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04.11.2021 | Original Article

Photobiomodulation intervention improves oxidative, inflammatory, and morphological parameters of skeletal muscle in cirrhotic Wistar rats

verfasst von: Diogo Scalon, Jaqueline Nascimento Picada, Jayne Torres de Sousa, Ariane Tainá da Silva, Josieli Raskopf Colares, Norma Anair Possa Marroni

Erschienen in: Lasers in Medical Science | Ausgabe 3/2022

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Abstract

Photobiomodulation (PBM) might be an intervention method to mitigate sarcopenia in cirrhotic patients. Given the lack of research on this issue, the goal of this study was to evaluate possible beneficial effects of PBM on the structural and functional properties of skeletal muscle from cirrhotic rats. Cirrhosis was induced by secondary bile duct ligation (BDL). Wistar rats were randomized into four groups: sham-operated control (Sham), Sham + PBM, BDL, and BDL + PBM. After cirrhosis induction, a dose of PBM (1 J; 100mW; 10 s; 880 nm; 6 × per week) was applied to each quadriceps, from the 15th to the 45th day after surgery. The locomotor ability was performed using an open-field task. The muscle structure was analyzed using histological methods. Cell damage was also evaluated assessing oxidative stress and DNA damage markers, and IL-1β pro-inflammatory interleukin by immunohistochemical analysis. An increase in the number of crossings was observed in the BDL + PBM group in relation to BDL. The BDL group showed muscle atrophy and increased IL-1β in relation to Sham, while in the BDL + PBM group, the fiber muscle was restructured and there was a decrease of IL-1 β. TBARS increased in the liver and muscle tissues in the BDL group and decreased it in the BDL + PBM group. SOD increased while CAT decreased in the BDL + PBM group in relation to the BDL group. No genotoxic or mutagenic effect was observed for PBM treatment. PBM improved the locomotion and the morphology of the muscle fibers, decreasing oxidative stress and inflammation, without causing DNA damage in cirrhotic rats.

Sharma B, John S (2020) Hepatic cirrhosis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan

Moon AM, Singal AG, Tapper EB (2020) Contemporary epidemiology of chronic liver disease and cirrhosis. Clin Gastroenterol Hepatol 18(12):2650–2666. https://doi.org/10.1016/j.cgh.2019.07.060CrossRefPubMed

Sinclair M, Gow PJ, Grossmann M, Angus PW (2016) Review article: sarcopenia in cirrhosis–aetiology, implications and potential therapeutic interventions. Aliment Pharmacol Ther 43(7):765–777. https://doi.org/10.1111/apt.13549CrossRefPubMed

Ebadi M, Bhanji RA, Mazurak VC, Montano-Loza AJ (2019) Sarcopenia in cirrhosis: from pathogenesis to interventions. J Gastroenterol 54(10):845–859. https://doi.org/10.1007/s00535-019-01605-6CrossRefPubMedPubMedCentral

Duarte-Rojo A, Ruiz-Margáin A, Montaño-Loza AJ, Macías-Rodríguez RU, Ferrando A, Kim WR (2018) Exercise and physical activity for patients with end-stage liver disease: improving functional status and sarcopenia while on the transplant waiting list. Liver Transpl 24(1):122–139. https://doi.org/10.1002/lt.24958CrossRefPubMed

Wijarnpreecha K, Werlang M, Panjawatanan P, Kroner PT, Cheungpasitporn W, Lukens FJ, Pungpapong S, Ungprasert P (2020) Association between sarcopenia and hepatic encephalopathy: a systematic review and meta-analysis. Ann Hepatol 19(3):245–250. https://doi.org/10.1016/j.aohep.2019.06.007CrossRefPubMed

Tandon P, Ismond KP, Riess K, Duarte-Rojo A, Al-Judaibi B, Dunn MA, Holman J, Howes N, Haykowsky MJF, Josbeno DA, McNeely M (2018) Exercise in cirrhosis: translating evidence and experience to practice. J Hepatol 69(5):1164–1177. https://doi.org/10.1016/j.jhep.2018.06.017CrossRefPubMed

Leal Junior EC, Lopes-Martins RA, Baroni BM, De Marchi T, Taufer D, Manfro DS, Rech M, Danna V, Grosselli D, Generosi RA, Marcos RL, Ramos L, Bjordal JM (2009) Effect of 830 nm low-level laser therapy applied before high-intensity exercises on skeletal muscle recovery in athletes. Lasers Med Sci 24(6):857–863. https://doi.org/10.1007/s10103-008-0633-4CrossRefPubMed

Felismino AS, Costa EC, Aoki MS, Ferraresi C, de Araújo Moura Lemos TM, de Brito Vieira WH, (2014) Effect of low-level laser therapy (808 nm) on markers of muscle damage: a randomized double-blind placebo-controlled trial. Lasers Med Sci 29(3):933–938. https://doi.org/10.1007/s10103-013-1430-2CrossRefPubMed

10.

Vanin AA, Verhagen E, Barboza SD, Costa LOP, Leal-Junior ECP (2018) Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: a systematic review and meta-analysis. Lasers Med Sci 33(1):181–214. https://doi.org/10.1007/s10103-017-2368-6CrossRefPubMed

11.

Hamblin MR (2018) Mechanisms and mitochondrial redox signaling in photobiomodulation. Photochem Photobiol 94(2):199–212. https://doi.org/10.1111/php.12864CrossRefPubMedPubMedCentral

12.

Dos Santos SA, Serra AJ, Stancker TG, Simões MCB, Dos Santos Vieira MA, Leal-Junior EC, Prokic M, Vasconsuelo A, Santos SS, de Carvalho PTC (2017) Effects of photobiomodulation therapy on oxidative stress in muscle injury animal models: a systematic review. Oxid Med Cell Longev 2017:5273403. https://doi.org/10.1155/2017/5273403CrossRefPubMedPubMedCentral

13.

de Brito Vieira WH, Ferraresi C, Schwantes MLB, de Andrade Perez SE, Baldissera V, Cerqueira MS, Parizotto NA (2018) Photobiomodulation increases mitochondrial citrate synthase activity in rats submitted to aerobic training. Lasers Med Sci 33(4):803–810. https://doi.org/10.1007/s10103-017-2424-2CrossRefPubMed

14.

de Oliveira HA, Antonio EL, Silva FA, de Carvalho PTC, Feliciano R, Yoshizaki A, Vieira SS, de Melo BL, Leal-Junior ECP, Labat R, Bocalini DS, Silva Junior JA, Tucci PJF, Serra AJ (2018) Protective effects of photobiomodulation against resistance exercise-induced muscle damage and inflammation in rats. J Sports Sci 36(20):2349–2357. https://doi.org/10.1080/02640414.2018.1457419CrossRefPubMed

15.

Berzigotti A, Saran U, Dufour JF (2016) Physical activity and liver diseases. Hepatology 63(3):1026–1040. https://doi.org/10.1002/hep.28132CrossRefPubMed

16.

Colares JR, Schemitt EG, Hartmann RM, Licks F, Soares MD, Bosco AD, Marroni NP (2016) Antioxidant and anti-inflammatory action of melatonin in an experimental model of secondary biliary cirrhosis induced by bile duct ligation. World J Gastroenterol 22(40):8918–8928. https://doi.org/10.3748/wjg.v22.i40.8918CrossRefPubMedPubMedCentral

17.

Leal Junior EC, Lopes-Martins RA, de Almeida P, Ramos L, Iversen VV, Bjordal JM (2010) Effect of low-level laser therapy (GaAs 904 nm) in skeletal muscle fatigue and biochemical markers of muscle damage in rats. Eur J Appl Physiol 108(6):1083–1088. https://doi.org/10.1007/s00421-009-1321-1CrossRefPubMed

18.

Vatansever F, Rodrigues NC, Assis LL, Peviani SS, Durigan JL, Moreira FM, Hamblin MR, Parizotto NA (2012) Low intensity laser therapy accelerates muscle regeneration in aged rats. Photonics Lasers Med 1(4):287–297. https://doi.org/10.1515/plm-2012-0035CrossRefPubMedPubMedCentral

19.

Picada JN, Schröder N, Izquierdo I, Henriques JA, Roesler R (2002) Differential neurobehavioral deficits induced by apomorphine and its oxidation product, 8-oxo-apomorphine-semiquinone, in rats. Eur J Pharmacol 443(1–3):105–111. https://doi.org/10.1016/s0014-2999(02)01553-4CrossRefPubMed

20.

Giusto M, Barberi L, Di Sario F, Rizzuto E, Nicoletti C, Ascenzi F, Renzi A, Caporaso N, D’Argenio G, Gaudio E, Musarò A, Merli M (2017) Skeletal muscle myopenia in mice model of bile duct ligation and carbon tetrachloride-induced liver cirrhosis. Physiol Rep 5(7):e13153. https://doi.org/10.14814/phy2.13153.

21.

Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254. https://doi.org/10.1006/abio.1976.9999CrossRef

22.

Buege JA, Aust SD (1978) Microsomal lipid peroxidation. Methods Enzymol 52:302–310. https://doi.org/10.1016/s0076-6879(78)52032-6CrossRefPubMed

23.

Misra HP, Fridovich I (1972) The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247(10):3170–3175CrossRef

24.

Boveris A, Chance B (1973) The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 134(3):707–716. https://doi.org/10.1042/bj1340707.

25.

Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC, Sasaki YF (2000) Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35(3):206–221. https://doi.org/10.1002/(sici)1098-2280(2000)35:3%3c206::aid-em8%3e3.0.co;2-jCrossRefPubMed

26.

Vercelino R, Tieppo J, Dias AS, Marroni CA, Garcia E, Meurer L, Picada JN, Marroni NP (2008) N-acetylcysteine effects on genotoxic and oxidative stress parameters in cirrhotic rats with hepatopulmonary syndrome. Basic Clin Pharmacol Toxicol 102(4):370–376. https://doi.org/10.1111/j.1742-7843.2007.00181.xCrossRefPubMed

27.

Mavournin KH, Blakey DH, Cimino MC, Salamone MF, Heddle JA (1990) The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res 239(1):29–80. https://doi.org/10.1016/0165-1110(90)90030-f.

28.

Tieppo J, Vercelino R, Dias AS, Silva Vaz MF, Silveira TR, Marroni CA, Marroni NP, Henriques JA, Picada JN (2007) Evaluation of the protective effects of quercetin in the hepatopulmonary syndrome. Food Chem Toxicol 45(7):1140–1146. https://doi.org/10.1016/j.fct.2006.12.020CrossRefPubMed

29.

Bosoi CR, Oliveira MM, Ochoa-Sanchez R, Tremblay M, Ten Have GA, Deutz NE, Rose CF, Bemeur C (2017) The bile duct ligated rat: a relevant model to study muscle mass loss in cirrhosis. Metab Brain Dis 32(2):513–518. https://doi.org/10.1007/s11011-016-9937-4CrossRefPubMed

30.

de Brito A, Alves AN, Ribeiro BG, Barbosa DVDE, Magalhaes EMR, Fernandes KPS, Bussadori SK, Goulardins JB, Mesquita-Ferrari RA (2018) Effect of photobiomodulation on connective tissue remodeling and regeneration of skeletal muscle in elderly rats. Lasers Med Sci 33(3):513–521. https://doi.org/10.1007/s10103-017-2392-6CrossRefPubMed

31.

Garcia TA, Camargo RCT, Koike TE, Ozaki GAT, Castoldi RC, Camargo Filho JCS (2017) Histological analysis of the association of low level laser therapy and platelet-rich plasma in regeneration of muscle injury in rats. Braz J Phys Ther 21(6):425–433. https://doi.org/10.1016/j.bjpt.2017.06.007CrossRefPubMedPubMedCentral

32.

Silva AA, Leal-Junior EC, D’Avila Kde A, Serra AJ, Albertini R, França CM, Nishida JA, de Carvalho PT (2015) Pre-exercise low-level laser therapy improves performance and levels of oxidative stress markers in mdx mice subjected to muscle fatigue by high-intensity exercise. Lasers Med Sci 30(6):1719–1727. https://doi.org/10.1007/s10103-015-1777-7CrossRefPubMed

33.

Capalonga L, Karsten M, Hentschke VS, Rossato DD, Dornelles MP, Sonza A, Bagnato VS, Ferraresi C, Parizotto NA, Dal Lago P (2016) Light-emitting diode therapy (LEDT) improves functional capacity in rats with heart failure. Lasers Med Sci 31(5):937–944. https://doi.org/10.1007/s10103-016-1922-yCrossRefPubMed

34.

Guaraldo SA, Serra AJ, Amadio EM, Antônio EL, Silva F, Portes LA, Tucci PJ, Leal-Junior EC, de Carvalho PT (2016) The effect of low-level laser therapy on oxidative stress and functional fitness in aged rats subjected to swimming: an aerobic exercise. Lasers Med Sci 31(5):833–840. https://doi.org/10.1007/s10103-016-1882-2CrossRefPubMed

35.

Assis L, Moretti AI, Abrahão TB, Cury V, Souza HP, Hamblin MR, Parizotto NA (2012) Low-level laser therapy (808 nm) reduces inflammatory response and oxidative stress in rat tibialis anterior muscle after cryolesion. Lasers Surg Med 44(9):726–735. https://doi.org/10.1002/lsm.22077CrossRefPubMedPubMedCentral

36.

Fernandes KP, Alves AN, Nunes FD, Souza NH, Silva JA Jr, Bussadori SK, Ferrari RA (2013) Effect of photobiomodulation on expression of IL-1β in skeletal muscle following acute injury. Lasers Med Sci 28(3):1043–1046. https://doi.org/10.1007/s10103-012-1233-xCrossRefPubMed

37.

Rizzi CF, Mauriz JL, Freitas Corrêa DS, Moreira AJ, Zettler CG, Filippin LI, Marroni NP, González-Gallego J (2006) Effects of low-level laser therapy (LLLT) on the nuclear factor (NF)-kappaB signaling pathway in traumatized muscle. Lasers Surg Med 38(7):704–713. https://doi.org/10.1002/lsm.20371CrossRefPubMed

38.

Tieppo J, Cuevas MJ, Vercelino R, Tuñón MJ, Marroni NP, González-Gallego J (2009) Quercetin administration ameliorates pulmonary complications of cirrhosis in rats. J Nutr 139(7):1339–1346. https://doi.org/10.3945/jn.109.105353CrossRefPubMed

39.

Vieira EK, Bona S, Di Naso FC, Porawski M, Tieppo J, Marroni NP (2011) Quercetin treatment ameliorates systemic oxidative stress in cirrhotic rats. ISRN Gastroenterol 2011:604071. https://doi.org/10.5402/2011/604071CrossRefPubMedPubMedCentral

40.

Fillipin LI, Mauriz JL, Vedovelli K, Moreira AJ, Zettler CG, Lech O, Marroni NP, González-Gallego J (2005) Low-level laser therapy (LLLT) prevents oxidative stress and reduces fibrosis in rat traumatized Achilles tendon. Lasers Surg Med 37(4):293–300. https://doi.org/10.1002/lsm.20225CrossRefPubMed

41.

Mussttaf RA, Jenkins DFL, Jha AN (2019) Assessing the impact of low level laser therapy (LLLT) on biological systems: a review. Int J Radiat Biol 95(2):120–143. https://doi.org/10.1080/09553002.2019.1524944CrossRefPubMed

42.

Biasibetti M, Rojas DB, Hentschke VS, Moura DJ, Karsten M, Wannmacher CM, Saffi J, Dal Lago P (2014) The influence of low-level laser therapy on parameters of oxidative stress and DNA damage on muscle and plasma in rats with heart failure. Lasers Med Sci 29(6):1895–1906. https://doi.org/10.1007/s10103-014-1597-1CrossRefPubMed

43.

Sergio LP, Silva AP, Amorim PF, Campos VM, Magalhães LA, de Paoli F, de Souza da Fonseca A (2015) DNA damage in blood cells exposed to low-level lasers. Lasers Surg Med 47(4):361-368. https://doi.org/10.1002/lsm.22344.

44.

Furlanetto MP, Grivicich I, Dihl RR, Lehmann M, de Souza DS, Plentz RDM (2018) In vivo analysis of photobiomodulation genotoxicity using the somatic mutation and recombination test. Photomed Laser Surg 36(10):536–540. https://doi.org/10.1089/pho.2018.4468CrossRefPubMed

Titel: Photobiomodulation intervention improves oxidative, inflammatory, and morphological parameters of skeletal muscle in cirrhotic Wistar rats
verfasst von: Diogo Scalon
Jaqueline Nascimento Picada
Jayne Torres de Sousa
Ariane Tainá da Silva
Josieli Raskopf Colares
Norma Anair Possa Marroni
Publikationsdatum: 04.11.2021
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 3/2022
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-021-03458-z

Springer Medizin

Abstract

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