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Erschienen in: Clinical Autonomic Research 2/2023

02.03.2023 | Review Article

Orthostatic hypotension in dementia with Lewy bodies: a meta-analysis of prospective studies

verfasst von: Ahmet Turan Isik, Fatma Sena Dost, Idil Yavuz, Mehmet Selman Ontan, Esra Ates Bulut, Derya Kaya

Erschienen in: Clinical Autonomic Research | Ausgabe 2/2023

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Abstract

Purpose

Orthostatic hypotension (OH), one of the supportive clinical features in the diagnosis of dementia with Lewy bodies (DLB), is a significant problem in advanced age because of its severe negative consequences. The aim of this meta-analysis was to investigate the prevalence and risk of OH in patients with DLB.

Methods

The indexes and databases cited to identify relevant studies were PubMed, ScienceDirect, Cochrane, and Web of Science. The keywords for the search were “Lewy body dementia” and “autonomic dysfunction” or “dysautonomia” or “postural hypotension” or “orthostatic hypotension.” English-language articles published from January 1990 to April 2022 were searched. The Newcastle–Ottawa scale was applied to evaluate the quality of the studies. Odds ratios (OR) and risk ratios (RR) were extracted with 95% confidence intervals (CI) and combined using the random effects model after logarithmic transformation. The prevalence in the patients with DLB was also combined using the random effects model.

Results

Eighteen studies (10 case controls and 8 case series) were included to evaluate the prevalence of OH in patients with DLB. Higher rates of OH were found to be associated with DLB (OR 7.71, 95% CI 4.42, 13.44; p < 0.001), and 50.8% of 662 patients had OH.

Conclusion

DLB increased the risk of OH by 3.62- to 7.71-fold compared to healthy controls. Therefore, it will be useful to evaluate postural blood pressure changes in the follow-up and treatment of patients with DLB.
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Literatur
Metadaten
Titel
Orthostatic hypotension in dementia with Lewy bodies: a meta-analysis of prospective studies
verfasst von
Ahmet Turan Isik
Fatma Sena Dost
Idil Yavuz
Mehmet Selman Ontan
Esra Ates Bulut
Derya Kaya
Publikationsdatum
02.03.2023
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Autonomic Research / Ausgabe 2/2023
Print ISSN: 0959-9851
Elektronische ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-023-00933-1

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