Introduction
Methods
Search strategy and selection criteria: literature search methods
Eligibility criteria. (inclusion criteria)
Information sources and search strategy
Data synthesis and abstract review
Confidence in cumulative evidence
Statistical methods
Availability of data and materials
Results
Description and methodology of studies
Study, year, location, ref. # | Prospective | Was study comparative? | Ocular prophylaxis Preparations | Prenatal screening for C. trachomatis | Number of Infants | Infants followed prospectively | Only Infants with conjunctivitis tested for C. trachomatis | All infants seen prospectively, and tested for C. trachomatis in eye and NP |
---|---|---|---|---|---|---|---|---|
1. Laga (1988) [15], Kenya | Yes | Yes | Silver nitrate Tetracycline | No* | 1233 1499 | Yes | Yes | Yes |
2. Chen (1992) [16], Taiwan | Yes | Yes | Silver nitrate Tetracycline Erythromycin No prophylaxis Erythromycin twice | No | 1082 1156 1163 1143 425 | No | No | No |
3. Rours (2006) [17], South Africa | Yes | No# | Tetracycline | Yes | 77 | Yes | Yes | Yes |
4. Ali (2007) [18], Iran | Yes | Yes | Betadine Erythromycin No prophylaxis | No | 110 110 110 | Yes | Yes | No |
5. Matinzadeh (2007) [19], Iran | Yes | Yes | Erythromycin No prophylaxis Normal saline | No | 320 337 335 | Yes | Yes | Yes |
6. Ramirez-Ortiz (2007) [20], Mexico | Yes | Yes | Povidone-iodine vs. chloramphenicol | No | 2004 | Yes | Yes | Yes |
7. David (2011) [21], Israel | Yes | No | Povidone iodine vs. tetracycline | No | 394 | Yes | Yes | No |
8. Alexandre (2015) [22], Angola | No | No | Povidone-iodine vs. no prophylaxis | No | 317 | No | No | No |
Hammerschlag (1980) [12] | Bell (1987) [23] | Hammerschlag (1989) [3] | |
---|---|---|---|
Location | Seattle, WA | Seattle, WA | Brooklyn, NY |
Type of Study | Prospective, randomized | Prospective, not randomized | Prospective, randomized |
Prophylaxis | a. Silver Nitrate, b. Erythromycin | a. Silver Nitrate, b. Erythromycin | a. Silver Nitrate, b. Erythromycin, c Tetracycline |
Number of Infants | 60 | 120 | 230 |
Chlamydial Conjunctivitis Number (%) | a. 12 (33) b. 0 | a. 21 (23) b. 4 (15) | a. 15 (20) b. 13 (14) c. 7 (11) |
NP Number (%) | a.10 (28) b. 5 | NR# | a. 1 (1) b. 4 (4) c. 3 (5) |
Pneumonia Number (%) | a. 3 (8) b. 1 (4) | NR | a. 2 (3) b. 0 c. 0 |
Excluded studies
Included studies
Study | Ref. No. | Prophylaxis | Odds ratio, 95% CI |
---|---|---|---|
Hammerschlag (1980) | 12 | Erythromycin v. Silver nitrate | 0.06 [0.00, 0.33], p = 0.002* |
Bell (1987) | 24 | Erythromycin v. Silver nitrate | 0.60 [0.14, 2.04], p = 0.436 |
Hammerschlag (1989) | 3 | Erythromycin v. Silver nitrate | 0.56 [0.23, 1.38], p = 0.206 |
Tetracycline v. Silver nitrate | 0.44, [0.14, 1.25], p = 0.104 |