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23.12.2022 | Review Article

Muscle strength and osteoarthritis of the knee: a systematic review and meta-analysis of longitudinal studies

verfasst von: Brooke E. Patterson, Michael A. Girdwood, Thomas J. West, Andrea M. Bruder, Britt Elin Øiestad, Carsten Juhl, Adam G. Culvenor

Erschienen in: Skeletal Radiology | Ausgabe 11/2023

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Abstract

Objective

To evaluate the sex-specific association between low knee extensor and flexor muscle strength and the risk of knee structural worsening.

Materials and methods

Systematic searches in five databases identified longitudinal studies (≥ 1 year follow-up) reporting an association between knee extensor or flexor strength and structural decline in individuals with, or at risk of, knee osteoarthritis. Results were pooled for tibiofemoral and patellofemoral osteoarthritis worsening (and stratified by sex/gender where possible) using a random-effects meta-analysis estimating the risk ratio and 95% confidence interval or a best-evidence synthesis. Risk of bias and overall certainty of evidence were assessed.

Results

Fourteen studies were included with participants (mean age 27–72 years) with osteoarthritis (n = 8), at risk of osteoarthritis (n = 3), or a combination with, or at risk of, osteoarthritis (n = 3). Low knee extensor strength was associated with an increased risk of worsening tibiofemoral (12 studies: RR 1.18, 95% CI 1.04 to 1.35) and patellofemoral osteoarthritis (4 studies: RR 1.62, 95% CI 1.01 to 2.61). Significant associations between low knee extensor strength and worsening tibiofemoral osteoarthritis were observed for women (4 studies: RR 1.25, 95% CI 1.04 to 1.51) but not men (4 studies: RR 1.10, 95% CI 0.87 to 1.39). Low knee flexor strength increased the risk of worsening tibiofemoral osteoarthritis (5 studies: RR 1.16, 95% CI 1.07 to 1.26). Ten studies were high risk of bias, and all estimates were graded as very low certainty of evidence.

Conclusion

Low knee extensor and flexor strength increased the risk of worsening tibiofemoral osteoarthritis. Low knee extensor strength increased the risk of worsening patellofemoral osteoarthritis. The relationship between low knee extensor strength and worsening tibiofemoral osteoarthritis may be modified by sex/gender.

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Titel: Muscle strength and osteoarthritis of the knee: a systematic review and meta-analysis of longitudinal studies
verfasst von: Brooke E. Patterson
Michael A. Girdwood
Thomas J. West
Andrea M. Bruder
Britt Elin Øiestad
Carsten Juhl
Adam G. Culvenor
Publikationsdatum: 23.12.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Skeletal Radiology / Ausgabe 11/2023
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI: https://doi.org/10.1007/s00256-022-04266-4

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Muscle strength and osteoarthritis of the knee: a systematic review and meta-analysis of longitudinal studies

Abstract

Objective

Materials and methods

Results

Conclusion

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Materials and methods

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