Skip to main content
Erschienen in: Die Ophthalmologie 8/2022

02.08.2022 | Netzhautablösung | Leitthema

Visusminderung und Silikonöltamponade

verfasst von: Prof. Dr. Armin Wolf, Mario R. Romano, Christos Haritoglou

Erschienen in: Die Ophthalmologie | Ausgabe 8/2022

Einloggen, um Zugang zu erhalten

Zusammenfassung

Silikonöl ist ein etabliertes und bis heute durch keine Alternative zu ersetzendes intraokular chirurgisches Hilfsmittel, das die Versorgung von komplexesten Ausgangssituationen ermöglicht. Verfügbare Daten weisen jedoch darauf hin, dass eine unklare Visusminderung während oder nach einer intraokularen Silikonöltamponade möglicherweise häufiger auftritt, als dies der klinische Alltag vermuten lässt. Unterschiedliche Pathomechanismen werden hierfür ursächlich diskutiert, tatsächlich sind die genauen Ursachen aber unklar. Neben atrophischen Veränderungen in der OCT(optische Kohärenztomographie)-Untersuchung finden sich ein deutlich reduzierter Visus sowie meist ein Zentralskotom bei sonst unauffälligen Befunden. Unklare Visusminderungen können auch nach einer Silikonölentfernung auftreten. Ob hier die gleichen Pathomechanismen ursächlich sind, ist unklar. Ferner gibt es keine reproduzierbaren Risikofaktoren, die eine unklare Visusminderung unter Silikonöl a priori wahrscheinlich erscheinen lassen, jedoch werden möglichst frühzeitige Ölentfernung und gute Einstellung des intraokularen Druckes von den Autoren empfohlen. Insgesamt sollte eine Silikonöltamponade auch unter Verwendung von modernen hoch-aufgereinigten Silikonölen sorgfältig abgewogen werden und damit weiterhin v. a. ungünstigen Ausgangssituationen oder komplizierten Verläufen mit Notwendigkeit einer Silikonöltamponade vorbehalten bleiben. Vor diesem Hintergrund scheint eine Studie zur systematischen Erfassung und Aufarbeitung der Fälle von unklarer Visusminderung nach Silikonöltamponade sinnvoll.
Literatur
1.
Zurück zum Zitat Asaria RH, Kon CH, Bunce C et al (2004) Silicone oil concentrates fibrogenic growth factors in the retro-oil fluid. Br J Ophthalmol 88:1439–1442PubMedPubMedCentralCrossRef Asaria RH, Kon CH, Bunce C et al (2004) Silicone oil concentrates fibrogenic growth factors in the retro-oil fluid. Br J Ophthalmol 88:1439–1442PubMedPubMedCentralCrossRef
2.
Zurück zum Zitat Azzolini C, Docchio F, Brancato R et al (1992) Interactions between light and vitreous fluid substitutes. Arch Ophthalmol 110:1468–1471PubMedCrossRef Azzolini C, Docchio F, Brancato R et al (1992) Interactions between light and vitreous fluid substitutes. Arch Ophthalmol 110:1468–1471PubMedCrossRef
3.
Zurück zum Zitat Budde M, Cursiefen C, Holbach LM et al (2001) Silicone oil-associated optic nerve degeneration. Am J Ophthalmol 131:392–394PubMedCrossRef Budde M, Cursiefen C, Holbach LM et al (2001) Silicone oil-associated optic nerve degeneration. Am J Ophthalmol 131:392–394PubMedCrossRef
4.
Zurück zum Zitat Cazabon S, Groenewald C, Pearce IA et al (2005) Visual loss following removal of intraocular silicone oil. Br J Ophthalmol 89:799–802PubMedPubMedCentralCrossRef Cazabon S, Groenewald C, Pearce IA et al (2005) Visual loss following removal of intraocular silicone oil. Br J Ophthalmol 89:799–802PubMedPubMedCentralCrossRef
5.
Zurück zum Zitat Christensen UC, la Cour M (2012) Visual loss after use of intraocular silicone oil associated with thinning of inner retinal layers. Acta Ophthalmol 90:733–737PubMedCrossRef Christensen UC, la Cour M (2012) Visual loss after use of intraocular silicone oil associated with thinning of inner retinal layers. Acta Ophthalmol 90:733–737PubMedCrossRef
6.
Zurück zum Zitat Chung J, Spaide R (2003) Intraretinal silicone oil vacuoles after macular hole surgery with internal limiting membrane peeling. Am J Ophthalmol 136:766–767PubMedCrossRef Chung J, Spaide R (2003) Intraretinal silicone oil vacuoles after macular hole surgery with internal limiting membrane peeling. Am J Ophthalmol 136:766–767PubMedCrossRef
7.
Zurück zum Zitat Coco-Martin RM, Andres-Iglesias C, Srivastava GK et al (2021) Intraocular toxicity caused by MEROCTANE perfluorocarbon liquid. Sci Rep 11:599PubMedPubMedCentralCrossRef Coco-Martin RM, Andres-Iglesias C, Srivastava GK et al (2021) Intraocular toxicity caused by MEROCTANE perfluorocarbon liquid. Sci Rep 11:599PubMedPubMedCentralCrossRef
8.
Zurück zum Zitat Dithmar S, Schuett F, Voelcker HE et al (2004) Delayed sequential occurrence of perfluorodecalin and silicone oil in the subretinal space following retinal detachment surgery in the presence of an optic disc pit. Arch Ophthalmol 122:409–411PubMedCrossRef Dithmar S, Schuett F, Voelcker HE et al (2004) Delayed sequential occurrence of perfluorodecalin and silicone oil in the subretinal space following retinal detachment surgery in the presence of an optic disc pit. Arch Ophthalmol 122:409–411PubMedCrossRef
9.
Zurück zum Zitat Dogramaci M, Williams K, Lee E et al (2013) Foveal light exposure is increased at the time of removal of silicone oil with the potential for phototoxicity. Graefes Arch Clin Exp Ophthalmol 251:35–39PubMedCrossRef Dogramaci M, Williams K, Lee E et al (2013) Foveal light exposure is increased at the time of removal of silicone oil with the potential for phototoxicity. Graefes Arch Clin Exp Ophthalmol 251:35–39PubMedCrossRef
10.
Zurück zum Zitat Dresp JH, Menz DH (2005) Interaction of different ocular endotamponades as a risk factor for silicone oil emulsification. Retina 25:902–910PubMedCrossRef Dresp JH, Menz DH (2005) Interaction of different ocular endotamponades as a risk factor for silicone oil emulsification. Retina 25:902–910PubMedCrossRef
11.
Zurück zum Zitat Eckardt C, Nicolai U, Czank M et al (1993) Ocular tissue after intravitreous silicone oil injection. Histologic and electron microscopy studies. Ophthalmologe 90:250–257PubMed Eckardt C, Nicolai U, Czank M et al (1993) Ocular tissue after intravitreous silicone oil injection. Histologic and electron microscopy studies. Ophthalmologe 90:250–257PubMed
12.
Zurück zum Zitat Eckle D, Kampik A, Hintschich C et al (2005) Visual field defect in association with chiasmal migration of intraocular silicone oil. Br J Ophthalmol 89:918–920PubMedPubMedCentralCrossRef Eckle D, Kampik A, Hintschich C et al (2005) Visual field defect in association with chiasmal migration of intraocular silicone oil. Br J Ophthalmol 89:918–920PubMedPubMedCentralCrossRef
13.
Zurück zum Zitat Errera MH, Liyanage SE, Elgohary M et al (2013) Using spectral-domain optical coherence tomography imaging to identify the presence of retinal silicone oil emulsification after silicone oil tamponade. Retina 33:1567–1573PubMedCrossRef Errera MH, Liyanage SE, Elgohary M et al (2013) Using spectral-domain optical coherence tomography imaging to identify the presence of retinal silicone oil emulsification after silicone oil tamponade. Retina 33:1567–1573PubMedCrossRef
14.
Zurück zum Zitat Gabel VP, Kampik A, Burkhardt J (1987) Analysis of intraocularly applied silicone oils of various origins. Graefes Arch Clin Exp Ophthalmol 225:160–162PubMedCrossRef Gabel VP, Kampik A, Burkhardt J (1987) Analysis of intraocularly applied silicone oils of various origins. Graefes Arch Clin Exp Ophthalmol 225:160–162PubMedCrossRef
15.
Zurück zum Zitat Gatto C, Romano MR, Giurgola L et al (2021) Ex vivo evaluation of retinal cytotoxicity after the use of multiple medical devices in pars plana vitrectomy in porcine eyes. Exp Eye Res 213:108837PubMedCrossRef Gatto C, Romano MR, Giurgola L et al (2021) Ex vivo evaluation of retinal cytotoxicity after the use of multiple medical devices in pars plana vitrectomy in porcine eyes. Exp Eye Res 213:108837PubMedCrossRef
16.
Zurück zum Zitat Ghosh YK, Banerjee S, Savant V et al (2004) Surgical treatment and outcome of patients with giant retinal tears. Eye (Lond) 18:996–1000CrossRef Ghosh YK, Banerjee S, Savant V et al (2004) Surgical treatment and outcome of patients with giant retinal tears. Eye (Lond) 18:996–1000CrossRef
17.
Zurück zum Zitat Gonvers M, Hornung JP, de Courten C (1986) The effect of liquid silicone on the rabbit retina. Histologic and ultrastructural study. Arch Ophthalmol 104:1057–1062PubMedCrossRef Gonvers M, Hornung JP, de Courten C (1986) The effect of liquid silicone on the rabbit retina. Histologic and ultrastructural study. Arch Ophthalmol 104:1057–1062PubMedCrossRef
18.
Zurück zum Zitat Heidenkummer HP, Kampik A, Thierfelder S (1992) Experimental evaluation of in vitro stability of purified polydimethylsiloxanes (silicone oil) in viscosity ranges from 1000 to 5000 centistokes. Retina 12:S28–32PubMedCrossRef Heidenkummer HP, Kampik A, Thierfelder S (1992) Experimental evaluation of in vitro stability of purified polydimethylsiloxanes (silicone oil) in viscosity ranges from 1000 to 5000 centistokes. Retina 12:S28–32PubMedCrossRef
19.
Zurück zum Zitat Herbert EN, Habib M, Steel D et al (2006) Central scotoma associated with intraocular silicone oil tamponade develops before oil removal. Graefes Arch Clin Exp Ophthalmol 244:248–252PubMedCrossRef Herbert EN, Habib M, Steel D et al (2006) Central scotoma associated with intraocular silicone oil tamponade develops before oil removal. Graefes Arch Clin Exp Ophthalmol 244:248–252PubMedCrossRef
20.
Zurück zum Zitat Herbert EN, Laidlaw DA, Williamson TH et al (2005) Loss of vision once silicone oil has been removed. Retina 25:808–809 (author reply 809)PubMedCrossRef Herbert EN, Laidlaw DA, Williamson TH et al (2005) Loss of vision once silicone oil has been removed. Retina 25:808–809 (author reply 809)PubMedCrossRef
21.
Zurück zum Zitat Hong EH, Cho H, Kim DR et al (2020) Changes in retinal vessel and retinal layer thickness after vitrectomy in retinal detachment via swept-source OCT angiography. Invest Ophthalmol Vis Sci 61:35PubMedPubMedCentralCrossRef Hong EH, Cho H, Kim DR et al (2020) Changes in retinal vessel and retinal layer thickness after vitrectomy in retinal detachment via swept-source OCT angiography. Invest Ophthalmol Vis Sci 61:35PubMedPubMedCentralCrossRef
22.
Zurück zum Zitat Iuliano L, Corbelli E, Ramoni A et al (2021) Unexplained visual loss after gas tamponade for macula-on retinal detachment: incidence and clinical characterization. Retina 41:957–964PubMedCrossRef Iuliano L, Corbelli E, Ramoni A et al (2021) Unexplained visual loss after gas tamponade for macula-on retinal detachment: incidence and clinical characterization. Retina 41:957–964PubMedCrossRef
23.
Zurück zum Zitat Januschowski K, Irigoyen C, Pastor JC et al (2018) Retinal toxicity of medical devices used during vitreoretinal surgery: a critical overview. Ophthalmologica 240:236–243PubMedCrossRef Januschowski K, Irigoyen C, Pastor JC et al (2018) Retinal toxicity of medical devices used during vitreoretinal surgery: a critical overview. Ophthalmologica 240:236–243PubMedCrossRef
24.
Zurück zum Zitat Kiilgaard JF, Milea D, Logager V et al (2011) Cerebral migration of intraocular silicone oil: an MRI study. Acta Ophthalmol 89:522–525PubMedCrossRef Kiilgaard JF, Milea D, Logager V et al (2011) Cerebral migration of intraocular silicone oil: an MRI study. Acta Ophthalmol 89:522–525PubMedCrossRef
25.
Zurück zum Zitat Klettner A, Harms A, Waetzig V et al (2020) Emulsified silicone oil is taken up by and induces pro-inflammatory response in primary retinal microglia. Graefes Arch Clin Exp Ophthalmol 258:1965–1974PubMedPubMedCentralCrossRef Klettner A, Harms A, Waetzig V et al (2020) Emulsified silicone oil is taken up by and induces pro-inflammatory response in primary retinal microglia. Graefes Arch Clin Exp Ophthalmol 258:1965–1974PubMedPubMedCentralCrossRef
26.
Zurück zum Zitat la Cour M, Lux A, Heegaard S (2010) Visual loss under silicone oil. Klin Monbl Augenheilkd 227:181–184PubMedCrossRef la Cour M, Lux A, Heegaard S (2010) Visual loss under silicone oil. Klin Monbl Augenheilkd 227:181–184PubMedCrossRef
27.
Zurück zum Zitat Lappas A, Dietlein TS, Rosentreter A et al (2018) Vision loss after silicone oil surgery. Klin Monbl Augenheilkd 235:725–729PubMedCrossRef Lappas A, Dietlein TS, Rosentreter A et al (2018) Vision loss after silicone oil surgery. Klin Monbl Augenheilkd 235:725–729PubMedCrossRef
29.
Zurück zum Zitat Marti M, Walton R, Boni C et al (2017) Increased intraocular pressure is a risk factor for unexplained visual loss during silicone oil endotamponade. Retina 37:2334–2340PubMedCrossRef Marti M, Walton R, Boni C et al (2017) Increased intraocular pressure is a risk factor for unexplained visual loss during silicone oil endotamponade. Retina 37:2334–2340PubMedCrossRef
30.
Zurück zum Zitat Mendichi R, Schieroni AG, Piovani D et al (2019) Comparative study of chemical composition, molecular and rheological properties of silicone oil medical devices. Transl Vis Sci Technol 8:9PubMedPubMedCentralCrossRef Mendichi R, Schieroni AG, Piovani D et al (2019) Comparative study of chemical composition, molecular and rheological properties of silicone oil medical devices. Transl Vis Sci Technol 8:9PubMedPubMedCentralCrossRef
31.
32.
Zurück zum Zitat Moya R, Chandra A, Banerjee PJ et al (2015) The incidence of unexplained visual loss following removal of silicone oil. Eye (Lond) 29:1477–1482CrossRef Moya R, Chandra A, Banerjee PJ et al (2015) The incidence of unexplained visual loss following removal of silicone oil. Eye (Lond) 29:1477–1482CrossRef
33.
Zurück zum Zitat Mrejen S, Sato T, Fisher Y et al (2014) Intraretinal and intra-optic nerve head silicone oil vacuoles using adaptive optics. Ophthalmic Surg Lasers Imaging Retina 45:71–73PubMedCrossRef Mrejen S, Sato T, Fisher Y et al (2014) Intraretinal and intra-optic nerve head silicone oil vacuoles using adaptive optics. Ophthalmic Surg Lasers Imaging Retina 45:71–73PubMedCrossRef
34.
Zurück zum Zitat Nakamura K, Refojo MF, Crabtree DV et al (1991) Ocular toxicity of low-molecular-weight components of silicone and fluorosilicone oils. Invest Ophthalmol Vis Sci 32:3007–3020PubMed Nakamura K, Refojo MF, Crabtree DV et al (1991) Ocular toxicity of low-molecular-weight components of silicone and fluorosilicone oils. Invest Ophthalmol Vis Sci 32:3007–3020PubMed
35.
Zurück zum Zitat Naseripour M, Ghasempour A, Falavarjani KG et al (2015) Perfluorocarbon liquid migration into the subarachnoid space in a patient with morning glory syndrome. J Curr Ophthalmol 27:60–62PubMedPubMedCentralCrossRef Naseripour M, Ghasempour A, Falavarjani KG et al (2015) Perfluorocarbon liquid migration into the subarachnoid space in a patient with morning glory syndrome. J Curr Ophthalmol 27:60–62PubMedPubMedCentralCrossRef
37.
Zurück zum Zitat Newsom RS, Johnston R, Sullivan PM et al (2004) Sudden visual loss after removal of silicone oil. Retina 24:871–877PubMedCrossRef Newsom RS, Johnston R, Sullivan PM et al (2004) Sudden visual loss after removal of silicone oil. Retina 24:871–877PubMedCrossRef
38.
Zurück zum Zitat Odrobina D, Laudanska-Olszewska I (2014) Analysis of the time and location of the silicone oil emulsification by spectral-domain optical coherence tomography after silicone oil tamponade. Biomed Res Int 2014:372045PubMedPubMedCentralCrossRef Odrobina D, Laudanska-Olszewska I (2014) Analysis of the time and location of the silicone oil emulsification by spectral-domain optical coherence tomography after silicone oil tamponade. Biomed Res Int 2014:372045PubMedPubMedCentralCrossRef
39.
Zurück zum Zitat Ozsaygili C, Bayram N (2021) Effects of different tamponade materials on macular segmentation after retinal detachment repair. Jpn J Ophthalmol 65:227–236PubMedCrossRef Ozsaygili C, Bayram N (2021) Effects of different tamponade materials on macular segmentation after retinal detachment repair. Jpn J Ophthalmol 65:227–236PubMedCrossRef
40.
Zurück zum Zitat Pastor JC, Coco RM, Fernandez-Bueno I et al (2017) Acute retinal damage after using a toxic perfluoro-octane for vitreo-retinal surgery. Retina 37:1140–1151PubMedCrossRef Pastor JC, Coco RM, Fernandez-Bueno I et al (2017) Acute retinal damage after using a toxic perfluoro-octane for vitreo-retinal surgery. Retina 37:1140–1151PubMedCrossRef
41.
Zurück zum Zitat Pastor JC, Zarco JM, Del Nozal MJ et al (1998) Clinical consequences of the use of highly purified silicone oil. Comparative study of highly and less purified silicone oil. Eur J Ophthalmol 8:179–183PubMedCrossRef Pastor JC, Zarco JM, Del Nozal MJ et al (1998) Clinical consequences of the use of highly purified silicone oil. Comparative study of highly and less purified silicone oil. Eur J Ophthalmol 8:179–183PubMedCrossRef
42.
Zurück zum Zitat Ratanapakorn T, Thongmee W, Meethongkam K et al (2020) Emulsification of different viscosity silicone oil in complicated retinal detachment surgery: a randomized double-blinded clinical trial. Clin Ophthalmol 14:359–367PubMedPubMedCentralCrossRef Ratanapakorn T, Thongmee W, Meethongkam K et al (2020) Emulsification of different viscosity silicone oil in complicated retinal detachment surgery: a randomized double-blinded clinical trial. Clin Ophthalmol 14:359–367PubMedPubMedCentralCrossRef
43.
Zurück zum Zitat Roca JA, Wu L, Berrocal M et al (2017) Un-explained visual loss following silicone oil removal: results of the pan American collaborative retina study (PACORES) group. Int J Retina Vitreous 3:26PubMedPubMedCentralCrossRef Roca JA, Wu L, Berrocal M et al (2017) Un-explained visual loss following silicone oil removal: results of the pan American collaborative retina study (PACORES) group. Int J Retina Vitreous 3:26PubMedPubMedCentralCrossRef
44.
Zurück zum Zitat Scheerlinck LM, Schellekens PA, Liem AT et al (2016) Incidence, risk factors, and clinical characteristics of unexplained visual loss after intraocular silicone oil for macula-on retinal detachment. Retina 36:342–350PubMedCrossRef Scheerlinck LM, Schellekens PA, Liem AT et al (2016) Incidence, risk factors, and clinical characteristics of unexplained visual loss after intraocular silicone oil for macula-on retinal detachment. Retina 36:342–350PubMedCrossRef
45.
Zurück zum Zitat Shalchi Z, Mahroo OA, Shunmugam M et al (2015) Spectral domain optical coherence tomography findings in long-term silicone oil-related visual loss. Retina 35:555–563PubMedCrossRef Shalchi Z, Mahroo OA, Shunmugam M et al (2015) Spectral domain optical coherence tomography findings in long-term silicone oil-related visual loss. Retina 35:555–563PubMedCrossRef
46.
Zurück zum Zitat Tode J, Purtskhvanidze K, Oppermann T et al (2016) Vision loss under silicone oil tamponade. Graefes Arch Clin Exp Ophthalmol 254:1465–1471PubMedCrossRef Tode J, Purtskhvanidze K, Oppermann T et al (2016) Vision loss under silicone oil tamponade. Graefes Arch Clin Exp Ophthalmol 254:1465–1471PubMedCrossRef
47.
Zurück zum Zitat Wickham L, Asaria RH, Alexander R et al (2007) Immunopathology of intraocular silicone oil: enucleated eyes. Br J Ophthalmol 91:253–257PubMedCrossRef Wickham L, Asaria RH, Alexander R et al (2007) Immunopathology of intraocular silicone oil: enucleated eyes. Br J Ophthalmol 91:253–257PubMedCrossRef
48.
Zurück zum Zitat Williams PD, Fuller CG, Scott IU et al (2008) Vision loss associated with the use and removal of intraocular silicone oil. Clin Ophthalmol 2:955–959PubMedPubMedCentral Williams PD, Fuller CG, Scott IU et al (2008) Vision loss associated with the use and removal of intraocular silicone oil. Clin Ophthalmol 2:955–959PubMedPubMedCentral
49.
Zurück zum Zitat Winter M, Eberhardt W, Scholz C et al (2000) Failure of potassium siphoning by Muller cells: a new hypothesis of perfluorocarbon liquid-induced retinopathy. Invest Ophthalmol Vis Sci 41:256–261PubMed Winter M, Eberhardt W, Scholz C et al (2000) Failure of potassium siphoning by Muller cells: a new hypothesis of perfluorocarbon liquid-induced retinopathy. Invest Ophthalmol Vis Sci 41:256–261PubMed
Metadaten
Titel
Visusminderung und Silikonöltamponade
verfasst von
Prof. Dr. Armin Wolf
Mario R. Romano
Christos Haritoglou
Publikationsdatum
02.08.2022
Verlag
Springer Medizin
Erschienen in
Die Ophthalmologie / Ausgabe 8/2022
Print ISSN: 2731-720X
Elektronische ISSN: 2731-7218
DOI
https://doi.org/10.1007/s00347-022-01702-7

Weitere Artikel der Ausgabe 8/2022

Die Ophthalmologie 8/2022 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.