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12.01.2022 | Neurologische Beteiligung bei Infektionserkrankungen | CME Zur Zeit gratis

Riech- und Schmeckstörungen

verfasst von: Dr. med. M. M. Speth, U. S. Speth, A. R. Sedaghat, T. Hummel

Erschienen in: HNO | Ausgabe 2/2022

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Zusammenfassung

Ziel der vorliegenden Übersicht ist es, einen Überblick über die Ätiologie und Diagnostik von Riech- und Schmeckstörungen zu geben. Da etwa 5 % der Allgemeinbevölkerung betroffen sind, ist es ein häufiges Krankheitsbild. Riechen und Schmecken erhielten v. a. zuletzt Aufmerksamkeit während des Aufkommens der SARS-CoV-2-Pandemie, wobei eine plötzlich aufgetretene Riech- und/oder Schmeckstörung zu den typischen Symptomen zählt. Daneben sind Riechstörungen in der Frühdiagnostik neurodegenerativer Erkrankungen von Bedeutung. Häufig zeigen Patienten mit Riechstörungen Zeichen einer Depression. Die Auswirkungen von Riech‑/Schmeckstörungen sind also umfangreich, die Therapiemöglichkeiten aktuell begrenzt. Nach einem Einblick in die Ätiologie werden Diagnostik und Therapiemöglichkeiten auf dem aktuellen Stand der Literatur erörtert. Auch zukunftsweisende Behandlungsvorstellungen, wie z. B. autologe Schleimhauttransplantationen oder olfaktorische Implantate, werden angesprochen.
Literatur
1.
Zurück zum Zitat Fokkens WJ et al (2020) European position paper on rhinosinusitis and nasal polyps 2020. Rhinology 58(S29):1–464PubMed Fokkens WJ et al (2020) European position paper on rhinosinusitis and nasal polyps 2020. Rhinology 58(S29):1–464PubMed
2.
Zurück zum Zitat Stogbauer J et al (2020) Prevalence and risk factors of smell dysfunction—a comparison between five German population-based studies. Rhinology 58(2):184–191PubMed Stogbauer J et al (2020) Prevalence and risk factors of smell dysfunction—a comparison between five German population-based studies. Rhinology 58(2):184–191PubMed
3.
Zurück zum Zitat Landis BN, Hummel T (2006) New evidence for high occurrence of olfactory dysfunctions within the population. Am J Med 119(1):91–92PubMed Landis BN, Hummel T (2006) New evidence for high occurrence of olfactory dysfunctions within the population. Am J Med 119(1):91–92PubMed
4.
Zurück zum Zitat Hummel T, Frasnelli J (2019) The intranasal trigeminal system. Handb Clin Neurol 164:119–134PubMed Hummel T, Frasnelli J (2019) The intranasal trigeminal system. Handb Clin Neurol 164:119–134PubMed
5.
Zurück zum Zitat Hummel T et al (2017) Position paper on olfactory dysfunction. Rhinol Suppl 54(26):1–30PubMed Hummel T et al (2017) Position paper on olfactory dysfunction. Rhinol Suppl 54(26):1–30PubMed
6.
Zurück zum Zitat Hura N et al (2020) Treatment of post-viral olfactory dysfunction: an evidence-based review with recommendations. Int Forum Allergy Rhinol 10(9):1065–1086PubMed Hura N et al (2020) Treatment of post-viral olfactory dysfunction: an evidence-based review with recommendations. Int Forum Allergy Rhinol 10(9):1065–1086PubMed
7.
Zurück zum Zitat Hatt H (2011) Geschmack und Geruch. In: Schmidt RF, Lang F, Heckmann M (Hrsg) Physiologie des Menschen: mit Pathophysiologie. Springer, Berlin, Heidelberg, S 386–400 Hatt H (2011) Geschmack und Geruch. In: Schmidt RF, Lang F, Heckmann M (Hrsg) Physiologie des Menschen: mit Pathophysiologie. Springer, Berlin, Heidelberg, S 386–400
8.
Zurück zum Zitat Van Regemorter V et al (2020) Mechanisms linking olfactory impairment and risk of mortality. Front Neurosci 14:140PubMedPubMedCentral Van Regemorter V et al (2020) Mechanisms linking olfactory impairment and risk of mortality. Front Neurosci 14:140PubMedPubMedCentral
9.
Zurück zum Zitat Kohli P et al (2016) The association between olfaction and depression: a systematic review. Chem Senses 41(6):479–486PubMedPubMedCentral Kohli P et al (2016) The association between olfaction and depression: a systematic review. Chem Senses 41(6):479–486PubMedPubMedCentral
10.
Zurück zum Zitat Pinto JM et al (2014) Olfactory dysfunction predicts 5‑year mortality in older adults. PLoS One 9(10):e107541PubMedPubMedCentral Pinto JM et al (2014) Olfactory dysfunction predicts 5‑year mortality in older adults. PLoS One 9(10):e107541PubMedPubMedCentral
11.
Zurück zum Zitat Drews T, Hummel T (2016) Treatment strategies for smell loss. Curr Otorhinolaryngol Rep 4(2):122–129 Drews T, Hummel T (2016) Treatment strategies for smell loss. Curr Otorhinolaryngol Rep 4(2):122–129
12.
Zurück zum Zitat Corwin J, Loury M, Gilbert AN (1995) Workplace, age, and sex as mediators of olfactory function: data from the national geographic smell survey. J Gerontol B Psychol Sci Soc Sci 50(4):P179–186PubMed Corwin J, Loury M, Gilbert AN (1995) Workplace, age, and sex as mediators of olfactory function: data from the national geographic smell survey. J Gerontol B Psychol Sci Soc Sci 50(4):P179–186PubMed
13.
Zurück zum Zitat Mascagni P et al (2003) Olfactory function in workers exposed to moderate airborne cadmium levels. Neurotoxicology 24(4–5):717–724PubMed Mascagni P et al (2003) Olfactory function in workers exposed to moderate airborne cadmium levels. Neurotoxicology 24(4–5):717–724PubMed
14.
Zurück zum Zitat Damm M et al (2004) Olfactory dysfunctions. Epidemiology and therapy in Germany, Austria and Switzerland. HNO 52(2):112–120PubMed Damm M et al (2004) Olfactory dysfunctions. Epidemiology and therapy in Germany, Austria and Switzerland. HNO 52(2):112–120PubMed
15.
Zurück zum Zitat Ogawa T, Rutka J (1999) Olfactory dysfunction in head injured workers. Acta Otolaryngol Suppl 540:50–57PubMed Ogawa T, Rutka J (1999) Olfactory dysfunction in head injured workers. Acta Otolaryngol Suppl 540:50–57PubMed
16.
Zurück zum Zitat Haehner A et al (2007) Olfactory loss may be a first sign of idiopathic Parkinson’s disease. Mov Disord 22(6):839–842PubMed Haehner A et al (2007) Olfactory loss may be a first sign of idiopathic Parkinson’s disease. Mov Disord 22(6):839–842PubMed
17.
Zurück zum Zitat Bernhardson BM, Tishelman C, Rutqvist LE (2007) Chemosensory changes experienced by patients undergoing cancer chemotherapy: a qualitative interview study. J Pain Symptom Manage 34(4):403–412PubMed Bernhardson BM, Tishelman C, Rutqvist LE (2007) Chemosensory changes experienced by patients undergoing cancer chemotherapy: a qualitative interview study. J Pain Symptom Manage 34(4):403–412PubMed
18.
Zurück zum Zitat Whitcroft KL, Hummel T (2019) Clinical diagnosis and current management strategies for olfactory dysfunction: a review. JAMA Otolaryngol Head Neck Surg 145(9):846–853PubMed Whitcroft KL, Hummel T (2019) Clinical diagnosis and current management strategies for olfactory dysfunction: a review. JAMA Otolaryngol Head Neck Surg 145(9):846–853PubMed
19.
Zurück zum Zitat Welge-Luessen A, Leopold DA, Miwa T (2013) Smell and taste disorders—diagnostic and clinical work-up. In: Welge-Luessen A, Hummel T (Hrsg) Management of smell and taste disorders—a practical guide for clinicians. Thieme, Stuttgart, S 49–57 Welge-Luessen A, Leopold DA, Miwa T (2013) Smell and taste disorders—diagnostic and clinical work-up. In: Welge-Luessen A, Hummel T (Hrsg) Management of smell and taste disorders—a practical guide for clinicians. Thieme, Stuttgart, S 49–57
20.
Zurück zum Zitat Poletti SC et al (2018) Olfactory cleft evaluation: a predictor for olfactory function in smell-impaired patients? Eur Arch Otorhinolaryngol 275(5):1129–1137PubMed Poletti SC et al (2018) Olfactory cleft evaluation: a predictor for olfactory function in smell-impaired patients? Eur Arch Otorhinolaryngol 275(5):1129–1137PubMed
21.
Zurück zum Zitat Lötsch J, Hummel T (2019) Clinical usefulness of self-rated olfactory performance—a data science-based assessment of 6000 patients. Chem Senses 44(6):357–364PubMed Lötsch J, Hummel T (2019) Clinical usefulness of self-rated olfactory performance—a data science-based assessment of 6000 patients. Chem Senses 44(6):357–364PubMed
22.
Zurück zum Zitat Zou LQ et al (2020) Self-reported mini olfactory questionnaire (Self-MOQ): a simple and useful measurement for the screening of olfactory dysfunction. Laryngoscope 130(12):E786–e790PubMed Zou LQ et al (2020) Self-reported mini olfactory questionnaire (Self-MOQ): a simple and useful measurement for the screening of olfactory dysfunction. Laryngoscope 130(12):E786–e790PubMed
23.
Zurück zum Zitat Welge-Lussen A et al (2010) Olfactory testing in clinical settings—is there additional benefit from unilateral testing? Rhinology 48(2):156–159PubMed Welge-Lussen A et al (2010) Olfactory testing in clinical settings—is there additional benefit from unilateral testing? Rhinology 48(2):156–159PubMed
24.
Zurück zum Zitat Walliczek-Dworschak U, Hummel T (2017) The human sense of olfaction. Facial Plast Surg 33(4):396–404PubMed Walliczek-Dworschak U, Hummel T (2017) The human sense of olfaction. Facial Plast Surg 33(4):396–404PubMed
25.
Zurück zum Zitat Apter AJ, Gent JF, Frank ME (1999) Fluctuating olfactory sensitivity and distorted odor perception in allergic rhinitis. Arch Otolaryngol Head Neck Surg 125(9):1005–1010PubMed Apter AJ, Gent JF, Frank ME (1999) Fluctuating olfactory sensitivity and distorted odor perception in allergic rhinitis. Arch Otolaryngol Head Neck Surg 125(9):1005–1010PubMed
26.
Zurück zum Zitat Landis BN, Hsieh JW, Coppin G (2018) Circadian anosmia: a rare clinical presentation. Laryngoscope 128(7):1537–1539PubMed Landis BN, Hsieh JW, Coppin G (2018) Circadian anosmia: a rare clinical presentation. Laryngoscope 128(7):1537–1539PubMed
27.
Zurück zum Zitat Negoias S et al (2016) Rapidly fluctuating anosmia: a clinical sign for unilateral smell impairment. Laryngoscope 126(2):E57–9PubMed Negoias S et al (2016) Rapidly fluctuating anosmia: a clinical sign for unilateral smell impairment. Laryngoscope 126(2):E57–9PubMed
28.
Zurück zum Zitat Seiden AM, Duncan HJ (2001) The diagnosis of a conductive olfactory loss. Laryngoscope 111(1):9–14PubMed Seiden AM, Duncan HJ (2001) The diagnosis of a conductive olfactory loss. Laryngoscope 111(1):9–14PubMed
29.
Zurück zum Zitat Ganjaei KG et al (2018) Variability in retronasal odor identification among patients with chronic rhinosinusitis. Am J Rhinol Allergy 32(5):424–431PubMed Ganjaei KG et al (2018) Variability in retronasal odor identification among patients with chronic rhinosinusitis. Am J Rhinol Allergy 32(5):424–431PubMed
30.
31.
Zurück zum Zitat Landis BN et al (2003) Retronasal olfactory function in nasal polyposis. Laryngoscope 113(11):1993–1997PubMed Landis BN et al (2003) Retronasal olfactory function in nasal polyposis. Laryngoscope 113(11):1993–1997PubMed
32.
Zurück zum Zitat Stevens MH (2001) Steroid-dependent anosmia. Laryngoscope 111(2):200–203PubMed Stevens MH (2001) Steroid-dependent anosmia. Laryngoscope 111(2):200–203PubMed
33.
Zurück zum Zitat Lane AP et al (2010) A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization. J Neurosci 30(6):2324–2329PubMedPubMedCentral Lane AP et al (2010) A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization. J Neurosci 30(6):2324–2329PubMedPubMedCentral
34.
Zurück zum Zitat Pfaar O et al (2006) Mechanical obstruction of the olfactory cleft reveals differences between orthonasal and retronasal olfactory functions. Chem Senses 31(1):27–31PubMed Pfaar O et al (2006) Mechanical obstruction of the olfactory cleft reveals differences between orthonasal and retronasal olfactory functions. Chem Senses 31(1):27–31PubMed
35.
Zurück zum Zitat Aziz M et al (2021) The association of “loss of smell” to COVID-19: a systematic review and meta-analysis. Am J Med Sci 361(2):216–225PubMed Aziz M et al (2021) The association of “loss of smell” to COVID-19: a systematic review and meta-analysis. Am J Med Sci 361(2):216–225PubMed
36.
Zurück zum Zitat Vaira LA et al (2020) Anosmia and ageusia: common findings in COVID-19 patients. Laryngoscope 130(7):1787PubMed Vaira LA et al (2020) Anosmia and ageusia: common findings in COVID-19 patients. Laryngoscope 130(7):1787PubMed
37.
Zurück zum Zitat Lechien JR et al (2020) Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 277(8):2251–2261PubMed Lechien JR et al (2020) Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 277(8):2251–2261PubMed
38.
Zurück zum Zitat Giacomelli A et al (2020) Self-reported olfactory and taste disorders in patients with severe acute respiratory Coronavirus 2 infection: a cross-sectional study. Clin Infect Dis 71(15):889–890PubMed Giacomelli A et al (2020) Self-reported olfactory and taste disorders in patients with severe acute respiratory Coronavirus 2 infection: a cross-sectional study. Clin Infect Dis 71(15):889–890PubMed
39.
Zurück zum Zitat Yan CH et al (2020) Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms. Int Forum Allergy Rhinol 10(7):806–813PubMed Yan CH et al (2020) Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms. Int Forum Allergy Rhinol 10(7):806–813PubMed
40.
Zurück zum Zitat Speth MM et al (2020) Olfactory dysfunction and sinonasal symptomatology in COVID-19: prevalence, severity, timing, and associated characteristics. Otolaryngol Head Neck Surg 163(1):114–120PubMedPubMedCentral Speth MM et al (2020) Olfactory dysfunction and sinonasal symptomatology in COVID-19: prevalence, severity, timing, and associated characteristics. Otolaryngol Head Neck Surg 163(1):114–120PubMedPubMedCentral
41.
Zurück zum Zitat Hopkins C et al (2020) Early recovery following new onset anosmia during the COVID-19 pandemic—an observational cohort study. J Otolaryngol Head Neck Surg 49(1):26PubMedPubMedCentral Hopkins C et al (2020) Early recovery following new onset anosmia during the COVID-19 pandemic—an observational cohort study. J Otolaryngol Head Neck Surg 49(1):26PubMedPubMedCentral
42.
Zurück zum Zitat Hahner A, Hummel T, Stuck BA (2014) Olfactory disorders and their therapy. HNO 62(12):860–864 (866)PubMed Hahner A, Hummel T, Stuck BA (2014) Olfactory disorders and their therapy. HNO 62(12):860–864 (866)PubMed
43.
Zurück zum Zitat Hummel T et al (2018) Olfactory training changes electrophysiological responses at the level of the olfactory epithelium. Rhinology 56(4):330–335PubMed Hummel T et al (2018) Olfactory training changes electrophysiological responses at the level of the olfactory epithelium. Rhinology 56(4):330–335PubMed
44.
Zurück zum Zitat Youngentob SL, Kent PF (1995) Enhancement of odorant-induced mucosal activity patterns in rats trained on an odorant identification task. Brain Res 670(1):82–88PubMed Youngentob SL, Kent PF (1995) Enhancement of odorant-induced mucosal activity patterns in rats trained on an odorant identification task. Brain Res 670(1):82–88PubMed
45.
Zurück zum Zitat Negoias S, Pietsch K, Hummel T (2017) Changes in olfactory bulb volume following lateralized olfactory training. Brain Imaging Behav 11(4):998–1005PubMed Negoias S, Pietsch K, Hummel T (2017) Changes in olfactory bulb volume following lateralized olfactory training. Brain Imaging Behav 11(4):998–1005PubMed
46.
Zurück zum Zitat Pellegrino R et al (2016) Olfactory function in patients with hyposmia compared to healthy subjects—an fMRI study. Rhinology 54(4):374–381PubMed Pellegrino R et al (2016) Olfactory function in patients with hyposmia compared to healthy subjects—an fMRI study. Rhinology 54(4):374–381PubMed
47.
Zurück zum Zitat Al Aïn S et al (2019) Smell training improves olfactory function and alters brain structure. Neuroimage 189:45–54PubMed Al Aïn S et al (2019) Smell training improves olfactory function and alters brain structure. Neuroimage 189:45–54PubMed
48.
Zurück zum Zitat Kollndorfer K et al (2014) Recovery of olfactory function induces neuroplasticity effects in patients with smell loss. Neural Plast 2014:140419PubMedPubMedCentral Kollndorfer K et al (2014) Recovery of olfactory function induces neuroplasticity effects in patients with smell loss. Neural Plast 2014:140419PubMedPubMedCentral
49.
Zurück zum Zitat Hummel T, Welge-Luessen A (2009) Riech- und Schmeckstörungen. Physiologie, Pathophysiologie und therapeutische Ansätze. Thieme, Stuttgart Hummel T, Welge-Luessen A (2009) Riech- und Schmeckstörungen. Physiologie, Pathophysiologie und therapeutische Ansätze. Thieme, Stuttgart
50.
Zurück zum Zitat Damm M et al (2014) Olfactory training is helpful in postinfectious olfactory loss: a randomized, controlled, multicenter study. Laryngoscope 124(4):826–831PubMed Damm M et al (2014) Olfactory training is helpful in postinfectious olfactory loss: a randomized, controlled, multicenter study. Laryngoscope 124(4):826–831PubMed
51.
Zurück zum Zitat Altundag A et al (2015) Modified olfactory training in patients with postinfectious olfactory loss. Laryngoscope 125(8):1763–1766PubMed Altundag A et al (2015) Modified olfactory training in patients with postinfectious olfactory loss. Laryngoscope 125(8):1763–1766PubMed
52.
Zurück zum Zitat Sorokowska A et al (2017) Effects of olfactory training: a meta-analysis. Rhinology 55(1):17–26PubMed Sorokowska A et al (2017) Effects of olfactory training: a meta-analysis. Rhinology 55(1):17–26PubMed
53.
Zurück zum Zitat Mahmut MK et al (2020) The effect of olfactory training on olfactory bulb volumes in patients with idiopathic olfactory loss. Rhinology 58(4):410–412PubMed Mahmut MK et al (2020) The effect of olfactory training on olfactory bulb volumes in patients with idiopathic olfactory loss. Rhinology 58(4):410–412PubMed
54.
Zurück zum Zitat Saatci O et al (2020) Olfactory training ball improves adherence and olfactory outcomes in post-infectious olfactory dysfunction. Eur Arch Otorhinolaryngol 277(7):2125–2132PubMed Saatci O et al (2020) Olfactory training ball improves adherence and olfactory outcomes in post-infectious olfactory dysfunction. Eur Arch Otorhinolaryngol 277(7):2125–2132PubMed
55.
Zurück zum Zitat Alanin MC, Hopkins C (2020) Effect of functional endoscopic sinus surgery on outcomes in chronic rhinosinusitis. Curr Allergy Asthma Rep 20(7):27PubMed Alanin MC, Hopkins C (2020) Effect of functional endoscopic sinus surgery on outcomes in chronic rhinosinusitis. Curr Allergy Asthma Rep 20(7):27PubMed
56.
Zurück zum Zitat Soler ZM et al (2016) Olfactory-specific quality of life outcomes after endoscopic sinus surgery. Int Forum Allergy Rhinol 6(4):407–413PubMed Soler ZM et al (2016) Olfactory-specific quality of life outcomes after endoscopic sinus surgery. Int Forum Allergy Rhinol 6(4):407–413PubMed
57.
Zurück zum Zitat DeConde AS et al (2014) Comparative effectiveness of medical and surgical therapy on olfaction in chronic rhinosinusitis: a prospective, multi-institutional study. Int Forum Allergy Rhinol 4(9):725–733PubMedPubMedCentral DeConde AS et al (2014) Comparative effectiveness of medical and surgical therapy on olfaction in chronic rhinosinusitis: a prospective, multi-institutional study. Int Forum Allergy Rhinol 4(9):725–733PubMedPubMedCentral
58.
Zurück zum Zitat Altun H, Hanci D (2015) Olfaction improvement after nasal septal perforation repair with the “cross-stealing” technique. Am J Rhinol Allergy 29(5):e142–145PubMed Altun H, Hanci D (2015) Olfaction improvement after nasal septal perforation repair with the “cross-stealing” technique. Am J Rhinol Allergy 29(5):e142–145PubMed
59.
Zurück zum Zitat Philpott CM et al (2008) A study of olfactory testing in patients with rhinological pathology in the ENT clinic. Rhinology 46(1):34–39PubMed Philpott CM et al (2008) A study of olfactory testing in patients with rhinological pathology in the ENT clinic. Rhinology 46(1):34–39PubMed
60.
Zurück zum Zitat Leopold DA et al (1991) Successful treatment of phantosmia with preservation of olfaction. Arch Otolaryngol Head Neck Surg 117(12):1402–1406PubMed Leopold DA et al (1991) Successful treatment of phantosmia with preservation of olfaction. Arch Otolaryngol Head Neck Surg 117(12):1402–1406PubMed
61.
Zurück zum Zitat Shu CH et al (2012) Topical corticosteroids applied with a squirt system are more effective than a nasal spray for steroid-dependent olfactory impairment. Laryngoscope 122(4):747–750PubMed Shu CH et al (2012) Topical corticosteroids applied with a squirt system are more effective than a nasal spray for steroid-dependent olfactory impairment. Laryngoscope 122(4):747–750PubMed
62.
Zurück zum Zitat Damm M, Leung RM, Kern RC (2014) Sinonasal olfactory disorders. In: Welge-Luessen A, Hummel T (Hrsg) Management of smell and taste disorders. Thieme, Stuttgart, S 76–90 Damm M, Leung RM, Kern RC (2014) Sinonasal olfactory disorders. In: Welge-Luessen A, Hummel T (Hrsg) Management of smell and taste disorders. Thieme, Stuttgart, S 76–90
63.
Zurück zum Zitat Benninger MS et al (2004) Techniques of intranasal steroid use. Otolaryngol Head Neck Surg 130(1):5–24PubMed Benninger MS et al (2004) Techniques of intranasal steroid use. Otolaryngol Head Neck Surg 130(1):5–24PubMed
64.
Zurück zum Zitat Sedaghat AR (2017) Chronic rhinosinusitis. Am Fam Physician 96(8):500–506PubMed Sedaghat AR (2017) Chronic rhinosinusitis. Am Fam Physician 96(8):500–506PubMed
65.
Zurück zum Zitat Vent J, Wang DW, Damm M (2010) Effects of traditional Chinese acupuncture in post-viral olfactory dysfunction. Otolaryngol Head Neck Surg 142(4):505–509PubMed Vent J, Wang DW, Damm M (2010) Effects of traditional Chinese acupuncture in post-viral olfactory dysfunction. Otolaryngol Head Neck Surg 142(4):505–509PubMed
67.
Zurück zum Zitat Hummel T et al (2017) Intranasal vitamin A is beneficial in post-infectious olfactory loss. Eur Arch Otorhinolaryngol 274(7):2819–2825PubMed Hummel T et al (2017) Intranasal vitamin A is beneficial in post-infectious olfactory loss. Eur Arch Otorhinolaryngol 274(7):2819–2825PubMed
68.
Zurück zum Zitat Mori E et al (2016) The administration of nasal drops in the “Kaiteki” position allows for delivery of the drug to the olfactory cleft: a pilot study in healthy subjects. Eur Arch Otorhinolaryngol 273(4):939–943PubMed Mori E et al (2016) The administration of nasal drops in the “Kaiteki” position allows for delivery of the drug to the olfactory cleft: a pilot study in healthy subjects. Eur Arch Otorhinolaryngol 273(4):939–943PubMed
69.
Zurück zum Zitat Whitcroft KL et al (2016) Intranasal sodium citrate solution improves olfaction in post-viral hyposmia. Rhinology 54(4):368–374PubMed Whitcroft KL et al (2016) Intranasal sodium citrate solution improves olfaction in post-viral hyposmia. Rhinology 54(4):368–374PubMed
70.
Zurück zum Zitat Philpott CM et al (2017) A randomised controlled trial of sodium citrate spray for non-conductive olfactory disorders. Clin Otolaryngol 42(6):1295–1302PubMed Philpott CM et al (2017) A randomised controlled trial of sodium citrate spray for non-conductive olfactory disorders. Clin Otolaryngol 42(6):1295–1302PubMed
71.
Zurück zum Zitat Whitcroft KL et al (2017) The effect of intranasal sodium citrate on olfaction in post-infectious loss: results from a prospective, placebo-controlled trial in 49 patients. Clin Otolaryngol 42(3):557–563PubMed Whitcroft KL et al (2017) The effect of intranasal sodium citrate on olfaction in post-infectious loss: results from a prospective, placebo-controlled trial in 49 patients. Clin Otolaryngol 42(3):557–563PubMed
72.
Zurück zum Zitat Whitcroft KL et al (2021) Intranasal sodium citrate in quantitative and qualitative olfactory dysfunction: results from a prospective, controlled trial of prolonged use in 60 patients. Eur Arch Otorhinolaryngol 278(8):2891–2897PubMedPubMedCentral Whitcroft KL et al (2021) Intranasal sodium citrate in quantitative and qualitative olfactory dysfunction: results from a prospective, controlled trial of prolonged use in 60 patients. Eur Arch Otorhinolaryngol 278(8):2891–2897PubMedPubMedCentral
73.
Zurück zum Zitat Hummel T, Heilmann S, Huttenbriuk KB (2002) Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract. Laryngoscope 112(11):2076–2080PubMed Hummel T, Heilmann S, Huttenbriuk KB (2002) Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract. Laryngoscope 112(11):2076–2080PubMed
74.
Zurück zum Zitat Yan CH, Mundy DC, Patel ZM (2020) The use of platelet-rich plasma in treatment of olfactory dysfunction: a pilot study. Laryngoscope Investig Otolaryngol 5(2):187–193PubMedPubMedCentral Yan CH, Mundy DC, Patel ZM (2020) The use of platelet-rich plasma in treatment of olfactory dysfunction: a pilot study. Laryngoscope Investig Otolaryngol 5(2):187–193PubMedPubMedCentral
75.
Zurück zum Zitat Schöpf V et al (2015) Intranasal insulin influences the olfactory performance of patients with smell loss, dependent on the body mass index: a pilot study. Rhinology 53(4):371–378PubMed Schöpf V et al (2015) Intranasal insulin influences the olfactory performance of patients with smell loss, dependent on the body mass index: a pilot study. Rhinology 53(4):371–378PubMed
76.
Zurück zum Zitat Rezaeian A (2018) Effect of intranasal insulin on olfactory recovery in patients with hyposmia: a randomized clinical trial. Otolaryngol Head Neck Surg 158(6):1134–1139PubMed Rezaeian A (2018) Effect of intranasal insulin on olfactory recovery in patients with hyposmia: a randomized clinical trial. Otolaryngol Head Neck Surg 158(6):1134–1139PubMed
77.
Zurück zum Zitat Mohamad SA, Badawi AM, Mansour HF (2021) Insulin fast-dissolving film for intranasal delivery via olfactory region, a promising approach for the treatment of anosmia in COVID-19 patients: design, in-vitro characterization and clinical evaluation. Int J Pharm 601:120600PubMed Mohamad SA, Badawi AM, Mansour HF (2021) Insulin fast-dissolving film for intranasal delivery via olfactory region, a promising approach for the treatment of anosmia in COVID-19 patients: design, in-vitro characterization and clinical evaluation. Int J Pharm 601:120600PubMed
78.
Zurück zum Zitat Carrie I et al (2009) PUFA for prevention and treatment of dementia? Curr Pharm Des 15(36):4173–4185PubMed Carrie I et al (2009) PUFA for prevention and treatment of dementia? Curr Pharm Des 15(36):4173–4185PubMed
79.
Zurück zum Zitat Yan CH et al (2020) Effect of omega‑3 supplementation in patients with smell dysfunction following endoscopic sellar and parasellar tumor resection: a multicenter prospective randomized controlled trial. Neurosurgery 87(2):E91–e98PubMedPubMedCentral Yan CH et al (2020) Effect of omega‑3 supplementation in patients with smell dysfunction following endoscopic sellar and parasellar tumor resection: a multicenter prospective randomized controlled trial. Neurosurgery 87(2):E91–e98PubMedPubMedCentral
80.
Zurück zum Zitat Schubert CR et al (2013) Association of exercise with lower long-term risk of olfactory impairment in older adults. JAMA Otolaryngol Head Neck Surg 139(10):1061–1066PubMed Schubert CR et al (2013) Association of exercise with lower long-term risk of olfactory impairment in older adults. JAMA Otolaryngol Head Neck Surg 139(10):1061–1066PubMed
81.
Zurück zum Zitat Sollai G, Crnjar R (2021) Age-related olfactory decline is associated with levels of exercise and non-exercise physical activities. Front Aging Neurosci 13:695115PubMedPubMedCentral Sollai G, Crnjar R (2021) Age-related olfactory decline is associated with levels of exercise and non-exercise physical activities. Front Aging Neurosci 13:695115PubMedPubMedCentral
82.
Zurück zum Zitat Dörig P et al (2021) Future therapeutic strategies for olfactory disorders: electrical stimulation, stem cell therapy, and transplantation of olfactory epithelium—an overview. HNO 69(8):623–632PubMed Dörig P et al (2021) Future therapeutic strategies for olfactory disorders: electrical stimulation, stem cell therapy, and transplantation of olfactory epithelium—an overview. HNO 69(8):623–632PubMed
Metadaten
Titel
Riech- und Schmeckstörungen
verfasst von
Dr. med. M. M. Speth
U. S. Speth
A. R. Sedaghat
T. Hummel
Publikationsdatum
12.01.2022
Verlag
Springer Medizin
Erschienen in
HNO / Ausgabe 2/2022
Print ISSN: 0017-6192
Elektronische ISSN: 1433-0458
DOI
https://doi.org/10.1007/s00106-021-01132-y

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