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29.01.2018 | Parkinson-Krankheit | Zertifizierte Fortbildung

Schmerzmanagement

Schmerz bei Patienten mit Morbus Parkinson — was sind die Ursachen?

verfasst von: PD Dr. med. Oliver Rommel

Erschienen in: DNP – Die Neurologie & Psychiatrie | Ausgabe 1/2018

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Zusammenfassung

Schmerz ist ein häufiges Symptom beim Morbus Parkinson, das schon in der Frühphase der Erkrankung auftreten kann und bei den Patienten zu einer schwerwiegenden Beeinträchtigung der Lebensqualität führt. Neben altersbedingt gehäuft auftretenden Wirbelsäulen- und Gelenkschmerzen führt die Parkinson-Erkrankung selbst durch Rigor, Akinese und Haltungsstörungen zu Schmerzen, die mit der Beweglichkeit fluktuieren und die orthopädisch bedingten Schmerzen überlagern können. Daher muss die Schmerztherapie bei Patienten mit Morbus Parkinson durch den behandelnden Neurologen geleitet und überwacht werden, nicht zuletzt, um den Patienten vor erfolglosen und belastenden operativen Eingriffen zu schützen.
Literatur
1.
Zurück zum Zitat Parkinson J. An essay on the shaking palsy. London: Sherwood, Neely, Jones 1817 Parkinson J. An essay on the shaking palsy. London: Sherwood, Neely, Jones 1817
2.
Zurück zum Zitat Lewy FH. Die Lehre vom Tonus und der Bewegung: Systematische Untersuchungen zur Klinik, Physiologie, Pathologie und Pathogenese der Paralysis agitans. Springer: Berlin 1923, S. 28–29 Lewy FH. Die Lehre vom Tonus und der Bewegung: Systematische Untersuchungen zur Klinik, Physiologie, Pathologie und Pathogenese der Paralysis agitans. Springer: Berlin 1923, S. 28–29
3.
Zurück zum Zitat Giuffrida R, Vingerhoets FJ, Bogousslavsky J, Ghika J. Pain in Parkinson’s disease. Rev Neurol 2005; 161:407–18CrossRefPubMed Giuffrida R, Vingerhoets FJ, Bogousslavsky J, Ghika J. Pain in Parkinson’s disease. Rev Neurol 2005; 161:407–18CrossRefPubMed
4.
Zurück zum Zitat Defazio G, Berardelli A, Fabbrini G et al. Pain as a Nonmotor Symptom of Parkinson Disease: Evidence from a Case-Controll Study Arch Neurol 2008; 65: 1191–4CrossRefPubMed Defazio G, Berardelli A, Fabbrini G et al. Pain as a Nonmotor Symptom of Parkinson Disease: Evidence from a Case-Controll Study Arch Neurol 2008; 65: 1191–4CrossRefPubMed
5.
Zurück zum Zitat Nègre-Pagès L, Regragui W, Bouhassira D et al. Chronic Pain in Parkinson`s Disease: The Cross-Sectional French DoPaMiP Survey. Mov Desorders 2008; 23:1361–9CrossRef Nègre-Pagès L, Regragui W, Bouhassira D et al. Chronic Pain in Parkinson`s Disease: The Cross-Sectional French DoPaMiP Survey. Mov Desorders 2008; 23:1361–9CrossRef
6.
Zurück zum Zitat Beiske AG, Loge JH, Rönningen A et al. Pain in Parkinsons`desease: Prevalence und characteristics. Pain 2009; 141:173–7CrossRefPubMed Beiske AG, Loge JH, Rönningen A et al. Pain in Parkinsons`desease: Prevalence und characteristics. Pain 2009; 141:173–7CrossRefPubMed
7.
Zurück zum Zitat Buhmann C, Wrobel N, Grashorn W, Fruend O, Wesemann K, Diedrich S, Bingel U. Pain in Parkinson disease: a cross-sectional survey of ist prevalence, specifics, and therapy. J Neurol 2017; 264:758–69CrossRefPubMed Buhmann C, Wrobel N, Grashorn W, Fruend O, Wesemann K, Diedrich S, Bingel U. Pain in Parkinson disease: a cross-sectional survey of ist prevalence, specifics, and therapy. J Neurol 2017; 264:758–69CrossRefPubMed
8.
Zurück zum Zitat Tison F., Wenning G.K., Volonte M.A. et al: Pain in multiple system atrophy J.Neurol 1996; 243: 153–156CrossRefPubMed Tison F., Wenning G.K., Volonte M.A. et al: Pain in multiple system atrophy J.Neurol 1996; 243: 153–156CrossRefPubMed
9.
Zurück zum Zitat Kass-Ilyya L, Kobylecki C, McDonald KR et al. Pain in multiple system atrophy and progressive supranuclear palsy compared to Parkinson’s disease. Brain and Behaviour 2015; 5(5), e00320,doi: 10.1002/brb3.320 Kass-Ilyya L, Kobylecki C, McDonald KR et al. Pain in multiple system atrophy and progressive supranuclear palsy compared to Parkinson’s disease. Brain and Behaviour 2015; 5(5), e00320,doi: 10.1002/brb3.320
10.
Zurück zum Zitat Ford B. Pain in Parkinson`s Disease. Clin Neuroscience 1998; 5:63–72CrossRef Ford B. Pain in Parkinson`s Disease. Clin Neuroscience 1998; 5:63–72CrossRef
11.
Zurück zum Zitat Ozturk EA, Gundogdu I, Kocer B, Comoglu S, Cakci A. Chronic pain in Parkinson’s disease: Frequency, characteristics, independent factors, and relationship with healty-related quality of life. J Back Musculoskelet Rehabil 2016; [Epub ahead of print] Ozturk EA, Gundogdu I, Kocer B, Comoglu S, Cakci A. Chronic pain in Parkinson’s disease: Frequency, characteristics, independent factors, and relationship with healty-related quality of life. J Back Musculoskelet Rehabil 2016; [Epub ahead of print]
12.
Zurück zum Zitat Djaldetti R, Shifrin A, Rogowski Z et al. Quantitative measurement of pain sensation in patients with Parkinson desease Neurology 2004; 62: 2171–5CrossRefPubMed Djaldetti R, Shifrin A, Rogowski Z et al. Quantitative measurement of pain sensation in patients with Parkinson desease Neurology 2004; 62: 2171–5CrossRefPubMed
13.
Zurück zum Zitat Tinazzi M, Del Vesco C, Fincati E et al. Pain and motor complications in Parkinson`s disease. J Neurol Neurosurgery Psychiatry 2006; 77:822–5CrossRef Tinazzi M, Del Vesco C, Fincati E et al. Pain and motor complications in Parkinson`s disease. J Neurol Neurosurgery Psychiatry 2006; 77:822–5CrossRef
14.
Zurück zum Zitat Indo T, Naito A, Sobue I. Clinical Characteristics of Headache in Parkinson`s Disease. Headache 1983; 13:211–2 Indo T, Naito A, Sobue I. Clinical Characteristics of Headache in Parkinson`s Disease. Headache 1983; 13:211–2
15.
Zurück zum Zitat Nunes JC, Costa Bergamaschi EN, Freitas FC, Diaz AP, Queiroz LP, Debona R et al. Prevalence of headache in patients with Parkinson’s disease and its association with the side of motor symptom onset. Neurol Sci 2014;35:595–600CrossRefPubMed Nunes JC, Costa Bergamaschi EN, Freitas FC, Diaz AP, Queiroz LP, Debona R et al. Prevalence of headache in patients with Parkinson’s disease and its association with the side of motor symptom onset. Neurol Sci 2014;35:595–600CrossRefPubMed
16.
Zurück zum Zitat Riley D, Lang AE, Blair RDG et al. Frozen shoulder and other shoulder disturbances in Parkinson`s disease. J Neurol. Neurosurg Psychiatrie 1989; 52:63–6CrossRef Riley D, Lang AE, Blair RDG et al. Frozen shoulder and other shoulder disturbances in Parkinson`s disease. J Neurol. Neurosurg Psychiatrie 1989; 52:63–6CrossRef
17.
Zurück zum Zitat Cleeves L, Findley LJ. Frozen shoulder an other shoulder disturbancies in Parkinsons`s disease. J Neurol Neurosurg Psychiatrie 1989; 52:813–4CrossRef Cleeves L, Findley LJ. Frozen shoulder an other shoulder disturbancies in Parkinsons`s disease. J Neurol Neurosurg Psychiatrie 1989; 52:813–4CrossRef
18.
Zurück zum Zitat Chang YT, Chang WN, Tsai NW, Cheng KY, Huang CC, Kung CT et al. Clinical features associated with frozen shoulder syndrome in Parkinson’s disease. Parkinson’s disease 2015; ID232958 Chang YT, Chang WN, Tsai NW, Cheng KY, Huang CC, Kung CT et al. Clinical features associated with frozen shoulder syndrome in Parkinson’s disease. Parkinson’s disease 2015; ID232958
19.
Zurück zum Zitat Sandyk R. Back pain as an early symptom of Parkinson`s Disease: S Afr Med J 1982; 61: 3PubMed Sandyk R. Back pain as an early symptom of Parkinson`s Disease: S Afr Med J 1982; 61: 3PubMed
20.
Zurück zum Zitat Etchepare F, Rozenberg S, Mirault T et al. Back problems in Parkinson`s disease: an unterrstimated problem. Joint Bone Spine 2006; 73:298–302CrossRefPubMed Etchepare F, Rozenberg S, Mirault T et al. Back problems in Parkinson`s disease: an unterrstimated problem. Joint Bone Spine 2006; 73:298–302CrossRefPubMed
21.
Zurück zum Zitat Broetz D, Eichner M, Gasser T et al. Radicular and Nonradicular Back Pain in Parkinson`s Disease: A. Controlled Study. Mov Disord 2007; 30(22):853–6CrossRef Broetz D, Eichner M, Gasser T et al. Radicular and Nonradicular Back Pain in Parkinson`s Disease: A. Controlled Study. Mov Disord 2007; 30(22):853–6CrossRef
22.
Zurück zum Zitat Watanabe K, Hirano T, Katsumi K, Ohashi M, Ishikawa A, Koike R et al. Characteristics and exacerbating factors of chronic low back pain in Parkinson’s disease. Int Orthop 2015; 39(12):2433–8CrossRefPubMed Watanabe K, Hirano T, Katsumi K, Ohashi M, Ishikawa A, Koike R et al. Characteristics and exacerbating factors of chronic low back pain in Parkinson’s disease. Int Orthop 2015; 39(12):2433–8CrossRefPubMed
23.
Zurück zum Zitat Grimes JD, Hassan MN, Trent G et al. Clinical und Radiographic Features of Scoliosis in Parkinson`s Disease. Adv Neurol 1986; 45: 353–5 Grimes JD, Hassan MN, Trent G et al. Clinical und Radiographic Features of Scoliosis in Parkinson`s Disease. Adv Neurol 1986; 45: 353–5
24.
Zurück zum Zitat Djaldetti R, Shifrin A, Rogowski Z et al. Quantitative measurement of pain sensation in patients with Parkinson desease. Neurology 2004; 62:2171–5CrossRefPubMed Djaldetti R, Shifrin A, Rogowski Z et al. Quantitative measurement of pain sensation in patients with Parkinson desease. Neurology 2004; 62:2171–5CrossRefPubMed
25.
Zurück zum Zitat Margraf NG, Wrede A, Rohr A et al. Camptocormia in Idiopathic Parkinsons`s Disease: A Focal Myopathy of the Paravertebral Muscles. Mov Disorders 2010; 25:542–51CrossRef Margraf NG, Wrede A, Rohr A et al. Camptocormia in Idiopathic Parkinsons`s Disease: A Focal Myopathy of the Paravertebral Muscles. Mov Disorders 2010; 25:542–51CrossRef
26.
Zurück zum Zitat Gelati S, Möller JC, Städler C. Ropirinole-induced Pisa-Syndrome in Parkinson’s disease. Clin Neuropharmacol 2014; 37:58–9CrossRef Gelati S, Möller JC, Städler C. Ropirinole-induced Pisa-Syndrome in Parkinson’s disease. Clin Neuropharmacol 2014; 37:58–9CrossRef
27.
Zurück zum Zitat Solla P, Cannas A, Congia S, Floris G, Aste R, Tacconi P et al. Levodopa/carbidopa/entracapone-induced acute Pisa syndrome in a Parkinson’s disease patient. J Neurol Sci 2008; 275:154–6CrossRefPubMed Solla P, Cannas A, Congia S, Floris G, Aste R, Tacconi P et al. Levodopa/carbidopa/entracapone-induced acute Pisa syndrome in a Parkinson’s disease patient. J Neurol Sci 2008; 275:154–6CrossRefPubMed
28.
Zurück zum Zitat Rommel O, Wejwer D, Jaeger G et al. Pisa-Syndrom: Skoliose und/oder dystone Störung der Rückenmuskulatur? Nervenarzt 2017 (in Vorbereitung) Rommel O, Wejwer D, Jaeger G et al. Pisa-Syndrom: Skoliose und/oder dystone Störung der Rückenmuskulatur? Nervenarzt 2017 (in Vorbereitung)
29.
Zurück zum Zitat Frazzita G, Balbi P, Gotti F, Maestri R, Sabetta A, Caremani L et al. Pisa-Syndrome in Parkinson’s disease: Electromyographic aspects and implications for rehabilitation. Parkinson’s disease 2015; ID 437190, 6 pages, doi.org/10.1155/2015/437190 Frazzita G, Balbi P, Gotti F, Maestri R, Sabetta A, Caremani L et al. Pisa-Syndrome in Parkinson’s disease: Electromyographic aspects and implications for rehabilitation. Parkinson’s disease 2015; ID 437190, 6 pages, doi.org/10.1155/2015/437190
30.
Zurück zum Zitat Doherty KM, Davagnanam I, Molloy S, Silveira-Moriyama L, Lees A. Pisa syndrome in Parkinson’s disease: a mobile or fixed deformity? J Neurol Neurosurg Psychiatry 2013; 84:1400–3CrossRefPubMedPubMedCentral Doherty KM, Davagnanam I, Molloy S, Silveira-Moriyama L, Lees A. Pisa syndrome in Parkinson’s disease: a mobile or fixed deformity? J Neurol Neurosurg Psychiatry 2013; 84:1400–3CrossRefPubMedPubMedCentral
31.
32.
Zurück zum Zitat Sigwald J, Solignac J. Manifestations douloureuses de la maladie de Parkinson et paraesthesies provoquées par les neuroleptiques. Sem Hop Paris 1960; 44:2222–5 Sigwald J, Solignac J. Manifestations douloureuses de la maladie de Parkinson et paraesthesies provoquées par les neuroleptiques. Sem Hop Paris 1960; 44:2222–5
33.
Zurück zum Zitat Grushka M, Sessle BJ. Burning mouth syndrome. Dent Clin North Am 1991; 35:171–84PubMed Grushka M, Sessle BJ. Burning mouth syndrome. Dent Clin North Am 1991; 35:171–84PubMed
34.
Zurück zum Zitat Tysnes OB, Müller B, Larsen JP. Are dysautonomic and sensory symptoms present in early Parkinson’s disease? Acta Neurol Scand 2010; 122(suppl. 190): 72–7CrossRef Tysnes OB, Müller B, Larsen JP. Are dysautonomic and sensory symptoms present in early Parkinson’s disease? Acta Neurol Scand 2010; 122(suppl. 190): 72–7CrossRef
35.
Zurück zum Zitat Wasner G, Deuschl G. Pain in Parkinson`s Disease. Cervero F Jansen TS (ED) Handbook of Clinical Neurology. Elsevier, 2006; S. 747–60 Wasner G, Deuschl G. Pain in Parkinson`s Disease. Cervero F Jansen TS (ED) Handbook of Clinical Neurology. Elsevier, 2006; S. 747–60
37.
Zurück zum Zitat Battista AF, Wolff BB. Levodopa and Induced-Pain Response: A Study of Patients with Parkinsonian and Pain Syndroms. Arch Intern Med 1973; 132:70–4CrossRefPubMed Battista AF, Wolff BB. Levodopa and Induced-Pain Response: A Study of Patients with Parkinsonian and Pain Syndroms. Arch Intern Med 1973; 132:70–4CrossRefPubMed
38.
Zurück zum Zitat Schestatsky P, Kumru H, Valls-Solè J et al. Neurophysiologic study of central pain in patients with Parkinson disease. Neurology 2007; 69:2162–9CrossRefPubMed Schestatsky P, Kumru H, Valls-Solè J et al. Neurophysiologic study of central pain in patients with Parkinson disease. Neurology 2007; 69:2162–9CrossRefPubMed
39.
Zurück zum Zitat Fabbri M, Coelho M, Guedes LC, Chendo I, Sousa C, Rose MM et al. Response of non-motor symptoms to levodopa in late-stage Parkinson’s disease: Results of a levodopa challenge test. Parkinson Relat Disord 2017; 39:37–43CrossRef Fabbri M, Coelho M, Guedes LC, Chendo I, Sousa C, Rose MM et al. Response of non-motor symptoms to levodopa in late-stage Parkinson’s disease: Results of a levodopa challenge test. Parkinson Relat Disord 2017; 39:37–43CrossRef
40.
Zurück zum Zitat Rommel O, Wejwer D, Schybek K, Przybilski T, Jäger G, Gräber S, Berg D. Lendenwirbelsäulenschmerzen bei Patienten mit Morbus Parkinson. Nervenarzt 2016; 87:418–25CrossRefPubMed Rommel O, Wejwer D, Schybek K, Przybilski T, Jäger G, Gräber S, Berg D. Lendenwirbelsäulenschmerzen bei Patienten mit Morbus Parkinson. Nervenarzt 2016; 87:418–25CrossRefPubMed
41.
Zurück zum Zitat Jost WH, Rizos A, Odin P, Löhle M, Storch A. King’s Parkinson’s disease scale- Interkulturelle Adaptation in deutscher Sprache. Nervenarzt 2017; DOI 10.1007/s00115-017-0333-z Jost WH, Rizos A, Odin P, Löhle M, Storch A. King’s Parkinson’s disease scale- Interkulturelle Adaptation in deutscher Sprache. Nervenarzt 2017; DOI 10.1007/s00115-017-0333-z
42.
Zurück zum Zitat Chaudhuri KR, Rizos A, Trenkwalder C et al. King’s Parkinson disease pain scale, the first scale for pain in PD: an international validation. Mov Disord 2015; 30:1623–31CrossRefPubMed Chaudhuri KR, Rizos A, Trenkwalder C et al. King’s Parkinson disease pain scale, the first scale for pain in PD: an international validation. Mov Disord 2015; 30:1623–31CrossRefPubMed
43.
Zurück zum Zitat Gierthmühlen J, Arning P, Binder A, Herzog J, Deuschl G, Wasner G, Baron R. Influence of deep brain stimulation and levodopa on sensory signs in Parkinson’s disease. Mov Disord 2010; 29:1195–1202CrossRef Gierthmühlen J, Arning P, Binder A, Herzog J, Deuschl G, Wasner G, Baron R. Influence of deep brain stimulation and levodopa on sensory signs in Parkinson’s disease. Mov Disord 2010; 29:1195–1202CrossRef
44.
Zurück zum Zitat Vela L, Cano-de-la-Cuerta R, Fil A, Munoz-Hellin E, Ortiz-Gutierrez R, Marcias-Marcias Y et al. Thermal and mechanical pain thresholds in patients with fluctuating Parkinson’s disease. Parkinsonism Relat Disord 2012; 18:953–7CrossRefPubMed Vela L, Cano-de-la-Cuerta R, Fil A, Munoz-Hellin E, Ortiz-Gutierrez R, Marcias-Marcias Y et al. Thermal and mechanical pain thresholds in patients with fluctuating Parkinson’s disease. Parkinsonism Relat Disord 2012; 18:953–7CrossRefPubMed
45.
Zurück zum Zitat Quinn NP, Koller WC, Lang AE, Marsden CD. Painful parkinson’s disease. Lancet 1986; 1:1366–9CrossRefPubMed Quinn NP, Koller WC, Lang AE, Marsden CD. Painful parkinson’s disease. Lancet 1986; 1:1366–9CrossRefPubMed
46.
Zurück zum Zitat Nebe A, Ebersbach G. Pain Intensity On and Off Levodopa in Patients with Parkinson`s Disease. Mov Disord 2009; 24:1233–7CrossRefPubMed Nebe A, Ebersbach G. Pain Intensity On and Off Levodopa in Patients with Parkinson`s Disease. Mov Disord 2009; 24:1233–7CrossRefPubMed
47.
Zurück zum Zitat Rana AQ, Depradine J. Abdominal pain: a symptom of levodopa wearing off end of dose in Parkinson’s disease. West Indian Med J 2011; 60:223–4PubMed Rana AQ, Depradine J. Abdominal pain: a symptom of levodopa wearing off end of dose in Parkinson’s disease. West Indian Med J 2011; 60:223–4PubMed
48.
Zurück zum Zitat Rosa-Grilo M, Qamar MA, Evans A, Chaudhuri KR. The efficacy of apomorphine — A non-motor perspective. Parkinsonism Relat Disord 2016; 33(suppl1):S28–S35CrossRefPubMed Rosa-Grilo M, Qamar MA, Evans A, Chaudhuri KR. The efficacy of apomorphine — A non-motor perspective. Parkinsonism Relat Disord 2016; 33(suppl1):S28–S35CrossRefPubMed
49.
Zurück zum Zitat Dellapina E, Gerdelat-Mas A, Ory-Magne F, Pourcel L, Galitzky M, Calvas F et al. Apomorphine effect on pain threshold in Parkinson’s disease: a clinical and positron emission tomography study. Mov Disord 2011; 26:153–7CrossRefPubMed Dellapina E, Gerdelat-Mas A, Ory-Magne F, Pourcel L, Galitzky M, Calvas F et al. Apomorphine effect on pain threshold in Parkinson’s disease: a clinical and positron emission tomography study. Mov Disord 2011; 26:153–7CrossRefPubMed
50.
Zurück zum Zitat Letvinenko IV, Odinak MM, Mogil’naia VI. Pain and depression in Parkinson’s disease: new therapeutic possibilities of Pramipexole. Zh Nevrol Psikhiatr Im SS Korsakova 2008; 108:36–8 Letvinenko IV, Odinak MM, Mogil’naia VI. Pain and depression in Parkinson’s disease: new therapeutic possibilities of Pramipexole. Zh Nevrol Psikhiatr Im SS Korsakova 2008; 108:36–8
51.
Zurück zum Zitat Rascol O, Zesiewicvz T, Chaudhuri KR, Asgharnedjad M, Surmann E, Dohin E et al. A randomized controlled exploratory pilot study to evaluate the effect of rotigotine transdermal patch on Parkinson’s disease-associated pain. J Clin Pharmacol 2016; 56:852–61CrossRefPubMed Rascol O, Zesiewicvz T, Chaudhuri KR, Asgharnedjad M, Surmann E, Dohin E et al. A randomized controlled exploratory pilot study to evaluate the effect of rotigotine transdermal patch on Parkinson’s disease-associated pain. J Clin Pharmacol 2016; 56:852–61CrossRefPubMed
52.
Zurück zum Zitat Timmermann L, Oehlwein C, Ransmayr G, Fröhlich H, Will E, Schroeder H et al. Patients’ perception of Parkinson’s disease-associated pain following initiation of rotigotine: a multicenter non-interventional study. Postgrad Med 2017; 129:46–54CrossRefPubMed Timmermann L, Oehlwein C, Ransmayr G, Fröhlich H, Will E, Schroeder H et al. Patients’ perception of Parkinson’s disease-associated pain following initiation of rotigotine: a multicenter non-interventional study. Postgrad Med 2017; 129:46–54CrossRefPubMed
53.
Zurück zum Zitat Berg D, Becker G, Reiners K. Reduction of dyskinesia and induction of akinesia induced by morphine in two parkinsonian patients with severe sciatica. M Neural Transm 1999; 106:725–8CrossRef Berg D, Becker G, Reiners K. Reduction of dyskinesia and induction of akinesia induced by morphine in two parkinsonian patients with severe sciatica. M Neural Transm 1999; 106:725–8CrossRef
54.
Zurück zum Zitat Berg D, Becker G, Maumann M et al. Morphine in tardive and idiopathic dystonia (short communication). J Neural Transm 2001; 108:1035–41CrossRefPubMed Berg D, Becker G, Maumann M et al. Morphine in tardive and idiopathic dystonia (short communication). J Neural Transm 2001; 108:1035–41CrossRefPubMed
55.
Zurück zum Zitat Trenkwalder C, Chaudhuri KR, Martinez-Martin P, Rascol O, Ehret R, Valis M et al. Prolonged-release oxycodone-naloxone for treatment of severe pain in patients with Parkinson’s disease (PANDA): a double-blind, randomized, placebo-controlled trial. Lancet Neurol 2015; 14:1161–70CrossRefPubMed Trenkwalder C, Chaudhuri KR, Martinez-Martin P, Rascol O, Ehret R, Valis M et al. Prolonged-release oxycodone-naloxone for treatment of severe pain in patients with Parkinson’s disease (PANDA): a double-blind, randomized, placebo-controlled trial. Lancet Neurol 2015; 14:1161–70CrossRefPubMed
56.
Zurück zum Zitat Olson WL, Gruenthal M, Müller ME et al. Gabapentin for parkinsonism: a double-blind, placebo-controlled, crossover trial. Am J Med 1997; 102:60–6CrossRefPubMed Olson WL, Gruenthal M, Müller ME et al. Gabapentin for parkinsonism: a double-blind, placebo-controlled, crossover trial. Am J Med 1997; 102:60–6CrossRefPubMed
57.
Zurück zum Zitat Van Blercom N, Lasa A, Verger K et al. Effects of gabapentin on the motor response to levodopa: a double-blind, placebo-controlled, crossover study in patients with complicated Parkinson disease. Clin Neuropharmacol 2004; 27: 124–8CrossRefPubMed Van Blercom N, Lasa A, Verger K et al. Effects of gabapentin on the motor response to levodopa: a double-blind, placebo-controlled, crossover study in patients with complicated Parkinson disease. Clin Neuropharmacol 2004; 27: 124–8CrossRefPubMed
58.
Zurück zum Zitat Djaletti R, Yust-Katz S, Kolianov V, Melamed E, Dabby R. The effect of duloxetine on primary pain symptoms in Parkinson’s disease. Clin Neuropharmacol 2007; 30:201–5 Djaletti R, Yust-Katz S, Kolianov V, Melamed E, Dabby R. The effect of duloxetine on primary pain symptoms in Parkinson’s disease. Clin Neuropharmacol 2007; 30:201–5
59.
Zurück zum Zitat Miyasaki JM, Shannon K, Voon V et al. Practice parameters: evaluation and treatment of depression, psychosis, and dementia in Parkinson’s disease. Neurology 2006; 66:996–1002CrossRefPubMed Miyasaki JM, Shannon K, Voon V et al. Practice parameters: evaluation and treatment of depression, psychosis, and dementia in Parkinson’s disease. Neurology 2006; 66:996–1002CrossRefPubMed
60.
Zurück zum Zitat Indaco A, Carrieri PB. Amitriptyline in the treatment of headache in patients with Parkinson’s disease: a double-blind placebo-controlled study. Neurology 1988; 38:1720–2CrossRefPubMed Indaco A, Carrieri PB. Amitriptyline in the treatment of headache in patients with Parkinson’s disease: a double-blind placebo-controlled study. Neurology 1988; 38:1720–2CrossRefPubMed
61.
Zurück zum Zitat Reinecke H, Sorgatz H. S3 guideline LONTS. Long-term administration of opioids for non-tumor pain. Schmerz 2009; 23:440–7CrossRefPubMed Reinecke H, Sorgatz H. S3 guideline LONTS. Long-term administration of opioids for non-tumor pain. Schmerz 2009; 23:440–7CrossRefPubMed
62.
Zurück zum Zitat Tomlinson CL, Herd CE, Clarke CE et al. Physiotherapy in Parkinson’s disease. A comparison of techniques. Cochrane Database Syst Rev 2014; 17:CD002815 Tomlinson CL, Herd CE, Clarke CE et al. Physiotherapy in Parkinson’s disease. A comparison of techniques. Cochrane Database Syst Rev 2014; 17:CD002815
63.
Zurück zum Zitat Ory Magne F, Fabre N, Gu C, Pastorelli C, Tardez S, Marchat JC et al. An individual rehabilitation program: evaluation by Parkinsonian patients and their physiotherapists. Rev Neurol 2014; 170:680–4CrossRefPubMed Ory Magne F, Fabre N, Gu C, Pastorelli C, Tardez S, Marchat JC et al. An individual rehabilitation program: evaluation by Parkinsonian patients and their physiotherapists. Rev Neurol 2014; 170:680–4CrossRefPubMed
64.
Zurück zum Zitat Manchikanti L, Singh V, Falco FJ et al. Evaluation of lumbar facet joint nerve blocks in managing chronic low back pain: a randomized, double-blind, controlled trial. Int J Med Sci 2010; 7:124–35CrossRefPubMedPubMedCentral Manchikanti L, Singh V, Falco FJ et al. Evaluation of lumbar facet joint nerve blocks in managing chronic low back pain: a randomized, double-blind, controlled trial. Int J Med Sci 2010; 7:124–35CrossRefPubMedPubMedCentral
65.
Zurück zum Zitat Lakemeier, Lind M, Schulz W et al. A comparison of intraarticular lumbar facet joint steroid injections and lumbar facet joint radiofrequency denervation in the treatment of low back pain: a randomized, controlled, double-blind trial. Anaesth Analg 2013; 117:228–35CrossRef Lakemeier, Lind M, Schulz W et al. A comparison of intraarticular lumbar facet joint steroid injections and lumbar facet joint radiofrequency denervation in the treatment of low back pain: a randomized, controlled, double-blind trial. Anaesth Analg 2013; 117:228–35CrossRef
66.
Zurück zum Zitat Michalsen A, Klotz S, Lüdtke R et al. Effectiveness of leech therapy in osteoarthritis of the knee: a randomized, controlled study. Ann Intern Med 2003; 139:724–30CrossRefPubMed Michalsen A, Klotz S, Lüdtke R et al. Effectiveness of leech therapy in osteoarthritis of the knee: a randomized, controlled study. Ann Intern Med 2003; 139:724–30CrossRefPubMed
67.
Zurück zum Zitat Cury RG, Galhardoni R, Fonoff ET, Dos Santos Ghilardi MG, Fonoff F, Arnaut D et al. Effects of deep brain stimulation on pain and other nonmotor symptoms in Parkinson disease. Neurology 2014; 83(16):1403–9CrossRefPubMed Cury RG, Galhardoni R, Fonoff ET, Dos Santos Ghilardi MG, Fonoff F, Arnaut D et al. Effects of deep brain stimulation on pain and other nonmotor symptoms in Parkinson disease. Neurology 2014; 83(16):1403–9CrossRefPubMed
68.
Zurück zum Zitat Nishioka K, Nakajima M. Beneficial therapeutic effects of Spinal Cord Stimulation in advanced cases of Parkinson’s disease with intractable chronic pain: a case series. Neuromodulation 2015; 18(8):751–3CrossRefPubMed Nishioka K, Nakajima M. Beneficial therapeutic effects of Spinal Cord Stimulation in advanced cases of Parkinson’s disease with intractable chronic pain: a case series. Neuromodulation 2015; 18(8):751–3CrossRefPubMed
69.
Zurück zum Zitat Agari T, Date I. Spinal cord stimulation for the treatment of abnormal posture and gait disorder in patients with Parkinson’s disease. Neurol Med Chir (Tokyo) 2012; 52:470–4CrossRef Agari T, Date I. Spinal cord stimulation for the treatment of abnormal posture and gait disorder in patients with Parkinson’s disease. Neurol Med Chir (Tokyo) 2012; 52:470–4CrossRef
70.
Zurück zum Zitat Koch LD, Cofield RH, Ahlskog JE. Total shoulder arthroplasty in patients with Parkinson’s disease. J Shoulder Elbow Surg 1997; 6:24–8CrossRefPubMed Koch LD, Cofield RH, Ahlskog JE. Total shoulder arthroplasty in patients with Parkinson’s disease. J Shoulder Elbow Surg 1997; 6:24–8CrossRefPubMed
71.
Zurück zum Zitat Kryszak TJ, Sperling JW, Schleck SC et al. Total shoulder arthroplasty in patients with Parkinson`s disease J. Shoulder Elbow Surg 2009; 18: 96–9CrossRef Kryszak TJ, Sperling JW, Schleck SC et al. Total shoulder arthroplasty in patients with Parkinson`s disease J. Shoulder Elbow Surg 2009; 18: 96–9CrossRef
72.
Zurück zum Zitat Dunn J, Byrne AN, Higgins LD. Reverse total shoulder arthroplasty in patients with Parkinson’s disease: a case series and review of the literature. Am J Orthop 2011; 40:625–9PubMed Dunn J, Byrne AN, Higgins LD. Reverse total shoulder arthroplasty in patients with Parkinson’s disease: a case series and review of the literature. Am J Orthop 2011; 40:625–9PubMed
73.
Zurück zum Zitat Cusick MC, Otto RJ, Clark RE, Frankle MA. Outcome of reverse shoulder arthroplasty for patients with Parkinson’s disease: a matches cohort study. Orthopedics 2017; 40:e675–e680CrossRefPubMed Cusick MC, Otto RJ, Clark RE, Frankle MA. Outcome of reverse shoulder arthroplasty for patients with Parkinson’s disease: a matches cohort study. Orthopedics 2017; 40:e675–e680CrossRefPubMed
74.
Zurück zum Zitat Oni OOA, Mackenney RP. Total knee replacement in patients with Parkinson’s disease. J Bone Joint Surg Br 1985; 67:424–5PubMed Oni OOA, Mackenney RP. Total knee replacement in patients with Parkinson’s disease. J Bone Joint Surg Br 1985; 67:424–5PubMed
75.
Zurück zum Zitat Vince KG, Insall JN, Bannerman CE. Total Knee Arthroplasty in the Patient With Parkinson`s Disease. J Bone Joint Surg Br 1989; 71:51–4PubMed Vince KG, Insall JN, Bannerman CE. Total Knee Arthroplasty in the Patient With Parkinson`s Disease. J Bone Joint Surg Br 1989; 71:51–4PubMed
76.
Zurück zum Zitat Tinning CG, Cochrane LA, Singer BR. Primary total knee arthroplasty in patients with Parkinson’s disease: analysis of outcomes. Acta Orthop Belg 2013; 79:301–6PubMed Tinning CG, Cochrane LA, Singer BR. Primary total knee arthroplasty in patients with Parkinson’s disease: analysis of outcomes. Acta Orthop Belg 2013; 79:301–6PubMed
77.
Zurück zum Zitat Sato M, Sainoh T, Orita S, Yamauchi K, Aoki Y, Ishikawa T et al. Posterior and anterior spinal fusion for the management of deformities in patients with Parkinson’s disease. Case Reports in Othopedics 2013; Article ID140916, doi org10.1155/2013/140916 Sato M, Sainoh T, Orita S, Yamauchi K, Aoki Y, Ishikawa T et al. Posterior and anterior spinal fusion for the management of deformities in patients with Parkinson’s disease. Case Reports in Othopedics 2013; Article ID140916, doi org10.1155/2013/140916
78.
Zurück zum Zitat Koller H, Acosta F, Zenner J, Ferraris L, Hitzl W, Meier O et al. Spinal surgery in patients with Parkinson’s disease: experiences with the challenges posed by sagittal imbalance and the Parkinson’s spine. Eur Spine J 2010; 19:1785–94CrossRefPubMedPubMedCentral Koller H, Acosta F, Zenner J, Ferraris L, Hitzl W, Meier O et al. Spinal surgery in patients with Parkinson’s disease: experiences with the challenges posed by sagittal imbalance and the Parkinson’s spine. Eur Spine J 2010; 19:1785–94CrossRefPubMedPubMedCentral
79.
Zurück zum Zitat Siewe J, Zarghooni K, Röllinghof M, Herren C, Koy T, Eysel P, Sobottke R. Complication analysis of spinal interventions in adult central movement disorders and scoliosis. Z Orthop Unfall 2013; 151:454–62CrossRefPubMed Siewe J, Zarghooni K, Röllinghof M, Herren C, Koy T, Eysel P, Sobottke R. Complication analysis of spinal interventions in adult central movement disorders and scoliosis. Z Orthop Unfall 2013; 151:454–62CrossRefPubMed
80.
Zurück zum Zitat Moon SH, Lee HM, Chun HJ et al. Surgical outcome for lumbar fusion surgery in patients with Parkinson’s disease. J Spinal Disord Tech 2012; 25:351–5CrossRefPubMed Moon SH, Lee HM, Chun HJ et al. Surgical outcome for lumbar fusion surgery in patients with Parkinson’s disease. J Spinal Disord Tech 2012; 25:351–5CrossRefPubMed
81.
Zurück zum Zitat Sarkiss CA, Fogg GA, Skovrlj B, Cho SK, Caridi JM. To operate or not? A literature review of surgical outcomes in 95 patients with Parkinson’s disease undergoing spine surgery. Clin Neurol Neurosurg 2015; 134:122–5CrossRefPubMed Sarkiss CA, Fogg GA, Skovrlj B, Cho SK, Caridi JM. To operate or not? A literature review of surgical outcomes in 95 patients with Parkinson’s disease undergoing spine surgery. Clin Neurol Neurosurg 2015; 134:122–5CrossRefPubMed
Metadaten
Titel
Schmerzmanagement
Schmerz bei Patienten mit Morbus Parkinson — was sind die Ursachen?
verfasst von
PD Dr. med. Oliver Rommel
Publikationsdatum
29.01.2018
Verlag
Springer Medizin
Erschienen in
DNP – Die Neurologie & Psychiatrie / Ausgabe 1/2018
Print ISSN: 2731-8168
Elektronische ISSN: 2731-8176
DOI
https://doi.org/10.1007/s15202-018-1877-x

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