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19.12.2022 | CME

Patientenabgeleitete Tumororganoide – ein Therapiemodell für die Präzisionsonkologie

verfasst von: Linus R. Schömig, M.Sc., Prof. Dr. med. Michael Quante

Erschienen in: Die Onkologie | Ausgabe 1/2023

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Zusammenfassung

Organoide sind stammzellbasierte In-vitro-Zellkulturen, die sich nicht nur durch ihre 3‑dimensionale Struktur, sondern auch durch ihre Multizellularität und ein hohes Maß an Selbstorganisation auszeichnen. Aufgrund ihrer starken Ähnlichkeit zu den Primärgeweben, aus denen sie isoliert wurden, stellen Organoide ein geeignetes Therapiemodell für molekulare und funktionelle Analysen innerhalb der personalisierten Medizin dar. Gerade im Bereich der Präzisionsonkologie, wo patientenspezifische Therapiemodelle dringend benötigt werden, können Organoide das vorhandene Repertoire, bestehend aus 2‑dimensionalen Zellkulturen und Modellen patientenabgeleiteter Xenografts, bereichern.
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Metadaten
Titel
Patientenabgeleitete Tumororganoide – ein Therapiemodell für die Präzisionsonkologie
verfasst von
Linus R. Schömig, M.Sc.
Prof. Dr. med. Michael Quante
Publikationsdatum
19.12.2022
Verlag
Springer Medizin
Erschienen in
Die Onkologie / Ausgabe 1/2023
Print ISSN: 2731-7226
Elektronische ISSN: 2731-7234
DOI
https://doi.org/10.1007/s00761-022-01268-8

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