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17.05.2022 | Original Article

Morphological parameters predicting subthreshold micropulse laser effectiveness in central serous chorioretinopathy

verfasst von: Peter Kiraly, Jaka Smrekar, Polona Jaki Mekjavić

Erschienen in: Lasers in Medical Science

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Abstract

Purpose

The purpose of this prospective study was to predict the effectiveness of subthreshold micropulse laser (SML) based on morphological parameters in patients with central serous chorioretinopathy (CSC).

Methods

Thirty-one patients were examined at presentation, 3 months, and 6 months after the disease onset. In patients with persistent subretinal fluid (SRF) at 3 months, SML was performed. The following morphological parameters were observed just before treatment: central retinal thickness (CRT), maximal SRF, choroidal thickness (CT), pigment epithelial detachment (PED) height and width, number of hyperreflective foci (HF) at fovea and leakage site, secondary choroidal neovascularization (CNV), and severity of retinal pigment epithelium (RPE) alterations using multimodal imaging.

Results

Good response was associated with lower SRF (p = 0.038), narrower PED (p = 0.078), and decreasing number of HF at fovea (difHFf) (p = 0 .016) just before the treatment. From a bivariate and multivariate point of view, the two groups differed significantly in the pair (SRF, PED width) (p = 0.048) and in the triple (SRF, PED width, difHFf) (p = 0.026).

Conclusion

Lower SRF, narrower PED, and decreasing HF could be associated with good response to SML in CSC patients.
Fußnoten
1
The p value of 0.048 was obtained using the spatial-rank-based test. Hotelling’s T2 test gives p = 0.055.
 
2
The p value of 0.026 was obtained using the spatial-rank-based test. Hotelling’s T2 test gives p = 0.008.
 
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Metadaten
Titel
Morphological parameters predicting subthreshold micropulse laser effectiveness in central serous chorioretinopathy
verfasst von
Peter Kiraly
Jaka Smrekar
Polona Jaki Mekjavić
Publikationsdatum
17.05.2022
Verlag
Springer London
Erschienen in
Lasers in Medical Science
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-022-03574-4