedPubMedCentralCrossRef
21.
Zurück zum Zitat Singh R et al (2007) Low molecular weight proteins of outer membrane of Salmonella typhimurium are immunogenic in Salmonella induced reactive arthritis revealed by proteomics. Clin Exp Immunol 148(3):486–493 PubMedPubMedCentralCrossRef Singh R et al (2007) Low molecular weight proteins of outer membrane of Salmonella typhimurium are immunogenic in Salmonella induced reactive arthritis revealed by proteomics. Clin Exp Immunol 148(3):486–493 PubMedPubMedCentralCrossRef
22.
Zurück zum Zitat Hermann E et al (1993) HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis. Lancet 342(8872):646–650 PubMedCrossRef Hermann E et al (1993) HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis. Lancet 342(8872):646–650 PubMedCrossRef
23.
Zurück zum Zitat Taurog JD et al (1994) The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med 180(6):2359–2364 PubMedCrossRef Taurog JD et al (1994) The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med 180(6):2359–2364 PubMedCrossRef
24.
Zurück zum Zitat Sieper J et al (2002) Diagnosing reactive arthritis: role of clinical setting in the value of serologic and microbiologic assays. Arthritis Rheum 46(2):319–327 PubMedCrossRef Sieper J et al (2002) Diagnosing reactive arthritis: role of clinical setting in the value of serologic and microbiologic assays. Arthritis Rheum 46(2):319–327 PubMedCrossRef
25.
Zurück zum Zitat Schiellerup P, Krogfelt KA, Locht H (2008) A comparison of self-reported joint symptoms following infection with different enteric pathogens: effect of HLA-B27. J Rheumatol 35(3):480–487 PubMed Schiellerup P, Krogfelt KA, Locht H (2008) A comparison of self-reported joint symptoms following infection with different enteric pathogens: effect of HLA-B27. J Rheumatol 35(3):480–487 PubMed
26.
Zurück zum Zitat Arabshahi B, Baskin KM, Cron RQ (2007) Reactive arthritis of the temporomandibular joints and cervical spine in a child. Pediatr Rheumatol Online J 5:4 PubMedPubMedCentralCrossRef Arabshahi B, Baskin KM, Cron RQ (2007) Reactive arthritis of the temporomandibular joints and cervical spine in a child. Pediatr Rheumatol Online J 5:4 PubMedPubMedCentralCrossRef
27.
Zurück zum Zitat Kanakoudi-Tsakalidou F et al (1998) Persistent or severe course of reactive arthritis following Salmonella enteritidis infection. A prospective study of 9 cases. Scand J Rheumatol 27(6):431–434 PubMedCrossRef Kanakoudi-Tsakalidou F et al (1998) Persistent or severe course of reactive arthritis following Salmonella enteritidis infection. A prospective study of 9 cases. Scand J Rheumatol 27(6):431–434 PubMedCrossRef
28.
Zurück zum Zitat Taccetti G et al (1994) Reactive arthritis triggered by Yersinia enterocolitica: a review of 18 pediatric cases. Clin Exp Rheumatol 12(6):681–684 PubMed Taccetti G et al (1994) Reactive arthritis triggered by Yersinia enterocolitica: a review of 18 pediatric cases. Clin Exp Rheumatol 12(6):681–684 PubMed
29.
30.
Zurück zum Zitat Johnson KE, Nolan CM (1985) Community-wide surveillance of Campylobacter jejuni infection. Evaluation of a laboratory-based method. Diagn Microbiol Infect Dis 3(5):389–396 PubMedCrossRef Johnson KE, Nolan CM (1985) Community-wide surveillance of Campylobacter jejuni infection. Evaluation of a laboratory-based method. Diagn Microbiol Infect Dis 3(5):389–396 PubMedCrossRef
31.
Zurück zum Zitat Hannu T et al (2004) Reactive arthritis following an outbreak of Campylobacter jejuni infection. J Rheumatol 31(3):528–530 PubMed Hannu T et al (2004) Reactive arthritis following an outbreak of Campylobacter jejuni infection. J Rheumatol 31(3):528–530 PubMed
32.
Zurück zum Zitat Rosenberg AM, Petty RE (1979) Reiter’s disease in children. Am J Dis Child 133(4):394–398 PubMed Rosenberg AM, Petty RE (1979) Reiter’s disease in children. Am J Dis Child 133(4):394–398 PubMed
33.
Zurück zum Zitat Fischel JD, Lipton J (1996) Acute anterior uveitis in juvenile Reiter’s syndrome. Clin Rheumatol 15(1):83–85 PubMedCrossRef Fischel JD, Lipton J (1996) Acute anterior uveitis in juvenile Reiter’s syndrome. Clin Rheumatol 15(1):83–85 PubMedCrossRef
35.
Zurück zum Zitat Huppertz HI, Sandhage K (1994) Reactive arthritis due to Salmonella enteritidis complicated by carditis. Acta Paediatr 83(11):1230–1231 PubMedCrossRef Huppertz HI, Sandhage K (1994) Reactive arthritis due to Salmonella enteritidis complicated by carditis. Acta Paediatr 83(11):1230–1231 PubMedCrossRef
36.
Zurück zum Zitat Mäki-Ikola O et al (1991) Antibodies to arthritis-associated microbes in inflammatory joint diseases. Rheumatol Int 10(6):231–234 PubMedCrossRef Mäki-Ikola O et al (1991) Antibodies to arthritis-associated microbes in inflammatory joint diseases. Rheumatol Int 10(6):231–234 PubMedCrossRef
37.
Zurück zum Zitat Fendler C et al (2001) Frequency of triggering bacteria in patients with reactive arthritis and undifferentiated oligoarthritis and the relative importance of the tests used for diagnosis. Ann Rheum Dis 60(4):337–343 PubMedPubMedCentralCrossRef Fendler C et al (2001) Frequency of triggering bacteria in patients with reactive arthritis and undifferentiated oligoarthritis and the relative importance of the tests used for diagnosis. Ann Rheum Dis 60(4):337–343 PubMedPubMedCentralCrossRef
39.
Zurück zum Zitat Hannu T et al (2006) Reactive arthritis or post-infectious arthritis? Best Pract Res Clin Rheumatol 20(3):419–433 PubMedCrossRef Hannu T et al (2006) Reactive arthritis or post-infectious arthritis? Best Pract Res Clin Rheumatol 20(3):419–433 PubMedCrossRef
41.
42.
43.
Zurück zum Zitat Carter JD et al (2010) Combination antibiotics as a treatment for chronic Chlamydia-induced reactive arthritis: a double-blind, placebo-controlled, prospective trial. Arthritis Rheum 62(5):1298–1307 PubMedPubMedCentralCrossRef Carter JD et al (2010) Combination antibiotics as a treatment for chronic Chlamydia-induced reactive arthritis: a double-blind, placebo-controlled, prospective trial. Arthritis Rheum 62(5):1298–1307 PubMedPubMedCentralCrossRef
45.
Zurück zum Zitat Putschky N et al (2006) Comparing 10-day and 4‑month doxycycline courses for treatment of Chlamydia trachomatis-reactive arthritis: a prospective, double-blind trial. Ann Rheum Dis 65(11):1521–1524 PubMedPubMedCentralCrossRef Putschky N et al (2006) Comparing 10-day and 4‑month doxycycline courses for treatment of Chlamydia trachomatis-reactive arthritis: a prospective, double-blind trial. Ann Rheum Dis 65(11):1521–1524 PubMedPubMedCentralCrossRef
46.
Zurück zum Zitat Gérard HC et al (1998) Synovial Chlamydia trachomatis in patients with reactive arthritis/Reiter’s syndrome are viable but show aberrant gene expression. J Rheumatol 25(4):734–742 PubMed Gérard HC et al (1998) Synovial Chlamydia trachomatis in patients with reactive arthritis/Reiter’s syndrome are viable but show aberrant gene expression. J Rheumatol 25(4):734–742 PubMed
47.
Zurück zum Zitat Carter JD, Hudson AP (2010) The evolving story of Chlamydia-induced reactive arthritis. Curr Opin Rheumatol 22(4):424–430 PubMedCrossRef Carter JD, Hudson AP (2010) The evolving story of Chlamydia-induced reactive arthritis. Curr Opin Rheumatol 22(4):424–430 PubMedCrossRef
48.
Zurück zum Zitat Barber CE et al (2013) Antibiotics for treatment of reactive arthritis: a systematic review and metaanalysis. J Rheumatol 40(6):916–928 PubMedCrossRef Barber CE et al (2013) Antibiotics for treatment of reactive arthritis: a systematic review and metaanalysis. J Rheumatol 40(6):916–928 PubMedCrossRef
49.
Zurück zum Zitat Lauhio A et al (1991) Double-blind, placebo-controlled study of three-month treatment with lymecycline in reactive arthritis, with special reference to Chlamydia arthritis. Arthritis Rheum 34(1):6–14 PubMedCrossRef Lauhio A et al (1991) Double-blind, placebo-controlled study of three-month treatment with lymecycline in reactive arthritis, with special reference to Chlamydia arthritis. Arthritis Rheum 34(1):6–14 PubMedCrossRef
50.
Zurück zum Zitat Toivanen A et al (1993) Effect of antimicrobial treatment on chronic reactive arthritis. Clin Exp Rheumatol 11(3):301–307 PubMed Toivanen A et al (1993) Effect of antimicrobial treatment on chronic reactive arthritis. Clin Exp Rheumatol 11(3):301–307 PubMed
51.
Zurück zum Zitat Sieper J et al (1999) No benefit of long-term ciprofloxacin treatment in patients with reactive arthritis and undifferentiated oligoarthritis: a three-month, multicenter, double-blind, randomized, placebo-controlled study. Arthritis Rheum 42(7):1386–1396 PubMedCrossRef Sieper J et al (1999) No benefit of long-term ciprofloxacin treatment in patients with reactive arthritis and undifferentiated oligoarthritis: a three-month, multicenter, double-blind, randomized, placebo-controlled study. Arthritis Rheum 42(7):1386–1396 PubMedCrossRef
52.
Zurück zum Zitat Wakefield D et al (1999) Ciprofloxacin treatment does not influence course or relapse rate of reactive arthritis and anterior uveitis. Arthritis Rheum 42(9):1894–1897 PubMedCrossRef Wakefield D et al (1999) Ciprofloxacin treatment does not influence course or relapse rate of reactive arthritis and anterior uveitis. Arthritis Rheum 42(9):1894–1897 PubMedCrossRef
53.
Zurück zum Zitat Yli-Kerttula T et al (2000) Effect of a three month course of ciprofloxacin on the outcome of reactive arthritis. Ann Rheum Dis 59(7):565–570 PubMedPubMedCentralCrossRef Yli-Kerttula T et al (2000) Effect of a three month course of ciprofloxacin on the outcome of reactive arthritis. Ann Rheum Dis 59(7):565–570 PubMedPubMedCentralCrossRef
54.
Zurück zum Zitat Hoogkamp-Korstanje JA, Moesker H, Bruyn GA (2000) Ciprofloxacin v placebo for treatment of Yersinia enterocolitica triggered reactive arthritis. Ann Rheum Dis 59(11):914–917 PubMedCrossRef Hoogkamp-Korstanje JA, Moesker H, Bruyn GA (2000) Ciprofloxacin v placebo for treatment of Yersinia enterocolitica triggered reactive arthritis. Ann Rheum Dis 59(11):914–917 PubMedCrossRef
55.
Zurück zum Zitat Smieja M et al (2001) Randomised, blinded, placebo controlled trial of doxycycline for chronic seronegative arthritis. Ann Rheum Dis 60(12):1088–1094 PubMedPubMedCentralCrossRef Smieja M et al (2001) Randomised, blinded, placebo controlled trial of doxycycline for chronic seronegative arthritis. Ann Rheum Dis 60(12):1088–1094 PubMedPubMedCentralCrossRef
56.
Zurück zum Zitat Kvien TK et al (2004) Three month treatment of reactive arthritis with azithromycin: a EULAR double blind, placebo controlled study. Ann Rheum Dis 63(9):1113–1119 PubMedPubMedCentralCrossRef Kvien TK et al (2004) Three month treatment of reactive arthritis with azithromycin: a EULAR double blind, placebo controlled study. Ann Rheum Dis 63(9):1113–1119 PubMedPubMedCentralCrossRef
57.
Zurück zum Zitat Kuuliala A et al (2013) Double-blind, randomized, placebo-controlled study of three-month treatment with the combination of ofloxacin and roxithromycin in recent-onset reactive arthritis. Rheumatol Int 33(11):2723–2729 PubMedCrossRef Kuuliala A et al (2013) Double-blind, randomized, placebo-controlled study of three-month treatment with the combination of ofloxacin and roxithromycin in recent-onset reactive arthritis. Rheumatol Int 33(11):2723–2729 PubMedCrossRef
58.
Zurück zum Zitat Astrauskiene D (2003) Efficacy of empirically prescribed amoxicillin and amoxicillin + clavulanic acid in children’s reactive arthritis: a randomised trial. Clin Exp Rheumatol 21(4):515–521 PubMed Astrauskiene D (2003) Efficacy of empirically prescribed amoxicillin and amoxicillin + clavulanic acid in children’s reactive arthritis: a randomised trial. Clin Exp Rheumatol 21(4):515–521 PubMed
60.
Zurück zum Zitat Mielants H et al (1993) Gut inflammation in children with late onset pauciarticular juvenile chronic arthritis and evolution to adult spondyloarthropathy—a prospective study. J Rheumatol 20(9):1567–1572 PubMed Mielants H et al (1993) Gut inflammation in children with late onset pauciarticular juvenile chronic arthritis and evolution to adult spondyloarthropathy—a prospective study. J Rheumatol 20(9):1567–1572 PubMed
61.
Zurück zum Zitat Mielants H et al (1987) Late onset pauciarticular juvenile chronic arthritis: relation to gut inflammation. J Rheumatol 14(3):459–465 PubMed Mielants H et al (1987) Late onset pauciarticular juvenile chronic arthritis: relation to gut inflammation. J Rheumatol 14(3):459–465 PubMed
62.
Zurück zum Zitat Burgos-Vargas R et al (2002) A 26 week randomised, double blind, placebo controlled exploratory study of sulfasalazine in juvenile onset spondyloarthropathies. Ann Rheum Dis 61(10):941–942 PubMedPubMedCentralCrossRef Burgos-Vargas R et al (2002) A 26 week randomised, double blind, placebo controlled exploratory study of sulfasalazine in juvenile onset spondyloarthropathies. Ann Rheum Dis 61(10):941–942 PubMedPubMedCentralCrossRef
63.
Zurück zum Zitat van Rossum MA et al (1998) Sulfasalazine in the treatment of juvenile chronic arthritis: a randomized, double-blind, placebo-controlled, multicenter study. Dutch Juvenile Chronic Arthritis Study Group. Arthritis Rheum 41(5):808–816 PubMedCrossRef van Rossum MA et al (1998) Sulfasalazine in the treatment of juvenile chronic arthritis: a randomized, double-blind, placebo-controlled, multicenter study. Dutch Juvenile Chronic Arthritis Study Group. Arthritis Rheum 41(5):808–816 PubMedCrossRef
64.
Zurück zum Zitat Clegg DO et al (1996) Comparison of sulfasalazine and placebo in the treatment of reactive arthritis (Reiter’s syndrome). A department of veterans affairs cooperative study. Arthritis Rheum 39(12):2021–2027 PubMedCrossRef Clegg DO et al (1996) Comparison of sulfasalazine and placebo in the treatment of reactive arthritis (Reiter’s syndrome). A department of veterans affairs cooperative study. Arthritis Rheum 39(12):2021–2027 PubMedCrossRef
65.
Zurück zum Zitat Tanaka T et al (2009) Successful treatment of reactive arthritis with a humanized anti-interleukin‑6 receptor antibody, tocilizumab. Arthritis Rheum 61(12):1762–1764 PubMedCrossRef Tanaka T et al (2009) Successful treatment of reactive arthritis with a humanized anti-interleukin‑6 receptor antibody, tocilizumab. Arthritis Rheum 61(12):1762–1764 PubMedCrossRef
66.
Zurück zum Zitat van Mens LJJ et al (2018) Brief report: interleukin-17 blockade with secukinumab in peripheral spondyloarthritis impacts synovial immunopathology without compromising systemic immune responses. Arthritis Rheumatol 70(12):1994–2002 PubMedCrossRef van Mens LJJ et al (2018) Brief report: interleukin-17 blockade with secukinumab in peripheral spondyloarthritis impacts synovial immunopathology without compromising systemic immune responses. Arthritis Rheumatol 70(12):1994–2002 PubMedCrossRef
68.
Zurück zum Zitat Meyer A et al (2011) Safety and efficacy of anti-tumor necrosis factor alpha therapy in ten patients with recent-onset refractory reactive arthritis. Arthritis Rheum 63(5):1274–1280 PubMedCrossRef Meyer A et al (2011) Safety and efficacy of anti-tumor necrosis factor alpha therapy in ten patients with recent-onset refractory reactive arthritis. Arthritis Rheum 63(5):1274–1280 PubMedCrossRef
69.
Zurück zum Zitat Oili KS et al (2003) Treatment of reactive arthritis with infliximab. Scand J Rheumatol 32(2):122–124 PubMedCrossRef Oili KS et al (2003) Treatment of reactive arthritis with infliximab. Scand J Rheumatol 32(2):122–124 PubMedCrossRef
70.
Zurück zum Zitat Gill H, Majithia V (2008) Successful use of infliximab in the treatment of Reiter’s syndrome: a case report and discussion. Clin Rheumatol 27(1):121–123 PubMedCrossRef Gill H, Majithia V (2008) Successful use of infliximab in the treatment of Reiter’s syndrome: a case report and discussion. Clin Rheumatol 27(1):121–123 PubMedCrossRef
71.
Zurück zum Zitat Schafranski MD (2010) Infliximab for reactive arthritis secondary to Chlamydia trachomatis infection. Rheumatol Int 30(5):679–680 PubMedCrossRef Schafranski MD (2010) Infliximab for reactive arthritis secondary to Chlamydia trachomatis infection. Rheumatol Int 30(5):679–680 PubMedCrossRef
72.
Zurück zum Zitat Wechalekar MD et al (2010) Prolonged remission of chronic reactive arthritis treated with three infusions of infliximab. J Clin Rheumatol 16(2):79–80 PubMedCrossRef Wechalekar MD et al (2010) Prolonged remission of chronic reactive arthritis treated with three infusions of infliximab. J Clin Rheumatol 16(2):79–80 PubMedCrossRef
73.
Zurück zum Zitat Flagg SD et al (2005) Decreased pain and synovial inflammation after etanercept therapy in patients with reactive and undifferentiated arthritis: an open-label trial. Arthritis Rheum 53(4):613–617 PubMedCrossRef Flagg SD et al (2005) Decreased pain and synovial inflammation after etanercept therapy in patients with reactive and undifferentiated arthritis: an open-label trial. Arthritis Rheum 53(4):613–617 PubMedCrossRef
74.
Zurück zum Zitat Edrees A (2012) Successful use of Etanercept for the treatment of Reiter’s syndrome: a case report and review of the literature. Rheumatol Int 32(1):1–3 PubMedCrossRef Edrees A (2012) Successful use of Etanercept for the treatment of Reiter’s syndrome: a case report and review of the literature. Rheumatol Int 32(1):1–3 PubMedCrossRef
75.
Zurück zum Zitat Ahogo KC et al (2017) A case of reactive arthritis (oculo-urethro-synovial syndrome) treated with infliximab. Ann Dermatol Venereol 144(12):804–805 PubMedCrossRef Ahogo KC et al (2017) A case of reactive arthritis (oculo-urethro-synovial syndrome) treated with infliximab. Ann Dermatol Venereol 144(12):804–805 PubMedCrossRef
78.
Zurück zum Zitat Carter JD, Hudson AP (2009) Reactive arthritis: clinical aspects and medical management. Rheum Dis Clin North Am 35(1):21–44 PubMedCrossRef Carter JD, Hudson AP (2009) Reactive arthritis: clinical aspects and medical management. Rheum Dis Clin North Am 35(1):21–44 PubMedCrossRef
Metadaten
Titel
Reaktive Arthritis – ein Update
verfasst von
Dr. T. Hospach
K. Minden
H.-I. Huppertz
Publikationsdatum
06.11.2020
Verlag
Springer Medizin
Erschienen in
Monatsschrift Kinderheilkunde / Ausgabe 2/2021
Print ISSN: 0026-9298
Elektronische ISSN: 1433-0474
DOI
https://doi.org/10.1007/s00112-020-01046-z

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