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Erschienen in: Oral Cancer 3-4/2019

08.11.2019 | Original Article

Pilot study: protective effect on mucosal tissue using dental waterjet and dexpanthenol rinsing solution during radiotherapy in head and neck tumor patients

verfasst von: Timo Wilhelm-Buchstab, Christopher Thelen, Frederik Amecke-Mönnighoff, Leonard Christopher Schmeel, Birgit Simon, Thomas Müdder, Felix Schoroth, Stephan Garbe, Fred Röhner, Susanne Vornholt, Andreas Schröck, Hans H. Schild, Heinrich Schüller, Christina Leitzen

Erschienen in: Oral Cancer | Ausgabe 3-4/2019

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Abstract

Purpose

Radiogenic side effects are frequently seen in patients undergoing radiotherapy for head and neck tumors. Intensified dental and mucosal care reduce oral hygienic deficits. The aim of this study was the optimization of mouth hygiene using dexpanthenol rinsing solution applied with a dental waterjet system (DWS).

Methods

30 consecutive head and neck tumor patients (44–75 years) were analyzed, who received intensity-modulated radiation treatment (IMRT; total dose range: 54–66 Gy) with helical Tomotherapy HiArt II. The group under investigation (n = 10) additionally received a professional DWS using dexpanthenol mouthrinse (Bepanthen). The first control group received dexpanthenol mouthrinse alone. The second control group only performed the standardized mouth hygiene protocol. Grade of xerostomia, taste, dysphagia, thrush, and mucositis was evaluated on a daily basis.

Results

29 of 30 patients completed radiation therapy. Change in taste occurred in all patients in all groups, however, with a delay in the study group. The occurrence of grade III stomatitis and Xerostomia grade II was significantly reduced in the study arm. No patient suffered from grade III xerostomia in the study arm versus four patients in the control groups. Dysphagia grade II was observed significantly less frequent in the study group (p = 0.0004). Thrush occurrence showed a delay in the study group.

Conclusions

Our study underlines the importance of an intensified mouth hygiene during radiation therapy. The combination of dexpanthenol rinsing solution + DWS reduces the incidence of high-grade early side effects which often lead to a reduced quality of life and abortion of the treatment.
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Metadaten
Titel
Pilot study: protective effect on mucosal tissue using dental waterjet and dexpanthenol rinsing solution during radiotherapy in head and neck tumor patients
verfasst von
Timo Wilhelm-Buchstab
Christopher Thelen
Frederik Amecke-Mönnighoff
Leonard Christopher Schmeel
Birgit Simon
Thomas Müdder
Felix Schoroth
Stephan Garbe
Fred Röhner
Susanne Vornholt
Andreas Schröck
Hans H. Schild
Heinrich Schüller
Christina Leitzen
Publikationsdatum
08.11.2019
Verlag
Springer International Publishing
Erschienen in
Oral Cancer / Ausgabe 3-4/2019
Elektronische ISSN: 2509-8837
DOI
https://doi.org/10.1007/s41548-019-00022-w

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