24.02.2023 | Original Article
Paramagnetic resonance spectroscopy of the 3-maleimido-proxyl (3-MP) scavenging properties of three photoactive substances in the context of photodynamic therapy—a pilot study
Lasers in Dental Science
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Photodynamic therapy is a novel therapeutic approach aimed primarily as an antibacterial method for the oral cavity. However, being a low-level laser therapy, photodynamic therapy could possibly show potential as a modulative method in managing aspects of the inflammation process in the oral tissues.
The presented study uses EPR to explore the relationship between three common photosensitizers and 3-maleimido-proxyl which is a marker for conformational changes in the albumin structure. Albumins are proteins which take central part in the inflammatory cascade in the body including the oral tissues.
The results show the pronounced potential of the tested photoactive molecules to restore the albumin molecule and neutralize oxidative stress in the tissues.
Photodynamic therapy-induced restoration of the albumin molecule in oral tissues with selected photoactive substances could be a viable inflammation-modulating pathway.