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Indian Journal of Otolaryngology and Head & Neck Surgery

Erschienen in:

06.10.2022 | Original Article

Over Expression of Cancer Stem Cell Marker CD44 and Its Clinical Significance in Patients with Oral Squamous Cell Carcinoma

verfasst von: Baldeep Singh, Sadhna Aggarwal, Priyanka Das, Sunil K. Srivastava, Suresh C. Sharma, Satya N. Das

Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery | Ausgabe 1/2023

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Abstract

Cancer stem cell marker CD44 is a cell-surface glycoprotein which is involved in various cellular functions such as cell–cell interactions, cell adhesion, haematopoiesis and tumour metastasis. The CD44 gene transcription is partly activated by beta-catenin and Wnt signalling pathway, the later pathway being linked to tumour development. However, the role of CD44 in oral squamous cell carcinoma (OSCC) is not well understood. We investigated the expression of CD44 in peripheral circulation, tumour tissues of oral cancer patients and oral squamous cell carcinoma cell lines by ELISA and quantitative (q)-RTPCR. Relative CD44s mRNA expression was significantly higher in peripheral circulation (p = 0.04), tumour tissues (p = 0.049) and in oral cancer cell lines (SCC4, SCC25 p = 0.02, SCC9 p = 0.03). Circulating CD44_total protein levels were also significantly (p < 0.001) higher in OSCC patients that positively correlated with increasing tumour load and loco-regional spread of the tumour. The circulating tumour stem cell marker CD44 appears to be a potent indicator of tumour progression and may be useful for developing suitable therapeutics strategies for patients with oral squamous cell carcinoma.

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Titel: Over Expression of Cancer Stem Cell Marker CD44 and Its Clinical Significance in Patients with Oral Squamous Cell Carcinoma
verfasst von: Baldeep Singh
Sadhna Aggarwal
Priyanka Das
Sunil K. Srivastava
Suresh C. Sharma
Satya N. Das
Publikationsdatum: 06.10.2022
Verlag: Springer India
Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery / Ausgabe 1/2023
Print ISSN: 2231-3796
Elektronische ISSN: 0973-7707
DOI: https://doi.org/10.1007/s12070-022-03200-3

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Over Expression of Cancer Stem Cell Marker CD44 and Its Clinical Significance in Patients with Oral Squamous Cell Carcinoma

Abstract

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