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28.05.2021 | Original Article

Photoacoustic detection of ammonia exhaled by individuals with chronic kidney disease

verfasst von: Liana Genuncio Silva, Sâmylla Cristina Espécie Bueno, Marcelo Gomes da Silva, Leonardo Mota, Marcelo Silva Sthel, Maria Priscila Pessanha de Castro, Raymundo Martins Santiago Neto, Valeska Mansur Kuba

Erschienen in: Lasers in Medical Science | Ausgabe 2/2022

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Abstract

Ammonia (NH₃) has been reported as a breath biomarker for chronic kidney disease (CKD) usually detected at concentrations greater than 0.25 parts per million by volume (ppmV). NH₃ was detected in breath of individuals with CKD through gaseous photoacoustic spectroscopy (PAS). The efficiency of hemodialysis (HD) was demonstrated. Eight volunteers aged between 20 and 60 years and without previous respiratory disease were eligible, among which six were control volunteers (CV) and two volunteers with advanced CKD, named CKDV1 and CKDV2. The presence of CKD was confirmed by the calculation of creatinine clearance (CC) according to the Cockcroft–Gault equation. Before HD, the mean NH₃ concentration exhaled by CKDV1 was 0.9 ± 0.1 ppmV and after HD was 0.20 ± 0.03 ppmV, which demonstrated an efficiency of 76% NH₃ reduction in breath. The CKDV2 exhaled 1.27 ± 0.03 ppmV of NH₃ pre-HD and 0.42 ± 0.08 ppmV post-HD, which resulted in efficiency of about 67%. It was not possible to quantify NH₃ from CV, what led us to infer that all of them exhaled amounts below the detection limit, i.e., 0.20 ppmV. This assumption is underpinned by CC, whose values hovered at 90 ≤ CC ≤ 120 mL/ min, confirming normal renal function.

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Titel: Photoacoustic detection of ammonia exhaled by individuals with chronic kidney disease
verfasst von: Liana Genuncio Silva
Sâmylla Cristina Espécie Bueno
Marcelo Gomes da Silva
Leonardo Mota
Marcelo Silva Sthel
Maria Priscila Pessanha de Castro
Raymundo Martins Santiago Neto
Valeska Mansur Kuba
Publikationsdatum: 28.05.2021
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 2/2022
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-021-03342-w

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Photoacoustic detection of ammonia exhaled by individuals with chronic kidney disease

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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